公开(公告)号：WO2009132234A3

公开(公告)日：2011-06-16

申请号：PCT/US2009041603

申请日：2009-04-24

Applicant: MEDTRONIC INC ,  LUO LIAN L ,  BENZ MICHAEL E ,  HOBOT CHRISTOPHER M ,  LYU SUPING

Inventor： LUO LIAN L ,  BENZ MICHAEL E ,  HOBOT CHRISTOPHER M ,  LYU SUPING

IPC: A61K47/48 ,  A61P35/00

CPC classification number: A61K47/593 ,  A61K47/58

Abstract: Polymers, compositions, and medical devices useful for delivering (e.g., by local and/or sustained delivery) a haloacetate (e.g., dichoroacetate) to a tissue are disclosed herein. Such methods can be useful for treatment of diseases such as cancer.

Abstract translation: 本文公开了用于将卤代乙酸酯（例如二氯乙酸酯）递送（例如，通过局部和/或持续递送）到组织的聚合物，组合物和医疗装置。 这样的方法可用于治疗诸如癌症的疾病。

公开(公告)号：WO2009129437A3

公开(公告)日：2010-02-18

申请号：PCT/US2009040910

申请日：2009-04-17

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  MCKAY WILLIAM F ,  WOHABREBBI AMIRA ,  MCDONALD PHILLIP EDWARD ,  CARTER TROY

Inventor： KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  MCKAY WILLIAM F ,  WOHABREBBI AMIRA ,  MCDONALD PHILLIP EDWARD ,  CARTER TROY

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/4162 ,  A61K47/34

CPC classification number: A61L31/16 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K31/4168 ,  A61K47/34 ,  A61L31/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/604

Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

Abstract translation: 本发明涉及可用于减少，预防或治疗需要这种治疗的患者的手术后疼痛的可植入药物贮存库，所述可植入药物储库包含治疗有效量的可乐定或其药学上可接受的盐和聚合物; 其中所述贮存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述贮库能够释放（i）约5％至约45％的可乐定或其药学上可接受的盐相对于 在最多48小时的第一时间内装载在药物贮库中的可乐定或其药学上可接受的盐的总量和（ii）可乐定或其药学上可接受的盐的约55％至约95％相对于 至少3天的随后期间，将可乐定或其药学上可接受的盐装载在药物贮库中。

公开(公告)号：WO2009129145A3

公开(公告)日：2010-01-14

申请号：PCT/US2009040223

申请日：2009-04-10

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  COX S MARK ,  HOBOT CHRISTOPHER M ,  ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  MCKAY WILLIAM F ,  REMSEN KATHY L

Inventor： COX S MARK ,  HOBOT CHRISTOPHER M ,  ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  MCKAY WILLIAM F ,  REMSEN KATHY L

IPC: A61K31/635 ,  A61F2/00 ,  A61F2/02 ,  A61K47/34 ,  A61P29/00

CPC classification number: A61K31/635 ,  A61K9/0024 ,  A61K47/34

Abstract: Effective treatments of acute pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulfasalazine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

Abstract translation: 提供了长时间的急性疼痛和/或炎症的有效治疗。 通过在目标部位或其附近施用有效量的柳氮磺吡啶可以缓解由不同来源引起的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：WO2009129531A3

公开(公告)日：2009-12-10

申请号：PCT/US2009041107

申请日：2009-04-20

Applicant: MEDTRONIC INC ,  HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

Inventor： HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

IPC: A61K9/16 ,  A61K31/445

CPC classification number: A61K31/445 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/1641 ,  A61K9/1694 ,  A61K9/5031 ,  A61L31/16 ,  A61L2300/402 ,  A61L2300/602

Abstract: Effective treatments of pain, such as chronic pelvic pain, for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of bupivacaine formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.

Abstract translation: 提供有效的治疗疼痛，如慢性盆腔疼痛，延长时间。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的布比卡因。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。

公开(公告)号：WO2009129527A3

公开(公告)日：2009-12-10

申请号：PCT/US2009041098

申请日：2009-04-20

Applicant: MEDTRONIC INC ,  HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

Inventor： HOBOT CHRISTOPHER M ,  BENZ MICHAEL E ,  HILDEBRAND KEITH R ,  PUDIL BRYANT J

IPC: A61K9/16 ,  A61K31/197

CPC classification number: A61K31/197 ,  A61K9/0024 ,  A61K47/34

Abstract: Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of baclofen formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.

Abstract translation: 提供长时间有效的疼痛治疗。 治疗包括脊髓内施用一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的巴氯芬。 通过施用一个或多个药物贮存库，可以缓解由各种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，脊椎间盘突出症（即坐骨神经痛），导丝术，狭窄，背痛和关节疼痛，以及 与手术有关的疼痛。 在一些实施方案中，缓解剂可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。

公开(公告)号：WO2009129509A2

公开(公告)日：2009-10-22

申请号：PCT/US2009041039

申请日：2009-04-17

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DR DANIELLE ,  SHAW KATARA ,  WOHABREBBI AMIRA ,  MCKAY WILLIAM F ,  MCDONALD PHILLIP EDWARD

Inventor： KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DR DANIELLE ,  SHAW KATARA ,  WOHABREBBI AMIRA ,  MCKAY WILLIAM F ,  MCDONALD PHILLIP EDWARD

IPC: A61K31/4458 ,  A61K9/20 ,  A61K47/34 ,  A61P29/00

CPC classification number: A61K31/445 ,  A61K9/0024 ,  A61K9/146 ,  A61K9/1647 ,  A61K9/7007 ,  A61K31/4458

Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a polymer and a therapeutically effective amount of a local anesthetic or pharmaceutically acceptable salt thereof, wherein the drug depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the drug depot is capable of releasing (i) a bolus dose of the local anesthetic or pharmaceutically acceptable salt thereof at a site beneath the skin and (ii) a sustained release dose of an effective amount of the local anesthetic or pharmaceutically acceptable salt thereof over a period of at least 4 days.

Abstract translation: 本发明涉及可用于减少，预防或治疗需要这种治疗的患者中的手术后疼痛的可植入药物储存库，所述可植入药物储库包含聚合物和治疗有效量的局部麻醉剂或药学上可接受的盐 其中所述药物储存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述药物储库能够释放（i）所述局部麻醉剂或药学上可接受的盐的推注剂量 （ii）在至少4天的时间内持续释放剂量的有效量的局部麻醉剂或其药学上可接受的盐。

公开(公告)号：WO2009129464A2

公开(公告)日：2009-10-22

申请号：PCT/US2009040961

申请日：2009-04-17

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  HILDEBRAND KEITH R

Inventor： ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  HILDEBRAND KEITH R

IPC: A61K31/415 ,  A61K9/20 ,  A61K31/56 ,  A61K31/573 ,  A61P29/00

CPC classification number: A61K31/415 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/06 ,  A61K9/5031 ,  A61K9/5073 ,  A61K31/56 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38

Abstract: Effective methods for treating pain are provided. Through the injection of liquid formulation comprising an active ingredient followed by the administration of drug depot comprising an active ingredient at or near a target site, one can effectively treat pain. This methodology is particularly effective to treat acute radicular pain.

Abstract translation: 提供了治疗疼痛的有效方法。 通过注射包含活性成分的液体制剂，然后在靶点处或靶标部位施用包含活性成分的药物贮库，可以有效治疗疼痛。 这种方法对于治疗急性根性疼痛特别有效。

公开(公告)号：WO2009129460A2

公开(公告)日：2009-10-22

申请号：PCT/US2009040953

申请日：2009-04-17

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DANIELLE ,  SHAW KATARA ,  MCDONALD PHILLIP EDWARD ,  MCKAY WILLIAM F ,  REMSEN KATHY L

Inventor： ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  BIGGS DANIELLE ,  SHAW KATARA ,  MCDONALD PHILLIP EDWARD ,  MCKAY WILLIAM F ,  REMSEN KATHY L

IPC: A61K9/00 ,  A61K31/4162

CPC classification number: A61K31/4168 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K47/34

Abstract: Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

Abstract translation: 提供长时间有效的疼痛治疗。 通过在目标部位处或附近施用有效量的可乐定，可以减轻由多种来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛，如 以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：WO2009129155A2

公开(公告)日：2009-10-22

申请号：PCT/US2009040295

申请日：2009-04-13

Applicant: WARSAW ORTHOPEDIC INC ,  MEDTRONIC INC ,  ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  COX S MARK ,  MCKAY WILLIAM F ,  REMSEN KATHY L

Inventor： ZANELLA JOHN MYERS ,  KING VANJA MARGARETA ,  HOBOT CHRISTOPHER M ,  COX S MARK ,  MCKAY WILLIAM F ,  REMSEN KATHY L

IPC: A61K9/00 ,  A61K31/573 ,  A61K47/34 ,  A61P29/00

CPC classification number: A61K31/573 ,  A61K9/0002 ,  A61K9/0024 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

Abstract: Effective treatments of acute pain for extended periods of time are provided. Through the administration of an effective amount of dexamethasone at or near a target site, one can relieve pain cause by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

Abstract translation: 提供了长期急性疼痛的有效治疗方法。 通过在目标部位或附近施用有效量的地塞米松，可以减轻不同来源的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：WO2005018702A3

公开(公告)日：2005-03-31

申请号：PCT/US2004025923

申请日：2004-08-11

Applicant: MEDTRONIC INC ,  DINH THOMAS Q ,  SPARER RANDALL V ,  LYU SUPING ,  DANG KIEM ,  HOBOT CHRISTOPHER M

Inventor： DINH THOMAS Q ,  SPARER RANDALL V ,  LYU SUPING ,  DANG KIEM ,  HOBOT CHRISTOPHER M

IPC: A61F2/00 ,  A61F2/82 ,  A61K9/00 ,  A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  A61F2/02

CPC classification number: A61L31/16 ,  A61F2/07 ,  A61F2/82 ,  A61F2250/0067 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/61

Abstract: An active agent delivery system that includes two or more active agents and two or more layers of polymers; wherein at least one layer includes miscible polymer blend comprising two or more miscible polymers; and further wherein delivery of at least one active agent occurs predominantly under permeation control.

Abstract translation: 包含两种或更多种活性剂和两层或更多层聚合物的活性剂递送系统; 其中至少一个层包括包含两种或更多种可混溶聚合物的可混溶聚合物共混物; 并且进一步其中至少一种活性剂的递送主要在渗透控制下发生。