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    METHOD AND DEVICE FOR REDUCING AXIAL THRUST AND RADIAL OSCILLATIONS AND ROTARY MACHINES USING SAME
    151.
    发明公开
    METHOD AND DEVICE FOR REDUCING AXIAL THRUST AND RADIAL OSCILLATIONS AND ROTARY MACHINES USING SAME 审中-公开
    方法和装置以降低AXIALDRUCKSCHWANKUNGEN和旋转的机器，

    公开(公告)号：EP2115304A2

    公开(公告)日：2009-11-11

    申请号：EP08728143.2

    申请日：2008-01-23

    Applicant: Technology Commercialization Corp.

    Inventor： GANELIN, Boris ,  KENWORTHY, Michael, W.

    IPC: F04D29/041

    CPC classification number: F01D3/00 ,  F01D11/02 ,  F04D29/0416 ,  F04D29/046 ,  F04D29/0513 ,  F04D29/056 ,  F05D2240/52 ,  F05D2240/53

    Abstract: A method and apparatus to reduce the axial thrust in rotary machines such as compressors, centrifugal pumps, turbines, etc. includes providing additional peripheral restrictive means (7) attached at the peripheral portion of the disk forming the subdividing means (4) on the side facing the rotating rotor (2). An additional ring element at the periphery of the subdividing means forms additional radial (11) and axial restrictive means (15). Such peripheral restrictive means (7, 11 and 15) function as sealing dams, which combined with the outward flow induced by the rotating impeller, form self-pressurizing hydrodynamic bearings in the axial and radial planes, improving rotordynamic stability. Additionally, a stationary ring element in the center of the cavity forms a seal with the rotor, reducing leakage to suction.

    Abstract translation: 一种方法和装置，以减少在旋转电机的轴向推力：如压缩机，离心式泵，涡轮机等包括提供额外的外围限制性装置（7）连接在盘成形（4）的一侧上的细分装置的周边部 面向旋转转子（2）。 在细分的外周的附加环元件装置形成附加的径向（11）和轴向限制装置（15）。 搜索外围限制手段（7,11和15）用作密封水坝，与由旋转的叶轮所引起的向外的流动相结合，形成在轴向和径向平面自加压的流体动力轴承，提高转子动态稳定性。 此外，在腔体的中心的固定环元件形成密封与所述转子，减少泄漏到抽吸。

    COLLAGEN-BASED THERAPEUTIC DELIVERY SYSTEMS
    156.
    发明公开
    COLLAGEN-BASED THERAPEUTIC DELIVERY SYSTEMS 审中-公开
    基于胶原蛋白的治疗性递送系统

    公开(公告)号：EP3185922A1

    公开(公告)日：2017-07-05

    申请号：EP15835953.9

    申请日：2015-08-27

    Applicant: Purdue Research Foundation Office of Technology Commercialization

    Inventor： VOYTIK-HARBIN, Sherry

    IPC: A61L31/04

    CPC classification number: A61L27/24 ,  A61K9/0024 ,  A61K9/19 ,  A61K38/18 ,  A61K47/42 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/604 ,  A61L2400/06

    Abstract: A collagen-based therapeutic delivery device includes an insoluble synthetic collagen-fibril matrix comprising a polymerization product of soluble oligomeric collagen or a polymerization product of a mixture of soluble oligomeric collagen with one or more type of non-oligomeric soluble collagen molecules, such as, for example, soluble telocollagen and/or soluble atelocollagen, and an active agent dispersed throughout the collagen-fibril matrix or within a portion of the collagen-fibril matrix. A pre-matrix composition includes an aqueous solution including soluble collagen-fibril building blocks and an active agent in the aqueous solution. The soluble collagen-fibril building blocks include soluble oligomeric collagen or a mixture of soluble oligomeric collagen with non-oligomeric soluble collagen molecules. The building blocks are operable to self-assemble into a macromolecular synthetic collagen-fibril matrix in the absence of an exogenous cross-linking agent. Methods of making and using the pre-matrix composition and the device are also provided.

    Abstract translation: 基于胶原的治疗递送装置包括不溶性合成胶原 - 原纤维基质，其包含可溶低聚胶原的聚合产物或可溶低聚胶原与一种或多种非寡聚可溶性胶原分子的混合物的聚合产物， 例如，可溶性端粒胶原和/或可溶性整链端胶原，以及分散在整个胶原 - 原纤维基质中或部分胶原 - 原纤维基质内的活性剂。 预基质组合物包括含有可溶性胶原 - 原纤结构单元和水溶液中的活性剂的水溶液。 可溶性胶原 - 原纤结构单元包括可溶性低聚胶原或可溶低聚胶原与非寡聚可溶性胶原分子的混合物。 在不存在外源交联剂的情况下，构建块可操作以自组装成大分子合成胶原 - 原纤维基质。 还提供了制造和使用预制基质组合物和装置的方法。

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