公开(公告)号：AU2004220539B8

公开(公告)日：2011-01-06

申请号：AU2004220539

申请日：2004-03-04

Applicant: US GOV SEC NAVY ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： JUSTUS BRIAN L ,  MILLER ROBERT ,  FALKENSTEIN PAUL ,  NING HOLLY ,  HUSTON ALAN LEE ,  ALTEMUS ROSEMARY ,  COLEMAN NORMAN C

IPC: A61N5/10

Abstract: A method and an apparatus for dose-guided radiotherapy for a patient (P) having an identified radiotherapy target utilizes a radiation detecting array (R) of radiation-sensitive dosimeters for the real-time remote measurement of radiotherapy at the radiation detecting array (R). The radiation detecting array is positioned within the patient's (P) body along the treatment path before or after the identified radiotherapy target or the device may be positioned beyond the patient (P) to measure transit dose. A radiation source (A) for emitting radiation for radiotherapy along a treatment path through the patient (P) to the identified radiotherapy target is utilized. The method includes generating a predicted dose pattern of radiation at the placed radiation detecting array (R). The predicted dose pattern assumes an on-target radiation source (A) emitting the radiotherapy beam along the treatment path through the patient (P) to the identified radiotherapy target. Gating of the radiation source (A) can occur responsive to the comparing of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array (R). Radiation intensity can vary between low levels to a treatment level responsive to coincidence of the predicted dose pattern of radiation to the real-time dose pattern at the radiation detecting array (R).

公开(公告)号：AU2004263135B2

公开(公告)日：2010-11-25

申请号：AU2004263135

申请日：2004-08-06

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： FRASCH CARL E ,  LEE CHE-HUNG ROBERT

IPC: A61K39/02 ,  A61K39/09 ,  A61K39/095 ,  A61K39/102 ,  A61K39/112 ,  A61K39/385 ,  A61K47/48

Abstract: Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.

公开(公告)号：AU2004217988C1

公开(公告)日：2010-06-03

申请号：AU2004217988

申请日：2004-02-13

Applicant: SOUTHWEST FOUNDATION FOR BIOMEDICAL RES ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： SIMMONS ANNE-MARIE ,  RAO PEMMARAJU N ,  KIM HYUN K

IPC: C07J7/00 ,  C07D20060101 ,  C07J21/00

公开(公告)号：AU2005203596C1

公开(公告)日：2009-12-10

申请号：AU2005203596

申请日：2005-08-12

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN

Inventor： DURBIN ANNA P ,  MURPHY BRIAN R ,  COLLINS PETER L ,  SKIADOPOULOS MARIO H

IPC: C12N15/00 ,  C12N15/09 ,  A61K39/155 ,  A61P31/14 ,  C07K14/115 ,  C07K14/135 ,  C12N7/00 ,  C12N7/04 ,  C12R1/93

Abstract: Attenuated, recombinant negative stranded RNA viruses suitable for vaccine use are produced from one or more isolated polynucleotide molecules encoding the virus. A recombinant genome or antigenome of the subject virus is modified to encode a mutation within a recombinant protein of the virus at one or more amino acid positions(s) corresponding to a site of an attenuating mutation in a heterologous, mutant negative stranded RNA virus. A similar attenuating mutation as identified in the heterologous negative stranded RNA virus is thus incorporated at a corresponding site within the recombinant virus to confer an attenuated phenotype on the recombinant virus. The attenuating mutation incorporated in the recombinant virus may be identical or conservative in relation to the attenuating mutation identified in the heterologous, mutant virus. By the transfer of mutations into recombinant negative stranded RNA viruses in this manner, candidate vaccine viruses are engineered to elicit a desired immune response against a subject virus in a host susceptible to infection thereby.

公开(公告)号：AU2004203609B2

公开(公告)日：2009-10-01

申请号：AU2004203609

申请日：2004-08-04

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEA

Inventor： SCHILLER JOHN T ,  LOWY DOUGLAS R ,  KIRNBAUER REINHARD

IPC: G01N33/53 ,  A61K39/00 ,  A61K39/12 ,  A61K39/23 ,  A61P17/12 ,  A61P31/12 ,  A61P31/20 ,  A61P35/00 ,  C07K14/025 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N7/04 ,  C12N15/09 ,  C12N15/37 ,  C12P21/02 ,  C12Q1/70 ,  C12R1/91 ,  G01N33/566 ,  G01N33/569

Abstract: Recombinant papillomavirus capsid proteins that are capable of self-assembly into capsomer structures and viral capsids that comprise conformational antigenic epitopes are provided. The capsomer structures and viral capsids, consisting of the capsid proteins that are expression products of a bovine, monkey or human papillomavirus L1 conformational coding sequence proteins, can be prepared as vaccines to induce a high-titer neutralizing antibody response in vertebrate animals. The self assembling capsid proteins can also be used as elements of diagnostic immunoassay procedures for papillomavirus infection.

公开(公告)号：AU2005244541B2

公开(公告)日：2008-03-20

申请号：AU2005244541

申请日：2005-12-15

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： YANG ZHI-YONG ,  NABEL GARY J

IPC: A61K39/295

公开(公告)号：AU2007234733A1

公开(公告)日：2007-10-18

申请号：AU2007234733

申请日：2007-04-06

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH

Inventor： ZHU ZHONGYU ,  DIMITROV DIMITER S

IPC: C07K16/22 ,  A61K39/395 ,  A61P35/00 ,  C12N5/10 ,  C12N15/13 ,  G01N33/00

Abstract: Antibody compositions and methods for treatment of neoplastic disease in a mammalian subject are provided. Methods of diagnosing cancer in a mammalian subject are also provided.

公开(公告)号：AU2001278875B2

公开(公告)日：2007-06-07

申请号：AU2001278875

申请日：2001-07-06

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： GREIG NIGEL H ,  HOLLOWAY HAROLD WAYNE ,  ZHU XIAO-XIANG ,  YU QIAN-SHENG ,  MATTSON MARK

IPC: C07D513/04 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  C07D263/58 ,  C07D277/68 ,  C07D277/82 ,  C07D498/04

Abstract: This invention relates generally to tetrahydrobenzothiazole analogues and tetrahydrobenzooxyzole analogues, to pharmaceutical compositions which include these compounds and a pharmaceutically acceptable carrier, and to methods of treatment using these compounds. The invention also encompasses pharmaceutically acceptable esters, amides, and salts of such compounds. The invention further provides a method of reducing or delaying apoptosis in a population of cells, comprising contacting the population of cells with a tetrahydrobenzothiazole analogue or a tetrahydrobenzooxyzole analogue, thereby reducing or delaying apoptosis in the population of cells.

公开(公告)号：AU2004201615B2

公开(公告)日：2007-01-25

申请号：AU2004201615

申请日：2004-04-16

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： SIM KIM LEE ,  NARUM DAVID L

IPC: C07K16/20 ,  A61K39/395 ,  A61P33/06 ,  C12N5/20

公开(公告)号：AU2004201550B2

公开(公告)日：2007-01-18

申请号：AU2004201550

申请日：2004-04-15

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY

Inventor： FISHER LARRY W ,  YOUNG MARIAN F ,  FEDARKO NEAL S

IPC: G01N33/53 ,  C07K14/47 ,  G01N33/68