公开(公告)号：EP2943777B1

公开(公告)日：2018-01-03

申请号：EP14737539.8

申请日：2014-01-07

Applicant: The Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College

Inventor： RACOWSKY, Catherine ,  DENG, Manqi ,  NEEDLEMAN, Daniel

IPC: G01N21/64 ,  C12Q1/00

CPC classification number: G01N21/6408 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2201/06193

Abstract: The invention provides novel non-invasive in vitro methods for assessing the metabolic condition of oocytes and/or embryos with fluorescence lifetime imaging microscope, that can be used, for example, in assessment of oocytes and embryos in assisted reproductive technologies.

公开(公告)号：EP2350616B1

公开(公告)日：2017-12-20

申请号：EP09785183.6

申请日：2009-10-01

Applicant: Tyco Fire & Security GmbH

Inventor： PENNEY, Stephen, John ,  SHAW, John, E., A. ,  TAYLOR, Paul, J. ,  BENNETT, Steven, Ian

IPC: G01N21/53 ,  G01N15/02 ,  G08B17/107 ,  F21K9/64 ,  F21V7/06

CPC classification number: G01N21/53 ,  F21K9/64 ,  F21V7/06 ,  F21V9/30 ,  F21Y2115/10 ,  G01J1/0214 ,  G01J1/0422 ,  G01J1/08 ,  G01N15/0211 ,  G01N2021/3181 ,  G01N2021/4733 ,  G01N2201/06193 ,  G01N2201/0625 ,  G01N2201/0696 ,  G08B17/107 ,  G08B17/113 ,  G08B17/117

Abstract: A particulate detector (10) comprises a radiation source (12) arranged to emit radiation in at least first and second predetermined wavebands towards a sampling region (18) suspected of containing particulates, and a detection element (14), shielded from the radiation source (12), and arranged to detect radiation from the sampling region (18) at least first and second instances. The radiation source (12) is such that the emissions in the wavebands temporarily overlap. The detector is such that, at the instances at which the radiation is detected, the relative contributions from the emissions in each predetermined waveband are distinguishable, thereby allowing characteristics of the particulates to be determined. The radiation source (12) may comprise a light emitting diode (24).

公开(公告)号：EP2553431B1

公开(公告)日：2017-05-10

申请号：EP11722878.3

申请日：2011-03-25

Applicant: Institut Pasteur

Inventor： ROGERS, Kelly ,  SHORTE, Spencer L. ,  DRAGAVON, Joseph ,  BLAZQUEZ, Samantha

IPC: G01N21/64 ,  B82Y15/00

CPC classification number: G01N21/6486 ,  B82Y15/00 ,  G01N21/6428 ,  G01N2201/06193

公开(公告)号：EP2943777A1

公开(公告)日：2015-11-18

申请号：EP14737539.8

申请日：2014-01-07

Applicant: The Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College

Inventor： RACOWSKY, Catherine ,  DENG, Manqi ,  NEEDLEMAN, Daniel

IPC: G01N21/64 ,  C12Q1/00

CPC classification number: G01N21/6408 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2201/06193

Abstract: The invention provides novel non-invasive in vitro to methods for assessing the metabolic condition of oocytes and/or embryos with fluorescence lifetime imaging microscope, that can be used, for example, in assessment of oocytes and embryos in assisted reproductive technologies.

公开(公告)号：EP2529199A1

公开(公告)日：2012-12-05

申请号：EP11700860.7

申请日：2011-01-27

Applicant: Roche Diagnostics GmbH ,  F.Hoffmann-La Roche AG

Inventor： HOENES, Joachim ,  WEHOWSKI, Frederic ,  MISCHLER, Reinhold ,  HARTTIG, Herbert

IPC: G01N21/31 ,  G01N21/86 ,  G01N33/487

CPC classification number: G01N21/3151 ,  G01N21/8483 ,  G01N2021/3155 ,  G01N2201/06193 ,  G01N2201/0696

Abstract: The invention relates to a measuring system, in particular for determining blood glucose, having a photometric measuring unit (16), which comprises a light source (22) and a detector (24), and an analytical test element (14) to which a sample can be applied, in particular a body fluid, and which can be moved in a beam path (18) between the light source (22) and the detector (24) for an optical detection of an analyte. For an improved multiwave length measurement, the light source (22) comprises a first emitter (26) that can be actuated in a first wavelength range for sending out pulsating alternating light (28) and a second emitter (30) that can be excited in a second wavelength range for emitting fluorescence light (32).

公开(公告)号：EP2147295A4

公开(公告)日：2012-04-04

申请号：EP08826290

申请日：2008-04-18

Applicant: BECTON DICKINSON CO

Inventor： NATAN MICHAEL J

IPC: G01N21/65 ,  C40B70/00

CPC classification number: C40B70/00 ,  B01J2219/00572 ,  B01J2219/00576 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y20/00 ,  B82Y30/00 ,  G01N21/658 ,  G01N2201/06193 ,  Y10S977/773

Abstract: A method of producing a surface enhanced Raman scattering spectrum which is useful for certain types of assays, in particular proximity assays. The method includes providing two SERS-active nanoparticles. The first SERS-active nanoparticle will absorb a photon at a first wavelength and emit a Raman-shifted photon at a second wavelength. The second SERS-active nanoparticle will absorb a photon at the second wavelength and emit a Raman-shifted photon at a third wavelength. Accordingly, when the first and second SERS-active nanoparticles are proximate to one another and the first SERS-active nanoparticle is illuminated at the first wavelength a Raman-shifted photon at the second wavelength may be emitted. This photon can be absorbed by the second SERS-active nanoparticle causing detectable emission of a second Raman-shifted photon at the third wavelength. Various assays may be designed based upon the above. Proximity assays using two SERS-active nanoparticles will have advantageous background signal characteristics.

Abstract translation: 一种产生表面增强拉曼散射光谱的方法，其可用于某些类型的测定，特别是邻近测定。 该方法包括提供两种SERS活性纳米粒子。 第一SERS活性纳米颗粒将吸收第一波长的光子并且在第二波长处发射拉曼移动的光子。 第二SERS活性纳米粒子将吸收第二波长的光子，并在第三波长处发射拉曼光子。 因此，当第一和第二SERS活性纳米颗粒彼此靠近并且第一SERS活性纳米颗粒在第一波长被照射时，可以发射第二波长的拉曼移动的光子。 该光子可以被第二SERS活性纳米粒子吸收，导致在第三波长处的第二拉曼光子的可检测发射。 可以基于上述设计各种测定。 使用两个SERS活性纳米粒子的接近测定将具有有利的背景信号特征。

公开(公告)号：EP2391871A2

公开(公告)日：2011-12-07

申请号：EP10736516.5

申请日：2010-02-01

Applicant: Egalon, Claudio Oliveira

Inventor： Egalon, Claudio Oliveira

IPC: G01D5/353 ,  G01D5/26 ,  G01F23/292 ,  G01N21/00 ,  G02B6/00

CPC classification number: G01N21/251 ,  G01D5/353 ,  G01D5/35345 ,  G01D5/35387 ,  G01F23/2927 ,  G01N21/17 ,  G01N21/64 ,  G01N21/645 ,  G01N21/648 ,  G01N21/76 ,  G01N21/7703 ,  G01N2021/635 ,  G01N2021/6484 ,  G01N2021/7736 ,  G01N2201/06193 ,  G01N2201/062 ,  G01N2201/088 ,  G02B6/00

Abstract: A side illuminated multi point multi parameter optical fiber sensor that requires no sensitive coating is provided. This sensor comprises an optical fiber having at least one removed cladding section as the sensitive region, at least one probing light source that side illuminates the fiber, a power supply, a detector, a signal processor and a display. The sensitive optical fiber is optically affected by the presence of a measurand medium that can fluoresce, phosphoresce, absorb and/or scatter the probing light. This probing light is guided by the fiber core towards a detector which measures the light intensity and this light intensity is correlated with a measurand.

公开(公告)号：EP0995095B1

公开(公告)日：2005-04-06

申请号：EP98926475.9

申请日：1998-06-09

Applicant: Cedars-Sinai Medical Center

Inventor： SHEHADA, Ramez, E. ,  MARMARELIS, Vasilis, Z. ,  GRUNDFEST, Warren, S.

IPC: G01N1/00 ,  G01N21/49

CPC classification number: G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1455 ,  A61B5/7267 ,  G01N21/49 ,  G01N21/6402 ,  G01N21/6428 ,  G01N2021/6484 ,  G01N2201/06193

公开(公告)号：EP0995095A2

公开(公告)日：2000-04-26

申请号：EP98926475.9

申请日：1998-06-09

Applicant: Cedars-Sinai Medical Center

Inventor： SHEHADA, Ramez, E. ,  MARMARELIS, Vasilis, Z. ,  GRUNDFEST, Warren, S.

IPC: G01N1/00

CPC classification number: G01N21/6486 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1455 ,  A61B5/7267 ,  G01N21/49 ,  G01N21/6402 ,  G01N21/6428 ,  G01N2021/6484 ,  G01N2201/06193

Abstract: The Laser Induced Fluorescence Attenuation Spectroscopy method and apparatus include a source (311) adapted to emit modulated radiation that is directed at a sample volume in a sample (314) to produce return light from the sample, a first sensor (321), displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor (322) displaced by a second distance from the sample volume for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor (323) adapted to process the first and second signals so as to determine the modulation of the sample. Methods and devices are well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence thereof, and can be used to determine the ischemic or hypoxic condition of biological tissue.

公开(公告)号：EP0370527B1

公开(公告)日：1994-02-02

申请号：EP89121775.4

申请日：1989-11-24

Applicant: OMRON TATEISI ELECTRONICS CO.

Inventor： Kobayashi, Shigeki TATEISI INST. OF ,  Takahara, Hideaki TATEISI INST. OF

IPC: G01N21/88

CPC classification number: G01N21/95684 ,  G01N2021/6439 ,  G01N2021/8887 ,  G01N2021/95646 ,  G01N2201/06193