公开(公告)号：KR1020100012076A

公开(公告)日：2010-02-05

申请号：KR1020080073605

申请日：2008-07-28

Applicant: (주)아모레퍼시픽

Inventor： 박선미 ,  신동욱 ,  이상민 ,  송민정 ,  김신형 ,  노민수 ,  김한곤

IPC: A61K8/97 ,  A61K35/28 ,  A61Q19/08

CPC classification number: A61K8/97 ,  A61K35/28 ,  A61Q19/08

Abstract: PURPOSE: A composition containing medicinal herb extract for skin care or plastic surgery is provided to promote differentiation of human mesenchymal stem cells to adipocytes and improve adipose. CONSTITUTION: A composition for promoting differentiation of adipocytes contains Crassirhizomae Rhizoma, Linderae Radix, Cinnamomum cassia, and Saphora flavescens extract as an active ingredient. The medicinal herb extract is obtained using organic solvent such as water and ethanol. The composition enhances adipose. The composition promotes differentiation of human mesenchymal stem cells to adipocytes. The composition is used in the form of skin softener, nutrition lotion, massage cream, pack, gel, or skin viscosity type cosmetic product.

Abstract translation: 目的：提供含有用于护肤或整形手术的药用草药提取物的组合物，以促进人类间充质干细胞向脂肪细胞分化并改善脂肪。 构成：用于促进脂肪细胞分化的组合物含有Crassirhizomae Rhizoma，Linderae Radix，Cinnamomum Cassia和Saphora flavescens提取物作为活性成分。 使用有机溶剂如水和乙醇获得草药提取物。 组合物增强脂肪。 该组合物促进人间充质干细胞向脂肪细胞的分化。 该组合物以皮肤柔软剂，营养乳液，按摩霜，包装，凝胶或皮肤粘度型化妆品的形式使用。

公开(公告)号：KR1020100008541A

公开(公告)日：2010-01-26

申请号：KR1020080069083

申请日：2008-07-16

Applicant: (주)아모레퍼시픽

Inventor： 이상민 ,  신동욱 ,  박선미 ,  송민정 ,  노민수 ,  김한곤

IPC: A61K36/428 ,  A61K36/60 ,  A61P3/10

Abstract: PURPOSE: A composition promoting adipocyte differentiation of human mesenchymal stem cells is provided to ensure volume and elasticity of the skin and effectively prevent or treat diabetes type 2. CONSTITUTION: A composition for promoting adipocyte differentiation contains Trichosanthis Semen extract or Cannabis Semen extract as an active ingredient. A composition for preventing or treating diabetes contains the Trichosanthis Semen extract or Cannabis Semen extract as an active ingredient. The composition promotes differentiation of human mesenchymal stem cells to adipocytes. The human mesenchymal stem cells are derived from human bone marrow.

Abstract translation: 目的：提供促进人类间充质干细胞脂肪细胞分化的组合物，以确保皮肤的体积和弹性，并有效预防或治疗2型糖尿病。构成：用于促进脂肪细胞分化的组合物含有Trichosanthis精液提取物或大麻精液提取物作为活性成分 成分。 用于预防或治疗糖尿病的组合物含有Trichosanthis Semen提取物或大麻精液提取物作为活性成分。 该组合物促进人间充质干细胞向脂肪细胞的分化。 人类间充质干细胞来自人骨髓。

公开(公告)号：KR1020090126692A

公开(公告)日：2009-12-09

申请号：KR1020080052915

申请日：2008-06-05

Applicant: (주)아모레퍼시픽

Inventor： 이상민 ,  송민정 ,  신동욱 ,  박선미 ,  노민수 ,  김한곤

IPC: A61K36/185 ,  A61P3/10 ,  A61P3/00

Abstract: PURPOSE: A composition for promoting adipocyte differentiation, containing Torreya nucifera extract is provided to use in skin cosmetic or plastic surgery, prevent and treat diabetes. CONSTITUTION: A composition for promoting adipocyte differentiation contains Torreya nucifera extract as an active ingredient. The composition has function of increasing adipose tissue through differentiation of the adipocytes. The adipocyte is differentiated adipocyte from preadipocyte or mesenchymal stem cell of mammal. The mesenchymal stem cell of mammal is human mesenchymal stem cell derived from human bone marrow. The composition increases adipose tissue for skin cosmetic or plastic surgery. The composition is used in preventing or treating diabetes type 2. The daily dose of an active ingredient is 0.0001mg/kg/day~2000g/kg/day.

Abstract translation: 目的：提供用于促进脂肪细胞分化的组合物，其含有Torreya Nucifera提取物用于皮肤美容或整形手术，预防和治疗糖尿病。 构成：用于促进脂肪细胞分化的组合物含有作为活性成分的Torreya Nucifera提取物。 该组合物具有通过脂肪细胞分化增加脂肪组织的功能。 脂肪细胞是哺乳动物前脂肪细胞或间充质干细胞分化的脂肪细胞。 哺乳动物的间充质干细胞来自人骨髓的人间充质干细胞。 组合物增加皮肤美容或整形手术的脂肪组织。 该组合物用于预防或治疗2型糖尿病。活性成分的日剂量为0.0001mg / kg /天〜2000g / kg /天。

公开(公告)号：KR1020090125948A

公开(公告)日：2009-12-08

申请号：KR1020080052041

申请日：2008-06-03

Applicant: (주)아모레퍼시픽

Inventor： 이상민 ,  송민정 ,  신동욱 ,  노민수 ,  김한곤

IPC: A61K8/97 ,  A61Q19/00

CPC classification number: A61K8/97 ,  A61K36/74 ,  A61K2800/92 ,  A61Q19/08

Abstract: PURPOSE: A composition conaining Oldenlandia diffusa extract for skin cosmetic or beauty as an active ingredient is provided to promote differentiation of human mesenchymal stem cells to adipocytes. CONSTITUTION: A composition for differentiation of adipocyte contains Oldenlandia diffusa extract as an active ingredient. The composition is for increasing adipose tissue. The composition promotes differentiation of human mesenchymal stem cells to adipocyte. The human mesenchymal stem cells are mesenchymal stem cells from human bone marrow. The cosmetic composition is used in the form of massage cream, nutrition cream, pack, and gel.

Abstract translation: 目的：为了促进人类间充质干细胞向脂肪细胞的分化，提供了一种赋予皮肤美容或美容作为活性成分的奥兰达氏锥体提取物的组合物。 构成：用于分化脂肪细胞的组合物含有苦参提取物作为活性成分。 该组合物用于增加脂肪组织。 该组合物促进人间充质干细胞向脂肪细胞的分化。 人类间充质干细胞是人骨髓间充质干细胞。 化妆品组合物以按摩霜，营养霜，包装和凝胶的形式使用。

公开(公告)号：KR1020080051235A

公开(公告)日：2008-06-11

申请号：KR1020060121955

申请日：2006-12-05

Applicant: (주)아모레퍼시픽

Inventor： 신의석 ,  신동욱 ,  이형호 ,  김대건 ,  이정아 ,  윤준원 ,  노호식 ,  백흥수

IPC: A61K31/12 ,  A61K31/05 ,  A61K31/136 ,  A61P3/04

Abstract: A pharmaceutical composition for treating and preventing lipid metabolism-related diseases is provided to increase activity of isocitrate dehydrogenase 3alpha(IDH3alpha) promoter and carnitine palmitoyl transferase 1A(CPT1A) promoter, so that blood sugar and neutral fat are reduced. A pharmaceutical composition for treating and preventing lipid metabolism-related diseases comprises compounds represented by the formula(1), wherein R1 is H or C1-C5 alkyl, R2 is H or OH and n is an integer from 1 to 3, and is formulated as tablet, pill, powder, sachet, elixir, suspension, emulsion, solution, syrup, aerosol, soft or hard gelatin capsule, sterile injection solution or sterile powder, wherein the daily dosage of the compounds is 0.1-100 mg/kg. Further, the lipid metabolism-related diseases are obesity, hyperlipemia and diabetes.

Abstract translation: 提供了用于治疗和预防脂质代谢相关疾病的药物组合物，以增加异柠檬酸脱氢酶3α（IDH3alpha）启动子和肉碱棕榈酰转移酶1A（CPT1A）启动子的活性，从而降低血糖和中性脂肪。 用于治疗和预防脂质代谢相关疾病的药物组合物包括由式（1）表示的化合物，其中R 1为H或C 1 -C 5烷基，R 2为H或OH，n为1至3的整数， 作为片剂，丸剂，粉末，香囊，酏剂，悬浮液，乳剂，溶液，糖浆，气溶胶，软或硬明胶胶囊，无菌注射溶液或无菌粉末，其中化合物的日剂量为0.1-100mg / kg。 此外，脂质代谢相关疾病是肥胖，高脂血症和糖尿病。