公开(公告)号：US07796261B2

公开(公告)日：2010-09-14

申请号：US11792097

申请日：2005-12-01

Applicant: Henrik Vilstrup Juhl

Inventor： Henrik Vilstrup Juhl

IPC: G01N21/00

CPC classification number: G01N21/0303 ,  G01N21/31 ,  G01N2021/036 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/1293

Abstract: A spectrophotometer (2) comprising a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest withiA spectrophotometer (2) comprise a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b) is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest within the retained sample can be obtained.

Abstract translation: 一种分光光度计（2），包括辐射源（6），优选光辐射，被设置成朝向样品保持器（4）中的样品发射多个波长的辐射;以及检测装置8，用于在与 例子。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，用分光光度计（2）存在感兴趣的物质的指示包括辐射源（6）， 优选地，光辐射被设置为以多个波长朝向样品保持器（4）中的样品发射辐射;以及检测装置8，用于在与样品相互作用之后检测辐射。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，可以获得在保留的样品内存在感兴趣物质的指示。

公开(公告)号：US5222389A

公开(公告)日：1993-06-29

申请号：US816596

申请日：1991-12-31

Applicant: Jacob Y. Wong

Inventor： Jacob Y. Wong

IPC: G01N1/00 ,  G01N1/22 ,  G01N21/03 ,  G01N21/05 ,  G01N21/35 ,  G01N21/61 ,  G01N21/85 ,  G01N33/00 ,  G08B17/117 ,  G08B29/20

CPC classification number: G01N1/2258 ,  G01N21/05 ,  G01N21/3504 ,  G01N33/0011 ,  G01N33/0016 ,  G01N33/0031 ,  G08B17/117 ,  G08B29/20 ,  G01N2001/2261 ,  G01N2021/0321 ,  G01N2021/0385 ,  G01N2021/052 ,  G01N2021/158 ,  G01N2021/8585 ,  G01N21/0332 ,  G01N2201/0228 ,  G01N2201/066

Abstract: A gas sample chamber for use in a gas analyzer consists of an elongated hollow tube having an inwardly-facing specularly-reflective surface that permits the tube to function also as a light pipe for conducting radiation from a source to a detector through the sample gas. A number of apertures in the wall of the elongated hollow tube permit the sample gas to enter and exit. Particles of smoke and dust of a size greater than 0.1 micron are kept out of the chamber by use of a semi-permeable membrane that spans the apertures in the hollow tube. Condensation of the sample gas components is prevented by heating the sample chamber electrically to a temperature above the dew point of the component of concern. In one embodiment, at least one detector are spaced around the periphery of the elongated hollow tube adjacent one end of it. In another embodiment, at least one detector are spaced along the length of the elongated hollow tube.

Abstract translation: 用于气体分析仪的气体样品室由具有向内的镜面反射表面的细长的中空管组成，该中空管允许该管还用作通过样品气体从源到检测器的辐射的光管。 细长中空管的壁中的许多孔允许样品气体进出。 通过使用跨越中空管中的孔的半透膜将尺寸大于0.1微米的烟尘颗粒保持在室外。 通过将样品室电加热到高于所关注部件的露点的温度来防止样品气体组分的冷凝。 在一个实施例中，至少一个检测器围绕其一端的细长中空管的周边间隔开。 在另一个实施例中，至少一个检测器沿着细长的中空管的长度间隔开。

公开(公告)号：US3652850A

公开(公告)日：1972-03-28

申请号：US3652850D

申请日：1970-03-06

Applicant: NAT RES DEV

Inventor： BRIGGS RONALD

IPC: G01J1/16 ,  G01N21/05 ,  G01N21/53 ,  G01N21/26

CPC classification number: G01J1/16 ,  G01N21/05 ,  G01N21/53 ,  G01N21/534 ,  G01N2201/066

Abstract: Method and apparatus for determining the optical density for radiation within a predetermined range of wavelengths in which a first signal is produced related to the attenuation of radiation over a known path length in the fluid, a second signal is produced related to the attenuation of the radiation over the same path length by solid matter suspended in the fluid and the second signal is utilized to correct the first signal for the presence of the suspended solid matter in the fluid.

Abstract translation: 用于确定在其中产生第一信号的预定波长范围内的辐射的光密度的方法和装置涉及在流体中已知路径长度上的辐射的衰减，产生与辐射的衰减相关的第二信号 通过悬浮在流体中的固体物质在相同的路径长度上，并且使用第二信号来校正第一信号以确定流体中悬浮固体物质的存在。

公开(公告)号：WO2017137502A1

公开(公告)日：2017-08-17

申请号：PCT/EP2017/052892

申请日：2017-02-09

Applicant: RUBIN, Tom

Inventor： RUBIN, Tom

IPC: G01N21/3504 ,  G01J3/42 ,  G02B17/00 ,  G01N21/03

CPC classification number: G01N21/031 ,  G01N21/3504 ,  G01N2021/0314 ,  G01N2201/066 ,  G01N2201/0668 ,  G02B17/004

Abstract: Die Erfindung betrifft Langwegzelle (10), insbesondere Herriott-Zelle, mit einem ersten Spiegel (12) und einem zweiten Spiegel (14). Erfindungsgemäß ist vorgesehen, dass der erste Spiegel (12) -ein erstes Erstspiegel-Segment (42.1) und -zumindest ein zweites Erstspiegel-Segment (42.2), das das erste Erstspiegel-Segment (42.1) radial umgibt, aufweist, -wobei sich die Erstspiegel-Segmente (42) in ihren Krümmungen (R 42.1, 42.2 ) oder Brennweiten unterscheiden, der zweite Spiegel (14) -ein erstes Zweitspiegel-Segment (44.1) und -zumindest ein zweites Zweitspiegel-Segment (44.2), das das erste Zweitspiegel-Segment (44.1) radial umgibt,aufweist, -wobei sich die Zweitspiegel-Segmente (44) in ihren Krümmungen (R 42.1 , R 42.2 ) oder Brennweiten unterscheiden, das erste Erstspiegel-Segment (42.1) und das erste Zweitspiegel-Segment (44.1) so einander zugeordnet sind, dass ein Lichtstrahl zwischen beiden hin- und zurückreflektiert wird und dass das zweite Erstspiegel-Segment (42.2) und das zweite Zweitspiegel-Segment (44.2) so einander zugeordnet sind, dass ein Lichtstrahl zwischen beiden hin- und zurückreflektiert wird.

Abstract translation: 本发明涉及具有第一反射镜（12）和第二反射镜（14）的Langwegzelle（10），特别是Herriott单元。 发明＆AUML;大街 它提供的是，第一反射镜（12） - 一个第一Erstspiegel段（42​​.1）和 - 至少一个第二Erstspiegel段（42​​.2），其围绕第一Erstspiegel段（42​​.1）径向具有的Erstspiegel - 所述 在他们的氪导航用途mmungen段（42）（R <子> 42.1，42.2 ）不同或焦距，第二反射镜（14） - 一个第一副镜段（44.1）和 - 至少一个第二副镜段 （44.2）围绕所述第一副镜段（44.1）具有径向，二次反射镜部分（44） - 其中在其氪导航用途mmungen（R <子> 42.1 ，R <子> 42.2 < /子>）或不同的焦距，第一Erstspiegel段（42​​.1）和所述第一副镜段（44.1）与彼此相关联的光的两个背面之间以及用于导航中使用的光束是ckreflektiert和第二Erstspiegel段（ 42.2）和第二第二反射镜区段（44.2）彼此相关联，从而在背面和背面之间形成光束 被反射回来。

公开(公告)号：WO2016109355A1

公开(公告)日：2016-07-07

申请号：PCT/US2015/067463

申请日：2015-12-22

Applicant: BRIBBLA DYNAMICS LLC

IPC: G01N21/49 ,  G01N21/17 ,  G01N21/47

CPC classification number: G01N21/59 ,  G01N21/49 ,  G01N2021/1782 ,  G01N2021/4709 ,  G01N2021/4711 ,  G01N2201/066 ,  G01N2201/0691 ,  G01N2201/0696 ,  G01N2201/12

Abstract: An illuminator/collector assembly (104) can deliver incident light (106) to a sample (102) and collect return light (112) returning from the sample (102). A sensor (114) can measure ray intensities as a function of ray position and ray angle for the collected return light (112). A ray selector can select a first subset of rays from the collected return light (112) at the sensor (114) that meet a first selection criterion. In some examples, the ray selector can aggregate ray intensities into bins, each bin corresponding to rays in the collected return light (112) that traverse within the sample (102) an estimated optical path length within a respective range of optical path lengths. A characterizer can determine a physical property of the sample (102), such as absorptivity, based on the ray intensities, ray positions, and ray angles for the first subset of rays. Accounting for variations in optical path length traversed within the sample can improve accuracy.

Abstract translation: 照明器/收集器组件（104）可将入射光（106）输送到样品（102）并收集从样品（102）返回的返回光（112）。 传感器（114）可以测量作为所收集的返回光（112）的射线位置和射线角度的函数的射线强度。 射线选择器可以从满足第一选择标准的传感器（114）处的收集的返回光（112）中选择光线的第一子集。 在一些示例中，射线选择器可以将射线强度聚集成箱体，每个仓对应于在采样（102）内横穿的所收集的返回光线（112）内的光线在光程长度的相应范围内的估计光程长度。 基于射线强度，射线位置和第一射线子集的射线角度，表征器可以确定样品（102）的物理性质，例如吸收率。 考虑样品内的光程长度变化可以提高精度。

公开(公告)号：WO2015132788A2

公开(公告)日：2015-09-11

申请号：PCT/IL2015/050232

申请日：2015-03-04

Applicant: ADOM, ADVANCED OPTICAL TECHNOLOGIES LTD.

Inventor： ARIELI, Yoel ,  COHEN, Yoel ,  EPSTEIN, Shlomi ,  ARBEL, Dror

CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/1005 ,  A61B3/152 ,  G01B9/02021 ,  G01B9/02025 ,  G01B9/02027 ,  G01B9/02044 ,  G01B9/02087 ,  G01B9/0209 ,  G01B11/06 ,  G01B11/0625 ,  G01B11/0675 ,  G01B2290/45 ,  G01N21/274 ,  G01N2201/066 ,  G01N2201/127 ,  G02B3/08

Abstract: In a system and method for performing tear film structure measurement and evaporation rate measurements a broadband light source illuminates the tear film and a spectrometer measures respective spectra of reflected light from at least one point of the tear film. A color camera obtains a large field of view image of the tear film so as to obtain color information for all points of the tear film imaged by the color camera and an autofocusing mechanism focusses the color camera and the spectrometer. A processing unit coupled to the camera and to the spectrometer calibrates the camera so that the color obtained by the camera at the at least one point measured by the spectrometer matches the color of the spectrometer at the same point, and determines from the color of each point of the calibrated camera the thickness of the lipids at the respective point.

Abstract translation: 在用于执行泪膜结构测量和蒸发速率测量的系统和方法中，宽带光源照射泪膜并且光谱仪测量来自泪膜的至少一个点的反射光的各个光谱。 彩色照相机获得泪膜的大视场图像，以获得由彩色照相机成像的泪膜的所有点的颜色信息，并且自动聚焦机构聚焦彩色照相机和光谱仪。 耦合到照相机和光谱仪的处理单元校准照相机，使得由照相机在由光谱仪测量的至少一个点处获得的颜色与在相同点处的光谱仪的颜色匹配，并且从每个照相机的颜色确定 校准摄像头的点在相应点的脂质厚度。

公开(公告)号：WO2013001431A1

公开(公告)日：2013-01-03

申请号：PCT/IB2012/053182

申请日：2012-06-25

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  NEIJZEN, Jacobus Hermanus Maria ,  DITTMER, Wendy Uyen ,  OVSYANKO, Mikhail Mikhaylovich

Inventor： NEIJZEN, Jacobus Hermanus Maria ,  DITTMER, Wendy Uyen ,  OVSYANKO, Mikhail Mikhaylovich

IPC: G01N21/55 ,  G01N33/543 ,  G01N21/03 ,  G01N21/31

CPC classification number: G01N21/59 ,  G01N21/0303 ,  G01N21/31 ,  G01N21/3151 ,  G01N21/552 ,  G01N33/54326 ,  G01N2021/0325 ,  G01N2021/1738 ,  G01N2021/1742 ,  G01N2201/024 ,  G01N2201/066

Abstract: The invention relates to means for the examination of a sample, wherein a first input light beam (L1) is totally internally reflected at a detection surface of a sample chamber (111), while a second input light beam (L1') is transmitted through the sample chamber (111). The resulting first and second output light beams (L2, L2') are detected and can be evaluated with respect to frustrated total internal reflection and optical absorbance, respectively. Preferably, both output light beams (L2, L2') are detected by a single image sensor (155).

Abstract translation: 本发明涉及一种用于检查样品的装置，其中第一输入光束（L1）在样品室（111）的检测表面处被全内反射，而第二输入光束（L1'）被透射 样品室（111）。 检测所得到的第一和第二输出光束（L2，L2'），并且可以分别对沮丧的全内反射和光吸收率进行评估。 优选地，两个输出光束（L2，L2'）由单个图像传感器（155）检测。

公开(公告)号：WO2006058741A1

公开(公告)日：2006-06-08

申请号：PCT/EP2005/012820

申请日：2005-12-01

Applicant: FOSS ANALYTICAL A/S ,  JUHL, Henrik, Vilstrup

Inventor： JUHL, Henrik, Vilstrup

IPC: G01N21/03 ,  G01N21/31

CPC classification number: G01N21/0303 ,  G01N21/31 ,  G01N2021/036 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/1293

Abstract: A spectrophotometer (2)comprising a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is adapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b)is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest withiA spectrophotometer (2)comprise a source of radiation (6), preferably optical radiation, disposed to emit radiation at a plurality of wavelengths towards a sample in a sample holder (4) and a detection arrangement 8 for detecting the radiation after its interaction with the sample. The sample holder (4) is dapted to present a plurality of different path lengths for the emitted radiation through the sample. An arithmetic unit (10;10b)is operably connected to receive an intensity dependent output from the detection arrangement (8) and is adapted to store an intensity value of the detected emitted radiation indexed to its wavelength at two or more path lengths of the plurality of different path lengths and to calculate a value dependent on the ratio of the indexed intensity values at each of two path lengths by which an indication of the presence of a substance of interest within the retained sample can be obtained.

Abstract translation: 一种分光光度计（2），包括辐射源（6），优选光辐射，被设置成朝向样品保持器（4）中的样品发射多个波长的辐射;以及检测装置8，用于在与 例子。 样品保持器（4）适于对通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，用分光光度计（2）存在感兴趣的物质的指示包括辐射源（6）， 优选地，光辐射被设置为以多个波长朝向样品保持器（4）中的样品发射辐射;以及检测装置8，用于在与样品相互作用之后检测辐射。 样品保持器（4）被折叠以对于通过样品的发射辐射呈现多个不同的路径长度。 算术单元（10; 10b）可操作地连接以接收来自检测装置（8）的与强度相关的输出，并且适于将检测到的发射的辐射的强度值存储在其波长的两个或更多个路径长度上 并且计算取决于两个路径长度中的每一个处的索引强度值的比率的值，通过该值，可以获得在保留的样品内存在感兴趣物质的指示。

公开(公告)号：WO00031512A1

公开(公告)日：2000-06-02

申请号：PCT/US1999/027394

申请日：1999-11-19

IPC: G01N21/03 ,  G01N21/05 ,  G01N21/31 ,  G01N21/59 ,  G01N30/62 ,  G01N30/74 ,  G01N21/00 ,  G01J5/02 ,  G01N1/10

CPC classification number: G01N21/0303 ,  G01N21/05 ,  G01N21/31 ,  G01N30/74 ,  G01N2021/0346 ,  G01N2030/625 ,  G01N2030/746 ,  G01N2201/066

Abstract: A flow cell (16) for absorbance detection with at least two different optical pathlengths (30, 32). It increases the range of analyte concentrations which can be measured compared with a conventional single path flow cell. Light from the two paths (30, 32) is combined onto the same photodetector (20). Calibration with known samples allows analyte concentrations to be measured. The dual or multi-pathlength flow cell may be used in equipment designed for single path flow cells.

Abstract translation: 一种用于利用至少两个不同光程长度（30,32）进行吸光度检测的流动池（16）。 与常规单路径流量池相比，它可以增加可测量的分析物浓度范围。 来自两个路径（30,32）的光被组合到相同的光电检测器（20）上。 用已知样品进行校准可以测量分析物浓度。 双通道或多通道流动池可用于为单路径流动池设计的设备。

公开(公告)号：JP5993388B2

公开(公告)日：2016-09-14

申请号：JP2014030357

申请日：2014-02-20

Applicant: エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： ダーコ クリネッチ

IPC: G01N21/27 ,  G01N21/359 ,  G01N21/59

CPC classification number: G01N33/491 ,  G01N15/06 ,  G01N21/253 ,  G01N21/3151 ,  G01N21/51 ,  G01N35/02 ,  G01N35/1016 ,  G01N2015/045 ,  G01N2015/0693 ,  G01N2035/0406 ,  G01N2035/1018 ,  G01N21/13 ,  G01N2201/066 ,  G01N2201/0662 ,  G01N2201/0668