公开(公告)号：WO2010127444A1

公开(公告)日：2010-11-11

申请号：PCT/CA2010/000681

申请日：2010-05-05

Applicant: UNIVERSITY HEALTH NETWORK ,  BERGER, Stuart, A.

Inventor： BERGER, Stuart, A.

IPC: C12N15/63 ,  C12N15/113 ,  C12N15/12 ,  C12N15/67 ,  C12N15/867 ,  C12P21/02 ,  C12P21/08

CPC classification number: C07K16/00 ,  C07K16/2812 ,  C07K2317/14 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2799/027 ,  C12P21/02

Abstract: The disclosure provides methods and materials for increasing the expression of a protein of interest such as an antibody by a cell. ABC50 expression or activity is increased which increases expression of the protein or antibody of interest. The disclosure also provides methods and materials for increasing the sensitivity of a cell to an endoplasmic reticulum stress agent such as Econozole by decreasing the level of ABC50.

Abstract translation: 本公开提供了用于增加感兴趣的蛋白质的表达的方法和材料，例如细胞的抗体。 增加ABC50表达或活性，这增加了感兴趣的蛋白质或抗体的表达。 本公开还提供了通过降低ABC50的水平来增加细胞对内质网应激剂（例如依曲唑）的敏感性的方法和材料。

公开(公告)号：WO2010121370A1

公开(公告)日：2010-10-28

申请号：PCT/CA2010/000596

申请日：2010-04-20

Applicant: UNIVERSITY HEALTH NETWORK ,  TSAO, Ming-Sound ,  ZHU, Chang-Qi ,  JURISICA, Igor ,  DER, Sandy D. ,  SHEPHERD, Frances A.

Inventor： TSAO, Ming-Sound ,  ZHU, Chang-Qi ,  JURISICA, Igor ,  DER, Sandy D. ,  SHEPHERD, Frances A.

IPC: C40B40/06 ,  C12Q1/68 ,  C40B30/04 ,  G06F19/00 ,  G01N33/574

CPC classification number: G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  G01N2800/50 ,  G06F19/20

Abstract: Provided is a gene expression signature consisting of 12 biomarkers for use in prognosing or classifying a subject with lung squamous cell carcinoma into a poor survival group or a good survival group. The 12-gene signature specific for squamous cell carcinoma consists of the biomarkers RPL22, VEGFA, G0S2, NES, TNFRSF25, DKFZP586P0123, COL8A2, ZNF3, PJPK5, RNFT2, ARHGEF12 and PTPN20A.

Abstract translation: 提供了一种基因表达特征，其由12个生物标志物组成，用于将患有肺鳞状细胞癌的受试者预后或分类为不良生存组或良好生存组。 特异于鳞状细胞癌的12基因特征由生物标志物RPL22，VEGFA，G0S2，NES，TNFRSF25，DKFZP586P0123，COL8A2，ZNF3，PJPK5，RNFT2，ARHGEF12和PTPN20A组成。

公开(公告)号：WO2010115279A1

公开(公告)日：2010-10-14

申请号：PCT/CA2010/000518

申请日：2010-04-06

Applicant: UNIVERSITY HEALTH NETWORK ,  SAMPSON, Peter Brent ,  Ll, Sze-Wan ,  LIU, Yong ,  PAULS, Heinz W. ,  EDWARDS, Louise G. ,  FORREST, Bryan T. ,  FEHER, Miklos ,  PATEL, Narendra Kumar B. ,  PAN, Guohua

Inventor： SAMPSON, Peter Brent ,  Ll, Sze-Wan ,  LIU, Yong ,  PAULS, Heinz W. ,  EDWARDS, Louise G. ,  FORREST, Bryan T. ,  FEHER, Miklos ,  PATEL, Narendra Kumar B. ,  PAN, Guohua

IPC: C07D403/04 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61P35/00 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

CPC classification number: A61K31/553 ,  A61K31/416 ,  A61K31/437 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10

Abstract: The invention is directed to a compound represented by the following structural formula and pharmaceutically acceptable salts thereof: Compounds represented by this structural formula are kinase inhibitors and are therefore disclosed herein for the treatment of cancer. Definitions for the variables in the structural formula are provided herein.

Abstract translation: 本发明涉及由以下结构式表示的化合物及其药学上可接受的盐：由该结构式表示的化合物是激酶抑制剂，因此本文公开了用于治疗癌症的化合物。 本文提供了结构式中变量的定义。

公开(公告)号：WO2010099621A1

公开(公告)日：2010-09-10

申请号：PCT/CA2010/000317

申请日：2010-03-05

Applicant: UNIVERSITY HEALTH NETWORK ,  ISLAM, Mohammad, Khairul ,  NORRLINGER, Bernhard, Dieter ,  SMALE, Jason, R. ,  HEATON, Robert, K. ,  JAFFRAY, David, A.

Inventor： ISLAM, Mohammad, Khairul ,  NORRLINGER, Bernhard, Dieter ,  SMALE, Jason, R. ,  HEATON, Robert, K. ,  JAFFRAY, David, A.

IPC: A61B6/00 ,  G01N23/04

CPC classification number: A61B6/5282 ,  A61N5/1049 ,  A61N2005/1061

Abstract: An apparatus and method obtain an image of an object from a first radiation source in the presence of a second radiation source. The first radiation source is directed at a first side of the object while the second radiation source is directed at the second side of the object. At least one portion of the radiation is detected at the second side of the object. A first signal is produced based on the at least one portion of detected radiation. The first signal has a first radiation component and a second radiation component. At least one other portion of radiation at the second side of the object is filtered and then detected. A second signal is produced based on the detected filtered radiation. The second signal has at least one of a filtered first radiation component and a filtered second radiation component. Then a third signal is produced from the first and second signals. The third signal is a representation of a first radiation component.

Abstract translation: 一种装置和方法在存在第二辐射源的情况下从第一辐射源获得物体的图像。 第一辐射源指向物体的第一侧，而第二辐射源指向物体的第二侧。 在物体的第二侧检测到辐射的至少一部分。 基于检测到的辐射的至少一部分产生第一信号。 第一信号具有第一辐射分量和第二辐射分量。 在物体的第二侧的至少一个其他辐射部分被过滤，然后被检测。 基于检测到的过滤辐射产生第二信号。 第二信号具有滤波的第一辐射分量和滤波的第二辐射分量中的至少一个。 然后从第一和第二信号产生第三信号。 第三信号是第一辐射分量的表示。

公开(公告)号：WO2010088775A1

公开(公告)日：2010-08-12

申请号：PCT/CA2010/000169

申请日：2010-02-05

Applicant: UNIVERSITY HEALTH NETWORK ,  ERWIN, William, Mark ,  FEHLINGS, Michael, George ,  INMAN, Robert, Davies

Inventor： ERWIN, William, Mark ,  FEHLINGS, Michael, George ,  INMAN, Robert, Davies

IPC: C12N5/071 ,  A61K35/32 ,  A61P19/04 ,  C12N5/077 ,  C12Q1/02

CPC classification number: C12N5/0655 ,  A61K35/12 ,  C12N2500/02 ,  C12N2533/74 ,  G01N2510/00

Abstract: The disclosure relates to methods of maintaining and/or expanding an in vitro population of hypoxia compartment cells comprising culturing said population of cells optionally in an oxygen controlled environment, wherein the population of hypoxia compartment cells is exposed to an oxygen concentration of between about 1.5% and about 10%, preferably between about 2% and about 5%, and uses of cells expanded according to these methods.

Abstract translation: 本公开涉及维持和/或扩展体外缺氧室细胞群体的方法，包括任选地在氧气控制环境中培养所述细胞群，其中所述缺氧室细胞群体暴露于约1.5％ 和约10％，优选约2％至约5％，以及根据这些方法扩增的细胞的用途。

公开(公告)号：WO2010048712A1

公开(公告)日：2010-05-06

申请号：PCT/CA2009/001546

申请日：2009-10-29

Applicant: UNIVERSITY HEALTH NETWORK ,  SCHIMMER, Aaron, D. ,  EBERHARD, Yanina

Inventor： SCHIMMER, Aaron, D. ,  EBERHARD, Yanina

IPC: A61K31/7068 ,  A61K31/4418 ,  A61P35/02

CPC classification number: A61K31/4418 ,  A61K9/0019 ,  A61K9/2806 ,  A61K31/7068 ,  A61K2300/00

Abstract: The present application relates to compositions and methods for treating leukemic disorders. In particular, the present application relates to compositions and methods for treating the leukemic disorders such as acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) using ciclopirox and cytarabine.

Abstract translation: 本申请涉及用于治疗白血病的组合物和方法。 特别地，本申请涉及使用环吡酮和阿糖胞苷治疗白血病的急性骨髓性白血病（AML）和急性淋巴细胞白血病（ALL）的组合物和方法。

公开(公告)号：WO2009079767A9

公开(公告)日：2009-07-02

申请号：PCT/CA2008/002227

申请日：2008-12-19

Applicant: UNIVERSITY HEALTH NETWORK ,  PAULS, Heinz, W. ,  FORREST, Bryan, T. ,  LAUFER, Radoslaw ,  FEHER, Miklos ,  SAMPSON, Peter, Brent ,  PAN, Guohua

Inventor： PAULS, Heinz, W. ,  FORREST, Bryan, T. ,  LAUFER, Radoslaw ,  FEHER, Miklos ,  SAMPSON, Peter, Brent ,  PAN, Guohua

IPC: C07D403/06 ,  A61K31/416 ,  A61K31/4192 ,  A61P35/00 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention is directed to a compound is represented by Structural Formula (A):or a pharmaceutically acceptable salt therof. The present invention is also directed to a pharmaceutical composition comprising a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject having cancer, wherein the method comprises administering a therapeutically effective amount of a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof.

公开(公告)号：WO2009059393A1

公开(公告)日：2009-05-14

申请号：PCT/CA2008/001072

申请日：2008-06-06

Applicant: UNIVERSITY HEALTH NETWORK ,  DIAMANDIS, Eleftherios, P. ,  KULASINGAM, Vathany

Inventor： DIAMANDIS, Eleftherios, P. ,  KULASINGAM, Vathany

IPC: G01N33/574 ,  G01N33/53 ,  G01N33/543 ,  G01N33/563 ,  G01N33/577 ,  G01N33/58 ,  G01N33/68

CPC classification number: G01N33/57415 ,  G01N2333/70596 ,  G01N2800/56

Abstract: The present application describes biomarkers and methods useful for screening for, diagnosing or detecting the presence and severity of breast cancer in a subject. The present application also provides methods for determining the prognosis of a subject with breast cancer as well as methods for monitoring the therapeutic response to a breast cancer treatment or therapy.

Abstract translation: 本申请描述了用于筛选，诊断或检测受试者乳腺癌的存在和严重性的生物标志物和方法。 本申请还提供了用于确定具有乳腺癌的受试者的预后的方法以及用于监测对乳腺癌治疗或治疗的治疗反应的方法。

公开(公告)号：WO2008134879A1

公开(公告)日：2008-11-13

申请号：PCT/CA2008/000849

申请日：2008-05-05

Applicant: UNIVERSITY HEALTH NETWORK ,  MEDIN, Jeffrey, A. ,  PAIGE, Christopher, J.

Inventor： MEDIN, Jeffrey, A. ,  PAIGE, Christopher, J.

IPC: C12N15/867 ,  A61K38/20 ,  A61K39/00 ,  A61K48/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/04 ,  C07K14/54 ,  C12N15/24 ,  C12N5/10 ,  C12P21/02

CPC classification number: A61K35/545 ,  A61K38/208 ,  A61K39/0011 ,  A61K48/005 ,  A61K2039/515 ,  A61K2039/53 ,  A61K2039/585 ,  C07K14/5434 ,  C07K2319/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16122 ,  C12N2730/10122 ,  C12N2740/13043 ,  C12N2740/15043 ,  C12N2740/15071 ,  C12N2740/16022 ,  C12N2800/40 ,  C12N2830/48 ,  C12N2830/60

Abstract: Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia.

Abstract translation: 公开了用于递送免疫调节分子以产生治疗效果的组合物和方法。 组合物和方法使用稳定整合的慢病毒递送系统。 该方法可用于治疗和预防性治疗诸如白血病的癌症。

公开(公告)号：WO2008066887A2

公开(公告)日：2008-06-05

申请号：PCT/US2007/024571

申请日：2007-11-29

Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY ,  UNIVERSITY OF MARYLAND, BALTIMORE ,  UNIVERSITY HEALTH NETWORK ,  MELNICK, Ari, Matthew ,  MACKERELL, Alexander, D., Jr. ,  PRIVE, Gilbert, Gerard

Inventor： MELNICK, Ari, Matthew ,  MACKERELL, Alexander, D., Jr. ,  PRIVE, Gilbert, Gerard

IPC: A61K31/415

CPC classification number: A61K31/415 ,  C07D417/04

Abstract: Provided are methods of inhibiting BCL6 repression in a mammalian cell. Also provided are methods of treating cancer in a mammal.

Abstract translation: 提供了抑制哺乳动物细胞中BCL6阻遏的方法。 还提供了治疗哺乳动物癌症的方法。