公开(公告)号：WO2013109144A1

公开(公告)日：2013-07-25

申请号：PCT/NL2013/050023

申请日：2013-01-17

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： VAN HEERDE, Waander Laurens ,  DE VISSER- VAN SOEST, Maria Catharina Henrica ,  HIDDINK-EMELIANOVA, Larissa Filaretovna

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: Disclosed is an in vitro method for diagnosing atherosclerosis, determining a predisposition for atherosclerosis; and/or predicting progression of atherosclerosis. The method examines the presence (or absence) of one, or a combination of defined point mutation(s), at defined positions in nucleotide sequences of the Annexin A5 gene.

Abstract translation: 公开了用于诊断动脉粥样硬化，确定动脉粥样硬化倾向的体外方法; 和/或预测动脉粥样硬化的进展。 该方法检查在Annexin A5基因的核苷酸序列中定义的位置存在（或不存在）一个或定义的点突变的组合。

公开(公告)号：WO2012078043A1

公开(公告)日：2012-06-14

申请号：PCT/NL2011/050839

申请日：2011-12-07

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  MEIJER, Afric Simone ,  VAN DER ZANDE, Willem Joan

Inventor： MEIJER, Afric Simone ,  VAN DER ZANDE, Willem Joan

IPC: H01J47/02

CPC classification number: G01J5/02 ,  G01J3/42 ,  G01N21/3563 ,  G01N21/3581 ,  H01J47/024

Abstract: Detector for terahertz radiation with a micro-plasma cell (1) having a cavity (5) comprising a plasma in operation when applying a DC bias to the micro-plasma cell (1). Furthermore, the detector is provided with read-out electronics (20) connected to the micro-plasma cell (1). the read-out electronics measure changes of an electron density in the plasma in the micro-plasma cell (1) with respect to the DC bias provided electron density. The cavity (5) comprises a gas composition near atmospheric pressure or higher, and the gas composition comprises a Penning mixture.

Abstract translation: 具有微等离子体电池（1）的太赫兹辐射的检测器，当在微等离子体电池（1）上施加DC偏压时，具有包括等离子体的空腔（5）。 此外，检测器设置有连接到微等离子体电池（1）的读出电子器件（20）。 读出的电子装置测量微等离子体电池（1）中的等离子体中的电子密度相对于所提供的DC偏压的电子密度的变化。 空腔（5）包括接近大气压或更高的气体组成，气体组成包含Penning混合物。

公开(公告)号：WO2011049442A2

公开(公告)日：2011-04-28

申请号：PCT/NL2010/050693

申请日：2010-10-19

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT, RADBOUD UNIVERSITEIT NIJMEGEN ,  LOOF, Arnoud Harmen ,  VAN HEERDE, Waander Laurens

Inventor： LOOF, Arnoud Harmen ,  VAN HEERDE, Waander Laurens

IPC: G01N33/86

CPC classification number: G01N33/86 ,  G01N33/6848

Abstract: The present invention is concerned with a method for measuring blood coagulation status in a saliva sample from a subject by measuring the concentration of various proteins which have been demonstrated to correlate with the international normalized ratio in said saliva. The invention further relates to a non-invasive device for performing said method, as well as a kit suitable for performing said method.

Abstract translation: 本发明涉及通过测量已经被证明与所述唾液中的国际标准化比例相关联的各种蛋白质的浓度来测量来自受试者的唾液样品中的凝血状态的方法。 本发明还涉及一种用于执行所述方法的非侵入性装置，以及适于执行所述方法的套件。

公开(公告)号：WO2010072743A1

公开(公告)日：2010-07-01

申请号：PCT/EP2009/067721

申请日：2009-12-22

Applicant: INTERVET INTERNATIONAL B.V. ,  STICHTING KATHOLIEKE UNIVERSITEIT, UNIVERSITAIR MEDISCH CENRUM ST. RADBOUD ,  SCHRIER, Carla Christina ,  NIERKENS, Stefan ,  ADEMA, Gosse ,  BROK den, Martijn ,  RUERS, Theodoor Jaques Marie

Inventor： SCHRIER, Carla Christina ,  NIERKENS, Stefan ,  ADEMA, Gosse ,  BROK den, Martijn ,  RUERS, Theodoor Jaques Marie

IPC: A61K31/704 ,  A61K31/7088 ,  A61K39/39 ,  A61P35/00

CPC classification number: A61K39/0011 ,  A61K31/704 ,  A61K39/39 ,  A61K2039/5152 ,  A61K2039/55505 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55577

Abstract: The present invention relates to pharmaceutical compositions for use in in situ tumor- destruction therapy comprising the steps of tumor destruction and administration of an immunostimulating amount of an immunopotentiator, and to the use of such pharmaceutical compositions in the manufacture of a medicament.

Abstract translation: 本发明涉及用于原位肿瘤破坏治疗的药物组合物，其包括以下步骤：肿瘤破坏和免疫刺激量的免疫增强剂的施用，以及这些药物组合物在制备药物中的用途。

公开(公告)号：WO2008075955A2

公开(公告)日：2008-06-26

申请号：PCT/NL2007/050676

申请日：2007-12-20

Applicant: STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN ,  STICHTING KATHOLIEKE UNIVERSITEIT NIJMEGEN ,  RUTJES, Floris, Petrus, Johannes, Theodorus ,  CORNELISSEN, Jeroen. Johannes, Lambertus, Maria ,  VAN BERKEL, Sander, Sebastiaan ,  DIRKS, Antonius, Johannes

Inventor： RUTJES, Floris, Petrus, Johannes, Theodorus ,  CORNELISSEN, Jeroen. Johannes, Lambertus, Maria ,  VAN BERKEL, Sander, Sebastiaan ,  DIRKS, Antonius, Johannes

IPC: C07D249/04 ,  C07D487/08 ,  C07D493/08

CPC classification number: C07D249/04 ,  C07D487/08 ,  C07D493/08

Abstract: The present invention relates to a process for the preparation of 1,4,5- trisubstituted triazoles and 3,4,5-trisubstituted triazoles according to Formulas (Ia) and 5 (Ib), and mesomers and tautomers thereof, wherein a compound according to Formula (II) or Formula (III): is reacted with a compound according to Formula (IV). The process is very useful for the selective and site-specific addition of azide compounds to optionally activated alkynes to form 1,4,5-trisubstuted triazoles and mesomers and tautomers thereof and the application of this process to the covalent functionalisation of biomolecules.

Abstract translation: 本发明涉及制备根据式（Ia）和式（Ib）的1,4,5-三取代的三唑和3,4,5-三取代的三唑的方法， 和其互变异构体，其中根据式（II）或式（III）的化合物：与根据式（IV）的化合物反应。 该方法对于选择性和位点特异性地将叠氮化合物添加到任选活化的炔烃中以形成1,4,5-三固体三唑及其中间体和互变异构体以及将该方法应用于生物分子的共价官能化是非常有用的。 p>

公开(公告)号：WO2007136243A1

公开(公告)日：2007-11-29

申请号：PCT/NL2006/000264

申请日：2006-05-24

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARY THE RADBOUD UNIVERSITY NIJMEGEN MEDICAL CENTRE ,  RASING, Theodorus Henricus Maria ,  KIRILIOUK, Andrei Ivanovitch ,  KIMEL, Alexey Voldemarovitsj ,  STANCIU, Claudiu Daniel ,  HANSTEEN, Fredrik ,  ITOH, Akiyoshi ,  TSUKAMOTO, Arata

Inventor： RASING, Theodorus Henricus Maria ,  KIRILIOUK, Andrei Ivanovitch ,  KIMEL, Alexey Voldemarovitsj ,  STANCIU, Claudiu Daniel ,  HANSTEEN, Fredrik ,  ITOH, Akiyoshi ,  TSUKAMOTO, Arata

IPC: G11B11/10 ,  G11B11/105

CPC classification number: G11B11/10539 ,  G11B5/02 ,  G11B11/10506 ,  G11B11/10584 ,  G11B11/10591 ,  G11B2005/0002 ,  G11C13/06 ,  G11C19/0808

Abstract: The invention relates to a magneto-optical switching device for switching magnetization in a medium, comprising a magnetizable medium. According to the invention, a radiation system suited for imparting angular momentum to the magnetic spin system of said magnetizable medium, so as to selectively orient the magnetization of said medium. In addition, the invention relates to a method of switching a magnetizable medium, comprising providing a magnetizable medium; providing a radiation beam of a selectively chosen angular momentum; and targeting said radiation beam to said medium so as to transfer said angular momentum to a magnetic spin system of said magnetizable medium. Accordingly, spin states in magnetic materials can be manipulated using radiation of a suitable angular momentum. An effective magnetic field is generated for orienting the magnetization of the domains and can simultaneously be used to locally heat the material.

Abstract translation: 本发明涉及用于在包括可磁化介质的介质中切换磁化的磁光开关装置。 根据本发明，适用于向所述可磁化介质的磁自旋系统施加角动量的辐射系统，以便选择性地定向所述介质的磁化。 另外，本发明涉及一种切换可磁化介质的方法，包括提供可磁化介质; 提供选择性选择的角动量的辐射束; 并将所述辐射束瞄准所述介质，以将所述角动量转移到所述可磁化介质的磁旋转系统。 因此，可以使用合适的角动量的辐射来操纵磁性材料中的自旋状态。 产生有效磁场用于定向畴的磁化，并且可以同时用于局部加热材料。

公开(公告)号：WO2004026909A3

公开(公告)日：2004-04-01

申请号：PCT/IB2003/005181

申请日：2003-09-19

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  FIGDOR, Carl, Gustav ,  TORENSMA, Ruurd ,  VAN LENT, Petrus, Leonardus, Everardus, Maria ,  VAN DEN BERG, Wim, B.

Inventor： FIGDOR, Carl, Gustav ,  TORENSMA, Ruurd ,  VAN LENT, Petrus, Leonardus, Everardus, Maria ,  VAN DEN BERG, Wim, B.

IPC: A61K31/70

Abstract: The C-type lectin DC-SIGN is absent in normal synovium but is highly expressed by CD68 positive macrophages in the synovium of rheumatoid arthritis patients. Accordingly, rheumatoid arthritis is diagnosed or treated by, respectively, assaying or blocking DC-SIGN. This can be accomplished by the use of agents, e.g., antibodies, which bind specifically to DCSIGN. Agents that bind to ICAM-3 are used to block inhibition of activation of macrophages by DC-SIGN-ICAM-3 interaction and cause inhibition of rheumatoid arthritis symptoms.

公开(公告)号：WO2002089866A1

公开(公告)日：2002-11-14

申请号：PCT/EP2002/004971

申请日：2002-05-03

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  VAN KUPPEVELT, Antonius, Henricus, Minardus ,  PIEPER, Jeroen, Sebastiaan ,  VAN MOERKER, Hermanus, Theodorus, Bernardus

Inventor： VAN KUPPEVELT, Antonius, Henricus, Minardus ,  PIEPER, Jeroen, Sebastiaan ,  VAN MOERKER, Hermanus, Theodorus, Bernardus

IPC: A61L27/24

CPC classification number: A61L27/24 ,  A61L2430/06

Abstract: The present invention relates to a matrix for use in engineering or regeneration of cartilage, which matrix consists of a network of modified type II collagen. The network is crosslinked in case the modified type II collagen is type II atelocollagen. Alternatively, the modified type II collagen comprises type II collagen fibrils that have been treated with high cutting to obtain fibril parts.

Abstract translation: 本发明涉及一种用于软骨工程或再生的基质，该基质由改性II型胶原蛋白网络组成。 如果修饰的II型胶原是II型胶原蛋白，则网络交联。 或者，修饰的II型胶原蛋白包括已经用高切割处理以获得原纤维部分的II型胶原原纤维。

公开(公告)号：WO2021023863A1

公开(公告)日：2021-02-11

申请号：PCT/EP2020/072246

申请日：2020-08-07

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  UCL BUSINESS PLC

Inventor： COLLIN, Robert Wilhelmus Johanna ,  GARANTO IGLESIAS, Alejandro ,  CREMERS, Franciscus Peter Maria ,  CHEETHAM, Michael Edward

IPC: C12N15/113

Abstract: The present invention relates to the field of medicine. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Stargardt disease.

公开(公告)号：WO2020130804A1

公开(公告)日：2020-06-25

申请号：PCT/NL2019/050777

申请日：2019-11-25

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： HUSSEY, Nigel Edward

IPC: B60L13/04 ,  B60L13/10

Abstract: The present invention is in the field of a National Individual Floating Transportation Infrastructure (NIf TI) wherein floating vehicles can travel by magnetic levitation and propagation. The vehicles can travel at a controllable height above the existing, albeit modified, road infrastructure and at relatively high speeds.