公开(公告)号：US20240301501A1

公开(公告)日：2024-09-12

申请号：US18281523

申请日：2022-03-11

Applicant: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH ,  NALAGENETICS PTE. LTD.

Inventor： Alexander Lezhava ,  Astrid Irwanto ,  Kanika Jain ,  Anar Sanjaykumar Kothary ,  Jocelyn Tan ,  Flona Ng ,  Zhihao Tan

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The invention relates to a method for assessing and evaluating the potential effect of therapeutics on an individual. In particular, the invention uses real-time PCR-based pharmacogenomic assays in assessing such potential effects. In an aspect of the present invention, there is provided a method of assessing or evaluating a subject's likelihood of developing an adverse reaction in response to an administration of a therapeutic agent, or a method of assessing or evaluating a therapeutic agent's efficacy on a subject, the method comprising determining in a single real-time polymerase chain reaction run the presence of a variant in a set of genes consisting of CYP2D6, CYP2C9, CYP2C19 and SLCO1B1 in a sample obtained from the subject, wherein the presence of a variant on any one of the genes in the set of genes is indicative of a risk to an adverse reaction and/or a change in efficacy to the therapeutic agent.

公开(公告)号：US20240273869A1

公开(公告)日：2024-08-15

申请号：US18569997

申请日：2022-06-30

Applicant: Agency for Science, Technology and Research

Inventor： Jian Wei Jayce CHENG ,  Pawan KUMAR ,  Anas ABUTAHA ,  Daniil BASH ,  Tonio BUONASSISI ,  Kedar HIPPALGAONKAR

IPC: G06V10/764 ,  G01N35/00 ,  G06V10/12 ,  G06V10/24 ,  G06V10/28 ,  G06V10/44 ,  G06V20/70

CPC classification number: G06V10/764 ,  G01N35/00732 ,  G06V10/12 ,  G06V10/24 ,  G06V10/28 ,  G06V10/44 ,  G06V20/70

Abstract: A data collection apparatus (10) and a computer-implemented data collection method (50) using the same are provided. The data collection apparatus (10) includes a first linear stage (12) and a second linear stage (14). A sample carriage (16) is attached to the first linear stage (12), the first linear stage (12) being operable to move the sample carriage (16) along a first axis. A probe carriage (18) is attached to the second linear stage (14), the second linear stage (14) being operable to move the probe carriage (18) along a second axis. A third linear stage (20) is attached to the probe carriage (18). In use, the third linear stage (20) is operable to receive a detachable characterisation probe (22) and to move the characterisation probe (22) along a third axis. A camera (24) is attached to the probe carriage (18). In use, the camera (24) is configured to capture an image of one or more samples on the sample carriage (16).

公开(公告)号：US12059431B2

公开(公告)日：2024-08-13

申请号：US17659183

申请日：2022-04-14

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： James L. Hedrick ,  Yi Yan Yang ,  Nathaniel H. Park ,  Jiayu Leong ,  Chuan Yang ,  Xin Ding ,  Yiran Zhen ,  Cherylette Anne Alexander ,  Jye Yng Teo

IPC: A61K31/785

CPC classification number: A61K31/785

Abstract: Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.

公开(公告)号：US12053754B2

公开(公告)日：2024-08-06

申请号：US17279001

申请日：2019-09-24

Applicant: Agency for Science, Technology and Research

Inventor： Praveen Thoniyot ,  Alexander M. Van Herk

IPC: B01J13/08 ,  C01B33/14

CPC classification number: B01J13/08 ,  C01B33/14

Abstract: There is provided a method of producing silica capsules, the method comprising: adding a silica precursor to emulsified droplets in the presence of salt and alcohol to enhance silica growth around the emulsified droplets by an ion association effect, thereby forming silica capsules. Also provided are silica capsules producible by such a method.

公开(公告)号：US12044921B2

公开(公告)日：2024-07-23

申请号：US18008520

申请日：2020-06-10

Applicant: Agency for Science, Technology and Research

Inventor： Shampy Mansha ,  Ramon Jose Paniagua Dominguez ,  Arseniy Kuznetsov

IPC: G02F1/1335

CPC classification number: G02F1/133553 ,  G02F1/133567 ,  G02F2203/12

Abstract: A spatial light modulator and a method for forming the spatial light modulator. The spatial light modulator may include a first reflector. The spatial light modulator may also include a second reflector. The spatial light modulator may further include a liquid crystal layer between the first reflector and the second reflector. The first reflector may include a first electrode. The second reflector may include a second electrode. At least one reflector selected from the first reflector and the second reflector may be or may include a distributed Bragg reflector (DBR). The first reflector and the second reflector may form a Fabry-Perot (FP) cavity.

公开(公告)号：US12036236B2

公开(公告)日：2024-07-16

申请号：US17507170

申请日：2021-10-21

Applicant: International Business Machines Corporation ,  Agency for Science, Technology and Research

Inventor： James L. Hedrick ,  Yi Yan Yang ,  Nathaniel H. Park ,  Victoria A. Piunova ,  Zhi Xiang Voo

IPC: A61K31/765 ,  A61K31/155 ,  C08K5/31 ,  C08L69/00

CPC classification number: A61K31/765 ,  A61K31/155 ,  C08K5/31 ,  C08L69/00

Abstract: Compositions and methods regarding antimicrobial guanidinium macromolecules with one or more targeting moieties for selectively targeting bacteria are provided. According to an embodiment, an antimicrobial macromolecule is provided that comprises a polymer backbone and one or more guanidinium moieties that extend from the polymer backbone. The antimicrobial macromolecule further comprises a targeting moiety that extends from the polymer backbone. The targeting moiety can comprise a substance favored for consumption by bacteria, such as a monosaccharide.

公开(公告)号：US20240217170A1

公开(公告)日：2024-07-04

申请号：US18557509

申请日：2022-04-27

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Weijie Cyrus BEH

IPC: B29C64/124 ,  B29C64/112 ,  B29C64/209 ,  B29C64/264 ,  B29C64/336 ,  B29C64/40 ,  B33Y10/00 ,  B33Y30/00

CPC classification number: B29C64/124 ,  B29C64/112 ,  B29C64/209 ,  B29C64/264 ,  B29C64/336 ,  B29C64/40 ,  B33Y10/00 ,  B33Y30/00

Abstract: There is provided a multimodality method and a system for printing a three-dimensional (3D) construct or part thereof, the method comprising: (i) supporting a flowable precursor with a flowable support at a position that allows said flowable precursor to be crosslinked through irradiation by an irradiation source; (ii) depositing one or more materials on/within the flowable precursor; and (iii) crosslinking through irradiation by the irradiation source, at least part of the flowable precursor that is in contact with the one or more materials in the flowable precursor to form the 3D construct or part thereof.

公开(公告)号：US20240160222A1

公开(公告)日：2024-05-16

申请号：US18279922

申请日：2022-03-02

Applicant: Agency for Science, Technology and Research

Inventor： Saurab VERMA ,  Syed Zeezhan Ahmed MUKHTAR ,  Kun ZHANG ,  Nicolas Andre GAUTHIER ,  Kam Pheng NG ,  Yuda CHEN ,  Chong Boon TAN ,  Albertus Hendrawan ADIWAHONO

IPC: G05D1/246 ,  G01S17/89 ,  G05D105/80 ,  G05D111/10 ,  G05D111/63 ,  G06T7/579 ,  G06T7/70

CPC classification number: G05D1/246 ,  G01S17/89 ,  G06T7/579 ,  G06T7/70 ,  G05D2105/87 ,  G05D2111/17 ,  G05D2111/65 ,  G06T2207/10028

Abstract: A method of localizing a mobile robot 100 with respect to a target object 601 using an initial map of a reference object which is a representation of the target object is disclosed herein. The method comprises obtaining LiDAR data 503 of the target object 601 captured by a LiDAR device 203 of the mobile robot 100 as the mobile robot 100 traverses in an environment associated with the target object 601 the LiDAR data including respective point cloud representations of the target object 501 and the environment in various sampling instances; iteratively updating pose data representing estimated pose of the mobile robot 100 with respect to a known reference location in corresponding sampling instances as the mobile robot traverses the environment; extracting a subset of LiDAR data points in the point cloud representation of a previous sampling instance, the subset of LiDAR data points corresponding to features of the target object 601 in the initial map based on the estimated pose of the mobile robot 100 associated with the previous sampling instance; obtaining desired LiDAR data points in the point cloud representation in a current sampling instance, the desired LiDAR data points including current LiDAR data points which correspond to the extracted subset of LiDAR data points in the previous sampling instance; and determining a localization pose of the mobile robot 100 with respect to the target object 601 in the current sampling instance based on the desired LiDAR data points. A system for localizing a mobile robot is also disclosed herein.

公开(公告)号：US20240148728A1

公开(公告)日：2024-05-09

申请号：US18547670

申请日：2022-02-23

Applicant: Nanyang Technological University ,  Agency for Science, Technology and Research

Inventor： Lei ZHONG ,  Kim Samirah ROBINSON ,  Gee Ann TOH ,  Zijin SUN

IPC: A61K31/506 ,  A61K31/365 ,  A61K31/428 ,  A61K31/519 ,  A61K31/69 ,  A61K35/748 ,  A61P35/00

CPC classification number: A61K31/506 ,  A61K31/365 ,  A61K31/428 ,  A61K31/519 ,  A61K31/69 ,  A61K35/748 ,  A61P35/00

Abstract: The present invention is directed to a method of modulating inflammation and/or related complications triggered by ZAKα kinase-activated NLRP1-driven pyroptosis; a compound or composition comprising said compound for use in the method, and use of said compounds in medicament preparation. More particularly, the inflammation is caused by a ribotoxin or UVB irradiation. Inhibition of said ZAKα kinase-activated NLRP1-driven pyroptosis may be used in the prophylaxis or treatment of human airway or skin inflammation and/or related complications, whereas activation of ZAKα kinase-activated NLRP1-driven pyroptosis may be used in the prophylaxis or treatment of cancer.

公开(公告)号：US20240137001A1

公开(公告)日：2024-04-25

申请号：US18548275

申请日：2021-03-21

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Sagnik GHOSH ,  Eldwin Jiaqiang NG ,  Jaibir SHARMA ,  Srinivas MERUGU

IPC: H03H9/13 ,  H03H3/02 ,  H03H9/17

CPC classification number: H03H9/13 ,  H03H3/02 ,  H03H9/17

Abstract: Various embodiments may relate to a resonator. The resonator may include a support including a substrate portion, and a membrane portion extending from the substrate portion over a cavity. The resonator may also include a piezoelectric layer on the membrane portion. The resonator may further include an electrode on the piezoelectric layer. The substrate portion may include dopants of a first conductivity type. The membrane portion may include dopants of a second conductivity type different from the first conductivity type. A ratio of a thickness of the membrane portion to a combined thickness of the electrode and the piezoelectric layer may be above 3:1 for temperature compensation.