中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

878 records (took 0.03 seconds)

    METHODS AND COMPOSITIONS FOR TREATING CANCER
    122.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING CANCER 审中-公开
    用于治疗癌症的方法和组合物

    公开(公告)号：WO2007059329A3

    公开(公告)日：2009-05-22

    申请号：PCT/US2006044829

    申请日：2006-11-16

    Applicant: PHARMACYCLICS INC ,  MAGDA DARREN

    Inventor： MAGDA DARREN

    IPC: A61K31/7135 ,  A61P35/00

    CPC classification number: A61K31/555 ,  A61K31/45 ,  A61K2300/00

    Abstract: The present disclosure involves the use of metal-containing texaphyrins and zinc (II) reagents for the treatment of tumors, atheromas and other neoplastic tissue. The present application demonstrates increased oxidative stress, alterations in zinc homeostasis, cell cycle arrest, and apoptosis of cancer cells in the presence of texaphyrins and/or zinc. One aspect is to monitor oxidative stress and/or alterations in zinc homeostasis in target cells prior to and/or after treatment with metal-containing texaphyrins and/or zinc (II) reagents as a predictor for treatment efficacy. The present disclosure provides molecular basis for the cell cycle arrest and apoptosis on cancer cells in the presence of texaphyrins and zinc. Another aspect is to monitor different genes involved in response to treatment with texaphyrins and zinc prior to and/or after treatment as predictors for treatment efficacy.

    Abstract translation: 本公开涉及使用含金属的泰克萨菲精和锌（II）试剂来治疗肿瘤，动脉粥样化和其它肿瘤组织。 本申请表明在泰克萨菲和/或锌存在下氧化应激增加，锌稳态的改变，细胞周期停滞和癌细胞的凋亡。 一个方面是在用含金属的泰克萨菲精和/或锌（II）试剂处理之前和/或之后监测靶细胞中锌稳态的氧化应激和/或改变作为治疗功效的预测因子。 本公开提供了在泰克萨菲精和锌存在下对癌细胞的细胞周期停滞和细胞凋亡的分子基础。 另一方面是监测与治疗之前和/或治疗后的泰克萨菲精和锌治疗相关的不同基因，作为治疗效果的预测因子。

    INHIBITORS OF BRUTON'S TYROSINE KINASE
    125.
    发明申请
    INHIBITORS OF BRUTON'S TYROSINE KINASE 审中-公开
    BRUTON的酪氨酸激酶抑制剂

    公开(公告)号：WO2008039218A2

    公开(公告)日：2008-04-03

    申请号：PCT/US2006/049626

    申请日：2006-12-28

    Applicant: PHARMACYCLICS, INC. ,  HONIGBERG, Lee ,  VERNER, Erik ,  PAN, Zhengying

    Inventor： HONIGBERG, Lee ,  VERNER, Erik ,  PAN, Zhengying

    IPC: A61K31/52 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02

    CPC classification number: A61K31/52 ,  A61K9/4825 ,  A61K31/00 ,  A61K31/519 ,  A61K39/3955 ,  A61K45/06 ,  A61K2300/00 ,  C07D487/04 ,  C07K16/2887 ,  C07K2317/24

    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

    Abstract translation: 本文公开了与布鲁顿酪氨酸激酶（Btk）形成共价键的化合物。 还描述了Btk的不可逆抑制剂。 公开了制备化合物的方法。 还公开了包含化合物的药物组合物。 公开了使用Btk抑制剂的方法，单独或与其它治疗剂组合用于治疗自身免疫性疾病或病症，异种免疫疾病或病症，癌症，包括淋巴瘤和炎性疾病或病症。

    A METHOD FOR TREATING NEUROLOGIC DISEASES
    126.
    发明申请
    A METHOD FOR TREATING NEUROLOGIC DISEASES 审中-公开
    一种治疗神经病变的方法

    公开(公告)号：WO2006078875A2

    公开(公告)日：2006-07-27

    申请号：PCT/US2006/001986

    申请日：2006-01-19

    Applicant: PHARMACYCLICS, INC. ,  MAGDA, Darren ,  MILLER, Richard

    Inventor： MAGDA, Darren ,  MILLER, Richard

    IPC: A61K31/555

    CPC classification number: A61K31/555

    Abstract: Disclosed herein are texaphyrin- metal complexes, compositions comprising such complexes, pharmaceutical formulations comprising such complexes, and methods for treating neurologic diseases, disorders and conditions and or free-radical associated diseases, disorders and conditions using such complexes, compositions and pharmaceutical formulations.

    Abstract translation: 本文公开了特沙弗林 - 金属络合物，包含这种复合物的组合物，包含这种复合物的药物制剂，以及使用这种复合物，组合物和药物制剂治疗神经疾病，病症和病症以及自由基相关疾病，病症和病症的方法。

    LIGHT DELIVERY DEVICE USING CONICAL DIFFUSING SYSTEM AND METHOD OF FORMING SAME
    129.
    发明申请
    LIGHT DELIVERY DEVICE USING CONICAL DIFFUSING SYSTEM AND METHOD OF FORMING SAME 审中-公开
    使用圆锥形扩散系统的光输送装置及其形成方法

    公开(公告)号：WO03065880A2

    公开(公告)日：2003-08-14

    申请号：PCT/US0303569

    申请日：2003-02-05

    Applicant: PHARMACYCLICS INC ,  BAYS ROLAND ,  MOSIMANN LAURENT ,  WOODTLI ALAIN ,  CHEONG WAI-FUNG

    Inventor： BAYS ROLAND ,  MOSIMANN LAURENT ,  WOODTLI ALAIN ,  CHEONG WAI-FUNG

    IPC: A61B20060101 ,  A61B18/20 ,  A61N1/00 ,  A61B

    CPC classification number: A61B18/24 ,  A61B90/39 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N5/062

    Abstract: The present invention provides devices, methods of manufacture, methods of use and kits related to transmitting and diffusing light for delivery to a target site. Techniques are provided which allow accurate control of the illumination profile with a diffuser tip design which is easily produceable, relatively inexpensive and provides countless variations to obtain desired illumination profiles. This is achieved with the use of at least one scattering region having a conical shape. The number of conical scattering regions, the dimensions of such regions, and the scattering properties of the scattering materials may be selected individually and/or collectively to selectively control the resulting illumination profile. In addition, the conical features allow for other beneficial design features, such as a smaller cross-sectional diameter than is typically achievable with other techniques. The resulting light transmission and diffusion apparatus is operable with a high efficiency, highly predictable illumination profile and ease of use.

    Abstract translation: 本发明提供了用于传输和漫射光以用于传送到目标部位的装置，制造方法，使用方法和相关的试剂盒。 提供了技术，其允许使用易于产生的，相对便宜的扩散器末端设计来精确地控制照明轮廓，并且提供无数的变化以获得期望的照明轮廓。 这是通过使用至少一个具有圆锥形状的散射区来实现的。 锥形散射区域的数量，这些区域的尺寸和散射材料的散射性质可以单独地和/或共同地选择性地选择性地控制所得的照明轮廓。 此外，锥形特征允许其他有益的设计特征，例如比通常用其它技术可实现的更小的横截面直径。 所得到的光传输和扩散装置可以以高效率，高度可预测的照明轮廓和易于使用的方式操作。

Patent Agency Ranking