FAST CURING POROUS MATERIALS AND CONTROL THEREOF
    123.
    发明申请
    FAST CURING POROUS MATERIALS AND CONTROL THEREOF 审中-公开
    快速固化多孔材料及其控制

    公开(公告)号:US20160243277A1

    公开(公告)日:2016-08-25

    申请号:US15024335

    申请日:2014-09-23

    Abstract: High internal phase emulsions (HIPEs) and polyHIPEs formed therefrom. HIPE components have been adjusted to delay and/or prevent polymerization and free radical decomposition at certain temperatures. Methods include preparing two water-in-oil emulsions; one emulsion includes an oxidizing initiator at a concentration not sufficient to induce polymerization, and another emulsion includes a reducing agent. The two emulsions may be stored for months. When combined, a redox reaction is induced, resulting in polymerization (polyHIPE formation) at temperatures below 100° C., such as between 20° C. and 40° C. This allows a final composition to be formed in situ, with or without highly sensitive materials, including biologically-derived or active constituents (e.g., cells, growth factors, enzymes, proteins, drugs, chemoactive agents). The polymerization rate may be short, as fast as thirty seconds. HIPE components as well as the redox reaction may be controlled to manipulate time to cure, pore size, distribution of pores, and/or internal contents.

    Abstract translation: 高内相乳液(HIPE)和由其形成的多HIPE。 HIPE组分已被调节以延迟和/或阻止在某些温度下的聚合和自由基分解。 方法包括制备两种油包水乳液; 一种乳液包括浓度不足以诱导聚合的氧化引发剂,另一种乳液包括还原剂。 两种乳液可以储存数月。 当组合时,诱导氧化还原反应,导致在低于100℃的温度(例如20℃至40℃)之间的聚合(聚HIP形成)。这允许最终组合物原位形成,有或没有 高度敏感的材料,包括生物衍生或活性成分(如细胞,生长因子,酶,蛋白质,药物,化学活性剂)。 聚合速率可以短到三十秒。 可以控制HIPE组分以及氧化还原反应以操纵固化时间,孔径,孔分布和/或内部物质。

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