公开(公告)号：KR1020120088895A

公开(公告)日：2012-08-09

申请号：KR1020100115853

申请日：2010-11-19

Applicant: (주)아모레퍼시픽

Inventor： 최현 ,  김윤경 ,  양승하 ,  이태룡 ,  노민수 ,  신동욱

IPC: C12Q1/68 ,  G01N33/15 ,  A61K8/00 ,  A61Q19/00

CPC classification number: C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/148 ,  C12Q2600/158 ,  A61K8/00 ,  G01N33/15

Abstract: PURPOSE: A method and a kit for screening a material which promotes skin cell differentiation is provided to quickly and simply screen the material. CONSTITUTION: A method for screening a material which promotes skin cell differentiation comprises: a step of treating a test material to skin cells; a step of identifying relative expression level of DUOX1(dual oxidase 1) gene(Genebank Accession No.: NM_017434) in the skin cells; and a step of determining a material which enhances the expression level is the material which promotes skin cell differentiation. The skin cells are keratinocytes. A composition for skin moisturizing, skin barrier function strengthening, or atopic dermatitis relief contains the material as an active ingredient.

Abstract translation: 目的：提供一种用于筛选促进皮肤细胞分化的材料的方法和试剂盒，以快速简便地筛选材料。 构成：筛选促进皮肤细胞分化的材料的方法包括：将测试材料处理至皮肤细胞的步骤; 识别皮肤细胞中DUOX1（双重氧化酶1）基因（Genebank登录号：NM_017434）的相对表达水平的步骤; 并且确定增强表达水平的材料的步骤是促进皮肤细胞分化的材料。 皮肤细胞是角质形成细胞。 用于皮肤保湿，皮肤屏障功能增强或特应性皮炎缓解的组合物含有作为活性成分的材料。

公开(公告)号：KR1020120059672A

公开(公告)日：2012-06-11

申请号：KR1020100120142

申请日：2010-11-30

Applicant: (주)아모레퍼시픽

Inventor： 김형준 ,  김윤경 ,  이명렬 ,  이종석 ,  박창훈 ,  이태룡 ,  김한곤 ,  노민수 ,  신동욱

IPC: C12Q1/68 ,  A61Q17/04

CPC classification number: C12Q1/68 ,  A61Q17/04 ,  C12Q2600/148 ,  C12Q2600/158 ,  G01N33/5008

Abstract: PURPOSE: A method for evaluating the efficiency of a sun screen is provided to accurately evaluate efficiency of blocking blue/violet light. CONSTITUTION: A method for evaluating the efficiency of a sun screen comprises: a step of applying a subject on a sunlight permeable material; a step of irradiating skin cells with the sunlight; and a step of collecting the skin cells and measuring gene expression level in the cells. The sunlight is UV ray with 290-400 nm of wavelength or blue/violet light with 400-500 nm of wavelength. The sunlight permeable material is a quartz plate or band pass filter. The skin cells include keratinocytes, fibroblast, or melanocytes.

Abstract translation: 目的：提供一种评估遮阳效率的方法，以准确评估阻挡蓝/紫光的效率。 构成：用于评估遮阳效率的方法包括：将受试者施加于阳光透射材料上的步骤; 用阳光照射皮肤细胞的步骤; 以及收集皮肤细胞并测量细胞中的基因表达水平的步骤。 阳光是具有290-400nm波长的紫外线或具有400-500nm波长的蓝/紫光。 阳光透射材料是石英板或带通滤光片。 皮肤细胞包括角质形成细胞，成纤维细胞或黑素细胞。

公开(公告)号：KR1020120058865A

公开(公告)日：2012-06-08

申请号：KR1020100120372

申请日：2010-11-30

Applicant: (주)아모레퍼시픽

Inventor： 심중현 ,  김지현 ,  조성아 ,  민대진 ,  김한곤 ,  이태룡 ,  노민수 ,  신동욱

IPC: A61K36/73 ,  A61K35/28 ,  A61K38/18 ,  A61K8/97 ,  A61Q19/00

CPC classification number: A61K36/73 ,  A61K8/97 ,  A61K35/28 ,  A61K38/1841 ,  A61K38/185 ,  A61K38/1858 ,  A61Q19/00

Abstract: PURPOSE: A composition containing apple stem cell extract is provided to enhance the stemness of adipose-derived stem cells and to promote regeneration of the stem cells. CONSTITUTION: A composition for enhancing the stemness of adipose-derived stem cells contains apple stem cell extract as an active ingredient. The stem cells are human adipose drived stem cells(hADSCs). The composition enhances the expression level of CD29, CD44, CD73, CD90 or CD105. A composition for beauty or plastic surgery contains 0.0001-10 wt% of the apple stem cell extract as an active ingredient.

Abstract translation: 目的：提供含有苹果干细胞提取物的组合物，以增强脂肪来源的干细胞的干性，促进干细胞的再生。 构成：用于增强脂肪干细胞的干性的组合物含有苹果干细胞提取物作为活性成分。 干细胞是人类脂肪干细胞（hADSCs）。 该组合物增强CD29，CD44，CD73，CD90或CD105的表达水平。 用于美容或整形手术的组合物含有0.0001-10重量％的苹果干细胞提取物作为活性成分。

公开(公告)号：KR1020120002965A

公开(公告)日：2012-01-09

申请号：KR1020110137405

申请日：2011-12-19

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  송민정 ,  노민수 ,  이형호 ,  이상민 ,  양승하 ,  김한곤

IPC: A61K36/48 ,  A61K36/9062 ,  A61K36/58 ,  A61P17/00

CPC classification number: A61K36/48 ,  A61K8/97 ,  A61K36/58 ,  A61K36/9062 ,  A61Q19/08

Abstract: PURPOSE: A composition which promotes differentiation of human mesenchymal stem cells into adipocytes is provided to enhance skin volume and elasticity and to prevent wrinkles. CONSTITUTION: An external use skin composition for anti-aging contains extract of Spatholobus suberectus Dunn., Alpinia officinarum Hance, or Angelica pubescens for. biserrata Shan Etyuan as an active ingredient. The composition is used for anti-wrinkling or elasticity improvement. The mesenchymal stem cells are derived from human. A pharmaceutical composition for promoting differentiation of adipocytes contains extract of Mucunae Caulis, Alpiniae officinari Rhizoma or Araliae cordatae Radix as an active ingredient.

Abstract translation: 目的：提供促进人间充质干细胞分化为脂肪细胞的组合物，以增强皮肤体积和弹性，并防止皱纹。 构成：外用皮肤抗衰老组合物含有Spatholobus suberectus Dunn，Alpinia officinarum Hance或Angelica pubescens的提取物。 biserrata Shan Eyuanuan作为活性成分。 该组合物用于抗皱或弹性改善。 间充质干细胞来源于人。 用于促进脂肪细胞分化的药物组合物含有木瓜（Mucunae Caulis），天竺葵（Alpiniae officinari Rhizoma）或堇菜（Araliae cordatae Radix）的提取物作为活性成分。

公开(公告)号：KR1020110129275A

公开(公告)日：2011-12-01

申请号：KR1020100048820

申请日：2010-05-25

Applicant: (주)아모레퍼시픽

Inventor： 노민수 ,  신동욱 ,  심중현 ,  김규한 ,  김형준 ,  이명렬 ,  김한곤

IPC: A61K8/97 ,  A61K36/185 ,  A61Q19/00 ,  C12N5/077

Abstract: PURPOSE: A composition for promoting the differentiation of human mesenchymal stem cells to adipocytes, containing Sterculiae scaphigerae semen extract, is provided to enhance the volume and elasticity of skin. CONSTITUTION: An external use skin composition for promoting the differentiation of adipocytes contains 0.0001-30 wt% of Sterculiae scaphigerae semen extract as an active ingredient. The mesenchymal stem cell is derived from humans. A pharmaceutical composition for promoting the differentiation into adipocytes contains Sterculiae scaphigerae semen extract as an active ingredient. The dose of the extract is 0.001mg/kg/day-2000mg/kg/day.

Abstract translation: 目的：提供一种用于促进人类间充质干细胞分化为脂肪细胞的组合物，其含有Sterculiae scaphigerae精液提取物，以增强皮肤的体积和弹性。 构成：用于促进脂肪细胞分化的外用皮肤组合物含有0.0001-30重量％的白e精液提取物作为活性成分。 间充质干细胞来源于人类。 用于促进分化成脂肪细胞的药物组合物含有仙人掌精液提取物作为活性成分。 提取物的剂量为0.001mg / kg /天-2000mg / kg /天。

公开(公告)号：KR1020110000717A

公开(公告)日：2011-01-05

申请号：KR1020100117493

申请日：2010-11-24

Applicant: (주)아모레퍼시픽

Inventor： 박선미 ,  신동욱 ,  이상민 ,  송민정 ,  김신형 ,  노민수 ,  김한곤

IPC: A61K8/97 ,  A61K36/54 ,  A61Q19/00

Abstract: PURPOSE: A composition for skin care or plasty is provided to promoter differentiation of human mesenchymal stem cells to adipocytes. CONSTITUTION: A composition for promoting differentiation of adipocytes contains Saphora flavescens extract as an active ingredient. The composition also contains Crassirhizomae Rhixoma, Linderae Radix, or Cinnamomum cassia extract as an active ingredient. The extract is obtained using water, or organic solvent such as ethanol. The composition is used in the form of external use composition such as massage cream, pack and gel or a cosmetic composition such as lotion, ointment, gel, cream, patch or spray.

Abstract translation: 目的：提供用于皮肤护理或整形的组合物以促进人间充质干细胞向脂肪细胞的分化。 构成：用于促进脂肪细胞分化的组合物含有黑曲霉提取物作为活性成分。 该组合物还含有Crassirhizomae Rhixoma，Linderae Radix或Cinnamomum cassia提取物作为活性成分。 提取物是使用水或有机溶剂如乙醇获得的。 组合物以外用组合物的形式使用，例如按摩膏，包装和凝胶或化妆品组合物如洗剂，软膏，凝胶，霜剂，贴片或喷雾剂。

公开(公告)号：KR1020100105093A

公开(公告)日：2010-09-29

申请号：KR1020090023936

申请日：2009-03-20

Applicant: (주)아모레퍼시픽

Inventor： 신동욱 ,  송민정 ,  노민수 ,  이형호 ,  이상민 ,  양승하 ,  김한곤

IPC: A61K8/97 ,  A61K36/9062 ,  A61K36/58 ,  A61P17/00

Abstract: PURPOSE: A composition for promoting differentiation of human mesenchymal stem cells to adipocytes is provided to enhance volume and elasticity and to ensure anti-wrinkle effect. CONSTITUTION: An external composition for promoting adipocyte differentiation contains extract of Spatholobus suberectus Dunn., Alpinia officinarum Hance, Angelica pubescens for. biserrata Shan Etyuan, or Melia azedarach var. japonica Makino as an active ingredient. The composition promotes differentiation of mesenchymal stem cells to adipocytes. The mesenchymal stem cell is human mesenchymal stem cell. The composition contains the extract in 0.0001-30 weight% based on total weight. The composition enhances skin volume and elasticity.

Abstract translation: 目的：提供用于促进人间充质干细胞向脂肪细胞分化的组合物，以增强体积和弹性，并确保抗皱效果。 构成：用于促进脂肪细胞分化的外用组合物含有Spatholobus suberectus Dunn，Alpinia officinarum Hance，Angelica pubescens的提取物。 biserrata Shan娥或Melia azedarach var。 粳稻作为活性成分。 该组合物促进间充质干细胞向脂肪细胞的分化。 间充质干细胞是人间充质干细胞。 该组合物含有基于总重量的0.0001-30重量％的提取物。 该组合物增强皮肤体积和弹性。

公开(公告)号：KR1020100060709A

公开(公告)日：2010-06-07

申请号：KR1020080119426

申请日：2008-11-28

Applicant: (주)아모레퍼시픽

Inventor： 권순상 ,  신동욱 ,  염명훈 ,  김덕희 ,  김한곤

IPC: B82B3/00 ,  G03F7/004 ,  C01B31/02 ,  H01L21/285

CPC classification number: A61K31/35 ,  A61K31/37 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/08

Abstract: PURPOSE: A method for extracting, purifying, and processing decursin from Angelica gigas nakai extract is provided to maximize efficiency of decursin on the skin and to enhance skin absorption rate. CONSTITUTION: A method for preparing decursin from Angelica gigas Nakai extract comprises: a step of extracting Angelica gigas Nakai by supercritical extraction using carbon dioxide; a step of isolating and purifying decursin through column chromatography using hexane and ethylacetate; and a step of capturing purified decursin in a polymer nano carrier. The polymer nano carrier is polycaprolactone-block polyethylene glycol block copolymer, polyethylene glycol and poly-D,L-lactic acid-co-glycolic acid block copolymer, or linear polyethylene imine and poly-carprolactone block copolymer.

Abstract translation: 目的：提供从当归提取物中提取，纯化和处理前胡素的方法，以最大限度地提高皮肤上前皮素的效率并增强皮肤吸收率。 构成：从当归提取物中提取前药的方法，包括：采用二氧化碳超临界萃取法萃取当归， 通过使用己烷和乙酸乙酯的柱色谱分离和纯化前脂素的步骤; 以及在聚合物纳米载体中捕获纯化的前胡素的步骤。 聚合物纳米载体是聚己内酯嵌段聚乙二醇嵌段共聚物，聚乙二醇和聚-D，L-乳酸 - 共 - 乙醇酸嵌段共聚物，或线性聚乙烯亚胺和聚己内酯嵌段共聚物。

公开(公告)号：KR1020100055733A

公开(公告)日：2010-05-27

申请号：KR1020080114594

申请日：2008-11-18

Applicant: (주)아모레퍼시픽

Inventor： 박준성 ,  박혜윤 ,  김동현 ,  이상민 ,  신동욱 ,  김신형 ,  노민수 ,  김덕희 ,  김한곤

IPC: A61K31/366 ,  A61K31/352 ,  A61P17/00

CPC classification number: A61K31/352 ,  A61K9/0014 ,  A61K31/366

Abstract: PURPOSE: An external use skin composition containing ortho-dihydroxyisoflavone derivative is provided to improve expression of DKK3 proein and FZD1 protein and to suppress hyperproliferation. CONSTITUTION: An external use skin composition for suppressing epidermis hyperproliferation and treating inflammatory skin diseases contains 0.001-30 weight% of ortho-dihydroxyisoflavone derivative, 4'6,7-trihydroxy isoflavone, 3',4'7-trihydroxyisoflavone, or mixture thereof as an active ingredient. The composition is used in the form of skin softener, astringent, lotion, eye cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, essence, or pack.

Abstract translation: 目的：提供含有邻二羟基异黄酮衍生物的外用皮肤组合物，以改善DKK3 proein和FZD1蛋白的表达，抑制过度增殖。 构成：用于抑制表皮过度增殖和治疗炎性皮肤病的外用皮肤组合物含有0.001-30重量％的邻二羟基异黄酮衍生物，4'6,7-三羟基异黄酮，3'，4,7-二羟基异黄酮，或其混合物 活性成分。 该组合物以皮肤柔软剂，收敛剂，洗剂，眼霜，按摩霜，清洁霜，清洁泡沫，清洁水，粉末，精华或包装的形式使用。

公开(公告)号：KR1020100042708A

公开(公告)日：2010-04-27

申请号：KR1020080101820

申请日：2008-10-17

Applicant: (주)아모레퍼시픽

Inventor： 이상민 ,  신동욱 ,  이찬우 ,  김한성 ,  김진웅 ,  김신형 ,  노민수 ,  김한곤

IPC: A61K31/352 ,  A61Q19/00

Abstract: PURPOSE: A composition containing amentoflavone as an active ingredient is provided to increase alpha-6 integrin and to promote kerationcyte stem cell proliferation. CONSTITUTION: A composition for promoting skin regeneration contains amentoflavone as an active ingredient of formula 1. The composition is a cosmetic composition. A cosmetic composition contains 0.001-10 weight% of amentoflavone. The cosmetic composition is contained in lotion type, cream type, and pack type formulation. The composition also is a pharmaceutical composition. The pharmaceutical composition contains 0.001-10 weight% of amentoflavone. The pharmaceutical composition is contained in soft capsule, tablet, or granule.

Abstract translation: 目的：提供含有黄酮黄酮作为活性成分的组合物以增加α-6整联蛋白并促进细胞干细胞增殖。 构成：用于促进皮肤再生的组合物含有作为式1的有效成分的黄酮黄酮。组合物是化妆品组合物。 化妆品组合物含有0.001-10重量％的叶黄酮。 化妆品组合物包含在洗剂型，奶油型和包装型制剂中。 组合物也是药物组合物。 药物组合物含有0.001-10重量％的黄酮黄酮。 药物组合物包含在软胶囊，片剂或颗粒中。