公开(公告)号：KR1020140112203A

公开(公告)日：2014-09-23

申请号：KR1020130026604

申请日：2013-03-13

Applicant: (주)아모레퍼시픽

Inventor： 김주원 ,  최현정 ,  이태룡 ,  조은경

IPC: G01N33/68 ,  A61K8/64 ,  A61Q19/02 ,  C12Q1/68

CPC classification number: G01N33/5023 ,  G01N33/5044 ,  G01N33/6881 ,  G01N33/6893 ,  G01N2333/4703 ,  G01N2500/00 ,  G01N2800/207 ,  A61K8/64 ,  A61Q19/02 ,  C12Q1/68

Abstract: The present invention relates to a method for screening a test substance having whitening efficacy and, more specifically, to a method for screening a test substance having whitening efficacy by checking whether or not the test substance activates Forkhead box O3A (FoxO3a) or promotes the expression thereof using FoxO3a which is a longevity gene, and thereby determining whether or not the test substance has whitening efficacy.

Abstract translation: 本发明涉及一种筛选具有增白效果的试验物质的方法，更具体地说，涉及通过检查试验物质是否活化Forkhead盒O3A（FoxO3a）或促进表达来筛选具有增白功效的试验物质的方法 使用作为长寿基因的FoxO3a，从而确定被检物质是否具有美白效果。

公开(公告)号：KR1020140093305A

公开(公告)日：2014-07-28

申请号：KR1020130002005

申请日：2013-01-08

Applicant: (주)아모레퍼시픽

Inventor： 한지연 ,  이은경 ,  조은경 ,  이태룡

IPC: G01N33/68 ,  G01N33/53 ,  G01N33/532

Abstract: The present invention relates to a method for detecting skin-active ingredients and a kit for detecting the skin-active ingredients using the same, and, more specifically, to a method for detecting skin-active ingredients which separates and purifies candidates for inducing expression of cytokine genes or proteins by activating skin immune cells using the cytokine genes or proteins that are produced and secreted from active skin immune cells, thereby detecting the skin-active ingredients including ingredients such as whitening ingredients or blackening ingredients for alleviating hypochromic and hyperchromic diseases.

Abstract translation: 本发明涉及一种检测皮肤活性成分的方法和用于检测皮肤活性成分的试剂盒，更具体地说，涉及一种分离和纯化诱导表达的候选物质的皮肤活性成分的方法 通过使用从活性皮肤免疫细胞产生和分泌的细胞因子基因或蛋白质来激活皮肤免疫细胞，从而检测皮肤活性成分，包括诸如增白成分或变黑成分的成分，以减轻低色素和变色疾病，从而检测细胞因子基因或蛋白质。

公开(公告)号：KR1020140064593A

公开(公告)日：2014-05-28

申请号：KR1020130040842

申请日：2013-04-15

Applicant: (주)아모레퍼시픽

Inventor： 박필준 ,  김형준 ,  신동욱 ,  이태룡 ,  조은경

IPC: A61N5/06 ,  A61B17/34 ,  A61M25/01

Abstract: The specification provides a light source irradiator which irradiates visible light, a kit for lipolysis with a manual described with a method for lipolysis by irradiating visible light, and a slimming method for irradiating visible light to the skin. According to the specification, the method can safely and effectively dissolve fat by dissolving triglyceride in fat cells by irradiating light with a visible light wavelength harmless to a human body and can be used for a slimming method since the method is more economical and convenient than an existing lipolysis method.

Abstract translation: 本说明书提供了照射可见光的光源照射器，用用于通过照射可见光的脂肪分解方法描述的手动进行脂肪分解的试剂盒，以及用于将可见光照射到皮肤上的减肥方法。 根据本说明书，该方法可以通过用对人体无害的可见光波长的光照射而将甘油三酯溶解在脂肪细胞中而可以安全有效地溶解脂肪，并且可以用于减肥方法，因为该方法比一种方法更经济和方便 现有脂肪分解法。

公开(公告)号：KR1020140034595A

公开(公告)日：2014-03-20

申请号：KR1020120101126

申请日：2012-09-12

Applicant: (주)아모레퍼시픽

Inventor： 김주원 ,  강영규 ,  염명훈 ,  이태룡 ,  조은경

IPC: A61K31/19 ,  A61K31/192 ,  A61K8/36 ,  A61Q19/02

Abstract: A composition for external skin application which comprises dehydroabietic acid as an active ingredient for skin whitening of the present invention can be usefully applied as a composition for external skin application with a purpose of skin whitening since effects of tyrosinase activity reduction and melanin generation reduction are excellent. The composition for external skin application contains 0.000025-0.025 wt% of the dehydroabietic acid compared to a total weight of the composition. [Reference numerals] (AA) Comparative example 1; (BB) Example 1; (CC) Example 2; (DD) Example 3

Abstract translation: 包含脱氢松香酸作为本发明的皮肤美白的活性成分的外用皮肤用组合物，作为皮肤美白用的外用皮肤用组合物，可以有用地应用，因为酪氨酸酶活性降低和黑色素产生降低的效果优异 。 与组合物的总重量相比，用于外用皮肤的组合物含有脱氢枞酸的0.000025-0.025wt％。 （附图标记）（AA）比较例1; （BB）实施例1; （CC）实施例2; （DD）实施例3

公开(公告)号：KR1020130117445A

公开(公告)日：2013-10-28

申请号：KR1020120039939

申请日：2012-04-17

Applicant: (주)아모레퍼시픽

Inventor： 김주원 ,  조은경 ,  이태룡

IPC: A61K8/49 ,  A61K31/352 ,  A61Q19/02 ,  A61P17/00

CPC classification number: A61K8/498 ,  A23L29/035 ,  A23V2200/318 ,  A61K31/353 ,  A61Q19/02

Abstract: PURPOSE: A whitening composition containing 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox) is provided to suppress the activity of tyrosinase and melanogenesis, thereby showing superior whitening effect. CONSTITUTION: A whitening composition contains 0.000025-0.025 wt% of Trolox of chemical formula 1, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. The active ingredient suppresses the activity of tyrosinase and dopaoxidase and generation of 3,4-dihydroxyphenylalanine (DOPA).

Abstract translation: 目的：提供含有6-羟基-2,5,7,8-四甲基苯并二氢吡喃-2-羧酸（Trolox）的美白组合物，以抑制酪氨酸酶的活性和黑素生成，从而显示优异的美白效果。 构成：增白组合物含有0.000025-0.025重量％的化学式1的Trolox，其衍生物或其药学上可接受的盐作为活性成分。 活性成分抑制酪氨酸酶和多巴胺酶的活性和3,4-二羟基苯丙氨酸（DOPA）的产生。

公开(公告)号：KR1020130093983A

公开(公告)日：2013-08-23

申请号：KR1020120015273

申请日：2012-02-15

Applicant: (주)아모레퍼시픽

Inventor： 김주원 ,  조은경 ,  이태룡

IPC: G01N33/68 ,  G01N33/52 ,  G01N33/15 ,  A61K8/00

Abstract: PURPOSE: An antioxidant screening method is provided to include a step of evaluating an extent that DAF-16 moves to a nucleus in an animal treated with candidate material, thereby easily and simply screening material having an excellent antioxidant effect in a short time. CONSTITUTION: An antioxidant screening method comprises: a step of treating an animal with candidate material; and a step of evaluating an extent that DAF-16 moves to a nucleus in the animal treated with the candidate material. The animal includes caenorhabditis elegans. The animal is caenorhabditis elegans which includes DAF-16 labeled by fluorescence.

Abstract translation: 目的：提供抗氧化剂筛选方法，包括评估DAF-16移动到用候选材料处理的动物中的核的程度的步骤，从而容易且简单地筛选在短时间内具有优异抗氧化作用的材料。 构成：抗氧化剂筛选方法包括：用候选物质处理动物的步骤; 以及评估DAF-16移动到用候选材料处理的动物中的核的程度的步骤。 动物包括秀丽隐杆线虫。 动物是秀丽隐杆线虫，其中包括通过荧光标记的DAF-16。