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    THIOAMIDE MOIETY-CONTAINING POLYMER DRUG CONJUGATES
    131.
    发明申请
    THIOAMIDE MOIETY-CONTAINING POLYMER DRUG CONJUGATES 审中-公开

    公开(公告)号：WO2001007013A3

    公开(公告)日：2001-02-01

    申请号：PCT/US2000/020090

    申请日：2000-07-24

    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  STEIN, Stanley ,  ZHANG, Guobao ,  QIU, Bo

    Inventor： STEIN, Stanley ,  ZHANG, Guobao ,  QIU, Bo

    IPC: A61K47/48

    Abstract: This invention pertains to disulfide-linked conjugates of therapeutic agents containing at least one thioamide group with polymer comprising at least one thiol group, so as to provide a controlled release pharmaceutical composition for administration to animals for the prophylaxis or treatment of various conditions or diseases. The therapeutic agent conjugate may comprise an inactive or weakly active prodrug form which may be converted into the original therapeutic compound by the natural action of reducing agents in vivo . The composition may comprise a mixture of polymers each with a different thioamide-containing agent attached, or a polymer conjugated with a mixture of thioamide-containing agents. Modified properties of the therapeutic compound potentially provided by the polymer itself, as well as by other compounds also appended to the polymer, include but are not limited to greater water solubility, longer in vivo half-life (due to larger size of the conjugate), slower release from a sustained-release depot (due to larger size of the conjugate), better oral bioavailability and tissue-specific targeting.

    LONG TERM MAINTENANCE OF LYMPHOCYTES IN VITRO
    132.
    发明申请
    LONG TERM MAINTENANCE OF LYMPHOCYTES IN VITRO 审中-公开
    长寿命维生素L在体内

    公开(公告)号：WO1996038158A1

    公开(公告)日：1996-12-05

    申请号：PCT/US1996008182

    申请日：1996-05-31

    Applicant: THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

    Inventor： THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  RON, Yacov ,  DOUGHERTY, Joseph

    IPC: A61K35/14

    CPC classification number: C12N5/0636 ,  A61K48/00 ,  C12N2501/115 ,  C12N2502/11 ,  C12N2502/28

    Abstract: Long term culture of resting T lymphocytes. The present invention provides methods and compositions for maintaining resting, mature T lymphocytes (cells) for long term in the absence of mitogens, antigens, or stimulatory cytokines, in which the T cells maintain their ability to respond to mitogens and allogeneic cells. T cells cultured under such conditions can be used as target cells for retroviral vector-mediated gene transfer and implemented in certain gene therapy applications. The culturing conditions described herein allow for the continuous availability of T lymphocytes for various pharmacological, diagnostic, gene therapy, and experimental purposes, and can be utilized for any application requiring non-stimulated T lymphocytes. In specific examples, umbilical cord blood and peripheral blood T lymphocytes and endothelial-like adherent monocytes are cultured in DMEM, 2 % 2-mercaptoethanol containing either 20 % horse serum, or RPMI 2 % 2-ME containing 10 % fetal calf serum supplemented with basic fibroblast growth factor for up to three months.

    Abstract translation: 休息T淋巴细胞的长期培养。 本发明提供了在缺乏有丝分裂原，抗原或刺激性细胞因子的情况下长期维持休息的成熟T淋巴细胞（细胞）的方法和组合物，其中T细胞保持其对丝裂原和同种异体细胞的响应能力。 在这种条件下培养的T细胞可用作逆转录病毒载体介导的基因转移的靶细胞，并在某些基因治疗应用中实施。 本文描述的培养条件允许用于各种药理，诊断，基因治疗和实验目的的T淋巴细胞的连续可用性，并且可以用于需要非刺激性T淋巴细胞的任何应用。 在具体实例中，将脐带血和外周血T淋巴细胞和内皮样粘附单核细胞在含有20％马血清的DMEM，含有10％胎牛血清的RPMI 2％2-ME的DMEM，2％2-巯基乙醇中培养， 碱性成纤维细胞生长因子长达三个月。

    AN INTERACTIVE SYSTEM USING A GRAPHICAL INTERFACE FOR ASSISTING MEDICAL PROFESSIONALS IN THE DIAGNOSIS, TREATMENT AND MANAGEMENT OF SURGICAL AND TRAUMA PATIENTS
    133.
    发明申请
    AN INTERACTIVE SYSTEM USING A GRAPHICAL INTERFACE FOR ASSISTING MEDICAL PROFESSIONALS IN THE DIAGNOSIS, TREATMENT AND MANAGEMENT OF SURGICAL AND TRAUMA PATIENTS 审中-公开
    使用图形界面辅助医学专业人员进行诊断，治疗和治疗外科手术和TRAUMA患者的交互式系统

    公开(公告)号：WO1996019774A1

    公开(公告)日：1996-06-27

    申请号：PCT/US1995016611

    申请日：1995-12-19

    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY

    Inventor： UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  SIEGEL, John, H. ,  MARSH, Philip

    IPC: G06F19/00

    CPC classification number: G06F19/325 ,  G06F19/00 ,  G06F19/3481

    Abstract: An interactive graphic computer methodology has been developed allowing a surgical resident or trauma surgeon to utilize a series of body images to record the location, type, complexity and physiology severity of trauma injuries via an interface device such as a mouse controller. The methodology incorporates, as a primary machine/human interface, a plurality of color graphic screens which share a common relational data base. Those graphic screen images include: (1) skin and superficial anatomy (for location of sites and types of injuries or burns), (2) skull, facial bones and CNS neurologic exam with automated calculation of GCS, (3) skeletal and joint anatomy (for orthopedic injuries), (4) spinal cord injury exam, (5) thoraco-abdominal viscera, (6) liver, pancreas and biliary tract, (7) retroperitoneal organs and structures, (8) vascular anatomy, (9) lung and tracheo bronchial tree. After data entry, injuries can be grouped for reporting and coding (i.e., fractures, organ injuries, lacerations, etc.). For specific types of injury, severity criteria are determined, therapeutic management guidelines estimated and state of the art therapeutic suggestions and cautions provided.

    Abstract translation: 已经开发了一种交互式图形计算机方法，其允许外科手术住院或创伤外科医生利用一系列身体图像来通过诸如鼠标控制器之类的接口设备记录创伤损伤的位置，类型，复杂性和生理学严重性。 该方法将作为主机/人机接口的多个彩色图形屏幕结合起来，共享公共关系数据库。 这些图形屏幕图像包括：（1）皮肤和浅层解剖（用于位置和伤害或灼伤类型），（2）头骨，面部骨骼和CNS神经系统检查，自动计算GCS，（3）骨骼和关节解剖 （骨科损伤），（4）脊髓损伤检查，（5）胸腹内脏，（6）肝，胰腺和胆道，（7）腹膜后器官和结构，（8）血管解剖，（9）肺 和气管支气管树。 数据录入后，伤害可以分组报告和编码（即骨折，器官损伤，撕裂等）。 对于特定类型的伤害，确定严重性标准，估计治疗管理指南和提供最新的治疗建议和注意事项。

    IMPROVED MICROFLUIDIC DEVICE AND METHOD AND SYSTEM FOR ITS USE
    136.
    发明申请
    IMPROVED MICROFLUIDIC DEVICE AND METHOD AND SYSTEM FOR ITS USE 审中-公开

    公开(公告)号：WO2013019881A3

    公开(公告)日：2013-02-07

    申请号：PCT/US2012/049191

    申请日：2012-08-01

    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  WIEDER, Robert ,  KUMAR, Rajan

    Inventor： WIEDER, Robert ,  KUMAR, Rajan

    IPC: G01N33/53 ,  G01N33/543 ,  C12M1/34 ,  B01L3/00

    Abstract: A method, device, and system is disclosed to detect whether one or more analytes of interest are present on a cell or cell organelle surface. The device includes a cartridge that includes a channel having a bottom surface that includes at least one immobilized patch of reagents with a binding affinity for one of the analytes of interest. The method introduces a fluid containing at least one cell or cell organelle into the channel, measures the velocity of at least one cell or cell organelle individually over each of the immobilized patches at a plurality of defined time intervals or distances for each patch, discards some of the largest velocity measurements, and compares the mean value of the remaining velocity measurements to a control value to determine whether the analyte of interest is present on the surface of the cell or cell organelle.

    TREATMENT OF TYPE II DIABETES AND DIABETES-ASSOCIATED DISEASES WITH SAFE CHEMICAL MITOCHONDRIAL UNCOUPLERS
    139.
    发明申请
    TREATMENT OF TYPE II DIABETES AND DIABETES-ASSOCIATED DISEASES WITH SAFE CHEMICAL MITOCHONDRIAL UNCOUPLERS 审中-公开

    公开(公告)号：WO2012068274A9

    公开(公告)日：2012-05-24

    申请号：PCT/US2011/061028

    申请日：2011-11-16

    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  JIN, Shengkan

    Inventor： JIN, Shengkan

    IPC: A61K31/165

    Abstract: This application discloses methods for treating, preventing and/or alleviating the symptoms of type II diabetes and diabetes-related disorders or complications. The invention provides a novel approach to treating and managing disorders and symptoms related to elevated plasma glucose concentrations and insulin resistance, characterized by few side effects and low toxicity. In particular, the invention provides 2-hydroxy-benzoic anilide compounds and derivatives, and compositions thereof, which can control blood- glucose and increase insulin sensitivity by reducing plasma glucose concentration and cellular energy efficiency.

    TREATMENT OF TYPE II DIABETES AND DIABETES-ASSOCIATED DISEASES WITH SAFE CHEMICAL MITOCHONDRIAL UNCOUPLERS
    140.
    发明申请
    TREATMENT OF TYPE II DIABETES AND DIABETES-ASSOCIATED DISEASES WITH SAFE CHEMICAL MITOCHONDRIAL UNCOUPLERS 审中-公开

    公开(公告)号：WO2012068274A8

    公开(公告)日：2012-05-24

    申请号：PCT/US2011/061028

    申请日：2011-11-16

    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY ,  JIN, Shengkan

    Inventor： JIN, Shengkan

    IPC: A61K31/165

    Abstract: This application discloses methods for treating, preventing and/or alleviating the symptoms of type II diabetes and diabetes-related disorders or complications. The invention provides a novel approach to treating and managing disorders and symptoms related to elevated plasma glucose concentrations and insulin resistance, characterized by few side effects and low toxicity. In particular, the invention provides 2-hydroxy-benzoic anilide compounds and derivatives, and compositions thereof, which can control blood- glucose and increase insulin sensitivity by reducing plasma glucose concentration and cellular energy efficiency.

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