公开(公告)号：WO1984000313A1

公开(公告)日：1984-02-02

申请号：PCT/US1983000771

申请日：1983-05-16

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  NIELSEN, Steven, T. ,  LEE, Carleton, C.

IPC: B01L03/14

CPC classification number: B01L3/5021

Abstract: A thin-wall centrifuge tube (10) having multiple chambers (24, 26) for use in fluid sample investigation with an ultracentrifuge. More particularly, the multiple chamber ultracentrifuge tube (10) can be used, for example, in lipoprotein separation. The ultracentrifuge tube (10) may have two or more separate chambers (24, 26) which, subsequent to centrifugation, can be sealed from each other to retain the separated constituents (50, 54) of the sample under investigation. The chambers (24, 26) in the tube (10) are joined by a constricted area (20) which permits fluid communication between the chambers (24, 26). The tube (10) is designed to be used in conjunction with a support spacer (32) adjacent the constriction (20) in the tube (10) so that the tube (10) is properly supported during high speed centrifugation.

Abstract translation: 一种具有多个腔室（24,26）的薄壁离心管（10），用于使用超速离心机进行流体样品检测。 更具体地，多室超离心管（10）可以用于例如脂蛋白分离。 超离心管10可以具有两个或更多个分开的室（24,26），其在离心之后可以彼此密封以保持所研究的样品的分离的组分（50,54）。 管（10）中的腔室（24,26）通过允许腔室（24,26）之间的流体连通的收缩区域（20）连接。 管（10）设计成与管（10）中的收缩部（20）相邻的支撑间隔件（32）结合使用，使得管（10）在高速离心期间被适当地支撑。

公开(公告)号：WO1983004379A1

公开(公告)日：1983-12-22

申请号：PCT/US1983000319

申请日：1983-03-07

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  WRIGHT, Herschel, E.

IPC: B04B05/04

CPC classification number: F16D1/092 ,  B04B5/0414 ,  B04B9/08 ,  B04B2007/025 ,  B04B2009/085 ,  F16B21/088

Abstract: A rotor attachment assembly to provide efficient and secure connection between a rotor (10) and a centrifuge drive mechanism (18). The assembly is designed in such a manner that not only attachment, but also disconnection is accomplished in a convenient one-step operation. The utilization of a single connecting shaft (24) with flexible fingers (30) contributes to the ease of operation as well as the ease of manufacture of the assembly.

Abstract translation: 一种用于在转子（10）和离心机驱动机构（18）之间提供有效和可靠的连接的转子附接组件。 组件的设计方式不仅在方便的一步操作中不仅附接，而且断开。 利用具有柔性指状物（30）的单个连接轴（24）有助于操作的容易性以及组件的易于制造。

公开(公告)号：WO1983000932A1

公开(公告)日：1983-03-17

申请号：PCT/US1982001194

申请日：1982-08-31

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  HARRIS, Arthur, Milton

IPC: G01N37/00

CPC classification number: B67D3/00 ,  B01L3/508 ,  B01L9/06 ,  G01N35/1095

Abstract: A reagent storage and delivery apparatus. The invention includes containers (11, 12, 13) with elastomeric septums (16) in the mouth portions (15) thereof. When attached to a supporting rack (19), a hollow needle (24) on the supporting rack (19) pierces the elastomeric septums (15) and allows the reagent to be dispensed from the containers (11, 12, 13) through the needle (24).

Abstract translation: 试剂储存和输送装置。 本发明包括在其口部（15）中具有弹性体隔片（16）的容器（11,12,13）。 当连接到支撑架（19）上时，支撑架（19）上的中空针（24）刺穿弹性体隔片（15），并允许试剂从容器（11,12,13）通过针头 （24）。

公开(公告)号：WO1998003862A1

公开(公告)日：1998-01-29

申请号：PCT/US1997010169

申请日：1997-06-05

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  BELL, Michael, L.

IPC: G01N27/447

CPC classification number: G01N27/44791 ,  G01N27/44743

Abstract: A capillary, interface and holder for a capillary electrophoresis system are provided herein. The capillary is disposed in a substantially planar housing having side surfaces. The capillary includes at least two, substantially coplanar capillary openings which extend through an interface surface located on one of the side surfaces. The interface includes at least two spaced apart receptacles for receiving an ionic fluid. Each receptacle includes a liquid permeable medium having a capillary area and a conductor area. Each capillary area is in fluid communication with one of the capillary openings and each conductor area is in contact with at least one electrical conductor. At least two of the capillary areas are substantially coplanar. The ionic fluid is disposed in each receptacle to create an electrical path between the capillary area and conductor area of each receptacle. The holder selectively retains the housing and the interface so that the capillary areas contact the capillary openings and the conductor areas contact the electrical conductors.

Abstract translation: 本文提供了用于毛细管电泳系统的毛细管，界面和保持器。 毛细管设置在具有侧表面的大致平坦的壳体中。 毛细管包括延伸通过位于一个侧表面上的界面的至少两个基本上共面的毛细管开口。 界面包括用于接收离子流体的至少两个间隔开的容器。 每个容器包括具有毛细管区域和导体区域的液体可渗透介质。 每个毛细管区域与毛细孔之一流体连通，并且每个导体区域与至少一个电导体接触。 至少两个毛细管区域基本上共面。 离子流体设置在每个容器中以在每个容器的毛细管区域和导体区域之间产生电路径。 保持器选择性地保持壳体和界面，使得毛细管区域接触毛细管开口并且导体区域与电导体接触。

公开(公告)号：WO1998001760A2

公开(公告)日：1998-01-15

申请号：PCT/US1997011718

申请日：1997-07-03

Applicant: BECKMAN INSTRUMENTS, INC. ,  PANG, Wing, S. ,  GROSS, Mark ,  TANUMIHARDJA, Hendra ,  RAUSKOLB, Ruediger, F. ,  PEDRAZZINI, G., Andrea ,  ALLEN, Santiago, F.

Inventor： BECKMAN INSTRUMENTS, INC.

IPC: G01N35/00

CPC classification number: G01N35/0099 ,  B04B2011/046 ,  G01N35/0095 ,  G01N35/026 ,  G01N2035/00495 ,  G01N2035/047 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/115831

Abstract: A system for a clinical lab that is capable of automatically processing, including sorting, of multiple specimen containers. The system comprises a central controller, a workstation (100), one or more analyzers (2000), and an automated centrifuge (1000). The workstation (100) has automatic detectors for detecting the presence of a holder (14) holding specimen containers (12). The workstation (100) has a bar code reader for reading bar codes on the containers. The system has a transport subsystem, preferably a workstation robotic arm (700) and an analyzer robotic arm (2002) for transporting the specimen containers (12), moving them to and from the workstation (100), to and from the analyzers (2000), and to and from the centrifuge (1000). The centrifuge is loaded with buckets (1200) containing specimen containers (12). The workstation (100) can be provided with a balance system (800) for balancing the weight of the buckets (1200) used. The workstation (100) can also have a decapper (900) for automatically removing caps from the specimen containers.

Abstract translation: 一种临床实验室的系统，能够自动处理多个标本容器，包括分选。 该系统包括中央控制器，工作站（100），一个或多个分析器（2000）和自动离心机（1000）。 工作站（100）具有用于检测保持样本容器（12）的保持器（14）的存在的自动检测器。 工作站（100）具有条形码读取器，用于读取容器上的条形码。 该系统具有运输子系统，优选地是工作站机械臂（700）和分析器机械手臂（2002），用于运送样本容器（12），将其移出工作站（100）并从工作站（100）移动到分析仪（2000） ），以及离心机（1000）。 离心机装有容纳标本容器（12）的桶（1200）。 工作站（100）可以设置有平衡系统（800），用于平衡使用的铲斗（1200）的重量。 工作站（100）还可以具有用于自动从样本容器中移除盖的拆包器（900）。

公开(公告)号：WO1998000236A1

公开(公告)日：1998-01-08

申请号：PCT/US1997009154

申请日：1997-05-30

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  GOODALE, David, L.

IPC: B01L03/00

CPC classification number: B01L3/508 ,  B01L9/06 ,  B01L2200/16 ,  G01N35/1002 ,  G01N2035/0443 ,  Y10T436/113332

Abstract: A one piece, injection molded single piece, well container (10) suitable for reagents for use in a clinical instrument such as a protein analyzer, normally molded from a high density polyethylene or other recyclable plastic. The container is one or more wells, uses standard caps, and is readily adapted to automatic filling equipment. The molded, single piece reagent cartridge (10) is used in a clinical instrument, the reagent cartridge (10) comprised of a plurality of storage wells (24, 26) located in a line in fixed relationship. The reagent cartridge (10) has a guide (16) at one end which is engageable with a means (40) on the receiving means on an analyzer to restrain the cartridge (10) from radial or lateral movement. Each of the wells (24, 26) has side walls (30) and a closed bottom (28), and the side walls (30) have an upper terminal position including an access opening. An integrally formed hollow shell (14) open at the bottom and otherwise substantially enclosing said wells (24, 26) from a point below the terminal portion is provided to form a hollow space within the shell (14) around the exterior of the wells to permit the flow of conditioned air around the walls. Positive retention is provided by forming a hole (67) through the wall, which engages a detent (68) formed on the retention means.

Abstract translation: 一种单一的注射成型的单件，容器（10），适用于通常由高密度聚乙烯或其他可回收塑料模塑的临床仪器如蛋白质分析仪中的试剂。 容器是一个或多个井，使用标准盖，并且容易适应于自动灌装设备。 成型的单件试剂盒（10）用于临床仪器中，试剂盒（10）包括以固定关系位于一行的多个存储井（24,26）。 试剂盒（10）的一端具有一个引导件（16），该引导件可与分析器上的接收装置上的装置（40）接合，以限制卡盘（10）的径向或横向运动。 每个孔（24,26）具有侧壁（30）和封闭的底部（28），并且侧壁（30）具有包括进入开口的上端子位置。 设置在底部开口并且从端子部分下方的点基本上包围所述孔（24,26）的整体形成的中空壳体（14）以在所述壳体（14）内围绕所述井的外部形成中空空间， 允许在墙壁周围流动调节空气。 通过形成穿过壁的孔（67）提供正保持，该孔接合形成在保持装置上的止动件（68）。

公开(公告)号：WO1997038317A1

公开(公告)日：1997-10-16

申请号：PCT/US1997005642

申请日：1997-04-04

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  SCHULTZ, Cecilia, Z. ,  YEIN, Fredrick, S.

IPC: G01N33/72

CPC classification number: C12Q1/54 ,  C12Q1/26 ,  C12Q1/60 ,  C12Q1/61 ,  C12Q1/62 ,  G01N33/728 ,  Y10S435/81

Abstract: An assay for detecting in a test sample, an analyte that undergoes auto-oxidation is disclosed. The assay comprises the steps of forming a reaction mixture by combining in an aqueous medium (i) a sample containing the analyte and (ii) a stabilizer that reduces the rate of radical mediated auto-oxidation of the analyte. The reaction mixture is incubated for a period of time and the rate of auto-oxidation is detected. When the detected rate of auto-oxidation is substantially zero, a sufficient quantity of an enzyme is added, that catalyzes the oxidation of the analyte. In the presence of the stabilizer, the analyte can be oxidized to a product species. The product species, the analyte, or both can be detected.

Abstract translation: 公开了一种用于在测试样品中检测经自动氧化的分析物的测定法。 该测定包括以下步骤：通过在水性介质（i）含有分析物的样品和（ii）降低分析物自由基介导的自动氧化速率的稳定剂中混合形成反应混合物。 将反应混合物温育一段时间，并检测自身氧化速率。 当检测到的自氧化速率基本上为零时，加入足量的酶，催化分析物的氧化。 在稳定剂存在下，分析物可被氧化成产物。 可以检测产物种类，分析物或二者。

公开(公告)号：WO1997022718A1

公开(公告)日：1997-06-26

申请号：PCT/US1996016530

申请日：1996-10-16

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  YAN, Cheng, F. ,  YEIN, Frederick, S.

IPC: C12Q01/68

CPC classification number: C12Q1/6823 ,  C12Q1/6813 ,  Y02A50/59

Abstract: An assay for detecting the presence or amount of a target polynucleotide sequence of interest in a test sample is disclosed. The assay comprises the steps of forming a reaction mixture by combining in an assay medium (i) a first reagent and (ii) an aliquot of the test sample suspected of containing the target polynucleotide sequence. The reaction mixture is subjected to denaturing conditions, and exposed to hybridization conditions allowing the first reagent to hybridize with any target polynucleotide present. A second reagent is then added, the reaction mixture undergoes hybridization conditions and the change in turbidity of the reaction mixture is detected, correlating with the presence of the target polynucleotide in the sample.

Abstract translation: 公开了用于检测测试样品中目的多核苷酸序列的存在或量的测定。 该测定包括通过在测定培养基（i）第一试剂和（ii）怀疑含有靶多核苷酸序列的测试样品的等分试样中混合来形成反应混合物的步骤。 将反应混合物进行变性条件，并暴露于允许第一试剂与存在的任何靶多核苷酸杂交的杂交条件。 然后加入第二试剂，反应混合物经历杂交条件，并检测反应混合物的浊度变化，与样品中靶多核苷酸的存在相关。

公开(公告)号：WO1997014967A1

公开(公告)日：1997-04-24

申请号：PCT/US1996016642

申请日：1996-10-18

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  BELL, Michael, L. ,  MCNEAL, Jack, D.

IPC: G01N35/10

CPC classification number: G01N35/1079 ,  A61M2005/1623

Abstract: A vented probe (10) for adding and removing a sample (30) from a container (28) having an opening (32) which is capped with a stopper (34) and a method for adding and/or removing a sample (30) from the container (28) are provided. The probe (10) comprises a hollow, tubular-shaped body (12) having an outer surface (14), an inner surface (16) which defines a lumen (17), and a first end (18) for inserting through the stopper (34) and a second end (20). A sample aperture (22) extends from the outer surface (14) into the lumen (17) proximate the first end (18) of the body (12) and a regulating aperture (24) extends through the body (12) into the lumen (17) proximate the second end (20) of the body (12). A vent passageway (26) is disposed in the body (12) between the first end (18) and the second end (20). The vent passageway (26) allows for venting of the container (28) when the probe (10) is disposed in the stopper (34). There is no direct communication between the vent passageway (26) and the lumen (17). The vent passageway (26) typically includes three spaced-apart grooves which extend longitudinally in the outer surface (14) of the body (12). These grooves each have a sufficient depth and width so that each groove is not occluded when the probe (10) is positioned in the stopper (34).

Abstract translation: 用于从具有用塞子（34）封盖的开口（32）的容器（28）中添加和去除样品（30）的排气探针（10）和用于添加和/或去除样品（30）的方法， 从容器（28）提供。 探针（10）包括具有外表面（14），限定内腔（17）的内表面（16）和用于插入通过塞子的第一端（18）的中空管状体（12） （34）和第二端（20）。 样品孔（22）从外表面（14）延伸到靠近主体（12）的第一端（18）的内腔（17）中，并且调节孔（24）延伸穿过主体（12）进入管腔 （17）邻近本体（12）的第二端（20）。 排气通道（26）设置在第一端（18）和第二端（20）之间的主体（12）中。 当探针（10）设置在止动器（34）中时，排气通道（26）允许容器（28）的排气。 排气通道（26）和内腔（17）之间没有直接的连通。 排气通道（26）通常包括在主体（12）的外表面（14）中纵向延伸的三个间隔开的凹槽。 这些槽各自具有足够的深度和宽度，使得当探针（10）定位在止动件（34）中时，每个凹槽不被阻塞。

公开(公告)号：WO1997011363A1

公开(公告)日：1997-03-27

申请号：PCT/US1996014848

申请日：1996-09-16

Applicant: BECKMAN INSTRUMENTS, INC.

Inventor： BECKMAN INSTRUMENTS, INC. ,  ALTER, Stephen, C. ,  KIM, Elsie, H.

IPC: G01N27/447

CPC classification number: G01N27/44747 ,  G01N27/44704

Abstract: A composition, which has utility as a storage buffer and as a sample diluent before analysis by capillary zone electrophoresis (CZE), is comprised of water, a borate compound, a buffer compound and a pH modifier for maintaining a physiological pH. In addition, a conductivity adjusting compound is present so that the conductivity of the composition is about the same as a prospective capillary electrophoresis running buffer. Containers with storage buffer/sample diluent can be assembled in a kit for conducting serum protein electrophoresis (SPE) or immunosubtraction (IFE/s) analysis. Moreover, the storage buffer/sample diluent can be used in methods of preparing samples for CZE analysis, such as quantitative dilutions and enzymatic or immunological reactions.

Abstract translation: 在通过毛细管区带电泳（CZE）分析之前作为储存缓冲液和作为样品稀释剂的作用的组合物由水，硼酸盐化合物，缓冲剂化合物和用于维持生理pH的pH调节剂组成。 此外，存在导电性调节化合物，使得组合物的导电性与预期毛细管电泳运行缓冲液大致相同。 具有储存缓冲液/样品稀释剂的容器可以组装在用于进行血清蛋白电泳（SPE）或免疫吸附（IFE / s）分析的试剂盒中。 此外，储存缓冲液/样品稀释剂可用于制备用于CZE分析的样品的方法，例如定量稀释和酶促或免疫反应。