公开(公告)号：WO1995005120A1

公开(公告)日：1995-02-23

申请号：PCT/JP1993001140

申请日：1993-08-12

Applicant: KURASHIKI BOSEKI KABUSHIKI KAISHA ,  KOASHI, Katsue ,  MINAMI, Shigeo

Inventor： KURASHIKI BOSEKI KABUSHIKI KAISHA

IPC: A61B05/14

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/7239 ,  G01N21/39 ,  G01N2201/065

Abstract: A laser beam, the wavelength of which is modulated periodically, emitted from a variable-wavelength semiconductor laser (11) is intensity-modulated periodically by an attenuator (12). This laser beam is separated into optical paths (13a, 13b) by a beam splitter (14) and applied via the optical path (13a) to a portion (17) at which a blood sugar level is to be measured. The intensity of the transmitting light through or reflected light of the object portion (17) and that of a laser beam in the optical path (13b) are detected by first and second detectors (21, 22) respectively, and a ratio of one of the intensities to the other is detected by a logarithmic ratio amplifier (25). A variation ratio of this ratio to a variation of a wavelength modulating wavelength is detected by a lock-in amplifier (26), and a differential spectrum signal of the absorption spectrum of glucose at the object portion is taken out from this variation rate. An arithmetic processing unit (27) is adapted to detect a blood sugar level of the object portion on the basis of this differential spectrum signal.

Abstract translation: 从可变波长半导体激光器（11）发射的其周期性调制的激光束被衰减器（12）周期性强度调制。 该激光束被分束器（14）分离成光路（13a，13b），并通过光路（13a）施加到要测量血糖水平的部分（17）。 通过第一和第二检测器（21,22）分别检测物体部分（17）的透射光或反射光的强度以及光路（13b）中的激光束的强度， 另一个的强度由对数比放大器（25）检测。 通过锁定放大器（26）检测该比率与波长调制波长的变化的变化比，并且从该变化率中取出对象部分的葡萄糖的吸收光谱的差分光谱信号。 算术处理单元（27）适于基于该差分频谱信号来检测对象部分的血糖值。

公开(公告)号：WO1994013203A1

公开(公告)日：1994-06-23

申请号：PCT/DK1993000416

申请日：1993-12-10

Applicant: NOVO NORDISK A/S ,  HANSEN, Henrik, Egesborg ,  EGE, Henrik ,  PLUM, Thomas, Munk

Inventor： NOVO NORDISK A/S

IPC: A61B05/14

CPC classification number: A61B5/1486 ,  A61B5/14532 ,  A61B5/6848

Abstract: A method for in vivo determination of the concentration in a body fluid of metabolically significant substances comprises storing of a needle with a sensor in a liquid-filled ampoule, brief insertion of the needle into a patient, recording of the output signal from the sensor, withdrawal of the needle, and calculation of the concentration looked for on the basis of the recorded signals. The method is preformed using an apparatus comprising a needle (5) with a sensor (6), an ampoule (1) containing a solution (2) and closed by two membranes (3, 4). The needle (5) is stored with its sensor (6) in the solution. The apparatus further comprises a mechanical unit for driving the needle (5) to protrude from the ampoule for a set moment, and an electronic unit storing the output signal from the sensor (6) and performing calculations on the basis of the stored signal values. The needle with its sensor (6) and the ampoule with the solution (2) are independent disposable parts mounted in a durable part containing the mechanical and electronic parts.

Abstract translation: 用于体内测定代谢物质体液中浓度的方法包括将针头与传感器一起储存在充满液体的安瓿中，将针短暂插入患者体内，记录来自传感器的输出信号， 取出针头，并根据记录的信号计算浓度。 该方法使用包括具有传感器（6）的针（5），含有溶液（2）并由两个膜（3,4）封闭的安瓿（1））的装置来进行。 针（5）与其传感器（6）一起存储在溶液中。 该装置还包括用于驱动针（5）以从安瓿突出一定时间的机械单元和存储来自传感器（6）的输出信号的电子单元，并且基于存储的信号值执行计算。 带有传感器（6）的针头和带有溶液（2）的安瓿是独立的一次性部件，安装在包含机械和电子部件的耐用部件中。

公开(公告)号：WO1993000044A1

公开(公告)日：1993-01-07

申请号：PCT/DK1992000192

申请日：1992-06-19

Applicant: NOVO NORDISK A/S ,  KELDMANN, Troels ,  KLITGAARD, Peter

Inventor： NOVO NORDISK A/S

IPC: A61B05/14

CPC classification number: A61B5/15142 ,  A61B5/150022 ,  A61B5/150343 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/150633

Abstract: A blood sampler comprises a cup shaped positioning part having a bottom (1) and a sidewall (2) and a sampling part having a bottom (4) and a sidewall (5). In the bottom (1) of the positioning part there is provided a central opening (9), which at the outer side of the cup is surrounded by a spacing ring (3). The sampling part has a needle (8) centrally through is bottom (4), which needle has at the outside of the sampling part a sharp end and inside the sampling part a sample collector (10). The sampling part fit displaceably into the positioning part with the sharp end of its needle (8) facing the opening (9) in the bottom (1) of this positioning part, but is by a snap lock (6, 7) releasably locked in a position with its bottom (4) near the upper edge of the positioning part. A cup shaped transparent cap (11) fits with its open end into the open end of the sampling part. In use the spacing ring (8) is pressed against the skin (12) by a finger (13) pressing the cap (11) until the snap lock (6, 7) releases and the sampling part passes into the positioning part with its needle (8) projecting through the opening (9) in the bottom (1) of this positioning part into the skin (12).

Abstract translation: 血液取样器包括具有底部（1）和侧壁（2）的杯形定位部件和具有底部（4）和侧壁（5）的取样部分。 在定位部分的底部（1）中设置有中心开口（9），其在杯的外侧被间隔环（3）围绕。 采样部分具有中心穿过的针（8），底部（4），该针在采样部分的外侧具有尖端，并且在采样部分内部具有采样收集器（10）。 采样部分可移位地配合到定位部分中，其针（8）的尖端与该定位部分的底部（1）中的开口（9）相对，但是通过可释放地锁定在其中的卡扣锁（6,7） 在底部（4）靠近定位部件的上边缘的位置。 杯形透明盖（11）与其开口端配合到采样部分的开口端。 在使用中，间隔环（8）通过按压盖（11）的手指（13）压靠皮肤（12），直到卡扣锁（6,7）释放，并且取样部分以其针头进入定位部件 （8）通过该定位部件的底部（1）中的开口（9）突出到皮肤（12）中。

公开(公告)号：WO1993000043A1

公开(公告)日：1993-01-07

申请号：PCT/DK1992000191

申请日：1992-06-19

Applicant: NOVO NORDISK A/S ,  KELDMANN, Troels ,  KLITGAARD, Peter

Inventor： NOVO NORDISK A/S

IPC: A61B05/14

CPC classification number: A61B5/157 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150259 ,  A61B5/150343 ,  A61B5/150412 ,  A61B5/15194

Abstract: A blood sampler comprises a small chamber (5) having a stiletto (7) mounted air-tightly through a flexible top wall (4) with a pointed end of the stiletto (7) positioned inside the chamber opposite an opening (3) in a bottom part (1) of the chamber (5). The sampler is designed to be mounted in a tool which compresses the chamber by pressing the flexible top wall against the bottom of the chamber. Further, the tool has means for imparting an impact on a blunt outer end of the stiletto (7) to drive this stiletto further through the top wall to make its sharp end protrude through the opening (3) in the bottom part (1) into the skin to which the sampler may be attached by an adhesive (10). When the sampler is ejected from the tool it regains its original shape providing in the chamber (5) a vacuum sucking blood from the perforated skin into this chamber.

Abstract translation: 血液取样器包括一个小室（5），其具有气密地穿过柔性顶壁（4）安装的高度（7），其中高跟部（7）的尖端位于室内与开口（3）相对的位置 腔室（5）的底部（1）。 采样器被设计成安装在工具中，该工具通过将柔性顶壁压靠在室的底部来压缩室。 此外，该工具具有用于对短筒（7）的钝的外端施加冲击以将该细长度进一步驱动穿过顶壁以使其尖端突出穿过底部（1）中的开口（3）的装置进入 采样器可以通过粘合剂（10）附着到其上的皮肤。 当取样器从工具中排出时，其恢复其在腔室（5）中提供的原始形状，从真空吸入从穿孔皮肤进入该腔室的血液。

公开(公告)号：WO1992016144A1

公开(公告)日：1992-10-01

申请号：PCT/AU1992000105

申请日：1992-03-10

Applicant: GOLDSPILL PTY. LTD. ,  ROBB, Darryl, Gordon

Inventor： GOLDSPILL PTY. LTD.

IPC: A61B05/14

CPC classification number: A61B5/153 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150259 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150473

Abstract: A device (1) for extracting body fluid in which depression of a plunger (4) into a tubular body (2) during a preparatory stroke creates a pressure reduction in a first chamber (12). After the preparatory stroke, the pressure reduction in the first chamber (12) exerts a force on a piston (3) to cause it to move and thereby to draw body fluid into a second chamber (15). The rate of extraction of the body fluid is governed by a frictional force on the plunger (4) which can be controlled by a cam arrangement (5).

Abstract translation: 一种用于提取体液的装置（1），其中在预备冲程期间将柱塞（4）压入管状体（2）中的体液在第一腔室（12）中产生压力降低。 在准备冲程之后，第一腔室（12）中的压力降低在活塞（3）上施加力以使其移动，从而将体液吸入第二腔室（15）。 体液的抽出速度由可由凸轮装置（5）控制的柱塞（4）上的摩擦力决定。

公开(公告)号：WO1991018551A1

公开(公告)日：1991-12-12

申请号：PCT/AT1991000066

申请日：1991-05-21

Applicant: AVL MEDICAL INSTRUMENTS AG ,  SKRABAL, Falko ,  KLEINHAPPL, Erich ,  LIST, Helmut

Inventor： AVL MEDICAL INSTRUMENTS AG

IPC: A61B05/14

CPC classification number: A61B5/155 ,  A61B5/15003 ,  A61B5/150229 ,  G01N35/025 ,  G01N35/1079 ,  G01N2035/00445

Abstract: A device for withdrawing body fluids with a withdrawal device (1) connected to a hollow needle (6) has a storage system (3) with a plurality of separate sample containers (4) arranged on a mobile holder. The containers are hermetically sealed with a membrane (5) which can be punctured and receive collected fractions of the body fluid at given time-intervals. A device (7) connected to a control device (2) can be positioned above each of the sample containers (4) in succession and can be introduced into the sample container through the membrane (5). The withdrawal device (1) is designed as a double-lumen cannula (18), one lumen (19) being connected through a first connecting line (25) to the hollow needle (6), which can be introduced into the sample containers (4), and the other lumen (20) being connected through a second connecting line (26) to a pump (8'; 21) which can be actuated by the control device (2). The individual unfilled sample containers (4) contain a quantity of gas or mixture of gases whose volume under atmospheric pressure is less than the volume of the body fluid to be withdrawn.

Abstract translation: 一种用连接到中空针（6）的取出装置（1）取出体液的装置具有一个具有多个分开的样本容器（4）的存储系统（3），该样本容器布置在移动支架上。 容器用膜（5）气密密封，膜（5）可以以给定的时间间隔穿刺并接收体液的收集部分。 连接到控制装置（2）的装置（7）可以连续地定位在每个样本容器（4）上方，并且可以通过膜（5）被引入到样本容器中。 抽出装置（1）被设计为双腔插管（18），一个管腔（19）通过第一连接管线（25）连接到中空针头（6），其可以被引入样品容器 4），另一个管腔（20）通过第二连接管线（26）连接到可由控制装置（2）致动的泵（8'; 21）。 单个未填充的样品容器（4）含有一定量的气体或气体混合物，其体积在大气压下小于要抽出的体液的体积。

公开(公告)号：WO1988006427A1

公开(公告)日：1988-09-07

申请号：PCT/NO1988000013

申请日：1988-02-17

Applicant: HEIMREID, Ken

IPC: A61B05/14

CPC classification number: A61B5/150755 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150343 ,  A61F13/023 ,  Y10S128/26

Abstract: A plaster for use in blood sampling in which plaster (4) a perforation is provided, and with a sump (1, 2) of a liquid impermeable material provided along the circumference of said perforation (3).

Abstract translation: 一种用于血液取样的石膏，其中提供了石膏（4）穿孔，以及沿着所述穿孔（3）的圆周设置的液体不可渗透材料的贮槽（1,2）。

公开(公告)号：WO1988003778A1

公开(公告)日：1988-06-02

申请号：PCT/FR1987000411

申请日：1987-10-20

Applicant: CHAOULLI, Jacques

IPC: A61B05/14

CPC classification number: A61B5/153 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150251 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150732

Abstract: Apparatus for the selective taking of desired body liquids without any air and with no contamination risk for the operator. The needle (4) is fixed to a syringe comprised of a cylinder (5) and a first piston (8) called ''piston'' in the text, the bottom of the cylinder (5) and of the piston (8) being nested either directly or via a pad (12) which is dissolvable when entering in contact with the liquid, and the piston is provided at its center (14) with a longitudinal hollow opening so that a second piston (2), called ''cannula'' in the text may easily slide therein. The cannula (2) penetrates also the needle (4) up to its extremity and the cannula (2) is movable either passively under the effect of the liquid pressure so that the cannula acts as a reference device to indicate that the needle (4) has just penetrated the liquid compartment searched for, or actively, manipulated by the operator.

Abstract translation: 用于选择性取出所需体液而无任何空气并且对操作者没有污染风险的装置。 针（4）固定在包括气缸（5）和称为“活塞”的第一活塞（8）的注射器中，气缸（5）的底部和活塞（8）为 直接或经由垫（12）嵌套，当与液体接触时可以溶解，并且活塞在其中心（14）处设置有纵向中空开口，使得称为“套管”的第二活塞（2） 在文本中可能很容易在其中滑动。 套管（2）也穿过针头（4）直到其末端，并且套管（2）可在液体压力的作用下被动地移动，使得套管充当参考装置，以指示针（4） 刚刚渗透到操作者搜索或主动操纵的液体室。

公开(公告)号：WO1987006813A1

公开(公告)日：1987-11-19

申请号：PCT/IT1987000044

申请日：1987-05-13

Applicant: ROBERTI, Lamberto

IPC: A61B05/14

CPC classification number: A61B5/154 ,  A61B5/15003 ,  A61B5/150389 ,  A61B5/150496 ,  A61B5/150732 ,  A61M5/32 ,  A61M2005/342

Abstract: A perfected needle for multiple vacuum blood sample devices, of the type composed of double opposed coplanar but not parallel needles (1, 2) connected by a length (12) that is oblique to them, and covered by a rigid length (15), such that the relevant test tube carrying cylinder (9), technically known as the ''HOLDER'', is not coaxial to the needle (1) to be introduced in the vein, the said second needle (2) being inclined with respect to the geometrical axis (18) of the test tube (4) so that the outflowing blood strikes against only the lateral walls (4a) of the test tube (4), and does so with the minimum angle of incidence.

Abstract translation: 一种用于多个真空血液样品装置的完美针头，其由双重相对的共面但不平行的针（1,2）组成，所述两个相对的共面但不平行的针（1,2）通过与其倾斜的长度（12）连接并被刚性长度（15）覆盖， 使得技术上称为“HOLDER”的相关试管承载气缸（9）与引入静脉的针（1）不同轴，所述第二针（2）相对于 所述试管（4）的几何轴线（18），使得所述流出的血液仅针对所述试管（4）的侧壁（4a），并以最小的入射角进行。

公开(公告)号：WO1987000027A1

公开(公告)日：1987-01-15

申请号：PCT/JP1986000342

申请日：1986-07-03

Applicant: MINOLTA CAMERA KABUSHIKI KAISHA ,  HAMAGURI, Kenji ,  SAKAI, Takao ,  YAMANISHI, Akio ,  KAMEZAWA, Hitoshi

Inventor： MINOLTA CAMERA KABUSHIKI KAISHA

IPC: A61B05/14

CPC classification number: A61B5/0002 ,  A61B5/145

Abstract: The information on a living body, such as the degree of oxygen saturation in the arterial blood and the pulse rate, which are measured with an oximeter itself, can be stored along with the information on the measurement time in a memory device, such as an IC card, which is detachable from the oximeter itself. When the memory device is detached from the oximeter itself to be attached to a data analyzer provided separately from the oximeter itself, the stored information on the living body can be analyzed by the data analyzer, and the results of the analysis can be represented by means of a graph. When a printer, which is provided separately from the oximeter itself, is attached thereto, the information on the living body which has been measured can be printed. Furthermore when a transmitter unit for a telemetry unit is attached to the oximeter itself with a receiver unit therefor connected to the data analyzer which is provided separately from the oximeter itself, the information on the living body, which has been measured with the oximeter itself, can be transmitted to the data analyzer without passing through a cord.

Abstract translation: 使用血氧计本身测量的生物体的信息，例如动脉血中的氧饱和度和脉搏率的信息可以与测量时间上的信息一起存储在诸如 IC卡，可与血氧计本身分离。 当存储装置与血氧计本身分离以附接到与血氧计本身分开设置的数据分析仪时，可以通过数据分析仪分析存储在生物体上的信息，并且分析结果可以用装置 的图表。 当与血氧计本身分离设置的打印机附着在其上时，可以打印已经测量的关于生物体的信息。 此外，当将用于遥测单元的发射器单元附接到血氧计本身，其接收器单元连接到与血氧计本身分开设置的数据分析器时，已经用血氧计本身测量的关于活体的信息， 可以传输到数据分析仪，而不会通过电线。