公开(公告)号：US20010043928A1

公开(公告)日：2001-11-22

申请号：US09790272

申请日：2001-02-21

Inventor： Mark E. Howard

IPC: A61K039/395 ,  A61K035/16 ,  A61K045/00 ,  A61K047/00

CPC classification number: C07K16/065 ,  A61K38/00 ,  A61K39/39516 ,  C07K16/1036

Abstract: Serum preparations obtained from sharks are used to prepare compositions, including pharmaceutical compositions, for inhibiting retrovirus replication in susceptible cells. Thus, the serum preparations are useful for inhibiting diseases associated with retroviral infection, such as acquired immunodeficiency syndrome. The serum concentrates are also used to inhibit growth of tumor cells, especially sarcomas and leukemias.

Abstract translation: 使用从鲨鱼获得的血清制剂用于制备用于抑制易感细胞中逆转录病毒复制的组合物，包括药物组合物。 因此，血清制剂可用于抑制与逆转录病毒感染相关的疾病，例如获得性免疫缺陷综合征。 血清浓缩物也用于抑制肿瘤细胞，特别是肉瘤和白血病的生长。

公开(公告)号：US5614366A

公开(公告)日：1997-03-25

申请号：US653091

申请日：1991-02-08

Applicant: Gregory R. Reyes ,  Kenneth G. Hadlock

Inventor： Gregory R. Reyes ,  Kenneth G. Hadlock

IPC: A61K39/12 ,  A61K38/00 ,  A61K39/00 ,  A61P31/12 ,  C07K1/22 ,  C07K7/06 ,  C07K7/08 ,  C07K14/15 ,  C07K16/00 ,  C07K16/10 ,  C12N1/21 ,  C12N15/09 ,  C12P21/02 ,  C12R1/19 ,  G01N33/53 ,  G01N33/574 ,  G01N33/577 ,  C07K5/00 ,  C07K7/00 ,  C12Q1/70

CPC classification number: C07K14/005 ,  C07K16/1036 ,  C07K7/06 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61 ,  C12N2740/14022 ,  Y10S435/974 ,  Y10S435/975

Abstract: Novel HTLV-I and HTLV-II peptide antigens are disclosed for use in diagnostics assays for screening and confirming HTLV-I and HTLV-II antisera. The peptides are derived from analogous regions of HTLV-I and HTLV-II gp46 envelope proteins, and are differentiated by their immunoreactivity with an HTLV-II specific monoclonal antibody and by HTLV-I and HTLV-II antisera. The peptides are also useful in vaccine compositions.

Abstract translation: 公开了新型HTLV-1和HTLV-II肽抗原用于筛选和确认HTLV-1和HTLV-II抗血清的诊断测定。 肽衍生自HTLV-1和HTLV-II gp46包膜蛋白的类似区域，并通过其与HTLV-II特异性单克隆抗体和HTLV-I和HTLV-II抗血清的免疫反应性来区分。 肽也可用于疫苗组合物。

公开(公告)号：US5545550A

公开(公告)日：1996-08-13

申请号：US250314

申请日：1994-05-27

Applicant: Sidney E. Grossberg ,  Vladimir M. Kushnaryov ,  L. William Cashdollar ,  Donald R. Carrigan ,  Konstance K. Knox

Inventor： Sidney E. Grossberg ,  Vladimir M. Kushnaryov ,  L. William Cashdollar ,  Donald R. Carrigan ,  Konstance K. Knox

IPC: A61K39/21 ,  C07K14/15 ,  C07K16/10 ,  C12N7/00 ,  G01N33/569 ,  C12N5/08 ,  C12N5/10

CPC classification number: G01N33/56983 ,  C07K14/005 ,  C07K16/1036 ,  C12N7/00 ,  C12N2740/10021 ,  C12N2740/10022

Abstract: A method for the detection of the presence or absence of antibodies which bind to antigens of an NMA virus Deficiency is disclosed. This method comprises contacting a solution containing antigens of an NMA virus with a biological sample of a patient and detecting the antibody-antigen complexes. Methods for detection of the presence or absence of antigens or nucleic acid sequences specific to an NMA virus are also disclosed. A substantially purified preparation of an NMA virus and a human cell line chronically infected with an NMA virus are also disclosed.

Abstract translation: 公开了一种检测结合NMA病毒缺陷抗原的抗体的存在或不存在的方法。 该方法包括将含有NMA病毒抗原的溶液与患者的生物样品接触并检测抗体 - 抗原复合物。 还公开了检测NMA病毒特异性的抗原或核酸序列的存在或不存在的方法。 还公开了NMA病毒和长期感染NMA病毒的人类细胞系的基本上纯化的制剂。

公开(公告)号：US5264342A

公开(公告)日：1993-11-23

申请号：US962603

申请日：1992-10-16

Applicant: Kurt B. Osther ,  Gottfried H. Kellermann

Inventor： Kurt B. Osther ,  Gottfried H. Kellermann

IPC: C07K16/08 ,  C07K16/10 ,  C07K16/12 ,  C07K16/20 ,  G01N33/569 ,  G01N33/68 ,  C12Q1/70 ,  C12Q1/00

CPC classification number: C07K16/12 ,  C07K16/081 ,  C07K16/1036 ,  C07K16/20 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/6854 ,  Y10S435/967 ,  Y10T436/106664

Abstract: A method for determining the sensitivity and/or specificity of assays that detect the presence or absence of antibodies to viral and/or other microbial infective agents using porcine seroconversion panels, and production of the seroconversion panels is provided.

Abstract translation: 提供了一种用于测定使用猪血清转换板检测病毒和/或其他微生物感染因子的抗体的存在或不存在的测定的灵敏度和/或特异性的方法，以及血清转换板的生产。

公开(公告)号：US5254457A

公开(公告)日：1993-10-19

申请号：US295933

申请日：1989-01-11

Applicant: Anton A. Minassian ,  Mikulas Popovic ,  Robert C. Gallo

Inventor： Anton A. Minassian ,  Mikulas Popovic ,  Robert C. Gallo

IPC: C07K16/10 ,  C12Q1/70 ,  A61K35/14 ,  C07K3/00 ,  C12N5/00

CPC classification number: C07K16/1045 ,  C07K16/1036 ,  Y10S435/974 ,  Y10S435/975

Abstract: Novel hybridoma cell lines and monoclonal antibodies are provided which can differentiate between HIV-1, HIV-2 and SIV retrovirus isolates. A synthetic peptide which is useful as a universal diagnostic reagent for detecting retroviral infection is also described.

Abstract translation: 提供了可以区分HIV-1，HIV-2和SIV逆转录病毒分离株的新型杂交瘤细胞系和单克隆抗体。 还描述了可用作检测逆转录病毒感染的通用诊断试剂的合成肽。

公开(公告)号：US5130232A

公开(公告)日：1992-07-14

申请号：US536860

申请日：1990-06-12

Applicant: Lucy F. Lee ,  Zhizhong Cui ,  Richard L. Witter

Inventor： Lucy F. Lee ,  Zhizhong Cui ,  Richard L. Witter

IPC: C07K16/10

CPC classification number: C07K16/1036 ,  Y10S435/973 ,  Y10S436/811

Abstract: The combination of monoclonal antibodies 11A25 and 11E32, which recognize two distinct antigenic sites on the 62-kd glycoprotein of reticuloendotheliosis virus (REV) in ELISA, enables an increase in the sensitivity of an ELISA assay for subtype 2 REV over what was heretofore possible. The combination of MAbs is useful for diagnosing REV antigen and antibody in poultry flocks and for detecting new strains and variants of the viral subtype.

Abstract translation: 在ELISA中识别网状内皮组织增生病毒（REV）的62-kd糖蛋白上的两个不同抗原位点的单克隆抗体11A25和11E32的组合使得能够增加针对亚型2 REV的ELISA测定的灵敏度比迄今为止可能的更高。 MAb的组合可用于诊断家禽群中的REV抗原和抗体，并用于检测病毒亚型的新菌株和变体。

公开(公告)号：US4804746A

公开(公告)日：1989-02-14

申请号：US713659

申请日：1985-03-19

Applicant: Mitsuaki Yoshida ,  Haruo Sugano ,  Fumio Shimizu ,  Kenichi Imagawa

Inventor： Mitsuaki Yoshida ,  Haruo Sugano ,  Fumio Shimizu ,  Kenichi Imagawa

IPC: C07K14/15 ,  C07K16/10 ,  C07K15/14 ,  A61K39/395

CPC classification number: C07K14/005 ,  C07K16/1036 ,  C12N2740/14022 ,  Y10S530/806 ,  Y10S930/221

Abstract: An antibody of a human leukemia virus-related peptide obtained by collecting an antibody produced in a mammal body by administering to the mammal an antigen prepared by reacting a human leukemia virus-related peptide selected from the group consisting of:(a) a peptide represented by formula (1):H-Tyr-Val-Glu-Pro-Thr-Ala-Pro-Gln-Val-Leu-H (1)(b) a peptide represented by formula (2): psR-Ile-Pro-His-Pro-Lys-Asn-Ser-Ile-Gly-Gly-Glu-Val-OH (2)wherein R is the same as defined above;(c) a peptide represented by formula (3):R-Thr-Trp-Thr-Pro-Lys-Asp-Lys-Thr-Lys-Val-Leu-OH (3)wherein R is the same as defined above;(d) a peptide represented by formula (4):H-Val-Val-Gln-Pro-Lys-Lys-Pro-Pro-Pro-Tyr-OH (4)(e) a peptide represented by formula (5):R-Met-Gly-Gln-Ile-Phe-Ser-Arg-Ser-Ala-Ser-Pro-OH (5)wherein R is the same as defined above; and(f) a peptide represented by formula (6):H-Tyr-Pro-Glu-Gly-Thr-Pro-Lys-Asp-Pro-Ile-Leu-Arg-Ser-Leu-OH (6)as a hapten, with a carrier in the presence of a haptencarrier binding agent.

Abstract translation: 通过对哺乳动物体内产生的抗体进行收集而获得的人类白血病病毒相关肽的抗体，其通过向哺乳动物施用通过使人白血病病毒相关肽反应而制备的抗原，所述人白血病病毒相关肽选自：（a） 式（1）表示的肽：H-Tyr-Val-Glu-Pro-Thr-Ala-Pro-Gln-Val-Leu-H（1）（b）由式（2）表示的肽：ps R-Ile-Pro -His-Pro-Lys-Asn-Ser-Ile-Gly-Gly-Glu-Val-OH（2）其中R与上述定义相同; （c）由式（3）表示的肽：R-Thr-Trp-Thr-Pro-Lys-Asp-Lys-Thr-Lys-Val-Leu-OH（3）其中R与上述定义相同; （d）由式（4）表示的肽：H-Val-Val-Gln-Pro-Lys-Lys-Pro-Pro-Pro-Tyr-OH（4）（e）由式（5）表示的肽： R-Met-Gly-Gln-Ile-Phe-Ser-Arg-Ser-Ala-Ser-Pro-OH（5）其中R与上述定义相同; 和（f）由式（6）表示的肽：作为半抗原的H-Tyr-Pro-Glu-Gly-Thr-Pro-Lys-Asp-Pro-Ile-Leu-Arg-Ser-Leu-OH 在载体中存在半载体结合剂。

公开(公告)号：US4722888A

公开(公告)日：1988-02-02

申请号：US717613

申请日：1985-03-29

Applicant: Samuel Broder ,  Shuzo Matsushita ,  Marjorie Robert-Guroff

Inventor： Samuel Broder ,  Shuzo Matsushita ,  Marjorie Robert-Guroff

IPC: C07K16/10 ,  C12Q1/70 ,  A61K39/42 ,  G01N33/53 ,  G01N33/577

CPC classification number: C07K16/1036 ,  C07K2317/734 ,  Y10S435/974 ,  Y10S435/975 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S530/826

Abstract: The present invention is an immortalized B-cell line which produces a human monoclonal antibody IgG-Kk which specifically binds to the envelope antigen of human T-cell leukemia virus Type 1 (HTLV-I). This monoclonal antibody is useful as a diagnostic reagent by binding to the antigen specifically expressed on the surface of HTLV producing cells. Furthermore, this monoclonal antibody is useful as a therapeutic reagent, in combination with complement, for the lysis of HTLV-1 producing cells.

Abstract translation: 本发明是产生与人T细胞白血病病毒1型（HTLV-I）的包膜抗原特异性结合的人单克隆抗体IgG-Kk的永生化B细胞系。 该单克隆抗体通过与在HTLV产生细胞表面特异性表达的抗原结合而用作诊断试剂。 此外，该单克隆抗体可用作治疗试剂，与补体结合用于产生HTLV-1的细胞的裂解。

公开(公告)号：US4454106A

公开(公告)日：1984-06-12

申请号：US386109

申请日：1982-06-07

Applicant: Otto A. Gansow ,  Mette Strand

Inventor： Otto A. Gansow ,  Mette Strand

IPC: A61K51/10 ,  C07K16/10 ,  C07K16/18 ,  C07K16/30 ,  G01N33/60 ,  A61K43/00 ,  A61K49/02

CPC classification number: C07K16/18 ,  A61K51/1093 ,  C07K16/1036 ,  C07K16/3015 ,  A61K2121/00 ,  Y10S436/804 ,  Y10S436/819

Abstract: Therapeutic and diagnostic methods employing metal chelate conjugated monoclonal antibodies are described. Metals employed in therapeutic conjugated antibodies include alpha particle, beta particle or Auger electron emitting isotopes. Diagnostic methods may be either in vivo or in vitro. Chelated metals employed in diagnostic techniques may include, inter alia, gamma or positron emitting metals as well as fluorogenic or paramagnetic metals.

Abstract translation: 描述了使用金属螯合物缀合的单克隆抗体的治疗和诊断方法。 用于治疗性结合抗体的金属包括α粒子，β粒子或俄歇电子发射同位素。 诊断方法可以是体内或体外。 用于诊断技术的螯合金属尤其可以包括γ或正电子发射金属以及荧光或顺磁金属。

公开(公告)号：KR1020160104785A

公开(公告)日：2016-09-06

申请号：KR1020150027251

申请日：2015-02-26

Applicant: 대한민국(농림축산식품부 농림축산검역본부장) ,  주식회사 메디안디노스틱

Inventor： 신연경 ,  김은주 ,  조수동 ,  이경기 ,  송재영 ,  정광면 ,  이상오 ,  김정화 ,  김춘회 ,  전은성 ,  이은정 ,  장상호

IPC: C07K16/10 ,  G01N33/569

CPC classification number: C07K16/1036 ,  C12N2740/14011 ,  G01N33/56983 ,  G01N2800/26

Abstract: 본발명은소류코시스바이러스의당단백질 51에대한단일클론항체, 및이 항체를생산하는하이브리도마세포주를제공한다. 본발명의소류코시스바이러스의당단백질 51에대한단일클론항체는소류코시스바이러스의당단백질 51에대한고친화도의특이적결합능력을가지므로, 소류코시스진단에유용하게사용될수 있다. 본발명의소류코시스바이러스에대한단일클론항체는소류코시스진단용키트의제조에도매우유용하다.

Abstract translation: 提供了用于牛白血病病毒的糖蛋白51的单克隆抗体和产生抗体的杂交瘤细胞系。 根据本发明，牛白血病病毒糖蛋白51的单克隆抗体对牛白血病病毒的糖蛋白51具有高亲和力特异性结合能力，可用于诊断牛白血病。 此外，牛白血病病毒的糖蛋白51的单克隆抗体对于制造用于诊断牛白血病的试剂盒是非常有用的。