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    Parallel reactor for sampling and conducting in situ flow-through reactions and a method of using same
    122.
    发明申请
    Parallel reactor for sampling and conducting in situ flow-through reactions and a method of using same 有权
    用于取样和进行原位流通反应的并联反应器及其使用方法

    公开(公告)号：US20020172631A1

    公开(公告)日：2002-11-21

    申请号：US09826606

    申请日：2001-04-05

    Applicant: Symyx Technologies, Inc.

    Inventor： William H. Chandler JR.

    IPC: G01N033/53 ,  B01J008/04

    CPC classification number: F28F27/00 ,  B01J19/0046 ,  B01J2219/00155 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00351 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00698 ,  B01J2219/00718 ,  C40B60/14 ,  Y10T436/11 ,  Y10T436/142222

    Abstract: An apparatus for parallel processing of reaction mixtures, including a reactor block including reaction chambers for containing reaction mixtures under pressure, the reactor block further including a first sidewall, a second sidewall, and a first plurality of fluid flow paths providing fluid communication with the first sidewall and respective reaction chambers and the second sidewall and respective reaction chambers; a stirring system including a base plate defining a second plurality of flow paths, wherein respective flow paths of said second plurality of flow paths are in fluid communication with respective reaction chambers and respective fluid flow paths of said first plurality of flow paths, and the base plate also supports a plurality of stirring blade assemblies for mixing the reaction mixtures; interchangeable manifolds supported by the first sidewall and the second sidewall, the interchangeable manifolds defining a plurality of manifold inlet/outlet ports, wherein respective inlet/outlet ports of said plurality of inlet/outlet ports are in communication with respective fluid flow paths of said first plurality of fluid flow paths and permit fluid to be introduced into or vented from the respective reaction chambers; and a sampling manifold assembly coupled in fluid communication with the respective reaction chambers, wherein a portion of the reaction mixture retained in the respective reaction chambers can be withdrawn from the respective reaction chamber through respective fluid flow paths of said first plurality of fluid flow paths and respective flow paths of said second plurality of flow paths, or both, without depressurizing or lowering the pressure in the respective reaction chamber.

    Abstract translation: 一种用于反应混合物的并行处理的装置，包括反应器块，其包括用于在压力下包含反应混合物的反应室，反应器模块还包括第一侧壁，第二侧壁和第一多个流体流动路径，其提供与第一 侧壁和相应的反应室以及第二侧壁和相应的反应室; 搅拌系统，其包括限定第二多个流动路径的基板，其中所述第二多个流动路径的相应流动路径与所述第一多个流动路径的相应反应室和相应的流体流动路径流体连通，并且所述基部 板还支撑用于混合反应混合物的多个搅拌叶片组件; 可互换歧管由第一侧壁和第二侧壁支撑，可互换歧管限定多个歧管入口/出口，其中所述多个入口/出口端口的相应入口/出口与所述第一侧壁和第二侧壁的相应流体流动路径连通 多个流体流动路径并允许流体从各个反应室引入或排出; 以及与各个反应室流体连通地连接的采样歧管组件，其中保留在各个反应室中的反应混合物的一部分可以通过所述第一多个流体流路的相应流体流动路径从相应的反应室中排出， 所述第二多个流动路径或两者的相应流动路径，而不减压或降低各个反应室中的压力。

    Instrument for high throughput measurement of material physical properties and method of using same
    123.
    发明申请
    Instrument for high throughput measurement of material physical properties and method of using same 失效
    用于材料物理性能高通量测量的仪器及其使用方法

    公开(公告)号：US20020029621A1

    公开(公告)日：2002-03-14

    申请号：US09779149

    申请日：2001-02-08

    Applicant: Symyx Technologies, Inc.

    Inventor： Damian Hajduk ,  Eric Carlson ,  J. Christopher Freitag ,  Oleg Kolosov ,  James R. Engstrom ,  Adam Safir ,  Ravi Srinivasan ,  Leonid Matsiev

    IPC: G01N003/48

    CPC classification number: B01L3/5085 ,  B01J2219/00707 ,  B01J2219/00718 ,  G01N5/00 ,  G01N11/00 ,  G01N19/00 ,  G01N29/02 ,  G01N29/222 ,  G01N2203/0286 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/02818 ,  G01N2291/106 ,  Y10T436/12

    Abstract: An apparatus and method for screening combinatorial libraries of materials by measuring the response of individual library members to mechanical perturbations is described. The apparatus generally includes a sample holder for containing the library members, an array of probes for mechanically perturbing individual library members, and an array of sensors for measuring the response of each of the library members to the mechanical perturbations. Library members undergoing screening make up a sample array, and individual library members constitute elements of the sample array that are confined to specific locations on the sample holder. During screening, the apparatus mechanically perturbs individual library members by displacing the sample array (sample holder) and the array of probes. Typically, all of the elements of the sample array are perturbed simultaneously, but the apparatus also can also perturb individual or groups of sample array elements sequentially. The flexible apparatus and method can screen libraries of materials based on many different bulk physical properties, including Young's modulus (flexure, uniaxial extension, biaxial compression, and shear); hardness (indentation), failure (stress and strain at failure, toughness), adhesion (tack, loop tack), and flow (viscosity, melt flow indexing, and rheology), among others.

    Abstract translation: 描述了通过测量单个文库成员对机械扰动的响应来筛选材料组合文库的装置和方法。 该装置通常包括用于容纳库构件的样本保持器，用于机械扰乱各个库构件的探针阵列，以及用于测量每个库构件对机械扰动的响应的传感器阵列。 正在进行筛选的图书馆成员组成一个样本数组，单独的图书馆成员构成了样本数组的元素，它们限于样本持有者的特定位置。 在筛选期间，设备通过移位样品阵列（样品架）和探针阵列来机械地干扰各个库成员。 通常，样本阵列的所有元素都被同时扰动，但是该装置也可以顺序扰乱单个或组的样本阵列元素。 灵活的装置和方法可以基于许多不同的体积物理性质（包括杨氏模量（挠曲，单轴延伸，双轴压缩和剪切））筛选材料库; 硬度（压痕），破坏（破坏时的应力和应变，韧性），粘附性（粘性，环粘性）和流动性（粘度，熔体流动指数和流变学）等。

    Instrument for high throughput measurement of material physical properties and method of using same
    124.
    发明申请
    Instrument for high throughput measurement of material physical properties and method of using same 失效

    公开(公告)号：US20020023507A1

    公开(公告)日：2002-02-28

    申请号：US09779148

    申请日：2001-02-08

    Applicant: Symyx Technologies, Inc.

    Inventor： Damian Hajduk ,  Eric Carlson ,  J. Christopher Freitag ,  Oleg Kosolov

    IPC: G01N003/48

    CPC classification number: B01L3/5085 ,  B01J2219/00707 ,  B01J2219/00718 ,  G01N5/00 ,  G01N11/00 ,  G01N19/00 ,  G01N29/02 ,  G01N29/222 ,  G01N2203/0286 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/02818 ,  G01N2291/106 ,  Y10T436/12

    Abstract: An apparatus and method for screening combinatorial libraries of materials by measuring the response of individual library members to mechanical perturbations is described. The apparatus generally includes a sample holder for containing the library members, an array of probes for mechanically perturbing individual library members, and an array of sensors for measuring the response of each of the library members to the mechanical perturbations. Library members undergoing screening make up a sample array, and individual library members constitute elements of the sample array that are confined to specific locations on the sample holder. During screening, the apparatus mechanically perturbs individual library members by displacing the sample array (sample holder) and the array of probes. Typically, all of the elements of the sample array are perturbed simultaneously, but the apparatus also can also perturb individual or groups of sample array elements sequentially. The flexible apparatus and method can screen libraries of materials based on many different bulk physical properties, including Young's modulus (flexure, uniaxial extension, biaxial compression, and shear); hardness (indentation), failure (stress and strain at failure, toughness), adhesion (tack, loop tack), and flow (viscosity, melt flow indexing, and rheology), among others.

    Catalyst ligands, catalytic metal complexes and processes using same
    126.
    发明申请
    Catalyst ligands, catalytic metal complexes and processes using same 审中-公开
    催化剂配体，催化金属络合物和使用它们的方法

    公开(公告)号：US20040249157A1

    公开(公告)日：2004-12-09

    申请号：US10881573

    申请日：2004-06-29

    Applicant: Symyx Technologies, Inc.

    Inventor： Anil Guram ,  Cheryl Lund ,  Howard W. Turner ,  Tetsuo Uno

    IPC: C07F005/02

    CPC classification number: C08F10/00 ,  C07C211/49 ,  C07C223/06 ,  C07C251/24 ,  C08F4/60013 ,  C08F4/7006

    Abstract: A new ligands that include a benzene ring in the backbone can be combined with a metal or metal precursor compound or formed into a metal-ligand complex catalyze a number of different chemical transformations, including olefin polymerization reactions. The ligands, complexes formed with the ligands and compositions including the ligands are useful catalysts, depending on the reaction.

    Abstract translation: 在骨架中包括苯环的新配体可以与金属或金属前体化合物组合或形成金属 - 配体配合物催化许多不同的化学转化，包括烯烃聚合反应。 根据反应，配体与配体和包含配体的组合物形成的配合物是有用的催化剂。

    Evaluating effects of exposure conditions on drug samples over time
    128.
    发明申请
    Evaluating effects of exposure conditions on drug samples over time 审中-公开
    评估暴露条件对药物样品随时间的影响

    公开(公告)号：US20040219602A1

    公开(公告)日：2004-11-04

    申请号：US10790956

    申请日：2004-03-01

    Applicant: Symyx Technologies, Inc.

    Inventor： Eric D. Carlson ,  Peter J. Desrosiers ,  Li Song

    IPC: G01N033/53 ,  G01N033/543

    CPC classification number: G01N33/15 ,  B01J2219/00599 ,  B01J2219/00686 ,  B01J2219/00702 ,  B01J2219/00756 ,  C40B60/12

    Abstract: The present invention relates to the field of research for drug formulations. More particularly, this invention is directed toward an apparatus and method of performing parallel synthesis and screening of multiple drug compositions for stability and compatibility when exposed to various conditions over time, including various environmental and/or chemical conditions. In one aspect, the invention includes a method of testing for effects of a condition on a drug sample. The method includes providing an array of drug samples, simultaneously exposing a first plurality of the drug samples in the array to a first controlled condition for a period of time within an exposure period, and evaluating a plurality of the exposed drug samples at a first time and a second time using a non-destructive test in order to determine whether the condition has an affect on one or more of the drug samples over time. At least a portion of the exposure period between said first and second time, and the non-destructive test is the same each time.

    Abstract translation: 本发明涉及药物制剂的研究领域。 更具体地说，本发明涉及当暴露于包括各种环境和/或化学条件在内的各种条件时，在稳定性和相容性方面进行多种药物组合物的平行合成和筛选的装置和方法。 一方面，本发明包括测试病症对药物样品的影响的方法。 该方法包括提供药物样品阵列，同时将阵列内的第一组多个药物样品暴露于暴露期内的第一受控状态一段时间，以及在第一次评估多个暴露的药物样品 并且第二次使用非破坏性测试来确定条件对一种或多种药物样品随时间的影响。 所述第一次和第二次之间的曝光期间的至少一部分与无损检测每次相同。

    Parallel gas chromatograph with microdetector array
    129.
    发明申请
    Parallel gas chromatograph with microdetector array 失效
    具有微量检测器阵列的平行气相色谱仪

    公开(公告)号：US20040139784A1

    公开(公告)日：2004-07-22

    申请号：US10718196

    申请日：2003-11-20

    Applicant: Symyx Technologies, Inc.

    Inventor： Ravi Srinivasan ,  Daniel Meron Pinkas ,  Shenheng Guan ,  Michael Myslovaty ,  Mikhail Spitkovsy ,  James R. Engstrom ,  H. Sam Bergh

    IPC: G01N030/04

    CPC classification number: G01N30/18 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00704 ,  G01N30/466 ,  G01N30/6004 ,  G01N30/6095 ,  G01N30/66 ,  G01N30/8631 ,  G01N2030/185 ,  G01N2030/208 ,  G01N2030/3084 ,  G01N2030/8881

    Abstract: Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.

    Abstract translation: 本发明的气相色谱通常包含四个或更多个分析通道。 具体地说，四个或更多个气相色谱柱被配置用于并行分析四种或更多种气态样品，其中使用包含四个或更多微量检测器的微量检测器阵列进行检测。 在一个实施例中，四个或更多个微检测器510是微制造的检测器，并且与基板或与安装在基板上的一个或多个微芯片体整体形成。 在优选实施例中，微检测器阵列包括具有一个或多个薄膜检测丝的四个或更多个热导检测器。 还公开了用于高度平行的气相色谱仪的优选的加热环境。

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