公开(公告)号：WO2002081629A2

公开(公告)日：2002-10-17

申请号：PCT/US2002/010522

申请日：2002-04-03

Applicant: CURAGEN CORPORATION ,  SPYTEK, Kimberly, A. ,  LI, Li ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  STONE, David, J. ,  MALYANKAR, Uriel, M. ,  SHIMKETS, Richard, A. ,  GUO, Xiaojia ,  ANDERSON, David, W. ,  PATTURAJAN, Meera ,  BERGHS, Constance ,  GERLACH, Valerie ,  TAUPIER, Raymond, J., Jr. ,  PENA, Carol, E., A. ,  PADIGARU, Muralidhara ,  LIU, Yi ,  BURGESS, Catherine, E. ,  MILLER, Charles, E. ,  GUSEV, Vladimir, Y. ,  KEKUDA, Ramesh ,  GORMAN, Linda ,  ZERHUSEN, Bryan, D. ,  BAUMGARTNER, Jason, C. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  SMITHSON, Glennda ,  HEYES, Melvyn, P. ,  SHENOY, Suresh, G. ,  LIU, Xiaohong ,  GANGOLLI, Esha, A.

Inventor： SPYTEK, Kimberly, A. ,  LI, Li ,  EDINGER, Shlomit, R. ,  ELLERMAN, Karen ,  STONE, David, J. ,  MALYANKAR, Uriel, M. ,  SHIMKETS, Richard, A. ,  GUO, Xiaojia ,  ANDERSON, David, W. ,  PATTURAJAN, Meera ,  BERGHS, Constance ,  GERLACH, Valerie ,  TAUPIER, Raymond, J., Jr. ,  PENA, Carol, E., A. ,  PADIGARU, Muralidhara ,  LIU, Yi ,  BURGESS, Catherine, E. ,  MILLER, Charles, E. ,  GUSEV, Vladimir, Y. ,  KEKUDA, Ramesh ,  GORMAN, Linda ,  ZERHUSEN, Bryan, D. ,  BAUMGARTNER, Jason, C. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  SMITHSON, Glennda ,  HEYES, Melvyn, P. ,  SHENOY, Suresh, G. ,  LIU, Xiaohong ,  GANGOLLI, Esha, A.

IPC: C12N

CPC classification number: C07K14/47

Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

Abstract translation: 公开了编码相同的多肽和核酸。 还公开了用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。

公开(公告)号：WO2002081625A2

公开(公告)日：2002-10-17

申请号：PCT/US2002/010366

申请日：2002-04-03

Applicant: CURAGEN CORPORATION ,  PADIGARU, Muralidhara ,  SHENOY, Suresh, G. ,  KEKUDA, Ramesh ,  RASTELLI, Luca ,  MEZES, Peter, D. ,  SMITHSON, Glennda ,  GUO, Xiaojia ,  GERLACH, Valerie ,  CASMAN, Stacie, J. ,  BOLDOG, Ferenc, L. ,  LI, Li ,  ZERHUSEN, Bryan, D. ,  TCHERNEV, Velizar, T. ,  GANGOLLI, Esha, A. ,  VERNET, Corine, A., M. ,  SPYTEK, Kimberly, A. ,  MALYANKAR, Uriel, M. ,  PATTURAJAN, Meera ,  MILLER, Charles, E. ,  TAUPIER, Raymond, J., Jr. ,  HEYES, Melvyn, P. ,  JU, Jingfang ,  PEYMAN, John, A. ,  CATTERTON, Elina ,  MACDOUGALL, John, R. ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  MAZUR, Ann

Inventor： PADIGARU, Muralidhara ,  SHENOY, Suresh, G. ,  KEKUDA, Ramesh ,  RASTELLI, Luca ,  MEZES, Peter, D. ,  SMITHSON, Glennda ,  GUO, Xiaojia ,  GERLACH, Valerie ,  CASMAN, Stacie, J. ,  BOLDOG, Ferenc, L. ,  LI, Li ,  ZERHUSEN, Bryan, D. ,  TCHERNEV, Velizar, T. ,  GANGOLLI, Esha, A. ,  VERNET, Corine, A., M. ,  SPYTEK, Kimberly, A. ,  MALYANKAR, Uriel, M. ,  PATTURAJAN, Meera ,  MILLER, Charles, E. ,  TAUPIER, Raymond, J., Jr. ,  HEYES, Melvyn, P. ,  JU, Jingfang ,  PEYMAN, John, A. ,  CATTERTON, Elina ,  MACDOUGALL, John, R. ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  MAZUR, Ann

IPC: C12N

CPC classification number: C12N15/113 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/5421 ,  C07K14/705 ,  C07K14/82 ,  C12N9/1051 ,  C12N9/1211 ,  C12N15/1135 ,  C12N15/1137 ,  C12N15/1138 ,  C12Y204/0115

Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.

Abstract translation: 本文公开了编码多肽的核酸序列。 还公开了免疫特异性结合多肽的抗体，以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防涉及这些新型人核酸，多肽或抗体或其片段中的任何一种的病症的治疗，诊断和研究方法。

公开(公告)号：WO2002081498A2

公开(公告)日：2002-10-17

申请号：PCT/US2002/010780

申请日：2002-04-03

Applicant: CURAGEN CORPORATION ,  GUO, Xiaojia ,  KEKUDA, Ramesh ,  MILLER, Charles, E. ,  MALYANKAR, Uriel, M. ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  LIU, Xiaohong ,  GUSEV, Vladimir, Y. ,  LI, Li ,  VERNET, Corine, A.M. ,  ZERHUSEN, Bryan, D. ,  GORMAN, Linda ,  SHENOY, Suresh, G. ,  PENA, Carol, E., A. ,  SMITHSON, Glennda ,  BURGESS, Catherine, E. ,  GERLACH, Valerie ,  PADIGARU, Muralidhara ,  SHIMKETS, Richard, A. ,  GANGOLLI, Esha, A. ,  TAUPIER, Raymond, J., Jr. ,  CASMAN, Stacie, J. ,  JI, Weizhen ,  ANDERSON, David, W. ,  LEITE, Mario, W. ,  RASTELLI, Luca ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  MACDOUGALL, John, R. ,  ROTHENBERG, Mark, E. ,  MAZUR, Ann ,  MILLET, Isabelle ,  PEYMAN, John, A. ,  ELLERMAN, Karen

Inventor： GUO, Xiaojia ,  KEKUDA, Ramesh ,  MILLER, Charles, E. ,  MALYANKAR, Uriel, M. ,  SPYTEK, Kimberly, A. ,  PATTURAJAN, Meera ,  LIU, Xiaohong ,  GUSEV, Vladimir, Y. ,  LI, Li ,  VERNET, Corine, A.M. ,  ZERHUSEN, Bryan, D. ,  GORMAN, Linda ,  SHENOY, Suresh, G. ,  PENA, Carol, E., A. ,  SMITHSON, Glennda ,  BURGESS, Catherine, E. ,  GERLACH, Valerie ,  PADIGARU, Muralidhara ,  SHIMKETS, Richard, A. ,  GANGOLLI, Esha, A. ,  TAUPIER, Raymond, J., Jr. ,  CASMAN, Stacie, J. ,  JI, Weizhen ,  ANDERSON, David, W. ,  LEITE, Mario, W. ,  RASTELLI, Luca ,  EDINGER, Shlomit, R. ,  STONE, David, J. ,  MACDOUGALL, John, R. ,  ROTHENBERG, Mark, E. ,  MAZUR, Ann ,  MILLET, Isabelle ,  PEYMAN, John, A. ,  ELLERMAN, Karen

IPC: C07K

CPC classification number: C12N15/113 ,  C07K14/47 ,  C07K14/5421 ,  C07K14/705 ,  C07K14/82 ,  C12N9/1051 ,  C12N9/1211 ,  C12N15/1135 ,  C12N15/1137 ,  C12N15/1138 ,  C12Y204/0115

Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.

Abstract translation: 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。

公开(公告)号：WO2002077671A3

公开(公告)日：2002-10-03

申请号：PCT/US2001/051399

申请日：2001-10-19

Applicant: VISCOTEK CORPORATION ,  STONE, David, Edward, Jr. ,  HANEY, Max, A.

Inventor： HANEY, Max, A.

IPC: G02N21/53

Abstract: A light scattering detector is provided for measuring elastic light scattered at low and right angles from polymer solutions, such as in gel permutation chromatography. A laser (102) emits an incident beam (204) to a first window (110), a test cell (112), a second window (114), and a first mirror (120). The first mirror (120) has a hole (122) that allows the remains of the incident beam of the laser to pass trough. The first mirror (120) reflects the low angle scattered light into a first photo-detector (136). A second mirror (124) can be aligned with the first mirror (120) to reflect the scattered light into the first photo-detector (136). The test cell (112) can have a window that is perpendicular to the incident laser beam (204) in order to detect right angle scatter of the beam using a second detector (118).

公开(公告)号：WO2002070707A3

公开(公告)日：2002-09-12

申请号：PCT/US2001/049168

申请日：2001-12-18

Applicant: CURAGEN CORPORATION ,  COR THERAPEUTICS, INC. ,  PADIGARU, Muralidhara ,  GERLACH, Valerie, L. ,  SMITHSON, Glennda ,  STONE, David ,  BIN-YANG, Ruey ,  CONLEY, Pamela ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  KEKUDA, Ramesh ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit ,  MACDOUGALL, John, R.

Inventor： PADIGARU, Muralidhara ,  GERLACH, Valerie, L. ,  SMITHSON, Glennda ,  STONE, David ,  BIN-YANG, Ruey ,  CONLEY, Pamela ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  KEKUDA, Ramesh ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit ,  MACDOUGALL, John, R.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2002068652A3

公开(公告)日：2002-09-06

申请号：PCT/US2002/005910

申请日：2002-02-26

Applicant: CURAGEN CORPORATION ,  ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BALLINGER, Robert, A. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  ELLERMAN, Karen, E. ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GILBERT, Jennifer, A. ,  GORMAN, Linda ,  GUO, Xiaojia ,  GUSEV, Vladimir, Y. ,  KEKUDA, Ramesh ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

Inventor： ALSOBROOK, John, P., II ,  ANDERSON, David, W. ,  BALLINGER, Robert, A. ,  BOLDOG, Ferenc, L. ,  BURGESS, Catherine, E. ,  CASMAN, Stacie, J. ,  ELLERMAN, Karen, E. ,  GANGOLLI, Esha, A. ,  GERLACH, Valerie, L. ,  GILBERT, Jennifer, A. ,  GORMAN, Linda ,  GUO, Xiaojia ,  GUSEV, Vladimir, Y. ,  KEKUDA, Ramesh ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel, M. ,  MILLER, Charles, E. ,  MILLET, Isabelle ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol, E., A. ,  PEYMAN, John, A. ,  RASTELLI, Luca ,  SHENOY, Suresh, G. ,  SHIMKETS, Richard, A. ,  SMITHSON, Glennda ,  SPYTEK, Kimberly, A. ,  STONE, David, J. ,  TAUPIER, Raymond, J., Jr. ,  TCHERNEV, Velizar, T. ,  VERNET, Corine, A., M. ,  ZERHUSEN, Bryan, D.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO1993011250A1

公开(公告)日：1993-06-10

申请号：PCT/GB1992002267

申请日：1992-12-07

Applicant: BRITISH TECHNOLOGY GROUP LTD. ,  ALMOND, Jeffrey, William ,  BARCLAY, Wendy, Sue ,  STONE, David, Michael

Inventor： BRITISH TECHNOLOGY GROUP LTD.

IPC: C12N15/86

CPC classification number: C07K14/005 ,  A61K39/00 ,  C12N15/86 ,  C12N2720/12322 ,  C12N2770/32643 ,  C12N2840/203 ,  Y02A50/466

Abstract: A eukaryotic RNA virus especially a picornavirus and most especially a poliovirus, which is made bicistronic with respect to its RNA function and is able to replicate and to express a foreign polypeptide in cells infected with the virus.

Abstract translation: 真核RNA病毒，特别是小核糖核酸病毒，特别是脊髓灰质炎病毒，其相对于其RNA功能被制成双顺反子，并且能够在感染病毒的细胞中复制和表达异源多肽。

公开(公告)号：WO1986001370A1

公开(公告)日：1986-03-13

申请号：PCT/GB1985000333

申请日：1985-07-26

Applicant: MASSEY-FERGUSON MANUFACTURING LIMITED ,  MASSEY-FERGUSON SERVICE N.V. ,  STONE, David, Edward ,  BAILEY, Alfred, John

Inventor： MASSEY-FERGUSON MANUFACTURING LIMITED ,  MASSEY-FERGUSON SERVICE N.V.

IPC: A01C07/12

CPC classification number: A01C15/16 ,  A01C7/123

Abstract: A metering mechanism comprises a housing (7) with a material inlet (12) and a rotary metering member (27) that is rotatably mounted between side walls (8, 9) of the housing with its periphery exposed to a chamber (48) within the housing so as to meter material from the chamber as it rotates, characterised in that a removable insert (74) is provided that is a close fit in said chamber and has a passage (75) through it that communicates at one end with said inlet (12) and at the other end with the periphery of the rotary metering member (27) so that the effective volume of said chamber (48) is reduced to the volume of said passage (75). Thus, of the metering mechanism incorporates the known shutter-type tramlining device in which a shutter (24) serves to close the inlet (12) to the housing, the quantity of seed retained in the chamber within the housing is reduced and therefore the length of a bout that will be sown after closing the shutter will be correspondingly reduced. The metering mechanism may also incorporate a tramlining device comprising an arcuate shutter member (84).

Abstract translation: 计量机构包括具有材料入口（12）的壳体（7）和旋转地安装在壳体的侧壁（8,9）之间的旋转计量构件（27），其周边暴露于腔室（48）内 壳体，以便当其旋转时从腔室测量材料，其特征在于，提供可移除的插入件（74），其紧密配合在所述室中并具有通过其的通道（75），所述通道在一端与所述入口 （12），另一端与旋转计量构件（27）的周边相连，使得所述腔室（48）的有效体积减小到所述通道（75）的体积。 因此，计量机构包括已知的快门式曲棍纱装置，其中挡板（24）用于将入口（12）关闭到壳体，保留在壳体内的腔室中的种子数量减少，因此长度 在关闭快门后播放的一个回合将相应地减少。 计量机构还可以包括包括弧形闸门构件（84）的曲线装置。

公开(公告)号：WO1984000467A1

公开(公告)日：1984-02-16

申请号：PCT/GB1983000190

申请日：1983-08-03

Applicant: PENTON, Elliott ,  STONE, David George Peter

IPC: A01G09/16

CPC classification number: A01G13/0231 ,  E04H15/40

Abstract: A portable or lightweight enclosure has a flexible cover sheet (1) which is anchored to a base (2) or to the ground. A number of flexurally stressed or spring-loaded arched supports (6) are located within the cover sheet, the lower of the supports being free and braced against the inside of the cover sheet (1) by the stressing or loading of the supports so as to maintain the cover sheet in tension. The opposite longitudinal edges (5) of the sheet may be attached to respective longitudinal base members (3) which may be filled with ballast. The lower ends of the arched supports (6) may be interconnected by longitudinal elements (7) through which irrigation water may be supplied.

公开(公告)号：WO2013039562A3

公开(公告)日：2014-04-17

申请号：PCT/US2012027741

申请日：2012-03-05

Applicant: RICOH PROD PRINT SOLUTIONS LLC ,  LEWIS HARRY R ,  HOHENSEE REINHARD H ,  STONE DAVID E

Inventor： LEWIS HARRY R ,  HOHENSEE REINHARD H ,  STONE DAVID E

IPC: G05G5/00

CPC classification number: G06F3/1208 ,  G06F3/1242 ,  G06F3/1288

Abstract: A method is disclosed. The method includes simulating a preprinted form using a presentation overlay. The presentation device is directed to present the overlay as if it had been preprinted on the paper. Document data is then mixed with the simulated preprinted form such that the result accurately simulates a real preprinted form.

Abstract translation: 公开了一种方法。 该方法包括使用演示叠加模拟预印形式。 演示设备被引导为将覆盖物呈现在纸张上被预先印刷的情况。 然后将文档数据与模拟的预印形式混合，使得结果准确地模拟真实的预打印形式。