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公开(公告)号：EP1954396B1
公开(公告)日：2018-06-06
申请号：EP06832055.5
申请日：2006-12-02
Applicant: Life Technologies AS
IPC: B03C1/28
CPC classification number: B03C1/288 , B03C2201/18 , B03C2201/26
Abstract: A magnetic separator unit for the selective separation of at least one component from a fluid mixture is described. The unit can include at least one mandrel-shaped magnet unit and tubing wrapped around it. Fluid containing magnetisable particles can be passed through the tubing to allow attraction of the particles to the magnet unit.
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公开(公告)号：EP2993232B1
公开(公告)日：2018-05-16
申请号：EP15179788.3
申请日：2011-11-28
Applicant: Life Technologies AS
Inventor： ELLIS, Darren James , HOFSLOKKEN KJUS, Nini , FONNUM, Geir
IPC: C12N15/10
CPC classification number: C12Q1/6806 , C12N15/1006 , C12N15/1013
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support.
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公开(公告)号：EP3317314A1
公开(公告)日：2018-05-09
申请号：EP16741201.4
申请日：2016-07-01
Applicant: Life Technologies Corporation , Life Technologies AS
Inventor： FONNUM, Geir , MENCHEN, Steven, M. , GOKMEN, Talha, M. , LUNDBERG, Pontus , THWAR, Prasanna Krishnan , LUI, Alfred , LU, Lily , HINZ, Wolfgang , HUSABOE, Lene , BREIVOLD, Elisabeth , MOLTEBERG, Astrid, Evenroed , LARSEN, Synne
IPC: C08F220/58 , C08F8/12
Abstract: A polymer substrate, such as a polymer particle, is formed from a carboxyl functional monomer. In an example, the carboxyl functional monomer has a protection group in place of the OH of the carboxyl group. Once the monomer is polymerized, such a protection group can be removed, providing a polymer network with carboxyl functional sites. Such sites can be used to attach other functionality to the polymer substrate.
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公开(公告)号：EP2424901B1
公开(公告)日：2017-05-31
申请号：EP10718956.5
申请日：2010-04-29
Applicant: Life Technologies AS
Inventor： MODAHL, Grete Irene , FONNUM, Geir , MOLTEBERG, Astrid , LIEN, Silje , KJUS, Nini Hofslokken
IPC: C08F2/22
CPC classification number: C08F2/22 , C08F8/30 , C08F12/08 , C08F212/36 , C08F257/02 , C08F2800/20 , C08J3/128 , C08J9/18 , C08J9/20 , C08J2325/08 , C12N11/08 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998 , C08F212/08
Abstract: This invention relates to monodisperse cross-linked polymer particles, comprising particles with a substantially smooth outer surface and an average diameter of less than 1 μm, wherein the particles are solid or porous, and wherein the coefficient of variation (CV) % of the particles, when measured by CPS disk centrifugation analysis, is less than 15%. These monodisperse cross-linked polymer particles may comprise magnetic material and are useful in various application. This invention also relates to monodisperse polymer particles for use as seed particles in the Ugelstad process.
Abstract translation: 本发明涉及单分散交联聚合物颗粒，其包含具有基本光滑的外表面和平均直径小于1μm的颗粒，其中颗粒是固体或多孔的，并且其中颗粒的变异系数（CV）％ 当通过CPS盘式离心分析测量时，小于15％。 这些单分散交联聚合物颗粒可以包含磁性材料并且可用于各种应用。 本发明还涉及在Ugelstad方法中用作种子颗粒的单分散聚合物颗粒。
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公开(公告)号：EP2944689A1
公开(公告)日：2015-11-18
申请号：EP15170320.4
申请日：2007-02-15
Inventor： AARVAK, Tanja , RASMUSSEN, Anne Marie , KVALHEIM, Gunnar , PIEDRAS, Walter Gabriell Borelli , BRUNSVIG, Anne
IPC: C12N5/0783
CPC classification number: C12N5/0636
Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25- T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.
Abstract translation: 公开了用于产生免疫抑制性调节性T细胞的方法。 所述方法可以包括使CD4 + CD25-T细胞群与T细胞受体（TCR）/ CD3激活剂，TCR共刺激剂激活剂和雷帕霉素接触。 还公开了用于产生免疫抑制性调节性T细胞的试剂盒，使用方法和细胞群。
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Patent Agency Ranking
公开(公告)号：EP1989292B1
公开(公告)日：2015-06-03
申请号：EP07705900.4
申请日：2007-02-15
Inventor： AARVAK, Tanja , RASMUSSEN, Anne Marie , KVALHEIM, Gunnar , PIEDRAS, Walter Gabriell Borelli , BRUNSVIG, Anne
IPC: C12N5/0783
CPC classification number: C12N5/0636
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公开(公告)号：EP2849885A1
公开(公告)日：2015-03-25
申请号：EP13722398.8
申请日：2013-05-08
Applicant: Life Technologies AS
Inventor： NOKLEBY, Lars , REED, Berit , HILDISCH, Tine , NEURAUTER, Axl
IPC: B01L9/06 , G01N33/543 , G01N35/00
CPC classification number: B03C1/14 , B01L9/06 , B03C1/0332 , B03C1/0335 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N35/0098
Abstract: This invention relates to a sample holder for isolating magnetically labelled particles from a non-magnetic medium in a plurality of samples. The holder comprises a magnetic base for applying a magnetic force to the magnetically labelled particles and a body which is mountable on the base and demountable therefrom. The body comprises an array of sample holding portions and a magnetisable member which is magnetically urged towards the magnetic base when the body is seated on the base, whereby the body is urged to remain seated on the base. The invention also relates to use of the sample holder to separate magnetic particles from a non-magnetic medium and methods of performing such a separation.
Abstract translation: 本发明涉及一种用于从多个样品中的非磁性介质中分离磁性标记颗粒的样品架。 支架包括用于向磁性标记的粒子施加磁力的磁性基座和可安装在基座上并且可从其上拆卸的主体。 本体包括一组样品保持部分和一个可磁化部件，当本体安放在基座上时，该磁性部件被磁性地推向磁性基座，由此促使本体保持坐在基座上。 本发明还涉及使用样品架从非磁性介质中分离磁性颗粒以及执行这种分离的方法。
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公开(公告)号：EP2109669B1
公开(公告)日：2015-01-07
申请号：EP07874286.3
申请日：2007-11-15
Applicant: Life Technologies AS
Inventor： BREKKE, Ole , NORDERHAUG, Lars , NEURAUTER, Axl , SONGE, Pal
IPC: C40B50/14 , G01N33/543 , G01N33/82
CPC classification number: G01N33/82 , C12M23/20 , C12M47/02 , C12N13/00 , C40B50/14 , G01N33/543 , G01N33/54326
Abstract: Methods of reversal of the binding between a biotin compound and a biotin-binding compound are disclosed. A method of reversibly releasing a biotinylated moiety from a streptavidin (or avidin) coated support is shown as an example. The strong interaction between streptavidin or avidin-biotin is made much weaker by using a combination of modified streptavidin or avidin and modified biotin like desthiobiotin or a derivative thereof like DSB-X Biotin. A protein, such as an antibody may be biotinylated with the modified biotin. When this protein is isolated by binding the modified biotin to the modified streptavidin or avidin bound to an solid surface, it may be released under very gently and very rapid conditions by addition of free biotin. In contrast to proteins obtained by the prior art release methods the protein obtained using the previously available release methods, the proteins obtained using the methods disclosed herein will maintain their native conformation. Uses of the methods in various procedures including cell detachment procedures and techniques of detection, identification, determination, purification, separation and/or isolation of target proteins or nucleic acid molecules are also described.
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公开(公告)号：EP2038320B1
公开(公告)日：2014-03-12
申请号：EP07812526.7
申请日：2007-06-29
Applicant: Life Technologies AS
Inventor： FONNUM, Geir , LILJEROTH, Lise
IPC: C08F293/00 , C08F287/00 , C08L53/00 , C09D153/00
CPC classification number: C08F293/00 , C08F287/00 , C08F292/00 , C08F293/005 , C08F2438/01 , C08L53/005 , C09D153/005 , C08L2666/02
Abstract: Polymer particles having a multi-block vinylic polymer attached to their surface are disposed. The particles can be used in a variety of purification and detection methods.
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公开(公告)号：EP4244350A1
公开(公告)日：2023-09-20
申请号：EP21801148.4
申请日：2021-11-10
Applicant: Life Technologies AS
Inventor： JOBERT, Laure , BOSNES, Marie , LINDSTRØM, Hannah, Kim
IPC: C12N15/10
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