-
公开(公告)号：US20170212044A1
公开(公告)日：2017-07-27
申请号：US15478982
申请日：2017-04-04
Inventor： Kevin Lear , Timothy Erickson
CPC classification number: G01N21/4133 , G01M11/33 , G01N33/1833 , G01N2021/4166 , G01N2201/0873 , G02B6/028 , G02B6/12004 , G02B6/1221 , G02B6/4291 , G02B27/56 , G02B2006/12123 , G02B2006/12138 , Y02A20/206
Abstract: A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation, BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.
-
公开(公告)号：US20170176335A1
公开(公告)日：2017-06-22
申请号：US15451305
申请日：2017-03-06
Applicant: Pacific Biosciences of California, Inc.
Inventor： Annette GROT , Ravi SAXENA , Paul LUNDQUIST
IPC: G01N21/64 , H01L27/146 , G02B6/136 , G01N21/77 , G02B6/132
CPC classification number: G01N21/6454 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N21/78 , G01N2021/6439 , G01N2021/6478 , G01N2021/7756 , G01N2021/7786 , G01N2201/068 , G01N2201/0873 , G02B5/1895 , G02B5/201 , G02B5/285 , G02B6/132 , G02B6/136 , G02B27/4238 , G02B27/4244 , G02B2006/12102 , G02B2006/12109 , H01L27/14621 , H01L27/14627 , H01L27/14685
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
-
公开(公告)号：US09606068B2
公开(公告)日：2017-03-28
申请号：US14836629
申请日：2015-08-26
Applicant: Pacific Biosciences of California, Inc.
Inventor： Annette Grot , Ravi Saxena , Paul Lundquist
CPC classification number: G01N21/6454 , G01N21/6428 , G01N21/648 , G01N21/7703 , G01N21/78 , G01N2021/6439 , G01N2021/6478 , G01N2021/7756 , G01N2021/7786 , G01N2201/068 , G01N2201/0873 , G02B5/1895 , G02B5/201 , G02B5/285 , G02B6/132 , G02B6/136 , G02B27/4238 , G02B27/4244 , G02B2006/12102 , G02B2006/12109 , H01L27/14621 , H01L27/14627 , H01L27/14685
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.
-
公开(公告)号：US20160334334A1
公开(公告)日：2016-11-17
申请号：US15158756
申请日：2016-05-19
Applicant: Pacific Biosciences of California, Inc.
Inventor： Ravi SAXENA , Michael Tzu RU , Takashi Whitney ORIMOTO , Annette GROT , Mathieu FOQUET , Hou-Pu CHOU
CPC classification number: G02B6/12004 , B29D11/0073 , B29D17/007 , B29L2011/005 , B29L2011/0066 , B29L2011/0075 , C12Q1/6869 , G01N21/6454 , G01N21/648 , G01N2021/6478 , G01N2201/0873 , G02B5/189 , G02B6/02123 , G02B6/124 , G02B6/136 , G02B2006/12038 , G02B2006/12109
Abstract: Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The integrated devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The arrays and methods of the invention make use of silicon chip fabrication and manufacturing techniques developed for the electronics industry and highly suited for miniaturization and high throughput.
Abstract translation: 提供了集成分析设备阵列及其生产方法。 阵列可用于高密度高分复用的光学反应，包括生化反应，如核酸测序反应。 集成器件允许使用诸如光谱，幅度和时间分辨率之类的特征或其组合来对光信号进行高灵敏度鉴别。 本发明的阵列和方法利用为电子工业开发的硅芯片制造和制造技术，并且非常适合于小型化和高吞吐量。
-
115.发明授权公开(公告)号：US09176051B2
公开(公告)日：2015-11-03
申请号：US14129554
申请日：2012-06-23
Applicant: Timo Mappes , Heinz Kalt , Tobias Grossmann , Torsten Beck , Tobias Wienhold , Marko Brammer
Inventor： Timo Mappes , Heinz Kalt , Tobias Grossmann , Torsten Beck , Tobias Wienhold , Marko Brammer
CPC classification number: G01N21/27 , G01N2021/7789 , G01N2201/0873 , G02B5/10 , G02B26/00 , H01S3/08059
Abstract: A micro-optical element includes a resonator substrate, at least one microresonator includes a rotationally symmetrical body mounted on the resonator substrate, and a light-reflecting element including a ring-shaped mirror that surrounds the rotationally symmetrical body.
Abstract translation: 微型光学元件包括谐振器基板，至少一个微谐振器包括安装在谐振器基板上的旋转对称的主体，以及包括围绕旋转对称体的环形反射镜的光反射元件。
-
Patent Agency Ranking
116.发明申请公开(公告)号：US20140226160A1
公开(公告)日：2014-08-14
申请号：US14129554
申请日：2012-06-23
Applicant: Timo Mappes , Heinz Kalt , Tobias Grossmann , Torsten Beck , Tobias Wienhold , Marko Brammer
Inventor： Timo Mappes , Heinz Kalt , Tobias Grossmann , Torsten Beck , Tobias Wienhold , Marko Brammer
CPC classification number: G01N21/27 , G01N2021/7789 , G01N2201/0873 , G02B5/10 , G02B26/00 , H01S3/08059
Abstract: A micro-optical element includes a resonator substrate, at least one microresonator includes a rotationally symmetrical body mounted on the resonator substrate, and a light-reflecting element including a ring-shaped mirror that surrounds the rotationally symmetrical body.
Abstract translation: 微型光学元件包括谐振器基板，至少一个微谐振器包括安装在谐振器基板上的旋转对称的主体，以及包括围绕旋转对称的主体的环形反射镜的光反射元件。
-
公开(公告)号：US20060164635A1
公开(公告)日：2006-07-27
申请号：US11044421
申请日：2005-01-27
Applicant: M. Saif Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Stanley Williams
Inventor： M. Saif Islam , Shih-Yuan Wang , Wei Wu , Zhiyong Li , R. Stanley Williams
CPC classification number: G01N21/658 , G01N2201/0873
Abstract: Devices, systems, and methods for enhancing Raman spectroscopy and hyper-Raman are disclosed. A molecular analysis device for performing Raman spectroscopy comprises a substrate and a laser source disposed on the substrate. The laser source may be configured for emanating a laser radiation, which may irradiate an analyte disposed on a Raman enhancement structure. The Raman enhancement structure may be disposed in a waveguide. The molecular analysis device also includes a wavelength demultiplexer and radiation sensors disposed on the substrate and configured for receiving a Raman scattered radiation, which may be generated by the irradiation of the analyte and Raman enhancement structure.
-
公开(公告)号：US20050017178A1
公开(公告)日：2005-01-27
申请号：US10788275
申请日：2004-03-01
Applicant: Taro Ogawa , Toshiki Sugawara , Kazuhiko Hosomi , Masataka Shirai , Toshio Katsuyama , Kaoru Umemura , Masaru Izawa , Kazuhiko Sagara , Hiroshi Kakibayashi
Inventor： Taro Ogawa , Toshiki Sugawara , Kazuhiko Hosomi , Masataka Shirai , Toshio Katsuyama , Kaoru Umemura , Masaru Izawa , Kazuhiko Sagara , Hiroshi Kakibayashi
IPC: G01J3/14 , B01J19/00 , B01L3/00 , G01J3/42 , G01N21/05 , G01N21/31 , G01N21/35 , G01N21/3577 , G01N37/00
CPC classification number: G01N21/31 , B01L3/502715 , B01L2200/027 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , G01N21/05 , G01N2021/0346 , G01N2021/058 , G01N2201/0873
Abstract: A micro-spectroscopic measuring device having a structure in which a spectroscopic element made of an array of photonic crystals with defects, flow paths for introducing a sample, and light detecting elements with sensitivity to a band from near infrared to infrared are stacked.
Abstract translation: 具有这样的结构的微分光学测量装置被堆叠，其中由具有缺陷的光子晶体阵列制成的分光元件，用于引入样品的流动路径和对从近红外线到红外线的频带具有灵敏度的光检测元件。
-
公开(公告)号：US5663790A
公开(公告)日：1997-09-02
申请号：US532546
申请日：1995-10-06
Applicant: Bjorn Ekstrom , Magnus Oberg
Inventor： Bjorn Ekstrom , Magnus Oberg
CPC classification number: G01N21/7746 , G01N21/41 , G01N2201/0873
Abstract: In a method of determining the refractive index of a gaseous, liquid or solid sample, preferably a gaseous or liquid sample, there is used a waveguide resonator (1) which includes an open waveguide (4) and a closed waveguide (5) located adjacent the open waveguide. The sample is brought to the vicinity of the closed waveguide (5) so as to influence the proximal surroundings of the waveguide and therewith its effective refractive index. Light derived from a light source (9) is coupled to one end of the open waveguide (4) and transmitted light is measured at the other end of the open waveguide to establish the influence of the sample on the resonance wavelength and therewith determine the refractive index of the sample or a sample-related refractive index difference. A device for carrying out the method includes a waveguide resonator having a sample contact area (12) adjacent the closed waveguide (5) of the waveguide resonator.
Abstract translation: PCT No.PCT / SE94 / 00312 Sec。 371日期1995年10月6日 102（e）日期1995年10月6日PCT 1994年4月8日PCT PCT。 第WO94 / 24542号公报 日期1994年10月27日在确定气体，液体或固体样品（优选气体或液体样品）的折射率的方法中，使用波导谐振器（1），其包括开放波导（4）和闭合波导 （5）位于开放波导附近。 将样品带到封闭波导（5）附近，以便影响波导的近端周边以及其有效折射率。 源自光源（9）的光耦合到开放波导（4）的一端，并且在开放波导的另一端测量透射光，以确定样品对共振波长的影响，从而确定折射率 样品指数或样品相关折射率差异。 用于执行该方法的装置包括具有与波导谐振器的闭合波导（5）相邻的样本接触区域（12）的波导谐振器。
-
公开(公告)号：US5377008A
公开(公告)日：1994-12-27
申请号：US862494
申请日：1992-04-02
Applicant: Richard W. Ridgway , Anthony A. Boiarski , Van E. Wood , James R. Busch
Inventor： Richard W. Ridgway , Anthony A. Boiarski , Van E. Wood , James R. Busch
CPC classification number: G01N21/7703 , G01N21/45 , G01N33/54373 , G02B6/122 , G01J2009/023 , G01N2021/1751 , G01N21/648 , G01N2201/0245 , G01N2201/0873 , G02B2006/12097 , G02B2006/12138 , G02B2006/12159
Abstract: An apparatus useful in immunoassay of a fluid, light is directed to an optical sensor wherein the light is transmitted to a replaceable optical device that is responsive to index of refraction in a sensing region thereof that is exposed to the fluid. One portion of the light is transmitted via a compensation path that includes the sensing region to a first detector. Another portion of the light is transmitted via a sensing path that includes the sensing region to another detector. In one embodiment a ratioing device receives an output from each detector and provides a signal responsive to the ratio of the outputs. The replaceable optical device typically comprises a pair of channel waveguides in directional coupling arrangement, or a pair of channel waveguides in an interferometer arrangement, or a ridge waveguide having a curved or serpentine path configured so that nonspecific sensing effects are compensated.
Abstract translation: 一种用于对流体进行免疫测定的装置，光被引导到光学传感器，其中光被传送到可在其暴露于流体的感测区域中的折射率的可更换光学装置。 光的一部分经由包括感测区域的补偿路径传送到第一检测器。 光的另一部分经由包括感测区域的感测路径传输到另一个检测器。 在一个实施例中，比例设备接收每个检测器的输出，并且响应于输出的比率提供信号。 可替换的光学器件通常包括一对定向耦合布置中的一个通道波导，或一个干涉仪布置中的一对通道波导，或者具有曲线或蛇形路径的脊波导，其配置为使得非特定的感测效果得到补偿。
-
-
-
-
-
-
-
-
-
Search Results
155
records
(took 0.033 seconds)
