公开(公告)号：WO2019166549A1

公开(公告)日：2019-09-06

申请号：PCT/EP2019/054984

申请日：2019-02-28

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： VAN WYK, Hendrikus Antonius Rudolfus ,  KREMER, Johanna Maria Josephina

IPC: C07K14/47 ,  A61K48/00

Abstract: The present invention relates to the field of medicine. In particular, it relates to therapy for the treatment of Usher syndrome type 2a and USH2A -associated retinitis pigmentosa.

公开(公告)号：WO2019145562A1

公开(公告)日：2019-08-01

申请号：PCT/EP2019/052116

申请日：2019-01-29

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： BOLTJE, Thomas Jan ,  HEISE, Torben ,  PIJNENBORG, Johan Franciscus Adrianus ,  BÜLL, Christian ,  ADEMA, Gosse Jan

IPC: C07H5/02 ,  C07H13/12 ,  A61K31/7012 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00

CPC classification number: C07H13/04 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07H13/12

Abstract: The present invention relates to anew class of sialyltransferase inhibitors. The class features a carbamate or similar moiety on the amine of a neuraminic acid derivative. Such inhibitors are suitable for use as a medicament, for example for treating, preventing, or delaying bacterial infection, viral infection, cancer, a disorder of sialic acid metabolism, or an autoimmune disease.

公开(公告)号：WO2018104324A1

公开(公告)日：2018-06-14

申请号：PCT/EP2017/081561

申请日：2017-12-05

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： KOUWER, Paul ,  ROWAN, Alan Edward ,  SCHOENMAKERS, Daniël

IPC: A61L27/52 ,  C08G61/04 ,  C08G65/333 ,  C12N5/00

Abstract: A polymer hydrogel comprising a polymer formed by the crosslinking reaction of a polymeric unit A according to formula (I), with a crosslinking unit B according to formula (II), and water, wherein n = 100 - 10,000, preferable 250 - 2500, more preferable 500 - 1500; m = independently 2-10, preferably 3 or 4; FG is a functional moiety that can be covalently coupled to the complementary functional moiety F1 or F2 of the crosslinking unit (B); k = 0.01 - 0.05; h = 0, 1 or 2; the spacer is an organic moiety, having a main chain comprising at least two functional moieties F1 and F2, wherein the length of the crosslinker in the extended conformation as determined by molecular modeling (including spacer and functional groups F1 and F2) is between 2.5 and 12 nm, or wherein the length is between 20 and 80 atoms.

公开(公告)号：WO2017194787A1

公开(公告)日：2017-11-16

申请号：PCT/EP2017/061624

申请日：2017-05-15

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： SMIT, Ewoud Joris ,  PROKOP, Wolfgang Mathias

IPC: G06T5/00 ,  G06T5/50

CPC classification number: G06T5/002 ,  G06T5/20 ,  G06T5/50 ,  G06T7/20 ,  G06T2207/10016 ,  G06T2207/10072 ,  G06T2207/10076 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/20028 ,  G06T2207/30004

Abstract: A system for filtering an input image dataset is disclosed. A plurality of sequences of input signal values, wherein each sequence corresponds to a different attribute, wherein an input signal value is associated with an attribute and a sampling point (i). At least one processor (4) is configured to control computing an output signal value corresponding to a sampling point and an attribute. For a particular sampling point (i) and for each of a plurality of different attributes of the set of attributes, associating a weight to an input signal value based on a similarity between the signal value and for a plurality of the sampling points j excluding the sampling point (i). Also the system computes a weighted sum based on the input signal values and weights. The attribute is a location or a frequency.

Abstract translation: 公开了一种用于过滤输入图像数据组的系统。 多个输入信号值序列，其中每个序列对应于不同的属性，其中输入信号值与属性和采样点（i）相关联。 至少一个处理器（4）被配置为控制计算对应于采样点和属性的输出信号值。 对于特定采样点（i）和对于该组属性中的多个不同属性中的每一个，基于信号值之间的相似度将权重关联到输入信号值，并且针对除了 采样点（i）。 系统还根据输入信号值和权重计算加权和。 该属性是一个位置或频率。

公开(公告)号：WO2017037293A1

公开(公告)日：2017-03-09

申请号：PCT/EP2016/070876

申请日：2016-09-05

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： FEITZ, Wouter Franciscus Joannes ,  OOSTERWIJK, Egbert ,  MIHAILA, Silvia Maria ,  ROWAN, Alan Edward

IPC: C12N5/00 ,  C08G65/325 ,  C12N5/077 ,  C12N5/0775 ,  C08G65/333

CPC classification number: C12N5/0062 ,  C08L71/02 ,  C12N5/0663 ,  C12N2506/1346 ,  C12N2513/00 ,  C12N2527/00 ,  C12N2533/30

Abstract: The invention is directed to a cell culture comprising: a) a cell culturing medium for growing stem cells, b) a three-dimensional (3D) cell growth matrix and c) stem cells, wherein the cell culture has a critical stress σ c of 2-30 Pa, wherein the critical stress is a stress which marks an onset of strain stiffening and wherein the cell culture has a storage modulus G' measured at 37°C of 50-1000 Pa.

Abstract translation: 本发明涉及一种细胞培养物，其包括：a）用于培养干细胞的细胞培养培养基，b）三维（3D）细胞生长基质和c）干细胞，其中细胞培养物的临界应力σc为2 -30Pa，其中临界应力是标记应变硬化开始的应力，并且其中细胞培养物在37℃下测得的储能模量G'为50-1000Pa。

公开(公告)号：WO2015135907A1

公开(公告)日：2015-09-17

申请号：PCT/EP2015/054906

申请日：2015-03-10

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY RADBOUD UNIVERSITEIT NIJMEGEN ,  DSM IP ASSETS B.V.

Inventor： KOENEN, Jacob ,  DAAMEN, Edwin ,  VAN TIENEN, Tony ,  BUMA, Pieter

IPC: A61F2/38 ,  A61F2/30

CPC classification number: A61F2/3872 ,  A61B34/10 ,  A61B2034/108 ,  A61F2/30756 ,  A61F2/30965 ,  A61F2002/30014 ,  A61F2002/30016 ,  A61F2002/30065 ,  A61F2002/30067 ,  A61F2002/30069 ,  A61F2002/3008 ,  A61F2002/30131 ,  A61F2002/30578 ,  A61F2002/30754 ,  A61F2002/30757

Abstract: The invention is directed to a meniscus prosthesis comprising an arc-shaped meniscus prosthesis body having a main portion (1) comprising a reinforcing part (2) and two end portions (1A, 1B) comprising fixation parts (2A, 2B), wherein the main portion (1) comprises a part made of a first biocompatible, non- resorbable material extending between the two end portions (1A, 1B), wherein the reinforcing part (2) and the fixation parts (2A, 2B) are made of a second biocompatible, non-resorbable material and wherein the reinforcing part (2) extends between the fixation parts (2A, 2B) and wherein the fixation parts (2A, 2B) have a through hole (3A, 3B), the first biocompatible, non-resorbable material has a tensile modulus of at most 100 MPa as determined by ISO 527-1 and the second biocompatible, non-resorbable material has a tensile modulus of at least 01 MPa as determined by ISO 527-1.

Abstract translation: 本发明涉及一种弯液面假体，其包括具有包括加强部分（2）的主要部分（1）和包括固定部分（2A，2B）的两个端部部分（1A，1B）的弧形弯月面假体，其中， 主要部分（1）包括在两个端部（1A，1B）之间延伸的第一生物相容不可吸收材料制成的部分，其中加强部分（2）和固定部分（2A，2B）由 第二生物相容性不可再吸收材料，并且其中所述加强部分（2）在所述固定部分（2A，2B）之间延伸，并且其中所述固定部分（2A，2B）具有通孔（3A，3B），所述第一生物相容的， - 可吸收材料具有根据ISO 527-1确定的至多100MPa的拉伸模量，并且第二生物相容性不可再吸收材料的拉伸模量通过ISO 527-1确定为至少01MPa。

公开(公告)号：WO2015007771A1

公开(公告)日：2015-01-22

申请号：PCT/EP2014/065233

申请日：2014-07-16

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY RADBOUD UNIVERSITEIT NIJMEGEN

Inventor： ROWAN, Alan Edward ,  EKSTEEN AKEROYD, Zaskia Hillet ,  WILSON, Christopher ,  GEUTJES, Petrus Johannes ,  FEITZ, Wouter F.j. ,  OOSTERWIJK, Egbert

IPC: A61K47/48 ,  C08G73/00 ,  C08G65/325 ,  C08G65/333

CPC classification number: C12N5/069 ,  C07K5/06026 ,  C08G65/325 ,  C08G65/33324 ,  C08G69/10 ,  C08G69/40 ,  C12N5/0691 ,  C12N2502/28 ,  C12N2533/50

Abstract: The invention relates to a process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process comprises the steps of: i) copolymerizing - a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and - a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is :500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula A-L-B, wherein the linking group and group A are chosen to react and form a first coupling and the cell adhesion factor and group B are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornadiene-based-azide couplings, vinylsulphone-thiol coupling, maleimide-thiol coupling, methyl methacrylate-thiol coupling, ether coupling, thioether coupling, biotin- strepavidin coupling, amine-carboxylic acid resulting in amides linkages, alcohol- carboxylic acid coupling resulting in esters linkages and NHS-Ester (N- Hydroxysuccinimide ester)-amine coupling and wherein group L is a linear chain segment having 10-60 bonds between atoms selected from C, N, O and S in the main chain.

Abstract translation: 本发明涉及一种制备低聚（亚烷基二醇）官能化共聚异氰尿苷的方法，其中该方法包括以下步骤：i）共聚 - 接枝有连接基团的寡（亚烷基二醇）官能化异氰脲酸的第一共聚单体和 - 非接枝的寡（亚烷基二醇）官能化的异氰尿苷的第二共聚单体，其中第一共聚单体和第二共聚单体之间的摩尔比为：500和1:30，和ii）添加间隔单元的反应物和细胞粘附因子 对于由步骤i）获得的共聚物，其中间隔单元由通式ALB表示，其中选择连接基团和基团A进行反应并形成第一偶联，并且选择细胞粘附因子和组B反应并形成 第二耦合，其中所述第一耦合和所述第二耦合独立地选自炔 - 叠氮偶合，二苯并环辛炔 - 叠氮偶联， 基 - 叠氮化物偶联，乙烯基砜 - 硫醇偶联，马来酰亚胺 - 硫醇偶联，甲基丙烯酸甲酯 - 硫醇偶联，醚偶联，硫醚偶联，生物素 - 链霉亲和素偶联，胺 - 羧酸导致酰胺键，醇 - 羧酸偶合，产生酯 连接和NHS-酯（N-羟基琥珀酰亚胺酯） - 胺偶联，其中基团L是在主链中选自C，N，O和S的原子之间具有10-60个键的直链链段。

公开(公告)号：WO2013172707A2

公开(公告)日：2013-11-21

申请号：PCT/NL2013/050356

申请日：2013-05-14

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： STRIK, Wilhelmus Albertus Johannes ,  CUCCHIARINI, Catia

IPC: G09B5/04

CPC classification number: G09B5/04 ,  G09B19/06

Abstract: The present invention is in the field of automated systems and methods for improving of oral language proficiency. As a result of increasing internationalization there is a growing demand from education and business community for people who speak foreign languages well. An intelligible pronunciation is regarded as important for e.g. successful inter- action and social acceptance. However, an important problem is that oral proficiency training requires so much time, feedback and practice, that very often it cannot be sufficiently provided in traditional language classes. Thereto an automated system is provided.

Abstract translation: 本发明涉及用于提高口语能力的自动化系统和方法领域。 由于国际化日益加深，教育和商业界对外语人士的需求日益增长。 一个可理解的发音被认为是重要的。 成功的相互作用和社会接受。 然而，一个重要的问题是口语能力培训需要很多时间，反馈和实践，这在传统的语言课程中往往不能充分提供。 提供了一个自动化系统。

公开(公告)号：WO2013131931A1

公开(公告)日：2013-09-12

申请号：PCT/EP2013/054449

申请日：2013-03-05

Applicant: COMPOUND HANDLING B.V. ,  STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： HOOIJ, VAN, Onno ,  SCHALKEN, Jacobus Antonius ,  VIËTOR, Hendrik Engelbertus ,  PIET, Dennis Patrick ,  MAAS, Petrus Emmanuel Marie ,  TIJHUIS, Johann Heinrich ,  DEERENBERG, Sirik ,  SPRENKELS, Nanda Elisabeth ,  TANG, Siu Ha

IPC: C07D417/04 ,  C07D417/14 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/4436 ,  A61P35/00

CPC classification number: C07D403/04 ,  A61K31/4155 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/454 ,  A61K45/06 ,  C07D417/04 ,  C07D417/14

Abstract: A compound having the structure according to formula III wherein: X is NH or S;R 1 is H or (1C-4C)alkyl;R 2 is (1C-4C)alkyl, phenyl or a monocyclic aromatic ring having one or more N-, O-or S-atoms in the ring, which alkyl, phenyl or aromatic ring is optionally substituted with one or more groups selected from (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, phenyloxy, phenylthio, halogen, or nitro;R 3 and R 4 are each independently H, (1C-6C)alkyl, (2C-6C) alkenyl, (2C-6C)alkynyl, cyano, (3C-6C)cycloalkyl, phenyl, a monocyclic aromatic ring having one or more N-, O- or S-atoms in the ring, a monocyclic non-aromatic ring having one or more N-, O- or S-atoms in the ring, each optionally substituted with hydroxyl, (1C-4C)alkoxy, phenyl, cycloalkyl, piperidyl, piperazinyl, furyl, thienyl, pirazinyl, pyrrolyl, 2H-pyrrolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyrrolidonyl, pyrrolinyl, imidazolinyl, imidazolyl, a monocyclic aromatic ring having one or more N-, O- or S- atoms in the ring, whereby each of these optional substituents is optionally further substituted with (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, halogen, nitro or (1C-2C)dioxol forming a ring;or R 3 and R 4 form together pyrrolyl, imidazolyl, pyrazolyl, pyrrolidinyl, pyrrolinylimidazolidinyl, imidazolinyl, piperidyl, piperazinylmorpholinyl, each optionally substituted with (1C-6C)alkyl, phenyl(1C-4C)alkyl, phenylketo(1C-4C)alkyl; R 5 is H, Cl, F, Br, Me, NO 2 , t-butyl, OCF 3 , OCH 3 , CF 3 ; R 6 is H, (1C-4C)alkyl, (1C-4C)alkyloxy, halo(1C-4C)alkyl, halo(1C-4C)alkyloxy, nitro or halogen;R 7 is H,F, Cl, Br, Me, NO 2 , t-butyl, OCF 3 , OCH 3 , CF 3 ; or pharmaceutically acceptable addition salts thereof for use in treatments of carcinoma, in particular to delay, prevent or reverse metastasis in prostate cancer.

Abstract translation: 具有式III结构的化合物其中：X为NH或S; R 1为H或（1C-4C）烷基; R 2为（C 1 -C 4）烷基，苯基或具有一个或多个N-， 烷基，苯基或芳环任选被一个或多个选自（1C-4C）烷基，（1C-4C）烷氧基，卤代（1C-4C）烷基，卤代 （1C-4C）烷基，（C 1 -C 6）烯基，（C 2 -C 6）炔基，氰基，（C 3 -C 6）烷氧基， 6C）环烷基，苯基，在环中具有一个或多个N，O-或S-原子的单环芳环，在环中具有一个或多个N，O-或S-原子的单环非芳族环， 各自任选被羟基取代，（1C-4C）烷氧基，苯基，环烷基，哌啶基，哌嗪基，呋喃基，噻吩基，吡嗪基，吡咯基，吡咯基，吡唑基，异噻唑基，异噻唑基，吡咯烷酮基，吡咯啉基，咪唑啉基，咪唑基， 环具有一个或多个N-，O-或S-原子 其中每个这些任选的取代基任选进一步被（1C-4C）烷基，（1C-4C）烷氧基，卤代（1C-4C）烷基，卤代（1C-4C）烷氧基，卤素，硝基或 （1C-2C）二氧杂环戊烯，或R 3和R 4一起形成吡咯基，咪唑基，吡唑基，吡咯烷基，吡咯烷基咪唑烷基，咪唑啉基，哌啶基，哌嗪基吗啉基，各自任选被（1C-6C）烷基取代，苯基（1C-4C） 苯基酮（1C-4C）烷基; R5是H，Cl，F，Br，Me，NO2，叔丁基，OCF3，OCH3，CF3; R6是H，（1C-4C）烷基，（1C-4C）烷氧基，卤代（1C-4C）烷基，卤代（1C-4C）烷氧基，硝基或卤素; R7是H，F，Cl，Br， NO 2，叔丁基，OCF 3，OCH 3，CF 3; 或其药学上可接受的加成盐，用于治疗癌症，特别是延迟，预防或逆转前列腺癌转移。

公开(公告)号：WO2013109145A1

公开(公告)日：2013-07-25

申请号：PCT/NL2013/050024

申请日：2013-01-17

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： VAN HEERDE, Waander Laurens ,  DE VISSER- VAN SOEST, Maria Catharina Henrica ,  HIDDINK-EMELIANOVA, Larissa Filaretovna

IPC: C12N15/11 ,  C12Q1/68

CPC classification number: C07K14/4721 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates to an in vitro method for predicting a tendency to pregnancy loss. The method involves determining whether at least one point mutation at a defined position is present or absent in the ANXA5 gene promoter sequence. The invention also encompasses the ANXA5 gene promoter sequence comprising the at least one specific point mutation. Also provided is a kit for predicting a tendency to pregnancy loss.

Abstract translation: 本发明涉及用于预测妊娠损失趋势的体外方法。 该方法涉及确定ANXA5基因启动子序列中是否存在或不存在在定义的位置处的至少一个点突变。 本发明还包括包含至少一个特定点突变的ANXA5基因启动子序列。 还提供了一个用于预测怀孕流失趋势的工具箱。