公开(公告)号：JP2003339733A

公开(公告)日：2003-12-02

申请号：JP2003125253

申请日：2003-04-30

Applicant: Alcon Inc ,  アルコン,インコーポレイティド

Inventor： GORDON RAPHAEL

IPC: A61B17/00 ,  A61B19/00 ,  A61M1/00

CPC classification number: A61M1/00 ,  A61B90/90 ,  A61B90/98 ,  A61B2017/00199 ,  A61M2205/123 ,  A61M2205/6018 ,  A61M2205/6063

Abstract: PROBLEM TO BE SOLVED: To provide a system for identifying a surgical cassette which needs to use no fragile tab. SOLUTION: The system comprises a surgical controlling system 10 and a cassette 22, wherein the cassette 22 has a set of identification tag 24 changing from opacity to transparency. Changing the opacity of the tag 24 enables the surgical controlling system 10 to identify easily the type of the working cassette 22. COPYRIGHT: (C)2004,JPO

Abstract translation: 要解决的问题：提供一种用于识别不需要使用脆弱标签的手术盒的系统。 解决方案：该系统包括手术控制系统10和盒22，其中盒22具有从不透明度变为透明度的一组识别标签24。 改变标签24的不透明度使得外科手术控制系统10容易识别工作盒带22的类型。版权所有（C）2004，JPO

公开(公告)号：JP2003339641A

公开(公告)日：2003-12-02

申请号：JP2003151216

申请日：2003-05-28

Applicant: Alcon Inc ,  アルコン,インコーポレイティド

Inventor： ZEPKIN NEIL ,  NGUYEN PHUOC KHANH

IPC: A61B3/10 ,  A61B3/113 ,  A61F9/007 ,  A61F9/008 ,  A61F9/01 ,  G02B26/08 ,  G02B27/00

CPC classification number: G02B27/0093 ,  A61B3/113 ,  A61F9/00804 ,  A61F2009/00846 ,  A61F2009/00872 ,  G02B26/0816 ,  G02B26/0883

Abstract: PROBLEM TO BE SOLVED: To provide a zooming mechanism for an eye tracking system. SOLUTION: The zooming mechanism 30 includes a pyramidal prism 31 having a plurality of reflecting small faces 32 or transmissive small surfaces crossing at an apex. Incident light beams 35 sent toward the respective small surfaces 32 of the prism 31 are reflected or refracted on a plane nearly vertical to an optical axis 34 to form a plurality of optical spots disposed around the optical axis 34. The prism 31 can make translation along the optical axis 34 among a plurality of axial direction positions for changing intervals between the optical spots substantially without varying its size. The optical spots are desirably sent toward a boundary regulated by the two adjacent surfaces of an eye having different reflectances. Reflected energy is detected from each of a plurality of positions to adjust the size of a pattern formed by the optical spots substantially without varying the diameters of the individual spots. COPYRIGHT: (C)2004,JPO

Abstract translation: 要解决的问题：提供一种用于眼睛跟踪系统的变焦机构。 解决方案：变焦机构30包括具有多个反射小面32或在顶点交叉的透射小表面的锥体棱镜31。 向棱镜31的各个小表面32发送的入射光束35在与光轴34几乎垂直的平面上被反射或折射，以形成围绕光轴34设置的多个光点。棱镜31可以沿着 用于改变光斑之间的间隔的多个轴向位置之间的光轴34基本上不改变其尺寸。 光点期望地被发送到由具有不同反射率的眼睛的两个相邻表面调节的边界。 从多个位置的每个位置检测反射能量，以基本上调整由光点形成的图案的尺寸，而不改变各个点的直径。 版权所有（C）2004，JPO

公开(公告)号：JP2015044858A

公开(公告)日：2015-03-12

申请号：JP2014240767

申请日：2014-11-28

Applicant: アルコン,インコーポレイテッド ,  Alcon Inc

Inventor： CLARK ABBOTT F ,  WANG WAN-HENG ,  MCNATT LORETTA

IPC: A61K48/00 ,  A61K31/7105 ,  A61P27/06 ,  C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/30

Abstract: 【課題】SAAのmRNAを標的にし、それによってSAAのmRNAの発現を干渉する干渉RNAの提供。【解決手段】SAAの発現を伴う緑内障における血清アミロイドA mRNAの発現を阻害するためのRNA干渉が提供される。対象の眼において血清アミロイドA mRNAの発現を弱める方法であって、19〜49ヌクレオチドの長さを有する干渉RNAの有効量および薬学的に許容可能な担体を含む組成物を該対象の眼に投与する工程を包含し;該干渉RNAが、センスヌクレオチド配列、アンチセンスヌクレオチド配列、および該センス配列と該アンチセンス配列との間の少なくともほぼ完全に連続して相補性の少なくとも19ヌクレオチドの領域を含む方法もまた提供される。【選択図】図3

Abstract translation: 要解决的问题：提供靶向SAA的干扰RNA干扰SAA mRNA表达的干扰RNA。解决方案：提供RNA干扰以抑制涉及SAA表达的青光眼中血清淀粉样蛋白A（SAA）mRNA的表达。 还提供了一种减轻受试者眼睛中SAA mRNA表达的方法，该方法包括向眼睛施用包含长度为19-49个核苷酸的有效量的干扰RNA的组合物和药学上可接受的载体的步骤 其中干扰RNA包含有义核苷酸序列，反义核苷酸序列和有义和反义序列之间至少近乎完美的至少19个核苷酸的连续互补的区域。

公开(公告)号：JP2014102516A

公开(公告)日：2014-06-05

申请号：JP2014005403

申请日：2014-01-15

Applicant: Alcon Inc ,  アルコン,インコーポレイティド

Inventor： HUCULAK JOHN C ,  HORVATH CHRISTOPHER

IPC: G02B26/02

CPC classification number: G02B26/04 ,  G02B6/266 ,  G02B6/3552 ,  G02B6/3568 ,  Y10S359/90

Abstract: PROBLEM TO BE SOLVED: To provide a system and a method for attenuating brightness of a light beam while minimizing undesirable effect such as shadow and color rings caused by positional attenuation.SOLUTION: Output brightness of a lighting device is varied by chopping an output light beam so that the beam is alternately shielded and unshielded. A light shield device is rapidly moved into and out of a transmission path of the light beam. Brightness of the light beam received at a certain site is attenuated on the basis of a time amount per cycle when the light beam is shielded or when the light beam is unshielded.

Abstract translation: 要解决的问题：提供一种用于衰减光束的亮度的系统和方法，同时最小化由位置衰减引起的诸如阴影和色环之类的不期望的影响。解决方案：通过切断输出光束来改变照明装置的输出亮度 使得光束交替屏蔽和非屏蔽。 遮光装置被快速地移入和移出光束的传输路径。 基于当光束被屏蔽时或当光束未被屏蔽时的每个周期的时间量，在某个位置接收的光束的亮度被衰减。

公开(公告)号：JP2014079644A

公开(公告)日：2014-05-08

申请号：JP2014000436

申请日：2014-01-06

Applicant: Alcon Inc ,  アルコン,インコーポレイティド

Inventor： JACK R AULD ,  SMITH RONALD T

IPC: A61F9/008

CPC classification number: A61B18/22 ,  A61B2018/208 ,  A61B2018/2211 ,  A61B2018/2294 ,  A61B2090/306 ,  A61F9/008 ,  A61F9/00821 ,  A61F2009/00863 ,  A61N5/0603 ,  G02B5/1814 ,  G02B6/264 ,  G02B6/32 ,  G02B27/106 ,  G02B27/1093

Abstract: PROBLEM TO BE SOLVED: To provide a multi-spot laser probe for use in photocoagulation.SOLUTION: A laser probe includes an emitting optical fiber, optics, and two or more receiving optical fibers. The emitting optical fiber emits a beam of laser light. The optics diffract the beam of light emitted by the emitting optical fiber. The receiving optical fibers each receive a beam of light diffracted by the optics.

Abstract translation: 要解决的问题：提供用于光凝的多点激光探针。解决方案：激光探测器包括发射光纤，光学器件和两个或更多个接收光纤。 发射光纤发射一束激光。 光学器件衍射由发射光纤发射的光束。 接收光纤各自接收由光学器件衍射的光束。

公开(公告)号：JP2013176644A

公开(公告)日：2013-09-09

申请号：JP2013125287

申请日：2013-06-14

Applicant: Alcon Inc ,  アルコン,インコーポレイティド

Inventor： BOUKHNY MIKHAIL ,  CHON JAMES ,  DOWNER DAVID ,  VAN NOY STEPHEN J

IPC: A61F2/16

CPC classification number: A61F2/1662

Abstract: PROBLEM TO BE SOLVED: To provide an intraocular lens delivery system having an injector body (125), a plunger (110), a nozzle portion (160), and a heater.SOLUTION: A plunger is slidably movable within an injector body. A nozzle portion is located on a distal end of the injector body and has a hollow interior adapted for receiving an intraocular lens. A heater is integrated with an intraocular lens delivery system and is adapted to heat the intraocular lens.

公开(公告)号：JP2013165980A

公开(公告)日：2013-08-29

申请号：JP2013084601

申请日：2013-04-15

Applicant: Alcon Inc ,  アルコン,インコーポレイテッド

Inventor： JINKERSON DAVID L ,  KARAKELLE MUTLU

IPC: A61F2/16 ,  A61F2/06

CPC classification number: A61L29/085 ,  A61L27/34 ,  A61L31/10

Abstract: PROBLEM TO BE SOLVED: To provide coated intraocular lenses and other medical implants.SOLUTION: Coated medical implants have an implant body 110 configured for securing in or adjacent to body tissue of a patient. The implant body has an implant surface and a coating 170 is formed on at least a portion of the implant surface. The coating includes a coating outer surface of a first chemical component 130 that is chemically bonded to a carboxylate functionality of a second chemical component 140. The second chemical component is immobilized by amide linkage to an underlying third chemical component 150 that is plasma coated directly onto implant body surfaces. The coating either inhibits or prevents the adhesion of protein and/or cellular proliferation or may be a non-fouling coating.

Abstract translation: 要解决的问题：提供涂覆的眼内透镜和其他医疗植入物。解决方案：涂覆医疗植入物具有被配置用于固定在患者身体组织中或邻近患者的身体组织的植入体110。 植入体具有植入物表面，并且涂层170形成在植入物表面的至少一部分上。 涂层包括化学键合到第二化学组分140的羧酸官能团的第一化学组分130的涂层外表面。第二化学组分通过酰胺键固定到下面的第三化学组分150，其被等离子体涂覆在 植入体表面。 该涂层可抑制或防止蛋白质和/或细胞增殖的粘附，或者可以是非结垢的涂层。

公开(公告)号：JP2013127005A

公开(公告)日：2013-06-27

申请号：JP2013061887

申请日：2013-03-25

Applicant: Alcon Inc ,  アルコン,インコーポレイテッド

Inventor： CASTILLO ERNESTO J ,  HAN WESLEY WEHSIN ,  ZHANG HUIXIANG ,  BHAGAT HARESH G ,  SINGH ONKAR N ,  BULLOCK JOSEPH PAUL ,  DIXIT SURESH C

IPC: A61K9/08 ,  A61K31/335 ,  A61K9/00 ,  A61K47/32 ,  A61K47/38 ,  A61K47/46 ,  A61P11/02 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P37/08

CPC classification number: A61K9/0043 ,  A61K9/0048 ,  A61K31/335 ,  A61K47/32 ,  Y10S514/912

Abstract: PROBLEM TO BE SOLVED: To provide topical formulations of olopatadine for treating allergic or inflammatory disorders of an eye and nose.SOLUTION: A solution formulation contains about 0.17-0. 62% (w/v) olopatadine and polyvinylpyrrolidone or polystyrene sulfonic acid in an amount sufficient to enhance the physical stability of the solution. A solution composition is topically administrable to treat allergic or inflammatory disorders of the eye and nose, which contains 0.17-0. 62% (w/v) olopatadine and a polymeric physical stability-enhancing ingredient consisting essentially of polyvinylpyrrolidone or polystyrene sulfonic acid in an amount sufficient to enhance the physical stability of the solution.

Abstract translation: 要解决的问题：提供用于治疗眼睛和鼻子的过敏或炎性疾病的奥洛他定的局部制剂。 解决方案：溶液制剂含有约0.17-0。 62％（w / v）奥洛他定和聚乙烯吡咯烷酮或聚苯乙烯磺酸，其量足以提高溶液的物理稳定性。 溶液组合物可局部施用于治疗眼睛和鼻子的过敏或炎性疾病，其含有0.17-0。 62％（w / v）奥洛他定和基本上由聚乙烯吡咯烷酮或聚苯乙烯磺酸组成的聚合物物理稳定性增强成分，其量足以提高溶液的物理稳定性。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2013090953A

公开(公告)日：2013-05-16

申请号：JP2013018273

申请日：2013-02-01

Applicant: Alcon Inc ,  アルコン,インコーポレイティド

Inventor： SMITH RONALD T

IPC: A61F9/008 ,  A61F9/007

CPC classification number: A61F9/007 ,  A61B3/0008 ,  A61B90/36 ,  A61B2090/306

Abstract: PROBLEM TO BE SOLVED: To provide a high throughput endo-illuminator and illumination surgical system.SOLUTION: The surgical system includes: a light source 12 for providing a light beam; a proximal optical fiber 13, optically coupled to the light source for receiving and transmitting the light beam; a distal optical fiber, optically coupled to a distal end of the proximal optical fiber, for receiving the light beam and emitting the light beam to illuminate a surgical site, wherein the distal optical fiber 20 comprises a tapered section having a proximal-end diameter larger than a distal-end diameter; a handpiece 10, operably coupled to the distal optical fiber; and a cannula 16, operably coupled to the handpiece, for housing and directing the distal optical fiber.

Abstract translation: 要解决的问题：提供高通量内照明器和照明手术系统。 解决方案：手术系统包括：用于提供光束的光源12; 近端光纤13，其光耦合到光源，用于接收和发射光束; 远端光纤，光学耦合到近端光纤的远端，用于接收光束并发射光束以照射外科手术部位，其中远端光纤20包括具有近端直径较大的锥形部分 比远端直径; 可操作地连接到远端光纤的手持件10; 以及可操作地联接到手持件的套管16，用于容纳和引导远端光纤。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2012254318A

公开(公告)日：2012-12-27

申请号：JP2012179832

申请日：2012-08-14

Applicant: Alcon Inc ,  アルコン,インコーポレイティド

Inventor： NAZARIFAR NADER ,  REED FREDERICK M ,  HUCULAK JOHN C ,  THOMAS ROGER D

IPC: A61F9/007

CPC classification number: A61M3/0233 ,  A61F9/007 ,  A61M3/0216 ,  A61M3/0254 ,  A61M2205/3331 ,  A61M2205/3389

Abstract: PROBLEM TO BE SOLVED: To provide an improved method for controlling intraocular pressure during ophthalmic surgery.SOLUTION: This method for controlling intraocular pressure with a microsurgical system includes steps of: providing an infusion chamber containing an irrigating fluid; selecting an intraocular pressure; pressurizing the infusion chamber with a pressurized gas to provide irrigating fluid to a surgical device; measuring a flow rate of the fluid within a fluid line fluidly coupled to the surgical device; providing a signal corresponding to the measured flow rate to a computer; calculating a predicted value of the intraocular pressure with the computer in response to the signal; and adjusting a level of the pressurized gas in response to a signal from the computer to maintain the predicted value proximate the selected intraocular pressure.

Abstract translation: 要解决的问题：提供一种用于在眼科手术期间控制眼内压的改进方法。 解决方案：用显微手术系统控制眼内压的方法包括以下步骤：提供含有冲洗液的浸泡室; 选择眼压; 用加压气体对输注腔加压，以向外科装置提供冲洗流体; 测量流体连接到所述外科装置的流体管线内的流体的流速; 向计算机提供对应于所测量的流量的信号; 响应于所述信号，用所述计算机计算眼压的预测值; 以及响应于来自所述计算机的信号来调节所述加压气体的水平以将所述预测值维持在所选择的眼内压附近。 版权所有（C）2013，JPO＆INPIT