公开(公告)号：WO2004041194A2

公开(公告)日：2004-05-21

申请号：PCT/US2003/034708

申请日：2003-10-31

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  PANDEY, Virendra, N. ,  KAUSHIK, Neerja ,  BASU, Amartya ,  PALUMBO, Paul ,  MYERS, Rene, L. ,  SHARMA, Bechan ,  TALELE, Tanaji, T.

Inventor： PANDEY, Virendra, N. ,  KAUSHIK, Neerja ,  BASU, Amartya ,  PALUMBO, Paul ,  MYERS, Rene, L. ,  SHARMA, Bechan ,  TALELE, Tanaji, T.

IPC: A61K

CPC classification number: A61K47/64

Abstract: Compositions for the inhibition of HIV-1 comprising the use of polyamide nucleic acids (PNAs) that bind to either the transactivation response element or primer binding sequence of the HIV virus are taught. The PNAs may be bound to a membrane transducing peptide, such as transportan. The methods for treating patients infected with HIV or for protecting non-infected patients against HIV infection using the anti-HIV compositions are also taught.

Abstract translation: 教导了用于抑制HIV-1的组合物，其包括使用结合HIV病毒的反式激活应答元件或引物结合序列的聚酰胺核酸（PNA）。 PNA可能与膜转导肽结合，如转运蛋白。 还教导了使用抗HIV组合物治疗感染艾滋病毒感染者或用于保护未感染HIV患者免受艾滋病毒感染的方法。

公开(公告)号：WO2004027046A2

公开(公告)日：2004-04-01

申请号：PCT/US2003/029932

申请日：2003-09-19

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  HEINDEL, Ned, H. ,  HECK, Diane, E. ,  GUILLON, Christophe ,  RAPP, Robert, D. ,  LASKIN, Jeffrey, D.

Inventor： HEINDEL, Ned, H. ,  HECK, Diane, E. ,  GUILLON, Christophe ,  RAPP, Robert, D. ,  LASKIN, Jeffrey, D.

IPC: C12N

CPC classification number: C07D405/04 ,  C07D249/10 ,  C07D409/04 ,  C07D409/12 ,  C07D513/04 ,  C12Q1/6886

Abstract: This invention claims the process for producing two structural variants of functionalized 4-amino-3-mercapto-1,2,4-triazoles as inhibitors of nitric oxide synthase (NOS) and as inhibitors of malignant cell growth. This fundamental molecular construct operates as a heterocyclic mimic of the open-chain N-aminoarginines (or N-aminoguanidines) previously established as NOS inhibitors.

Abstract translation: 本发明要求保护作为一氧化氮合酶（NOS）抑制剂和作为恶性细胞抑制剂的功能化4-氨基-3-巯基-1,2,4-三唑的两种结构变体的方法 生长。 这种基本的分子构建体作为先前建立为NOS抑制剂的开链N-氨基精氨酸（或N-氨基胍）的杂环模拟物起作用。

公开(公告)号：WO2003065935A1

公开(公告)日：2003-08-14

申请号：PCT/US2003/003508

申请日：2003-02-05

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  KHAW, Kenneth

Inventor： KHAW, Kenneth

IPC: A61F2/06

CPC classification number: A61F2/954 ,  A61F2/856 ,  A61F2/958 ,  A61F2002/065 ,  A61F2250/006 ,  A61M25/0043 ,  A61M25/09 ,  A61M2025/0035 ,  A61M2025/0037

Abstract: The present invention is directed to an apparatus for and method of treatment or vascular procedures. An exitable lumen guide wire sheath (3) is disclosed and advantages thereof. The exitable lumen guide wire sheath (3) and method may be used as a multiple exitable lumen or single exitable lumen. A method of treatment of multiple branch vascular lesions is disclosed in which a desired branch of a multiple branch lesion may be protected for further procedures by an interventionalist or other practitioner. Other combinations and uses for the disclosed invention will be apparent to those skilled in the art.

Abstract translation: 本发明涉及用于治疗或血管手术的装置和方法。 公开了一种可出口管腔引导线护套（3）及其优点。 可出口管引导线护套（3）和方法可以用作多个可出口腔或单出口腔。 公开了治疗多个分支血管病变的方法，其中可以通过介入医生或其他从业者保护多支分支病变的期望分支进一步的手术。 所公开的发明的其它组合和用途对于本领域技术人员是显而易见的。

公开(公告)号：WO2003059290A2

公开(公告)日：2003-07-24

申请号：PCT/US2003/000761

申请日：2003-01-09

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  RUBIN, Eric, H. ,  SALEEM, Ahamed ,  RASHEED, Zeshaan ,  HALUSKA, Paul, Jr.

Inventor： RUBIN, Eric, H. ,  SALEEM, Ahamed ,  RASHEED, Zeshaan ,  HALUSKA, Paul, Jr.

IPC: A61K

CPC classification number: C07K14/4703 ,  A61K2039/505 ,  C07K16/18

Abstract: Topors and topors antibody can be used to manipulate the presence and function of both Top1 and p53 in cells, thus controlling the function of the Top1 and p53 proteins. Topors is implicated in prevention of tumorigenesis through its role in DNA repair and preventing faulty or mutated DNA from replicating. Topors can be used therapeutically as a medicament and topors DNA can be used in gene therapy. Topors antibody may be used to detect the presence of cancer by screening for the absence of topors in a given cell or tissue sample. Kits comprising the topors antibody are also contemplated.

Abstract translation: TOPOR和TOPORS抗体可用于操纵细胞中Top1和p53两者的存在和功能，从而控制Top1和p53蛋白的功能。 Topors通过其在DNA修复中的作用与预防有缺陷或突变的DNA复制有关，从而预防肿瘤发生。 托普林可作为药物用于治疗，托普尔DNA可用于基因治疗。 Topors抗体可用于通过筛选给定细胞或组织样品中缺少托布来检测癌症的存在。 还考虑了包含托普林抗体的试剂盒。

公开(公告)号：WO2003022224A3

公开(公告)日：2003-03-20

申请号：PCT/US2002/028930

申请日：2002-09-11

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  O'CONNOR, Patrick, J.

Inventor： O'CONNOR, Patrick, J.

IPC: C12N15/00

Abstract: The invention relates to compositions and methods for enhancing bone healing, bone formation and wound healing. More specifically, it relates to the use of cyclooxygenase 2 (COX-2) following bone fracture, orthopaedic procedure or wound infliction to enhance healing.

公开(公告)号：WO2003022224A2

公开(公告)日：2003-03-20

申请号：PCT/US2002/028930

申请日：2002-09-11

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  O'CONNOR, Patrick, J.

Inventor： O'CONNOR, Patrick, J.

IPC: A61K

CPC classification number: C12N9/0083 ,  A61K31/415 ,  A61K31/635 ,  A61K38/00 ,  A61K48/00

Abstract: The invention relates to compositions and methods for enhancing bone healing, bone formation and wound healing. More specifically, it relates to the use of cyclooxygenase 2 (COX-2) following bone fracture, orthopaedic procedure or wound infliction to enhance healing.

Abstract translation: 本发明涉及用于增强骨愈合，骨形成和伤口愈合的组合物和方法。 更具体地说，它涉及在骨折，矫形手术或伤口施加之后使用环氧合酶2（COX-2）以增强愈合。

公开(公告)号：WO2003020908A3

公开(公告)日：2003-03-13

申请号：PCT/US2002/028045

申请日：2002-09-04

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  BLACK, Ira, B. ,  WOODBURY, Dale

Inventor： BLACK, Ira, B. ,  WOODBURY, Dale

IPC: A01N63/00

Abstract: Methods of inducing differentiation of mammalian bone marrow stromal cells into cells of multiple embryonic lineages by contacting marrow stromal cells with precursor differentiation-inducing compounds followed by contacting the partially differentiated precursor cells with specific cell type differentiation-inducing compounds. In one embodiment, the MSC derived precursor cell cultures comprise cells, at least some of which simultaneously express markers that are characteristic of endodermal and ectodermal cell types. In another embodiment, the differentiated cells are insulin-secreting pancreatic islet cells. Precursor differentiation-inducing compounds of the invention include anti-oxidants such as, but not limited to, beta-mercaptoethanol, dimethylsulfoxide, butylated hydroxyanisole, butylated hydroxytoluene, ascorbic acid, dimethylfumarate, and n-acetylcysteine. Endodermal cell differentiation-inducing compounds of the invention inclue but are not limited to anti-oxidants and growth factors including basic fibroblast growth factor. Once induced to differentiate into a particular cell type, the cells can be used for cell therapy, gene therapy, or both, for treatment of diseases, disorders, or conditions associated with tissues of multiple embryonic origins.

公开(公告)号：WO2003020882A3

公开(公告)日：2003-03-13

申请号：PCT/US2002/025249

申请日：2002-08-07

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  PILCH, Daniel, S. ,  LI, Tsai-Kun

Inventor： PILCH, Daniel, S. ,  LI, Tsai-Kun

IPC: A61K31/70

Abstract: This invention relates to anti-viral agents that target RNase H substrates of reverse transcriptase and methods of using these agents to inhibit reverse transcriptase and viral replication. The invention also relates to methods for screening anti-viral agents capable of inhibiting the RNase activity of reverse transcriptase by targeting RNA-DNA hybrid substrates.

公开(公告)号：WO2003020882A2

公开(公告)日：2003-03-13

申请号：PCT/US2002/025249

申请日：2002-08-07

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  PILCH, Daniel, S. ,  LI, Tsai-Kun

Inventor： PILCH, Daniel, S. ,  LI, Tsai-Kun

IPC: C12N

CPC classification number: C12Q1/48 ,  G01N2500/02

Abstract: This invention relates to anti-viral agents that target RNase H substrates of reverse transcriptase and methods of using these agents to inhibit reverse transcriptase and viral replication. The invention also relates to methods for screening anti-viral agents capable of inhibiting the RNase activity of reverse transcriptase by targeting RNA-DNA hybrid substrates.

Abstract translation: 本发明涉及靶向逆转录酶的RNA酶H底物的抗病毒剂和使用这些试剂抑制逆转录酶和病毒复制的方法。 本发明还涉及通过靶向RNA-DNA杂交底物来筛选能够抑制逆转录酶的RNA酶活性的抗病毒剂的方法。

公开(公告)号：WO2002028884A1

公开(公告)日：2002-04-11

申请号：PCT/US2001/031289

申请日：2001-10-04

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  RANA, Tariq ,  TAMILARASU, Natarajan

Inventor： RANA, Tariq ,  TAMILARASU, Natarajan

IPC: C07K1/00

CPC classification number: C07K14/005 ,  C07K1/1077 ,  C07K1/113 ,  C07K1/13 ,  C12N2740/16322

Abstract: Site-specific modified proteins and method for producing site-specific modified proteins using amino acid analogs are disclosed. Methods for labeling proteins at a desired site in the presence of nucleophilic side chains, including lysine and cysteine side chains, are also disclosed. Methods for labeling the site-specific modified proteins are also disclosed.

Abstract translation: 公开了位点特异性修饰蛋白质和使用氨基酸类似物产生位点特异性修饰蛋白质的方法。 还公开了在亲核侧链（包括赖氨酸和半胱氨酸侧链）存在下在所需位点标记蛋白质的方法。 还公开了用于标记位点特异性修饰蛋白质的方法。