公开(公告)号：EP2910632A1

公开(公告)日：2015-08-26

申请号：EP13846643.8

申请日：2013-10-17

Applicant: Tokushima University ,  Meiji Pharmaceutical University ,  LSIP, LLC

Inventor： ITO Koji ,  SAKURABA Hitoshi ,  TSUJI Daisuke

IPC: C12N15/09 ,  A61K38/46 ,  A61K48/00 ,  A61P25/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/88

CPC classification number: C12N9/2402 ,  A61K38/00 ,  A61K38/47 ,  C12Y302/01052

Abstract: Provided is a modified β-subunit of human β-hexosaminidase which has the activity derived from the α-subunit of wild-type human β-hexosaminidase and has the resistance to protease.
A protein comprising an amino acid sequence having substitutions of the 312th to the 318th amino acids with glycine, serine, glutamic acid, proline, serine, glycine and threonine in order, respectively, in an amino acid sequence of a β-subunit of wild-type human β-hexosaminidase.

Abstract translation: 提供了具有源自野生型人²-己糖胺酶的± - 亚单位的活性的人²-氨基己糖苷酶的修饰的二亚基，并具有对蛋白酶的抗性。 一种蛋白质，其含有分别具有312位至第318位氨基酸的氨基酸序列，其具有甘氨酸，丝氨酸，谷氨酸，脯氨酸，丝氨酸，甘氨酸和苏氨酸，分别依次为野生型的二亚基的氨基酸序列， 型人²-己糖胺酶。

公开(公告)号：EP4393516A1

公开(公告)日：2024-07-03

申请号：EP22861082.0

申请日：2022-08-02

Applicant: Tokushima University

Inventor： SEITO, Tsutomu ,  SEGAWA, Tatsuya ,  SHIMIZU, Mamoru ,  TAKAYAMA, Tetsuji ,  MUGURUMA, Naoki ,  FUJIMOTO, Shota ,  KASHIHARA, Takanori

IPC: A61K47/68 ,  A61K39/395 ,  A61K41/00 ,  A61K49/00 ,  A61P35/00 ,  A61K31/409

CPC classification number: A61K49/00 ,  A61K39/395 ,  A61K41/00 ,  A61K47/68 ,  A61P35/00 ,  A61K31/409

Abstract: The purpose of the present invention is to provide a detecting agent (diagnostic agent) and a treatment agent that are taken into tumors in vivo promptly and that bind to c-KIT molecules. In the quest for a molecular species that specifically binds to c-KIT, and a labelling agent and a treatment agent that bind to said molecular species, the inventors found that by combining an anti-c-KIT antibody fragment and IR700, rapid accumulation into tumors takes place in just several hours after administration, and detection and treatment becomes possible. Accordingly, the present invention pertains to an antigen-binding fragment of an anti-c-KIT antibody, IR700, and a composite body, and also pertains to a detecting agent and a treatment agent that contain said composite body as an active ingredient. Specifically, the present invention pertains to: a complementary determining region (CDR) in the antibody heavy chain which has the amino acid sequence described in SEQ ID NO: 2; and a composite body having IR700 and an antigen-binding fragment of an antibody having a CDR in the antibody light chain which has the amino acid sequence described in SEQ ID NO: 4.

公开(公告)号：EP4388869A1

公开(公告)日：2024-06-26

申请号：EP21954255.2

申请日：2021-08-20

Applicant: JTEKT Corporation ,  Tokushima University

Inventor： TAKESHIMA Masayuki ,  SHIBATA Yoshiyuki ,  SOKU Toshimasa ,  NUMAZAKI Kazuya ,  MORIMATSU Fumiki ,  TAKAGAKI Kentaroh ,  HIRATA Maki

IPC: A01K1/03

CPC classification number: A01K1/03

Abstract: A management system for an experimental animal is provided. This management system includes an information identifying unit configured to identify experimental information on the experimental animal to be transported to an experiment site, and a stress value calculating unit configured to calculate a stress value indicating stress to be suffered by the experimental animal during transportation based on the experimental information. The experimental information includes at least a part of a transportation distance for the transportation of the experimental animal, a transportation period for the transportation of the experimental animal, the number of the experimental animals to be transported at a time, an age of the experimental animal, and information on pretreatment given to the experimental animal prior to the transportation.

公开(公告)号：EP4279483A1

公开(公告)日：2023-11-22

申请号：EP21919517.9

申请日：2021-10-08

Applicant: Tokushima University ,  Aichi Steel Corporation

Inventor： NAMBA, Kosuke ,  MERA, Akane ,  SUZUKI, Motofumi

IPC: C07D207/16

Abstract: Provided is a simple method for producing a heterocycle-containing amino acid compound. A heterocycle-containing amino acid compound is produced by a method comprising step A of reacting a compound represented by the following formula (2) or a salt thereof:

wherein R 4 is a hydrogen atom or a carboxyl-protecting group, and
n is an integer of 1 to 3,
acrolein, a cyanating agent, and a compound represented by the following formula (3) or a salt thereof:
wherein R 1a is a hydrogen atom or CC 2 R 1b , R 1b is a hydrogen atom or a carboxyl-protecting group, R 2a is a hydrogen atom or OR 2b , R 2b is a hydrogen atom or a hydroxyl-protecting group, and R 3 is a hydrogen atom or an amino-protecting group.

公开(公告)号：EP4129995A1

公开(公告)日：2023-02-08

申请号：EP20928629.3

申请日：2020-12-10

Applicant: Aichi Steel Corporation ,  Tokushima University

Inventor： MERA Akane ,  SUZUKI Motofumi ,  HOSODA Kensuke ,  NAMBA Kosuke

IPC: C07D403/06 ,  C07F15/02 ,  A01P21/00 ,  C05C11/00 ,  A01N43/36

Abstract: The purpose of the present invention is to provide: a compound which has a metal uptake ability and is suitable as an iron supply material for cultivation using foliar spraying and hydroponics when used as an iron complex; a complex; and a fertilizer and a plant growth regulator containing the compound or the complex. The lactam compound and a salt thereof in the present invention are represented by general formulae (1) and (2).


(In the formula, R 1 and R 2 may be the same or different, and each represent a hydrogen atom or a protective group of a carboxyl group, and X - is a halogen ion, an organic acid ion, or an inorganic acid ion.)

公开(公告)号：EP3984554A1

公开(公告)日：2022-04-20

申请号：EP20822287.7

申请日：2020-06-10

Applicant: ONO Pharmaceutical Co., Ltd. ,  Tokushima University

Inventor： OKAZAKI, Taku ,  SUGIURA, Daisuke ,  OKAZAKI, Il-mi ,  SHIBAYAMA, Shiro

IPC: A61K39/395 ,  A61P37/06 ,  A61P37/08 ,  C07K16/28 ,  C07K16/46

Abstract: The present disclosure provides an immunosuppressant containing a bispecific molecule including a first binding site that specifically binds to LAG3 and a second binding site that specifically binds to CD3 or CD8.

公开(公告)号：EP3967714A1

公开(公告)日：2022-03-16

申请号：EP20805833.9

申请日：2020-05-08

Applicant: Sekisui Chemical Co., Ltd. ,  Tokushima University

Inventor： NISHIMURA, Yohei ,  YAMAZAKI, Risa ,  UTE, Koichi ,  OSHIMURA, Miyuki ,  HIRANO, Tomohiro ,  KAGITANI, Ryo

IPC: C08F8/30 ,  C08F16/06 ,  C08F16/38

Abstract: The present invention provides a vinyl alcohol-amino acid ester copolymer that is excellent in properties such as cell culture properties, biocompatibility, antibacterial properties, and solubility in organic solvents, and is applicable to the medical field, the biomaterial field, and the agricultural field (medical and life science fields). Provided is a vinyl alcohol-amino acid ester copolymer including a unit represented by the following formula (1) and a unit represented by the following formula (2):

where, in the formula (2), R 1 represents a hydrocarbon group that may optionally have a substituent, R 2 and R 3 each independently represent a hydrogen atom or a hydrocarbon group, and R 1 and R 2 , or R 2 and R 3 , may optionally be bonded together to form a cyclic structure.

公开(公告)号：EP3889264A1

公开(公告)日：2021-10-06

申请号：EP19890179.5

申请日：2019-11-28

Applicant: Tokushima University ,  OncoTherapy Science, Inc.

Inventor： KATAGIRI, Toyomasa ,  YOSHIMARU, Tetsuro ,  OTAKA, Akira ,  MIYAMOTO, Takashi ,  OKAMOTO, Yasuhide

IPC: C12N15/12 ,  A61K38/10 ,  A61K38/12 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47

Abstract: The present invention provides peptides containing the BIG3 polypeptide-binding site in a PHB2 polypeptide, which inhibit the binding between a PHB2 polypeptide and a BIG3 polypeptide, and pharmaceutical compositions containing the peptide. The peptides of the present invention have the ability to bind not to PHB2, whose expression is found in organs throughout the human body, but to BIG3, which is a protein highly expressed specifically in particularly estrogen receptor-positive cancer, and have excellent growth suppressive effects on BIG3-positive cancer cells. Accordingly, the peptides of the present invention are useful as therapeutic agents for breast cancer which can avoid expression of side effects.

公开(公告)号：EP3848350A1

公开(公告)日：2021-07-14

申请号：EP19854627.7

申请日：2019-08-22

Applicant: Tokushima University ,  Aichi Steel Corporation

Inventor： NAMBA Kosuke ,  SUZUKI Motofumi ,  MERA Akane

IPC: C07D207/16 ,  A01N43/36 ,  A01N59/16 ,  A01P21/00 ,  C05C11/00 ,  C05D9/02 ,  C05F11/10 ,  C07F15/02

Abstract: The present invention is a heterocycle-containing amino acid compound represented by a general formula (1):

wherein R 1 and R 2 are identical with or different from each other, and each represent a hydrogen atom or a carboxy-protecting group;
R 3 represents a carboxyl group or a hydroxyl group; and
n is 1 or 2,
or a salt thereof.

公开(公告)号：EP3715390A1

公开(公告)日：2020-09-30

申请号：EP18879535.5

申请日：2018-11-14

Applicant: Tokushima University ,  Sekisui Chemical Co., Ltd.

Inventor： UTE, Koichi ,  HIRANO, Tomohiro ,  OSHIMURA, Miyuki ,  KUSAKA, Yasunari ,  NISHIMURA, Yohei ,  SENOO, Misaki

IPC: C08F218/08 ,  C08F216/08

Abstract: The present invention provides a vinyl alcohol-vinyl acetate copolymer having excellent solubility and capable of providing a film having high flexibility, high mechanical strength, and high adhesion, and a method for producing a vinyl alcohol-vinyl acetate copolymer. Provided is a vinyl alcohol-vinyl acetate copolymer including a unit of vinyl alcohol and a unit of vinyl acetate, the vinyl alcohol-vinyl acetate copolymer having a triad unit chain ratio T OO of 7.5 or less, where the triad unit chain ratio T OO is obtained using the following formula (1):
[Math. 1] T OO = Vac content × OOO proportion × 2 VOH content × AOO proportion wherein the VOH content ratio represents the amount of the unit of vinyl alcohol, the Vac content ratio represents the amount of the unit of vinyl acetate, the OOO proportion represents the proportion of a triad OOO,and the AOO proportion represents the proportion of a triad AOO.