公开(公告)号：WO2012004757A2

公开(公告)日：2012-01-12

申请号：PCT/IB2011/053006

申请日：2011-07-06

Applicant: UNIVERSITY HEALTH NETWORK ,  INSTITUT NATIONAL D'OPTIQUE ,  RINK, Alexandra ,  JAFFRAY, David ,  MERMUT, Ozzy ,  CARON, Serge ,  CROTEAU, André ,  ROY-MOISAN, François

Inventor： RINK, Alexandra ,  JAFFRAY, David ,  MERMUT, Ozzy ,  CARON, Serge ,  CROTEAU, André ,  ROY-MOISAN, François

CPC classification number: G01T1/06 ,  G01T1/04 ,  G01T1/201 ,  Y10T29/49826

Abstract: A fiber optic dosimeter probe for sensing radiation dose including an optical fiber having a free end and a sensitive end, a window having a sensitive side and a rear side; a radiation sensitive layer between the sensitive end of the optical fiber and a sensitive side of the window, the radiation sensitive layer being made of a material having an optical property that changes with absorbed radiation dose, an amount of the material corresponding to a predetermined sensitivity to radiation; wherein the window and the optical fiber have a near water equivalent interaction with radiation and are MR compatible.

Abstract translation: 一种用于感测辐射剂量的光纤剂量计探针，其包括具有自由端和敏感端的光纤，具有敏感侧和后侧的窗口; 在光纤的敏感端和窗口的敏感侧之间的辐射敏感层，辐射敏感层由具有随吸收的辐射剂量而变化的光学性质的材料制成，该材料的量对应于预定的灵敏度 辐射; 其中窗户和光纤与辐射具有近水等效的相互作用并且与MR兼容。

公开(公告)号：WO2011137514A1

公开(公告)日：2011-11-10

申请号：PCT/CA2011/000513

申请日：2011-05-03

Applicant: UNIVERSITY HEALTH NETWORK ,  JAFFRAY, David A. ,  ALLEN, Christine ,  CHITHRANI, Devika ,  ZHENG, Jinzi ,  GRANT, Justin

Inventor： JAFFRAY, David A. ,  ALLEN, Christine ,  CHITHRANI, Devika ,  ZHENG, Jinzi ,  GRANT, Justin

IPC: A61K41/00 ,  A61K49/00 ,  A61N5/00 ,  A61N7/00 ,  A61K9/127 ,  G01T1/164

CPC classification number: A61N5/00 ,  A61K9/0009 ,  A61K9/127 ,  A61K41/0028 ,  A61K41/0038 ,  A61K49/1812 ,  A61M31/005 ,  A61N5/10 ,  A61N2005/1094 ,  A61N2005/1098

Abstract: Imageable disruptable capsules containing a sensitizing agent or a protecting agent are used to enhance radiation therapy. Said capsules may be imaged by a non-invasive imaging modality, allowing for the determination of the precise timing to disrupt the capsule and release the sensitizing agent or protecting agent using an external energy source. This controlled and timed release of the sensitizing agent or protecting agent provides for enhanced radiation therapy by optimizing the delivery of the sensitizing agent or protecting agent to the target tissues. Systems comprising non-invasive imaging modalities, external energy sources and radiation energy sources are also taught for use with these imageable disruptable capsules.

Abstract translation: 使用含有敏化剂或保护剂的可成像的可破坏胶囊来增强放射治疗。 可以通过非侵入性成像模式对所述胶囊进行成像，从而允许确定干扰胶囊的精确时间并使用外部能量源释放敏化剂或保护剂。 敏感剂或保护剂的这种受控和定时的释放通过优化敏化剂或保护剂向目标组织的递送来提供增强的放射治疗。 还教导了包括非侵入性成像模式，外部能量源和辐射能源的系统与这些可成像的可破坏胶囊一起使用。

公开(公告)号：WO2011123947A1

公开(公告)日：2011-10-13

申请号：PCT/CA2011/000387

申请日：2011-04-06

Applicant: UNIVERSITY HEALTH NETWORK ,  CUMMINGS, Graham ,  PATEL, Narenda Kumar B. ,  FORREST, Bryan, T. ,  LIU, Yong ,  LI, Sze-Wan ,  SAMPSON, Peter Brent ,  EDWARDS, Louise, G. ,  PAULS, Heinz W.

Inventor： CUMMINGS, Graham ,  PATEL, Narenda Kumar B. ,  FORREST, Bryan, T. ,  LIU, Yong ,  LI, Sze-Wan ,  SAMPSON, Peter Brent ,  EDWARDS, Louise, G. ,  PAULS, Heinz W.

IPC: C07D403/04 ,  C07D231/56 ,  C07D413/14

CPC classification number: C07D403/10 ,  A61K31/5377 ,  A61K45/06 ,  C07D231/56 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14

Abstract: The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.

Abstract translation: 本发明涉及用于制备由结构式（A）表示的环丙基吲哚啉酮化合物的新型合成方法：（A）或其药学上可接受的盐。 还包括本文所述的合成中间体。

公开(公告)号：WO2011123946A1

公开(公告)日：2011-10-13

申请号：PCT/CA2011/000386

申请日：2011-04-06

Applicant: UNIVERSITY HEALTH NETWORK ,  SAMPSON, Peter Brent ,  LIU, Yong ,  LI, Sze-Wan ,  FORREST, Bryan T. ,  PAULS, Heinz W. ,  EDWARDS, Louise G. ,  FEHER, Miklos ,  PATEL, Narendra Kumar B. ,  LAUFER, Radoslaw ,  PAN, Guohua

Inventor： SAMPSON, Peter Brent ,  LIU, Yong ,  LI, Sze-Wan ,  FORREST, Bryan T. ,  PAULS, Heinz W. ,  EDWARDS, Louise G. ,  FEHER, Miklos ,  PATEL, Narendra Kumar B. ,  LAUFER, Radoslaw ,  PAN, Guohua

IPC: C07D413/14 ,  A61K31/5377 ,  A61P35/00 ,  C07D403/04

CPC classification number: C07D403/10 ,  A61K31/5377 ,  A61K45/06 ,  C07D231/56 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14

Abstract: The invention is directed to a compound represented by the following structural formula pharmaceutically acceptable salts thereof: (I). Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.

Abstract translation: 本发明涉及由以下结构式表示的化合物其药学上可接受的盐：（I）。 由该结构式表示的化合物是激酶抑制剂，因此在此公开用于治疗癌症。 本文提供了结构式中变量的定义。

公开(公告)号：WO2011109899A1

公开(公告)日：2011-09-15

申请号：PCT/CA2011/000258

申请日：2011-03-10

Applicant: UNIVERSITY HEALTH NETWORK ,  SCHIMMER, Aaron, D. ,  SKRTIC, Marko

Inventor： SCHIMMER, Aaron, D. ,  SKRTIC, Marko

IPC: A61K31/65 ,  A61P35/00 ,  G01N33/48

CPC classification number: A61K31/65 ,  A61K9/0019 ,  C12Q1/6886 ,  C12Q2600/142 ,  G01N33/5091 ,  G01N2800/52

Abstract: Cancer stem cells exhibit different metabolic profiles from other cancer cells, such that they do not readily respond to treatment using conventional chemotherapeutic agents. Studies disclosed herein now demonstrate that the glycylcycline antibiotic tigecycline (a tetracycline derivative) exhibits anti-cancer activity, including activity against cancer stem cells. This anti-neoplastic activity appears to be due to inhibition of mitochondrial protein synthesis in the cancer cells. In preferred embodiments, the cancer to be treated is a hematological cancer, such as leukemia, lymphoma or myeloma.

Abstract translation: 癌症干细胞表现出与其他癌细胞不同的代谢特征，使得它们不容易响应于使用常规化学治疗剂的治疗。 现在公开的研究表明，甘氨酰环霉素抗生素替加环素（四环素衍生物）具有抗癌活性，包括抗癌干细胞的活性。 这种抗肿瘤活性似乎是由于癌细胞中线粒体蛋白质合成的抑制。 在优选实施方案中，待治疗的癌症是血液癌症，例如白血病，淋巴瘤或骨髓瘤。

公开(公告)号：WO2011088571A1

公开(公告)日：2011-07-28

申请号：PCT/CA2011/000090

申请日：2011-01-25

Applicant: UNIVERSITY HEALTH NETWORK ,  KIM, Anthony Taywon ,  WILSON, Brian Campbell

Inventor： KIM, Anthony Taywon ,  WILSON, Brian Campbell

IPC: G01N21/64 ,  A61B5/00 ,  A61K41/00 ,  A61K49/00 ,  G01N21/55 ,  G01N33/52

CPC classification number: A61B5/0059 ,  G01N21/4738 ,  G01N21/6428

Abstract: Methods for quantifying fluorescence and optical properties in a turbid medium such as tissue. Devices and systems suitable for the methods are also disclosed.

Abstract translation: 用于定量混浊介质如组织中的荧光和光学性质的方法。 还公开了适用于该方法的装置和系统。

公开(公告)号：WO2011072401A1

公开(公告)日：2011-06-23

申请号：PCT/CA2010/002082

申请日：2010-12-17

Applicant: UNIVERSITY HEALTH NETWORK ,  WILSON, Brian, Campbell ,  KIM, Anthony, Taywon

Inventor： WILSON, Brian, Campbell ,  KIM, Anthony, Taywon

IPC: G01N21/64 ,  A61B6/00 ,  G01N33/483 ,  G01N33/52 ,  G01N33/53 ,  G01J3/10 ,  G01J3/443 ,  G02B21/00 ,  G07D7/12

CPC classification number: G01N21/6458 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/415 ,  A61B5/418 ,  A61B5/445 ,  A61B2562/0242 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/10 ,  G01J3/4406 ,  G01N2021/6419 ,  G02B21/16 ,  G02B21/367 ,  G07D7/1205 ,  G07D7/128

Abstract: A system for sub-surface fluorescence imaging is provided, the system comprising: an excitation source for selectably emitting light at at least one of at least two excitation wavelengths or wavelength ranges at a target surface; and a light detector for detecting fluorescence emission wavelengths or wavelength ranges from the target surface; wherein at least one of the at least two excitation wavelengths or wavelength ranges causes fluorescing of at least one marker at a sub-surface depth, the emitted light at each of the at least two excitation wavelengths or wavelength ranges having different depths of optical penetration and causing fluorescing at respective different depths. A method for sub-surface fluorescence imaging is also provided, in some cases exemplified by a reconstruction of the sub-surface fluorescence topography.

Abstract translation: 提供了一种用于亚表面荧光成像的系统，所述系统包括：用于可选择地在目标表面处至少两个激发波长或波长范围中的至少一个发光的激发源; 以及用于检测来自目标表面的荧光发射波长或波长范围的光检测器; 其中所述至少两个激发波长或波长范围中的至少一个激发波长或波长范围在亚表面深度处引起至少一个标记的荧光，所述至少两个激发波长或波长范围中的每一个处的发射光具有不同的光学穿透深度， 在各个不同深度引起荧光。 还提供了用于亚表面荧光成像的方法，在某些情况下通过重新构建亚表面荧光形貌来示例。

公开(公告)号：WO2011044671A1

公开(公告)日：2011-04-21

申请号：PCT/CA2010/001573

申请日：2010-10-05

Applicant: UNIVERSITY HEALTH NETWORK ,  ZHENG, Gang ,  LOVELL, Jonathan F.

Inventor： ZHENG, Gang ,  LOVELL, Jonathan F.

IPC: A61K47/24 ,  A61K41/00 ,  A61K49/00 ,  A61K51/04 ,  A61K9/127

CPC classification number: A61K41/0071 ,  A61K47/544 ,  A61K49/0036 ,  A61K49/0084 ,  Y10T428/2991

Abstract: The application relates to a nanovesicle comprising a bilayer of at least 15 mol% porphyrin-phospholipid conjugate, wherein the conjugate comprises a porphyrin, porphyrin derivative or porphyrin analog covalently attached to the phospholipid side chain. The nanovesicle can be used for photothermal therapy, photoacoustic imaging, and fluorescence imaging. The application also discloses a method of preparing the said nanovesicle.

Abstract translation: 本申请涉及包含至少15mol％卟啉 - 磷脂缀合物的双层的纳米囊，其中所述缀合物包含共价连接到磷脂侧链的卟啉，卟啉衍生物或卟啉类似物。 纳米囊可用于光热治疗，光声成像和荧光成像。 本申请还公开了一种制备所述纳米囊的方法。

公开(公告)号：WO2011041912A1

公开(公告)日：2011-04-14

申请号：PCT/CA2010/001625

申请日：2010-10-08

Applicant: UNIVERSITY HEALTH NETWORK ,  DICK, John ,  NOTTA, Faiyaz ,  DOULATOV, Sergei ,  LAURENT, Elisa

Inventor： DICK, John ,  NOTTA, Faiyaz ,  DOULATOV, Sergei ,  LAURENT, Elisa

IPC: C12N5/0789 ,  C12N5/078 ,  C12N5/0784

CPC classification number: C12N5/0647

Abstract: This invention relates to human hematopoietic stem cells. Specifically the invention relations to the identification of single human hematopoietic stem cells capable of long- term multilineage engraftment and self-renewal. The invention also relates to an early lymphoid progenitor with monocytic potential, including dendritic cell potential.

Abstract translation: 本发明涉及人类造血干细胞。 具体地说，本发明与鉴定能够长期多系植入和自我更新的单人造血干细胞的关系。 本发明还涉及具有单核细胞电位的早期淋巴样祖细胞，包括树突状细胞电位。

公开(公告)号：WO2011029190A4

公开(公告)日：2011-03-17

申请号：PCT/CA2010/001409

申请日：2010-09-09

Applicant: ENGINEERING SERVICES INC. ,  UNIVERSITY HEALTH NETWORK ,  GOLDENBERG, Andrew A. ,  TRACHTENBERG, John ,  YANG, Yi ,  MA, Liang

Inventor： GOLDENBERG, Andrew A. ,  TRACHTENBERG, John ,  YANG, Yi ,  MA, Liang

IPC: A61B19/00 ,  A61B5/055 ,  A61B8/00

Abstract: A medical device is for use in association with a medical image of the gland or organ having a known reference point. The medical device comprises a structural frame, a horizontal joint, a vertical joint, a pan join, a tilt joint a medical instrument assembly and a control system. The medical device is positioned at a predetermined location relative to the medical image reference point. Each of the horizontal joint, the vertical joint, the pan joint and the tilt joint have a position sensor and are operably connected to the frame. The medical instrument assembly is operably connected to a sensor and to the horizontal joint, the vertical joint, the pan joint and the tilt joint. The control system is operably connected to the other elements whereby the control system determines the position of a predetermined location on the medical instrument assembly relative to the structural frame.

Abstract translation: 医疗装置用于与具有已知参考点的腺体或器官的医学图像相关联。 医疗设备包括结构框架，水平接头，垂直接头，平底接头，医疗器械组件和控制系统的倾斜接头。 医疗设备被定位在相对于医学图像参考点的预定位置处。 水平关节，垂直关节，平底关节和倾斜关节中的每一个都具有位置传感器并且可操作地连接到框架。 医疗器械组件可操作地连接到传感器以及水平关节，垂直关节，平底关节和倾斜关节。 控制系统可操作地连接到其他元件，由此控制系统确定医疗器械组件上的预定位置相对于结构框架的位置。