公开(公告)号：US09818383B2

公开(公告)日：2017-11-14

申请号：US14811114

申请日：2015-07-28

Applicant: University of Connecticut through its Center for Science & Technology Commercialization

Inventor： Sina Shahbazmohamadi ,  Robert S. Howe ,  Richard Bass

IPC: G01N23/04 ,  G10D9/02 ,  G06T17/00 ,  G06T19/20 ,  G10D7/00 ,  B29C67/00 ,  B33Y80/00 ,  B33Y50/02

CPC classification number: G10D9/02 ,  B29C64/386 ,  B33Y50/02 ,  B33Y80/00 ,  G06T17/00 ,  G06T19/20 ,  G06T2210/41 ,  G06T2219/2021 ,  G10D7/005

Abstract: In one aspect, the present disclosure provides a method including rotating a rotatable surface with an object positioned thereon to a plurality of angular positions. The method also includes capturing, via an x-ray microtomography device at each of the plurality of angular positions, a tomograph of the object. The method also includes summing each tomograph of the object to create a three-dimensional image of the object. The method also includes using an additive manufacturing machine to create a three-dimensional replica of the object using the three-dimensional image of the object.

公开(公告)号：US09616088B2

公开(公告)日：2017-04-11

申请号：US14208820

申请日：2014-03-13

Applicant: University of Maryland, Office of Technology Commercialization

Inventor： Kevin Diehn ,  Matthew Dowling ,  Srinivasa R. Raghavan ,  David R. King

IPC: A61K31/765 ,  A61K31/734 ,  A61K38/39 ,  A61K31/717 ,  A61K31/722

CPC classification number: A61K31/734 ,  A61K31/717 ,  A61K31/722 ,  A61K38/39

Abstract: A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. The viscoelastic nature of the putty is tunable by the composition and enables the putty to conform to a variety of wound topographies. Likewise, a hemostatic polymer, for example chitosan or hydrophobically modified chitosan, is included in this matrix to impart hemostatic properties and tissue adhesive on the putty. The hemostatic polymers disclosed prevent microbial infection and are suitable for oxygen transfer required during normal wound metabolism.

公开(公告)号：US20160351968A1

公开(公告)日：2016-12-01

申请号：US15114997

申请日：2015-01-28

Applicant: Office of Technology Commercialization

Inventor： Chunsheng WANG ,  Kang XU ,  Liumin SUO

IPC: H01M10/36 ,  H01M4/46 ,  H01M4/485

CPC classification number: H01M10/36 ,  H01M4/466 ,  H01M4/48 ,  H01M4/485 ,  H01M2200/20 ,  H01M2220/20 ,  H01M2300/0002

Abstract: The present invention is directed to a hybrid high voltage aqueous electrolyte battery that combines Ni/Mg2NiH4 and Mg-ion rechargeable battery chemistries. The hybrid aqueous electrolyte battery can be used for plug-in hybrid electrical vehicles and electric vehicles.

Abstract translation: 本发明涉及一种组合Ni / Mg2NiH4和Mg-离子可再充电电池化学物质的混合高压水性电解质电池。 混合型含水电解质电池可用于插电式混合电动车辆和电动车辆。

公开(公告)号：US20160346940A1

公开(公告)日：2016-12-01

申请号：US15117255

申请日：2014-02-07

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION (CIMTEC)

Inventor： Jeffrey Scott BAX ,  Christopher Stanley Robert WARING ,  Aaron FENSTER

IPC: B25J19/00 ,  A61B90/50 ,  A61B34/30 ,  A61B90/11

CPC classification number: B25J19/0016 ,  A61B34/30 ,  A61B90/11 ,  A61B90/50 ,  A61B2090/374 ,  A61B2090/5025 ,  A61B2090/506 ,  F16M2200/041 ,  F16M2200/044 ,  F16M2200/063

Abstract: Disclosed is a modular base link for use in a counterbalancing arm. The base link includes two base plates and four connection points. Two stabilizing members are connected to and extend between the base plates. Two resilient members, one of which is hingeably connected to and in communication with the two connection points, the other resilient member is hingeably connected to and in communication with the other connection points. The connection points are eccentrically and orthogonally disposed relative to each other. The resilient members are sufficiently resilient to permit movement of the base plates relative to each other so as to counterbalance the arm when a load is applied to either base plate.

Abstract translation: 公开了一种用于平衡臂的模块化基座连杆。 基座连接件包括两个基板和四个连接点。 两个稳定构件连接到基板之间并在基板之间延伸。 两个弹性构件，其中一个可铰接地连接到两个连接点并与两个连接点连通，另一个弹性构件可铰接地连接到其它连接点并与其连接点连通。 连接点相对于彼此偏心地且正交地设置。 弹性构件具有足够的弹性，以允许基板相对于彼此移动，以便当将负载施加到任一基板时抵抗臂的平衡。

公开(公告)号：US20160008046A1

公开(公告)日：2016-01-14

申请号：US14859908

申请日：2015-09-21

Applicant: University of Connecticut through its Center for Science & Technology Commercialization

Inventor： Sangamesh G. Kumbar ,  Cato T. Laurencin

IPC: A61B17/86 ,  B29C39/02 ,  B29C39/38 ,  A61L31/04

CPC classification number: A61B17/866 ,  A61B2017/00004 ,  A61B2017/00526 ,  A61L31/042 ,  A61L31/125 ,  B29C39/02 ,  B29C39/38 ,  B29C67/04 ,  B29C67/24 ,  B29K2001/08 ,  B29K2001/12 ,  B29K2005/00 ,  B29K2105/251 ,  B29L2031/7546

Abstract: A bone fixation device made of polysaccharide particles or microspheres fused into a solid structure is provided herein. The bone fixation device may be in the form of an orthopedic screw, orthopedic pin, or orthopedic plate. Methods of making the bone fixation devices described herein are provided as are methods of treating patients in need of bone repair or replacement by implanting a bone fixation device described herein in the patient at a site of bone damage, ligament damage, or bone deformity.

Abstract translation: 本发明提供一种由固体结构融合的多糖粒子或微球体构成的骨固定装置。 骨固定装置可以是矫形螺钉，矫形针或矫形板的形式。 提供制造本文所述的骨固定装置的方法是通过在骨损伤，韧带损伤或骨畸形的部位植入本文所述的骨固定装置来治疗需要骨修复或置换的患者的方法。

公开(公告)号：US20150201910A1

公开(公告)日：2015-07-23

申请号：US14158407

申请日：2014-01-17

Applicant: CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION (CIMTEC)

Inventor： Shuang-ren ZHAO ,  Aaron Fenster ,  Tharindu De Silva ,  Aaron D. Ward

IPC: A61B8/08 ,  G01S7/52 ,  A61B10/04 ,  A61B8/12 ,  A61B8/00 ,  G06T7/00

CPC classification number: A61B8/483 ,  A61B8/085 ,  A61B8/5261 ,  A61B8/5276 ,  A61B10/04 ,  G06T7/33 ,  G06T2207/10132

Abstract: Disclosed herein is a system and method for generating a motion-corrected 2D image of a target. The method comprises acquiring a 3D static image of the target before an interventional procedure. During the procedure, a number of 2D real time images of the target are acquired and displayed. A slice of the 3D static image is acquired and registered with one 2D real time image and then the location of the 3D static image is corrected to be in synchrony with body motion. The motion corrected 2D image of the target is then displayed.

Abstract translation: 本文公开了一种用于生成目标的运动校正的2D图像的系统和方法。 该方法包括在介入程序之前获取目标的3D静态图像。 在该过程中，获取并显示目标的多个2D实时图像。 获取3D静态图像的切片并用一个2D实时图像进行记录，然后将3D静态图像的位置校正为与身体运动同步。 然后显示目标的运动校正的2D图像。

公开(公告)号：US20150168179A1

公开(公告)日：2015-06-18

申请号：US14414541

申请日：2013-07-15

Applicant: UNIVERSITY OF WESTERN ONTARIO ,  CENTRE FOR IMAGING TECHNOLOGY COMMERCIALIZATION

Inventor： Jeffrey Bax ,  Aaron Fenster

IPC: G01D5/14 ,  G01D5/26 ,  A61B8/00 ,  A61B5/055 ,  A61B6/03

CPC classification number: G01D5/14 ,  A61B5/055 ,  A61B6/032 ,  A61B8/0841 ,  A61B8/085 ,  A61B8/0858 ,  A61B8/4218 ,  A61B8/4263 ,  A61B8/466 ,  A61B8/483 ,  A61B34/20 ,  A61B34/30 ,  A61B90/11 ,  A61B2034/2059 ,  A61B2090/378 ,  G01B5/004 ,  G01D5/26

Abstract: A mechanical tracking system comprises a first set of linkage arms, a second set of linkage arms, a pair of shafts connected at a first end to one arm of the first set of linkage antis and at a second end to one arm of said second set of the linkage arms, wherein each arm of the second set of linkage arms is oriented out of phase with a respective arm of the first set of linkage arms, an attachment shaft positioned adjacent to the first set of linkage arms to accommodate a tool, and a sensor arrangement configured to sense the orientation and position of the attachment shaft.

Abstract translation: 机械跟踪系统包括第一组联动臂，第二组联动臂，一对轴，在第一端连接到第一组联动装置的一个臂，并且在第二端连接到所述第二组的一个臂 其中所述第二组连杆臂的每个臂与所述第一组联动臂的相应臂定向成异相;附接轴，其定位成邻近所述第一组连杆臂以容纳工具;以及 传感器装置，被配置为感测附接轴的取向和位置。

公开(公告)号：US20130345277A1

公开(公告)日：2013-12-26

申请号：US13867658

申请日：2013-04-22

Applicant: STC.UNM ,  Kansas University Center for Technology Commercialization, Inc.

Inventor： Angela Wandinger-Ness ,  Larry Sklar ,  Zurab Surviladze ,  Tudor Oprea ,  Laurie Hudson ,  Jeffrey Aube ,  Jennifer E. Golden ,  Chad E. Schroeder ,  Denise S. Simpson ,  Julica J. Noth

IPC: A61K31/415 ,  A61K45/06 ,  C07D231/06

CPC classification number: A61K31/407 ,  A61K31/403 ,  A61K31/415 ,  A61K45/06 ,  C07D231/06 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/573 ,  Y02A50/473 ,  Y02A50/486 ,  A61K2300/00

Abstract: The present invention relates to molecules which function as selective modulators of the Ras-homologous (Rho) family of small GTPases, in particular, Cdc42 GTPase and their use to treat diseases, for example cancers, including metastatic cancer, genetic and acquired diseases where activation of Cdc42 GTPase plays a pivotal role, such as neurodegenerative diseases, rheumatoid arthritis, atherosclerosis, diabetes type I, autosomal polycystic kidney disease, cystic kidney disease, precystic kidney disease, microbial infections, including Chlamydia infections, E. coli infections, H. pylori infections and its secondary effects including gastric ulcers, Coxiella Brunetti (Q-fever) infections and Streptococcus pneumonia infections, fungal infections including Paracoccidiodes brasiliensis and Candida albicans and their secondary effects including lung edema. Additionally, compounds according to the present invention may be used to inhibit rejection in transplant patients (pursuant to transplantation), to promote immunosuppression, anti-inflammatory response and to mobilize stem cell (migration) in patients in need, among others.

Abstract translation: 本发明涉及用作小GTP酶的Ras同源（Rho）家族，特别是Cdc42GTP酶的选择性调节剂的分子及其用于治疗疾病的用途，例如癌症，包括转移性癌症，遗传和获得性疾病，其中激活 的Cdc42 GTPase起着关键的作用，如神经退行性疾病，类风湿关节炎，动脉粥样硬化，I型糖尿病，常染色体多囊肾病，囊性肾病，前期肾脏疾病，微生物感染，包括衣原体感染，大肠杆菌感染，幽门螺杆菌 感染及其次要作用包括胃溃疡，布氏梭菌（Qex fever）感染和肺炎链球菌感染，包括巴西隐孢子虫和白色念珠菌在内的真菌感染及其副作用，包括肺水肿。 此外，根据本发明的化合物可以用于抑制移植患者的排斥（根据移植），以促进免疫抑制，抗炎反应和在需要的患者中调动干细胞（迁移）等。

公开(公告)号：US20130239308A1

公开(公告)日：2013-09-19

申请号：US13836099

申请日：2013-03-15

Applicant: University of Maryland, College Park Office of Technology Commercialization

Inventor： Amr M. Baz ,  Marino diMarzo

IPC: A62B17/00

CPC classification number: A62B17/003 ,  A41D31/0027 ,  B32B5/26

Abstract: A method and devices are described, in which a transformable fiber at a first crystal structure is shaped from its pre-determined configuration into a new shaped configuration. The new shaped configuration of the transformable fiber is inserted into a cavity of a heat and fire protective item. The new shaped configuration of the transformable fiber is heated to above its transformation temperature to a second crystal structure. The heating transforms the new shaped configuration to its pre-determined configuration, wherein the pre-determined configuration forms an air pocket within the heat and fire protective item. The transformable fiber is cooled below its transformation temperature to revert the transformable fiber back to the new shaped configuration at the first crystal structure.

Abstract translation: 描述了一种方法和装置，其中第一晶体结构的可变形光纤从其预定构型成形为新的成形构型。 可变形纤维的新型结构被插入到防火保护物品的空腔中。 将可变形纤维的新形状构造加热至高于其转变温度至第二晶体结构。 加热将新的成形构型转变成其预定构型，其中预定构型在加热和防火保护物品内形成空气袋。 将可变形纤维冷却到其转变温度以下以使可变形纤维在第一晶体结构处回到新的成形构型。

公开(公告)号：EP3976070A1

公开(公告)日：2022-04-06

申请号：EP20814159.8

申请日：2020-05-29

Applicant: Children's Hospital Medical Center, Center for Technology Commercialization

Inventor： HELMRATH, Michael A. ,  MAHE, Maxime, Mickael ,  POLING, Holly M.

IPC: A61K35/407 ,  C12N5/071