公开(公告)号：EP3134468A1

公开(公告)日：2017-03-01

申请号：EP15782535.7

申请日：2015-04-23

Applicant: American Aerogel Corporation

Inventor： KOMON, Zachary ,  WYRSTA, Michael

IPC: C08J9/35 ,  C08J9/28 ,  B29K105/04

CPC classification number: C08J9/35 ,  B29C65/02 ,  B29L2031/7128 ,  C08J9/286 ,  C08J9/405 ,  C08J2201/048 ,  C08J2201/05 ,  C08J2205/05 ,  C08J2323/06 ,  C08J2323/12 ,  C08J2361/06 ,  C08J2461/06

Abstract: The present disclosure provides composites comprising an open cell foam and a small pore area material, methods for their preparation, articles of manufacture comprising them and methods for preparing the same.

Abstract translation: 本公开提供了包含开孔泡沫和小孔区材料的复合材料，其制备方法，包含它们的制品及其制备方法。

公开(公告)号：EP2900744A2

公开(公告)日：2015-08-05

申请号：EP13774624.4

申请日：2013-09-26

Applicant: Sofradim Production

Inventor： LADET, Sébastien ,  PROST, Nicolas

IPC: C08J9/28 ,  A61L27/20 ,  A61L27/56 ,  C08J5/18 ,  A61L31/04 ,  A61L31/14

CPC classification number: C08J9/28 ,  A61L27/20 ,  A61L31/042 ,  A61L31/146 ,  A61L2400/18 ,  C08J5/18 ,  C08J2201/048 ,  C08J2207/10 ,  C08J2305/04 ,  C08J2305/08 ,  C08L5/04 ,  C08L5/08

Abstract: The present invention relates to a process for preparing a porous layer of biocompatible polymer, having a uniform density and porosity, comprising the following steps: - a) a quantity Qp of solution of the said polymer, having a viscosity Vp, is poured into a mould in order to form a first sublayer, the surface of the first sublayer being left to the open air; - b) a quantity Qs of solvent, having a viscosity Vs, lower than Vp, is spread uniformly over the surface of the first sublayer so as to form a second sublayer; - c) the first and second sublayers are subjected to a step of lyophilisation, in which the said polymer is a polysaccharide chosen from hyaluronic acid, alginic acid and chitosan, salts thereof and mixtures thereof.

公开(公告)号：EP2760661A1

公开(公告)日：2014-08-06

申请号：EP12780304.7

申请日：2012-10-01

Applicant: Polyganics B.V.

Inventor： CHANDRASHEKHAR-BHAT, Bhushan ,  TOOREN, Martin Franke ,  DE GRAAF, Robbert Arnold ,  RIBBELS, Romke Stephan Rudolf

IPC: B29C67/20 ,  C08J9/28 ,  A61L31/04

CPC classification number: C08G18/14 ,  A61K9/122 ,  A61K47/34 ,  A61L24/0036 ,  A61L27/56 ,  A61L2400/08 ,  B29C67/202 ,  C08J9/0066 ,  C08J9/0095 ,  C08J9/28 ,  C08J2201/048

Abstract: The invention relates to processes for preparing a synthetic foam having present therein particles with a controlled particle distribution and the use of said foam, as well as to foams as such. Accordingly the invention is directed to a process for preparing a synthetic foam having present therein particles, wherein the distribution of said particles is controlled by the following steps of dissolving at least one synthetic polymer in one or more solvents to form a solution; contacting particles with said solution to form a polymer/particles mixture; and freeze-drying the polymer/particles mixture by: freezing the polymer/particles mixture; and subsequently subliming the one or more solvents to form a synthetic foam comprising said particles.

公开(公告)号：EP1860142A4

公开(公告)日：2009-07-22

申请号：EP06715519

申请日：2006-03-10

Applicant: JMS CO LTD

Inventor： SAJIKI TOSHINOBU ,  IDE JUNICHI ,  HANAKI NAOYUKI ,  MATSUURA YOJI

IPC: C08J9/28 ,  C12N5/00 ,  C12N11/08

CPC classification number: C12N5/0068 ,  A61L27/56 ,  C08J9/28 ,  C08J2201/048 ,  C08J2367/04 ,  C12N11/08 ,  C12N2533/40

Abstract: A process for producing a porous object is provided that makes it possible to control pore sizes, particularly not only smaller pore sizes but also larger pore sizes. The pore sizes are controlled by: preparing a mixed solution containing a polymer including a copolymer of lactide and caprolactone, a solvent in which the polymer has a relatively low solubility, and a solvent in which the polymer has a relatively high solubility and that is compatible with the solvent in which the polymer has a relatively low solubility; varying the content of the solvent in which the polymer has a relatively low solubility in the mixed solution, when the mixed solution is frozen and dried to produce the porous object; and cooling the mixed solution at a rate of 300°C/hr or lower in freeze-treating. Thus a porous object with a pore size of 30 to 1800 µm can be obtained.

公开(公告)号：EP2002851A9

公开(公告)日：2009-04-22

申请号：EP07739214.0

申请日：2007-03-20

Applicant: JMS Co., Ltd.

Inventor： SAJIKI, Toshinobu ,  HANAKI, Naoyuki ,  IDE, Junichi ,  HIRAYAMA, Fumiko

IPC: A61L27/00 ,  C08J9/28

CPC classification number: A61L31/148 ,  A61L31/146 ,  C08J5/18 ,  C08J9/28 ,  C08J2201/048 ,  C08J2207/10 ,  C08J2300/14 ,  C08J2367/04

Abstract: [PROBLEMS]
To provide a thin film-shaped porous bioabsorbable material that is a dense structure in which the pore size average is small and the pore size is uniform and which further has a large maximum stress, in particular, a porous bioabsorbable material extremely useful as an adhesion preventing material.
[MEANS FOR SOLVING PROBLEMS]
A porous bioabsorbable material characterized by being formed of a porosified bioabsorbable polymer which is obtained in a manner that a bioabsorbable polymer is gelled with a good solvent and a poor solvent, compatible with each other, for the bioabsorbable polymer and the gelled bioabsorbable polymer is subjected to freeze-drying to be porosified; and a method of producing the porous bioabsorbable material, the method being characterized in that a bioabsorbable polymer is gelled with a mixed solvent composed of a good solvent and a poor solvent, compatible with each other, for the bioabsorbable polymer and the gelled bioabsorbable polymer is subjected to freeze-drying to be porosified.

公开(公告)号：EP1651712B1

公开(公告)日：2007-10-10

申请号：EP04743591.2

申请日：2004-07-29

Applicant: UNILEVER PLC ,  UNILEVER N.V.

Inventor： COOPER, Andrew ,  BUTLER, Rachel

IPC: C08J9/12 ,  C08J9/28

CPC classification number: A61L27/56 ,  C08J9/28 ,  C08J2201/048 ,  C08J2201/0504 ,  C08J2203/06

Abstract: The present invention relates to a method for producing a porous material comprising the steps of; (a) providing a C/W emulsion comprising an aqueous phase, a matrix building material, a surfactant and liquid CO2 phase; (b) at least partially freezing the aqueous phase; (c) gasifying CO2 from the liquid CO2 phase to form an intermediate porous material; (d) venting the gasified CO2 from the intermediate porous material; and (e) freeze drying the intermediate porous material at least substantially to remove the aqueous phase and form the porous material. The present invention also relates to a porous material obtainable by the method.

公开(公告)号：EP1651712A1

公开(公告)日：2006-05-03

申请号：EP04743591.2

申请日：2004-07-29

Applicant: UNILEVER PLC ,  UNILEVER N.V.

Inventor： COOPER, Andrew ,  BUTLER, Rachel

IPC: C08J9/12 ,  C08J9/28

CPC classification number: A61L27/56 ,  C08J9/28 ,  C08J2201/048 ,  C08J2201/0504 ,  C08J2203/06

Abstract: The present invention relates to a method for producing a porous material comprising the steps of; (a) providing a C/W emulsion comprising an aqueous phase, a matrix building material, a surfactant and liquid CO2 phase; (b) at least partially freezing the aqueous phase; (c) gasifying CO2 from the liquid CO2 phase to form an intermediate porous material; (d) venting the gasified CO2 from the intermediate porous material; and (e) freeze drying the intermediate porous material at least substantially to remove the aqueous phase and form the porous material. The present invention also relates to a porous material obtainable by the method.

公开(公告)号：EP0440198B1

公开(公告)日：1995-11-02

申请号：EP91101213.6

申请日：1991-01-30

Applicant: GUNZE LIMITED

Inventor： Morita, Shinichiro ,  Takahashi, Nobuya ,  Shimamoto, Takeshi ,  Matsuda, Kazuya ,  Suzuki, Shigehiko

IPC: C08J9/00 ,  A61L27/00

CPC classification number: C08J9/28 ,  A61F2/10 ,  A61F2310/00365 ,  A61L27/24 ,  A61L27/56 ,  C08J2201/048 ,  C08J2389/06

Abstract: The invention provides a process for preparing collagen sponge, the process comprising the steps of impregnating crosslinked collagen sponge with an aqueous solution of a hydrophilic organic solvent, freezing the sponge at a temperature of about -80 DEG C or lower, and vacuum-drying the sponge.

公开(公告)号：WO2014108517A3

公开(公告)日：2014-09-04

申请号：PCT/EP2014050419

申请日：2014-01-10

Applicant: NORNER IP AS

Inventor： SOLER CARLOS BARRETO ,  FREDRIKSEN SIW BODIL

IPC: C08G64/42 ,  C08J3/24 ,  C08J9/12

CPC classification number: C08G64/42 ,  C08J3/24 ,  C08J9/28 ,  C08J2201/026 ,  C08J2201/048 ,  C08J2205/026 ,  C08J2369/00

Abstract: A process for crosslinking a poly(alkylene carbonate) (PAC) in the presence of a metal ion, said process comprising: a) adding a crosslinking agent to said poly(alkylene carbonate) and b) crosslinking the resulting product of step a); so as to form a crosslinked PAC in which the crosslinks formed involve the complexation of the metal ion to said PAC and said crosslinking agent.

Abstract translation: 一种在金属离子存在下交联聚（碳酸亚烷基酯）（PAC）的方法，所述方法包括：a）向所述聚（碳酸亚烷基酯）中加入交联剂，和b）将步骤a）的所得产物交联; 从而形成交联的PAC，其中形成的交联涉及金属离子与所述PAC和所述交联剂的络合。

公开(公告)号：WO2014049055A2

公开(公告)日：2014-04-03

申请号：PCT/EP2013/070070

申请日：2013-09-26

Applicant: SOFRADIM PRODUCTION

Inventor： LADET, Sébastien ,  PROST, Nicolas

IPC: C08J9/28 ,  A61L27/20 ,  A61L27/56 ,  C08J5/18 ,  A61F2/02

CPC classification number: C08J9/28 ,  A61L27/20 ,  A61L31/042 ,  A61L31/146 ,  A61L2400/18 ,  C08J5/18 ,  C08J2201/048 ,  C08J2207/10 ,  C08J2305/04 ,  C08J2305/08 ,  C08L5/04 ,  C08L5/08

Abstract: The present invention relates to a process for preparing a porous layer of biocompatible polymer, having a uniform density and porosity, comprising the following steps: - a) a quantity Qp of solution of the said polymer, having a viscosity Vp, is poured into a mould in order to form a first sublayer, the surface of the first sublayer being left to the open air; - b) a quantity Qs of solvent, having a viscosity Vs, lower than Vp, is spread uniformly over the surface of the first sublayer so as to form a second sublayer; - c) the first and second sublayers are subjected to a step of lyophilisation, in which the said polymer is a polysaccharide chosen from hyaluronic acid, alginic acid and chitosan, salts thereof and mixtures thereof.

Abstract translation: 本发明涉及制备具有均匀密度和孔隙率的生物相容性聚合物多孔层的方法，其包括以下步骤：a）所述聚合物的溶液量Qp，其具有 将粘度Vp注入模具中以形成第一子层，第一子层的表面留在敞开的空气中; - b）将具有低于Vp的粘度Vs的溶剂量Qs均匀地分散在第一子层的表面上以形成第二子层; - c）将第一和第二子层进行冻干步骤，其中所述聚合物是选自透明质酸，海藻酸和壳聚糖的多糖，其盐和它们的混合物。