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公开(公告)号：KR101349245B1
公开(公告)日：2014-01-16
申请号：KR1020100117492
申请日：2010-11-24
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 피부 미용 또는 성형용 조성물에 관한 것으로서, 보다 상세하게는 관중(
Crassirhizomae
Rhizoma ), 오약(
Linderae
Radix ), 계피(
Cinnamomum
cassia ) 및 고삼(
Saphora
flavescens ) 추출물로 이루어진 군에서 선택된 1종 이상을 유효성분으로 함유하여 사람의 중간엽줄기세포를 지방세포로 분화시키는 것을 촉진하는 피부 미용 또는 성형용 조성물에 관한 것이다.-
公开(公告)号：KR1020130049589A
公开(公告)日：2013-05-14
申请号：KR1020110114689
申请日：2011-11-04
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
IPC: C12N15/63 , C12N15/861 , C12Q1/68 , G01N33/53
CPC classification number: C12N15/635 , C12N15/861 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G01N33/5023 , G01N33/5302 , G01N33/6881
Abstract: PURPOSE: A method for screening a material which enhances a skin barrier function is provided to effectively screening the material, and to diagnose diseases related to the skin barrier function. CONSTITUTION: A method for screening a material which enhances a skin barrier function comprises a step of determining a material which suppresses the expression of PDZK1 genes as the material which enhances the skin barrier function by screening the material which suppresses the expression of the PDZK1 genes. The method comprises a step of treating a nucleic acid molecule of PDZK1 with a candidate material, and a step of detecting expression change. The treatment with the candidate material comprises a step of treating a skin cell which is transformed with a vector containing the nucleic acid molecule with the candidate material. The skin cell is keratinocyte. The vector is adenovirus. A composition for enhancing the skin barrier function contains the material which suppresses the expression of the PDZK1 genes as an active ingredient. [Reference numerals] (AA) Comparative example 1; (BB) Example 1
Abstract translation: 目的：提供一种筛选增强皮肤屏障功能的材料的方法，以有效筛选材料，并诊断与皮肤屏障功能相关的疾病。 构成：用于筛选增强皮肤屏障功能的材料的方法包括测定通过筛选抑制PDZK1基因表达的材料来抑制PDZK1基因表达的材料作为增强皮肤屏障功能的材料的步骤。 该方法包括用候选物质处理PDZK1的核酸分子的步骤和检测表达变化的步骤。 用候选材料的处理包括用候选材料处理用含有核酸分子的载体转化的皮肤细胞的步骤。 皮肤细胞是角质形成细胞。 载体是腺病毒。 用于增强皮肤屏障功能的组合物含有抑制作为活性成分的PDZK1基因表达的材料。 （附图标记）（AA）比较例1; （BB）实施例1
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公开(公告)号：KR1020120088895A
公开(公告)日：2012-08-09
申请号：KR1020100115853
申请日：2010-11-19
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/6881 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , A61K8/00 , G01N33/15
Abstract: PURPOSE: A method and a kit for screening a material which promotes skin cell differentiation is provided to quickly and simply screen the material. CONSTITUTION: A method for screening a material which promotes skin cell differentiation comprises: a step of treating a test material to skin cells; a step of identifying relative expression level of DUOX1(dual oxidase 1) gene(Genebank Accession No.: NM_017434) in the skin cells; and a step of determining a material which enhances the expression level is the material which promotes skin cell differentiation. The skin cells are keratinocytes. A composition for skin moisturizing, skin barrier function strengthening, or atopic dermatitis relief contains the material as an active ingredient.
Abstract translation: 目的：提供一种用于筛选促进皮肤细胞分化的材料的方法和试剂盒，以快速简便地筛选材料。 构成：筛选促进皮肤细胞分化的材料的方法包括：将测试材料处理至皮肤细胞的步骤; 识别皮肤细胞中DUOX1（双重氧化酶1）基因（Genebank登录号：NM_017434）的相对表达水平的步骤; 并且确定增强表达水平的材料的步骤是促进皮肤细胞分化的材料。 皮肤细胞是角质形成细胞。 用于皮肤保湿，皮肤屏障功能增强或特应性皮炎缓解的组合物含有作为活性成分的材料。
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公开(公告)号：KR1020120059672A
公开(公告)日：2012-06-11
申请号：KR1020100120142
申请日：2010-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/68 , A61Q17/04 , C12Q2600/148 , C12Q2600/158 , G01N33/5008
Abstract: PURPOSE: A method for evaluating the efficiency of a sun screen is provided to accurately evaluate efficiency of blocking blue/violet light. CONSTITUTION: A method for evaluating the efficiency of a sun screen comprises: a step of applying a subject on a sunlight permeable material; a step of irradiating skin cells with the sunlight; and a step of collecting the skin cells and measuring gene expression level in the cells. The sunlight is UV ray with 290-400 nm of wavelength or blue/violet light with 400-500 nm of wavelength. The sunlight permeable material is a quartz plate or band pass filter. The skin cells include keratinocytes, fibroblast, or melanocytes.
Abstract translation: 目的：提供一种评估遮阳效率的方法，以准确评估阻挡蓝/紫光的效率。 构成：用于评估遮阳效率的方法包括：将受试者施加于阳光透射材料上的步骤; 用阳光照射皮肤细胞的步骤; 以及收集皮肤细胞并测量细胞中的基因表达水平的步骤。 阳光是具有290-400nm波长的紫外线或具有400-500nm波长的蓝/紫光。 阳光透射材料是石英板或带通滤光片。 皮肤细胞包括角质形成细胞，成纤维细胞或黑素细胞。
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公开(公告)号：KR1020120058865A
公开(公告)日：2012-06-08
申请号：KR1020100120372
申请日：2010-11-30
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/73 , A61K8/97 , A61K35/28 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61Q19/00
Abstract: PURPOSE: A composition containing apple stem cell extract is provided to enhance the stemness of adipose-derived stem cells and to promote regeneration of the stem cells. CONSTITUTION: A composition for enhancing the stemness of adipose-derived stem cells contains apple stem cell extract as an active ingredient. The stem cells are human adipose drived stem cells(hADSCs). The composition enhances the expression level of CD29, CD44, CD73, CD90 or CD105. A composition for beauty or plastic surgery contains 0.0001-10 wt% of the apple stem cell extract as an active ingredient.
Abstract translation: 目的：提供含有苹果干细胞提取物的组合物，以增强脂肪来源的干细胞的干性，促进干细胞的再生。 构成：用于增强脂肪干细胞的干性的组合物含有苹果干细胞提取物作为活性成分。 干细胞是人类脂肪干细胞（hADSCs）。 该组合物增强CD29，CD44，CD73，CD90或CD105的表达水平。 用于美容或整形手术的组合物含有0.0001-10重量％的苹果干细胞提取物作为活性成分。
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Patent Agency Ranking
公开(公告)号：KR1020120002965A
公开(公告)日：2012-01-09
申请号：KR1020110137405
申请日：2011-12-19
Applicant: (주)아모레퍼시픽
IPC: A61K36/48 , A61K36/9062 , A61K36/58 , A61P17/00
CPC classification number: A61K36/48 , A61K8/97 , A61K36/58 , A61K36/9062 , A61Q19/08
Abstract: PURPOSE: A composition which promotes differentiation of human mesenchymal stem cells into adipocytes is provided to enhance skin volume and elasticity and to prevent wrinkles. CONSTITUTION: An external use skin composition for anti-aging contains extract of Spatholobus suberectus Dunn., Alpinia officinarum Hance, or Angelica pubescens for. biserrata Shan Etyuan as an active ingredient. The composition is used for anti-wrinkling or elasticity improvement. The mesenchymal stem cells are derived from human. A pharmaceutical composition for promoting differentiation of adipocytes contains extract of Mucunae Caulis, Alpiniae officinari Rhizoma or Araliae cordatae Radix as an active ingredient.
Abstract translation: 目的：提供促进人间充质干细胞分化为脂肪细胞的组合物，以增强皮肤体积和弹性，并防止皱纹。 构成：外用皮肤抗衰老组合物含有Spatholobus suberectus Dunn，Alpinia officinarum Hance或Angelica pubescens的提取物。 biserrata Shan Eyuanuan作为活性成分。 该组合物用于抗皱或弹性改善。 间充质干细胞来源于人。 用于促进脂肪细胞分化的药物组合物含有木瓜（Mucunae Caulis），天竺葵（Alpiniae officinari Rhizoma）或堇菜（Araliae cordatae Radix）的提取物作为活性成分。
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公开(公告)号：KR1020110129275A
公开(公告)日：2011-12-01
申请号：KR1020100048820
申请日：2010-05-25
Applicant: (주)아모레퍼시픽
IPC: A61K8/97 , A61K36/185 , A61Q19/00 , C12N5/077
Abstract: PURPOSE: A composition for promoting the differentiation of human mesenchymal stem cells to adipocytes, containing Sterculiae scaphigerae semen extract, is provided to enhance the volume and elasticity of skin. CONSTITUTION: An external use skin composition for promoting the differentiation of adipocytes contains 0.0001-30 wt% of Sterculiae scaphigerae semen extract as an active ingredient. The mesenchymal stem cell is derived from humans. A pharmaceutical composition for promoting the differentiation into adipocytes contains Sterculiae scaphigerae semen extract as an active ingredient. The dose of the extract is 0.001mg/kg/day-2000mg/kg/day.
Abstract translation: 目的：提供一种用于促进人类间充质干细胞分化为脂肪细胞的组合物，其含有Sterculiae scaphigerae精液提取物，以增强皮肤的体积和弹性。 构成：用于促进脂肪细胞分化的外用皮肤组合物含有0.0001-30重量％的白e精液提取物作为活性成分。 间充质干细胞来源于人类。 用于促进分化成脂肪细胞的药物组合物含有仙人掌精液提取物作为活性成分。 提取物的剂量为0.001mg / kg /天-2000mg / kg /天。
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公开(公告)号：KR1020110056820A
公开(公告)日：2011-05-31
申请号：KR1020090113295
申请日：2009-11-23
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q17/04 , A61K8/37 , A61K8/4946
Abstract: PURPOSE: A composition containing octyl salicylate or phenylbenaimidazole sulfonic acid is provided to effectively block UVC and UVB. CONSTITUTION: A composition for blocking UVC contains one or more selected from the group consisting of octyl salicylate or phenylbenzimidazole sulfonic acid as an active ingredient. The composition is used in the form of solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, foundation, oil-in-water, or water-in-oil. The maximum absorbance is in the wavelength of 200-290 nm.
Abstract translation: 目的：提供含有辛基水杨酸酯或苯乙咪唑磺酸的组合物，以有效阻断UVC和UVB。 构成：用于封闭UVC的组合物含有选自水杨酸辛酯或苯基苯并咪唑磺酸作为活性成分的一种或多种。 该组合物以溶液，悬浮液，乳液，糊剂，凝胶，霜剂，洗剂，粉末，肥皂，含表面活性剂的清洁剂，油，粉底液，水包油或油包水的形式使用。 最大吸光度为200-290nm波长。
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公开(公告)号：KR1020110000717A
公开(公告)日：2011-01-05
申请号：KR1020100117493
申请日：2010-11-24
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A composition for skin care or plasty is provided to promoter differentiation of human mesenchymal stem cells to adipocytes. CONSTITUTION: A composition for promoting differentiation of adipocytes contains Saphora flavescens extract as an active ingredient. The composition also contains Crassirhizomae Rhixoma, Linderae Radix, or Cinnamomum cassia extract as an active ingredient. The extract is obtained using water, or organic solvent such as ethanol. The composition is used in the form of external use composition such as massage cream, pack and gel or a cosmetic composition such as lotion, ointment, gel, cream, patch or spray.
Abstract translation: 目的：提供用于皮肤护理或整形的组合物以促进人间充质干细胞向脂肪细胞的分化。 构成：用于促进脂肪细胞分化的组合物含有黑曲霉提取物作为活性成分。 该组合物还含有Crassirhizomae Rhixoma，Linderae Radix或Cinnamomum cassia提取物作为活性成分。 提取物是使用水或有机溶剂如乙醇获得的。 组合物以外用组合物的形式使用，例如按摩膏，包装和凝胶或化妆品组合物如洗剂，软膏，凝胶，霜剂，贴片或喷雾剂。
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公开(公告)号：KR1020100105093A
公开(公告)日：2010-09-29
申请号：KR1020090023936
申请日：2009-03-20
Applicant: (주)아모레퍼시픽
IPC: A61K8/97 , A61K36/9062 , A61K36/58 , A61P17/00
Abstract: PURPOSE: A composition for promoting differentiation of human mesenchymal stem cells to adipocytes is provided to enhance volume and elasticity and to ensure anti-wrinkle effect. CONSTITUTION: An external composition for promoting adipocyte differentiation contains extract of Spatholobus suberectus Dunn., Alpinia officinarum Hance, Angelica pubescens for. biserrata Shan Etyuan, or Melia azedarach var. japonica Makino as an active ingredient. The composition promotes differentiation of mesenchymal stem cells to adipocytes. The mesenchymal stem cell is human mesenchymal stem cell. The composition contains the extract in 0.0001-30 weight% based on total weight. The composition enhances skin volume and elasticity.
Abstract translation: 目的：提供用于促进人间充质干细胞向脂肪细胞分化的组合物，以增强体积和弹性，并确保抗皱效果。 构成：用于促进脂肪细胞分化的外用组合物含有Spatholobus suberectus Dunn，Alpinia officinarum Hance，Angelica pubescens的提取物。 biserrata Shan娥或Melia azedarach var。 粳稻作为活性成分。 该组合物促进间充质干细胞向脂肪细胞的分化。 间充质干细胞是人间充质干细胞。 该组合物含有基于总重量的0.0001-30重量％的提取物。 该组合物增强皮肤体积和弹性。
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