公开(公告)号：KR1020090122819A

公开(公告)日：2009-12-01

申请号：KR1020080048813

申请日：2008-05-26

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  김현석

IPC: B01J31/38 ,  B01J31/00 ,  C07F7/28

CPC classification number: B01J31/38 ,  B01J21/063

Abstract: PURPOSE: A novel catalyst for intermolecular hydroamination and a method for manufacturing cyclic imine compounds using the catalyst are provided to produce the novel catalyst by using an amino Alkynes derivative. CONSTITUTION: A novel catalyst for intermolecular hydroamination uses a catalyst composition including a titanium-amino metal compound, a 4B family metal complex, a 4B family metal compound and specified ligand. The catalyst for intermolecular hydroamination is a titanium - amino compound indicated as a chemical formula 2. The chemical formula 2 is TiClp(NR2)q. R is a straight-chain or a branched-chain alkyl group of C1~C6. P is 0 or 1 and p+q=4. The catalyst is the 4B family metal complex indicated by a chemical formula 3a, 3b or 3c. X and Q is one of the straight-chain or a branched-chain alkyl group of C1~C6, a phenyl radical or a benzyl radical. M is 4B family metal atoms.

Abstract translation: 目的：提供一种用于分子间水解的新型催化剂和使用该催化剂制备环状亚胺化合物的方法，通过使用氨基炔烃衍生物制备新型催化剂。 构成：用于分子间水解的新型催化剂使用包含钛 - 氨基金属化合物，4B族金属络合物，4B族金属化合物和特定配体的催化剂组合物。 分子间水解催化剂是化学式2表示的钛 - 氨基化合物。化学式2是TiClp（NR2）q。 R是C1〜C6的直链或支链烷基。 P为0或1，p + q = 4。 催化剂是由化学式3a，3b或3c表示的4B族金属络合物。 X和Q是C1〜C6，苯基或苄基的直链或支链烷基之一。 M是4B族金属原子。

公开(公告)号：KR1020090088173A

公开(公告)日：2009-08-19

申请号：KR1020080013564

申请日：2008-02-14

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  박찬수

IPC: C07D307/30

Abstract: A dihydrofuran derivative is provided to improve yield of the dihydrofuran derivative through intramolecular cyclization of alenyl alcohol compound and use as a precursor in synthesis of medicine or perfume. A dihydrofuran derivative is denoted by the chemical formula 1. In the chemical formula 1, R is independently (C1-C7) alkyl group, A is hydrogen, (C1-C7)alkyl, (C3-C8)cycloalkyl, (C6-C20)aryl or (C6-C20)aryl(C1-C7)alkyl. The dihydrofuran derivative is a compound of the chemical formula 2 or 3. The dihydrofuran derivative of the chemical formula 1 is produced through intramolecular cyclization of homoalenyl alcohol compound.

Abstract translation: 提供二氢呋喃衍生物以通过烯丙醇化合物的分子内环化提高二氢呋喃衍生物的产率，并用作药物或香料的合成中的前体。 二氢呋喃衍生物由化学式1表示。在化学式1中，R独立地为（C 1 -C 7）烷基，A为氢，（C 1 -C 7）烷基，（C 3 -C 8）环烷基，（C 6 -C 20 ）芳基或（C 6 -C 20）芳基（C 1 -C 7）烷基。 二氢呋喃衍生物是化学式2或化学式3的化合物。化学式1的二氢呋喃衍生物通过分子内环化均聚烯醇化合物而产生。

公开(公告)号：KR100841407B1

公开(公告)日：2008-06-25

申请号：KR1020070058871

申请日：2007-06-15

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  김선대

IPC: C07C33/042 ,  C07C33/04

Abstract: A allenyn-1,6-diol derivative, and a method for preparing the derivative are provided to obtain a source material useful as a source material for the intermolecular cyclization using a transition metal catalyst. An allenyn-1,6-diol derivative is represented by the formula 1, wherein A and B are H, a C1-C6 alkyl group, a C5-C8 cycloalkyl group, a phenyl group substituted or unsubstituted with a halogen atom, a nitro group, a C1-C6 alkyl group, a C1-C6 alkoxy group, a C2-C6 alkylcarbonyl group, a C2-C6 alkoxycarbonyl group or a C2-C6 alkanoate group, a phenyl-C1-C6 alkyl group, a phenyl-C2-C6 alkenyl group, or a 5 to 8-membered heterocyclic group containing an oxygen atom, but A and B cannot be H simultaneously.

Abstract translation: 提供全烯-1,6-二醇衍生物和制备该衍生物的方法，以获得可用作使用过渡金属催化剂的分子间环化的源材料的源材料。 全烯-1,6-二醇衍生物由式1表示，其中A和B是H，C1-C6烷基，C5-C8环烷基，被卤素原子取代或未取代的苯基，硝基 基团，C1-C6烷基，C1-C6烷氧基，C2-C6烷基羰基，C2-C6烷氧基羰基或C2-C6链烷酸酯基，苯基-C1-C6烷基，苯基C2 -C 6烯基或含有氧原子的5至8元杂环基，但A和B不能同时为H。

公开(公告)号：KR100821936B1

公开(公告)日：2008-04-15

申请号：KR1020060130535

申请日：2006-12-20

Applicant: 강원대학교산학협력단

Inventor： 이필호 ,  이구연 ,  서문동 ,  김현석

IPC: C07C13/11 ,  C07C13/00 ,  C07D209/10 ,  C07D267/04

CPC classification number: C07C67/317 ,  C07C1/325 ,  C07C13/465 ,  C07C67/327 ,  C07C253/30 ,  C07C315/04 ,  C07C2601/08 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2603/24 ,  C07D209/08 ,  C07D267/04 ,  C07D267/22 ,  C07C69/74 ,  C07C69/753 ,  C07C69/757 ,  C07C317/12 ,  C07C317/44 ,  C07C255/47

Abstract: A method for coupling carbon atoms in an unsaturated hydrocarbon compound molecule by using organoindium is provided to avoid an additional purification step for separating an intermediate compound produced by a transition metal catalyst and indium, to solve the problem related with toxicity of an organotin compound, and to obtain a cyclic compound at a high yield. A method for coupling carbon atoms in an unsaturated hydrocarbon compound molecule comprises a step of carrying out in-situ reaction of an allyl substituent of the following formula 3 or 4 containing an unsaturated hydrocarbon compound with indium halide and a tertiary amine represented by the formula of NR2R3R4, in the presence of a palladium catalyst to form an allyl indium compound in which Z of the allyl substituent of formula 3 or 4 is substituted with indium, thereby providing a cyclic compound having a vinyl substituent represented by the following formula 1 or formula 2 through an in-situ intramolecular cyclization reaction. In the above formulae, X is Cl, Br or I; Y is (CH2)pCR11R12, NR13 or (CH2)qONR14; Z is Cl, Br, I, OAc or OCO2CH3; each of A, B, C and D independently represents H, a C1-C5 alkyl, phenyl or benzyl, or A and B or C and D are linked to each other via a C2-C10 alkylene, C2-C5 alkenylene, fused ring-containing C2-C10 alkylene or fused ring-containing C2-C5 alkenylene to form a ring optionally further comprising at least one heteroatom selected from N, O and S; R1 represents H, fluorine-substituted or non-substituted C1-C5 alkyl, C1-C5 alkoxy, C1-C5 alkoxycarbonyl or C1-C5 alkoxycarbonyl; each of R2, R3 and R4 represents a C1-C5 alkyl, phenyl or benzyl; each of R11 and R12 represents H, a C1-C5 alkyl, C1-C5 alkoxy, C1-C5 alkylcarbonyl or C1-C5 alkoxycarbonyl; R13 is a C1-C5 alkyl or SO2R21; R14 is t-butoxycarbonyl or a C1-C5 alkyl; R21 is a C1-C5 alkyl or phenyl; n is an integer of 1-4; m is an integer of 1-3; p is an integer of 0-5; and q is an integer of 1-3.

Abstract translation: 提供了通过使用有机铟偶联不饱和烃化合物分子中的碳原子的方法，以避免用于分离由过渡金属催化剂和铟生成的中间体化合物的另外的纯化步骤，以解决与有机锡化合物的毒性有关的问题，以及 以高收率得到环状化合物。 用于偶联不饱和烃化合物分子中的碳原子的方法包括以下步骤：将含有不饱和烃化合物的下式3或4的烯丙基取代基与卤化铟和由式 NR2R3R4，在钯催化剂存在下，形成烯键式铟化合物，其中式3或4的烯丙基取代基的Z被铟取代，从而提供具有由下式1或式2表示的乙烯基取代基的环状化合物 通过原位分子内环化反应。 在上式中，X是Cl，Br或I; Y是（CH 2）pCR 11 R 12，NR 13或（CH 2）qONR 14; Z是Cl，Br，I，OAc或OCO 2 CH 3; A，B，C和D各自独立地表示H，C1-C5烷基，苯基或苄基，或A和B或C和D通过C 2 -C 10亚烷基，C 2 -C 5亚烯基，稠环彼此连接 含有C 2 -C 10亚烷基或稠环的C 2 -C 5亚烯基以形成任选地进一步包含至少一个选自N，O和S的杂原子的环; R 1表示H，氟取代或未取代的C 1 -C 5烷基，C 1 -C 5烷氧基，C 1 -C 5烷氧基羰基或C 1 -C 5烷氧基羰基; R2，R3和R4各自表示C1-C5烷基，苯基或苄基; R11和R12各自表示H，C1-C5烷基，C1-C5烷氧基，C1-C5烷基羰基或C1-C5烷氧基羰基; R13是C1-C5烷基或SO2R21; R14是叔丁氧基羰基或C1-C5烷基; R 21是C 1 -C 5烷基或苯基; n为1-4的整数; m为1-3的整数; p是0-5的整数; q为1-3的整数。