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    Immunomodulatory protein constructs with a helical polymeric backbone.
    134.
    发明公开
    Immunomodulatory protein constructs with a helical polymeric backbone. 审中-公开
    免疫调节蛋白 - Konstrukte mit einem helikalen Polymer-Rückgrat

    公开(公告)号：EP2404618A1

    公开(公告)日：2012-01-11

    申请号：EP10168747.3

    申请日：2010-07-07

    Applicant: Stichting Katholieke Universiteit meer in het bijzonder Radboud Universiteit Nijmegen ,  Stichting Katholieke Universiteit

    Inventor： Rowan, Alan Edward ,  Figdor, Carl Gustav

    IPC: A61K47/48 ,  A61P37/02

    CPC classification number: A61K47/48192 ,  A61K47/59 ,  A61K47/60 ,  A61K47/646

    Abstract: The present invention relates to protein constructs that comprise one or more peptides, proteins, factors, compounds or other components as further described herein that are linked to and/or are linked to each other via a helical polymeric backbone. The constructs of the invention are suitable for administration to a human or animal body and can be used for pharmaceutical purposes, for example for immunotherapy such as for treating cancer and for other immunological applications, as well as for other therapeutic, prophylactic and/or diagnostic purposes.

    Abstract translation: 本发明涉及包含一个或多个肽，蛋白质，因子，化合物或本文进一步描述的其它组分的蛋白质构建体，其通过螺旋聚合物主链相互连接和/或彼此连接。 本发明的构建体适用于给予人或动物体并且可用于药物目的，例如用于免疫治疗，例如用于治疗癌症和其它免疫应用，以及用于其它治疗，预防和/或诊断 目的。

    OROPHARYNGEAL AIRWAY DEVICE
    137.
    发明申请
    OROPHARYNGEAL AIRWAY DEVICE 审中-公开

    公开(公告)号：WO2020256547A1

    公开(公告)日：2020-12-24

    申请号：PCT/NL2020/050390

    申请日：2020-06-18

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： BRUHN, Jörgen ,  VAN GEFFEN, Geert-Jan

    IPC: A61M16/04 ,  A61M16/08

    Abstract: Oropharyngeal airway device having a singular body (2) of a first material. The singular body (2) has an elongate shape along a substantially longitudinal axis (3) and has a uniform cross section perpendicular to the substantially longitudinal axis (3). The substantially uniform cross section has at least three stub portions (4) extending radially from the substantially longitudinal axis (3) and defining open airway sections of the oropharyngeal airway device. The at least three stub portions (4) are at an equal angle to each other in the substantially uniform cross section.

    HEART ASSIST DEVICE
    138.
    发明申请
    HEART ASSIST DEVICE 审中-公开

    公开(公告)号：WO2020180176A1

    公开(公告)日：2020-09-10

    申请号：PCT/NL2020/050129

    申请日：2020-02-28

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： VAN DORT, Daniël Immanuel Michaël

    IPC: A61M1/10 ,  A61M1/12

    Abstract: A device (2) for providing circulatory assistance is provided and comprises a balloon (4) comprising a membrane defining a cavity having an internal volume (Vc), wherein the balloon comprises a proximal portion (4a) comprising a proximal end and a distal portion (4b) comprising a distal end. The device (2) further comprises a first catheter, affixed to the distal end of the balloon (4) at a first fixation point (P1) and a second catheter (8), affixed to the proximal end of the balloon at a second fixation point (P2). The second catheter (8) is configured for axial movement with respect to the first catheter or guide wire (6) between a first position in which the first and second fixation points (P1, P2) are spaced apart from each other in the longitudinal direction by a first distance (Dx), which is variable to bring about inversion of the balloon.

    BREATH SAMPLER
    139.
    发明申请
    BREATH SAMPLER 审中-公开

    公开(公告)号：WO2020053431A1

    公开(公告)日：2020-03-19

    申请号：PCT/EP2019/074580

    申请日：2019-09-13

    Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

    Inventor： DE JONGE, Marinus Isaäk ,  VAN DEN KIEBOOM, Cornelis Hubertus

    IPC: A61B5/097 ,  A61B5/08 ,  A61B5/091

    Abstract: A breath sampler (100) for collecting a breath sample from a patient is disclosed. The breath sampler comprises a non-rebreather part (110) comprising a sample inlet (130), a one-way outlet valve (160) downstream of the sample inlet (130), and an air inlet (140). The one-way outlet valve (160) and the sample inlet (130) define a first portion of an internal breath flow pathway therebetween. The air inlet (140) is arranged to be closed by a one-way inlet valve arranged to allow air to enter the nonrebreather part (110). The breath sampler also comprises a sample delivery part (120) in fluid communication with the non-rebreather part (110) at an upstream end via the one-way outlet valve (160). The sample delivery part (120) defines a second portion of the internal breath flow pathway, and comprises an air diverter (170), a sample outlet (190), a return inlet (195) and a sample collection chamber connector (150). The air diverter (170) is arranged to divide the sample delivery part (120) into an upstream portion upstream of the air diverter (170) and a downstream portion downstream of the air diverter and is configured to divert the breath sample into a sample collection chamber (200) comprising a liquid capture interface. The breath sampler further comprises the sample collection chamber (200) coupled to the sample collection chamber connector, the sample collection chamber comprising a liquid capture interface.

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