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    A GOLD NANOPARTICLE BASED PROTEASE IMAGING PROBES AND USE THEREOF
    121.
    发明申请
    A GOLD NANOPARTICLE BASED PROTEASE IMAGING PROBES AND USE THEREOF 审中-公开
    一种基于金属纳米材料的蛋白成像探针及其应用

    公开(公告)号：WO2008127019A1

    公开(公告)日：2008-10-23

    申请号：PCT/KR2008/002021

    申请日：2008-04-10

    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KWON, Ick-Chan ,  CHOI, Kui-Won ,  KIM, Kwang-Meyung ,  AHN, Cheol-Hee ,  YOUN, In-Chan ,  LEE, Seul-Ki ,  PARK, Kyeong-Soon

    Inventor： KWON, Ick-Chan ,  CHOI, Kui-Won ,  KIM, Kwang-Meyung ,  AHN, Cheol-Hee ,  YOUN, In-Chan ,  LEE, Seul-Ki ,  PARK, Kyeong-Soon

    IPC: A61K33/38

    CPC classification number: A61K49/0056 ,  A61K49/0032 ,  A61K49/0065 ,  A61K49/0093 ,  C12Q1/37

    Abstract: Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell imaging method and a drug screening method of inhibiting a protease overexpression are provided. In detail, the present invention is directed to a metal nanoparticle having a peptide substrate and fluorophore coupled thereto, the peptide substrate and the fluorophore being specifically degraded by due to a protease activated in various ways in cell and in a human body to exhibit fluorescence. Hence, the metal nanoparticle can be used to rapidly screen activation and inhibition of the protease in the imaging manner. Also, the metal nanoparticle is capable of being selectively absorbed into a cell and a tissue so as to be possibly used as a sensor for real-time cell imaging and early diagnosis of non-invasive diseases.

    Abstract translation: 公开了一种金属纳米颗粒，其上通过蛋白酶和荧光团特异性降解的肽底物被化学修饰，用于选择性地成像在人体中细胞和组织中表达的蛋白酶及其用途。 另外，提供了使用金属纳米粒子的蛋白酶的定量分析方法，细胞成像方法和抑制蛋白酶过表达的药物筛选方法。 详细地说，本发明涉及一种具有肽底物和与其连接的荧光团的金属纳米颗粒，肽底物和荧光团由于在细胞和人体中以各种方式活化的蛋白酶而被特异性地降解以显示出荧光。 因此，金属纳米颗粒可用于以成像方式快速筛选蛋白酶的活化和抑制。 此外，金属纳米粒子能够被选择性地吸收到细胞和组织中，以便可能用作用于实时细胞成像和非侵入性疾病的早期诊断的传感器。

    PIEZO ELECTRIC LINEAR MOTOR
    122.
    发明申请
    PIEZO ELECTRIC LINEAR MOTOR 审中-公开
    PIEZO电动直线电机

    公开(公告)号：WO2008050932A1

    公开(公告)日：2008-05-02

    申请号：PCT/KR2006/005350

    申请日：2006-12-08

    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KANG, Chong Yun ,  YOON, Seok Jin ,  JEONG, Dae Yong ,  KIM, Hyun Jai ,  VASILJEV, Piotr ,  CHOI, Ji Won

    Inventor： KANG, Chong Yun ,  YOON, Seok Jin ,  JEONG, Dae Yong ,  KIM, Hyun Jai ,  VASILJEV, Piotr ,  CHOI, Ji Won

    IPC: H02N2/00

    CPC classification number: H02N2/026 ,  H02N2/0015

    Abstract: The present invention relates to a piezoelectric linear motor that can make relatively low abrasion and accurate linear movement since stationary AC voltages are applied to two piezoelectric elements with a phase difference. The present invention provides a piezoelectric linear motor, comprising: a piezoelectric substrate having a first piezoelectric element and a second piezoelectric element, wherein AC voltages are applied to the first and second piezoelectric elements with a phase difference; a metallic elastic body having first and second elastic bodies coupled to the piezoelectric elements and a central protrusion protruded at the central portion connecting the first and second elastic bodies, wherein the central protrusion oscillates elliptically during an application of the voltage; and a mover brought into contact with the central protrusion of the metallic elastic body for a linear movement, and wherein the movement of the mover is orthogonal to the central protrusion.

    Abstract translation: 本发明涉及一种压电线性电动机，其可以使相对低的磨损和精确的线性运动，因为固定的AC电压被施加到具有相位差的两个压电元件。 本发明提供一种压电线性电动机，包括：具有第一压电元件和第二压电元件的压电基板，其中交流电压以相位差施加到第一和第二压电元件; 金属弹性体，其具有联接到所述压电元件的第一和第二弹性体以及在连接所述第一和第二弹性体的中心部分处突出的中心突起，其中所述中心突起在施加所述电压期间椭圆形振荡; 以及与金属弹性体的中心突起接触的动子，用于线性运动，并且其中移动器的运动与中心突起正交。

    SPIN TRANSISTOR USING FERROMAGNET
    124.
    发明申请
    SPIN TRANSISTOR USING FERROMAGNET 审中-公开
    使用FERROMAGNET的旋转晶体管

    公开(公告)号：WO2007148854A1

    公开(公告)日：2007-12-27

    申请号：PCT/KR2006/004462

    申请日：2006-10-30

    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KOO, Hyun-Cheol ,  HAN, Suk-Hee ,  EOM, Jong-Hwa ,  CHANG, Joon-Yeon ,  KIM, Hyung-Jun ,  YI, Hyun-Jung

    Inventor： KOO, Hyun-Cheol ,  HAN, Suk-Hee ,  EOM, Jong-Hwa ,  CHANG, Joon-Yeon ,  KIM, Hyung-Jun ,  YI, Hyun-Jung

    IPC: H01L27/105

    CPC classification number: H01L29/66984 ,  H01L29/7787

    Abstract: A spin transistor comprises a semiconductor substrate part having a lower cladding layer, a channel layer and an upper cladding layer sequentially stacked therein, a ferromagnetic source and drain on the substrate part, and a gate on the substrate part to control spins of electrons passing through the channel layer. The lower cladding layer comprises a first lower cladding layer and a second lower cladding layer having a higher band gap than that of the first lower cladding layer. The upper cladding layer comprises a first upper cladding layer and a second upper cladding layer having a higher band gap than that of the first upper cladding layer. The source and the drain are buried in an upper surface of the substrate part and extend downwardly to or under the first upper cladding layer.

    Abstract translation: 自旋晶体管包括具有下包层，沟道层和顺序地堆叠在其中的上包层的半导体衬底部分，在衬底部分上的铁磁源极和漏极，以及衬底部分上的栅极，以控制电子穿过的旋转 通道层。 下包层包括具有比第一下包层更高的带隙的第一下包层和第二下包层。 上包层包括具有比第一上包层高的带隙的第一上包层和第二上包层。 源极和漏极被埋在衬底部分的上表面中并向下延伸到第一上覆层的下方或下方。

    MONITORING DEVICE FOR ROTATING BODY
    125.
    发明申请
    MONITORING DEVICE FOR ROTATING BODY 审中-公开
    监控设备旋转体

    公开(公告)号：WO2007139262A1

    公开(公告)日：2007-12-06

    申请号：PCT/KR2006/004850

    申请日：2006-11-17

    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  HWANG, Yoha ,  LEE, Sang Bae ,  LEE, Jong Min

    Inventor： HWANG, Yoha ,  LEE, Sang Bae ,  LEE, Jong Min

    IPC: G01B11/16

    CPC classification number: G01B11/18 ,  G01M11/085

    Abstract: The present invention relates to a monitoring device for a rotating body, which can accurately measure signals from a fiber Bragg grating sensor provided on the rotating body by compensating a transmission loss variation and a distortion of the sensor signals. A rotation-side optical fiber has at least one deformation sensor at a portion thereof and a reference sensor at one end thereof. The sensors are made by forming a Bragg grating in the rotation-side optical fiber. A fixed-side optical fiber is mounted to the fixed body so as to be opposed to the one end of the rotation-side optical fiber. A signal processing unit detects a deformation of the rotating body by subtracting a signal corresponding to the light reflected from the reference sensor from a signal corresponding to the light reflected from the deformation sensor.

    Abstract translation: 本发明涉及一种用于旋转体的监测装置，其可以通过补偿传输损耗变化和传感器信号的失真来精确地测量设置在旋转体上的光纤布拉格光栅传感器的信号。 旋转侧光纤在其一部分具有至少一个变形传感器，其一端具有基准传感器。 传感器通过在旋转侧光纤中形成布拉格光栅而制成。 固定侧光纤被安装到固定体上以与旋转侧光纤的一端相对。 信号处理单元从对应于从变形传感器反射的光的信号中减去与从基准传感器反射的光相对应的信号来检测旋转体的变形。

    USE OF THE EXTRACT OF CAESALPINIA SAPPAN L. AND COMPOUNDS THEREFROM
    128.
    发明申请
    USE OF THE EXTRACT OF CAESALPINIA SAPPAN L. AND COMPOUNDS THEREFROM 审中-公开
    芍药提取物的使用及其化合物

    公开(公告)号：WO2007066928A1

    公开(公告)日：2007-06-14

    申请号：PCT/KR2006/005084

    申请日：2006-11-29

    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  YANG, Hyun Ok ,  KIM, Min Young ,  KWON, Young-Guen ,  CHOI, Yeon Hee

    Inventor： YANG, Hyun Ok ,  KIM, Min Young ,  KWON, Young-Guen ,  CHOI, Yeon Hee

    IPC: A61K36/48 ,  A61K31/352 ,  A23L1/29 ,  A61P19/02 ,  A61P17/00 ,  A61P25/28 ,  A61P3/04 ,  A61P35/00 ,  A61P27/02

    CPC classification number: A61K36/48 ,  A23L33/105 ,  A61K2300/00

    Abstract: The present invention relates to an extract of Caesalpinia sappan L. having an angiogenesis inhibition activity and a use of the compound isolated therefrom, more precisely an extract of Caesalpinia sappan L. extracted by using water, alcohol or a mixture thereof , and a use of brazilin, sappanchalcone and brazilein isolated from the extract as an angiogenesis inhibitor. The extract of Caesalpinia sappan L. of the invention and a compound isolated therefrom have angiogenesis inhibition activity, so that they can be effectively used for the prevention and treatment of angiogenesis associated diseases such as vascular diseases, cardiovascular diseases, ophthalmic diseases, chronic inflammatory diseases, dermatological diseases, Alzheimer's disease, obesity and cancer.

    Abstract translation: 本发明涉及具有血管生成抑制活性的Caesalpinia sappan L.的提取物和使用从其分离的化合物，更准确地说，是使用水，醇或其混合物提取的Caesalpinia sappan L.提取物，以及使用 巴西，sappanchalcone和brazilein作为血管发生抑制剂从提取物中分离出来。 本发明的Caesalpinia sappan L.提取物及其分离的化合物具有血管生成抑制活性，因此可有效地用于预防和治疗血管生成相关疾病如血管疾病，心血管疾病，眼科疾病，慢性炎性疾病 ，皮肤病，阿尔茨海默病，肥胖症和癌症。

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