公开(公告)号：JP4528123B2

公开(公告)日：2010-08-18

申请号：JP2004532054

申请日：2003-08-06

Applicant: ニコックス エス エイ

Inventor： サンタス，ジャンカルロ ,  ソルダト，ピエロ デル ,  ベネディニ，フランセスカ

IPC: A61K31/618 ,  C07C201/04 ,  A61K31/216 ,  C07B61/00 ,  C07C67/10 ,  C07C69/734 ,  C07C201/02 ,  C07C201/08 ,  C07C203/00 ,  C07C203/04 ,  C07C269/06 ,  C07C271/28

CPC classification number: C07C269/06 ,  C07C67/10 ,  C07C69/734 ,  C07C201/02 ,  C07C203/04 ,  C07C271/28 ,  C07C303/28 ,  C07C309/73

Abstract: The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, and p is 0 or 1, and X is O, S, SO, SO2, NR13 or PR13 or an aryl, heteroaryl group, said process comprising reacting a compound of formula (B) R—COOZ (B) wherein R is as defined above and Z is hydrogen or a cation selected from: Li+, Na+, K+, Ca++, Mg++, tetralkylammonium, tetralkylphosphonium, with a compound of formula (C), as reported in the description, wherein R1-R12 and m, n, o, p, q, r, s are as defined above and Y is a suitable leaving group.

公开(公告)号：JP2007137881A

公开(公告)日：2007-06-07

申请号：JP2006310874

申请日：2006-11-17

Applicant: Josef Meissner Gmbh & Co Kg ,  ヨーゼフ マイスナー ゲーエムベーハー ウント コー カーゲー

Inventor： POHLMANN JURGEN ,  POTTHARST FRANK ,  HERMANN HEINRICH ,  KONIECZNY PETER ,  HAENDEL MIRKO ,  GEBAUER JURGEN

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C07C201/02 ,  C07C203/04

Abstract: PROBLEM TO BE SOLVED: To provide an optimal method for preparing a nitrate of a monohydric alcohol.
SOLUTION: The present invention provides the method for preparing the nitrate of the monohydric alcohol. In the preparation method, the monohydric alcohol or a mixture of monohydric alcohols is converted to the ester by nitric acid under adiabatic reaction conditions in the presence of sulfuric acid.
COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供制备一元醇硝酸盐的最佳方法。 解决方案：本发明提供了制备一元醇的硝酸盐的方法。 在制备方法中，在硫酸存在下，在绝热反应条件下，通过硝酸将一元醇或一元醇的混合物转化为酯。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2006506417A

公开(公告)日：2006-02-23

申请号：JP2004550943

申请日：2003-11-06

Applicant: ディファルマ・ソシエタ・ペル・アチオニDIPHARMA S.p.A.

Inventor： グラツィアーノ・カスタルディ ,  ティツィアーノ・スクブラ ,  ネヴィオ・フランチェスクッティ ,  ファウスト・ゴラッシーニ

IPC: C07C201/02 ,  C07C20060101 ,  C07C203/04

CPC classification number: C07C203/04 ,  C07C201/02

Abstract: A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.

公开(公告)号：JP2005510557A

公开(公告)日：2005-04-21

申请号：JP2003547348

申请日：2002-11-26

Applicant: ニコックス・ソシエテ・アノニム

Inventor： アルド・ベッリ ,  アンドレーアス・ヴェステルマルク ,  ヴィンチェンツォ・カンナータ ,  テリ・フォンデュカ ,  マルコ・ヴィーラ ,  マルティン・ヘドベルイ

IPC: A61K31/21 ,  A61K31/216 ,  A61P29/00 ,  C07B61/00 ,  C07C67/08 ,  C07C67/58 ,  C07C201/02 ,  C07C203/04 ,  C07C301/00 ,  C07C303/28 ,  C07C309/66 ,  C07C309/67 ,  C07C309/73

CPC classification number: C07C309/73 ,  A61K31/21 ,  C07C67/08 ,  C07C67/58 ,  C07C201/02 ,  C07C303/28 ,  C07C309/66 ,  C07C309/67 ,  C07C69/734 ,  C07C203/04

Abstract: At the present invention relates to a new process for the preparation of the (S)-naproxen 4-nitrooxybutyl ester and to new intermediates obtained and used therein. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active compounds such as (S)-naproxen 4-nitrooxybutyl ester. The invention also relates to the use of (S)-naproxen 4-nitrooxybutyl ester prepared according to the process of the present invention for the manufacturing of a medicament for the treatment of pain.

公开(公告)号：EP4139279B1

公开(公告)日：2024-04-17

申请号：EP21720269.6

申请日：2021-04-21

IPC: C07C201/02 ,  C07C67/08 ,  C07C69/16 ,  C07C203/04

CPC classification number: C07C67/08 ,  C07C201/02

公开(公告)号：EP3008036A1

公开(公告)日：2016-04-20

申请号：EP14733160.7

申请日：2014-06-25

Applicant: Josef Meissner GmbH & Co. KG

Inventor： PÖHLMANN, Jürgen ,  HERMANN, Heinrich ,  HÄNDEL, Mirko ,  GEBAUER, Jürgen

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C07C201/02 ,  B01D11/0473 ,  B01J19/1812 ,  C07C203/04

Abstract: The invention relates to a method and to a device for removing contaminants arising during the production of aliphatic or alicyclic nitric acid esters, in particular for removing contaminants from nitrated crude nitric acid esters, which nitrated crude nitric acid esters arise during the nitration of monovalent or multivalent aliphatic or alicyclic alcohols capable of nitration, after the separation of the final nitrating acid, and to a production system for nitrating monovalent or multivalent aliphatic alcohols capable of nitration with subsequent purification of the nitrated nitric acid esters.

Abstract translation: 本发明涉及一种方法和一种用于，特别是用于从硝化粗硝酸酯，一价或硝化过程中产生硝化粗硝酸酯中除去污染物去除污染物生产脂肪或脂环硝酸酯的过程中所产生的装置 多价脂族或能够硝化的脂环醇，最终的硝酸亭酸的分离之后，并且到生产系统，用于硝酸婷单价或多价的脂族醇能够与硝化硝酸酯的后续纯化硝化。

公开(公告)号：EP2844614B1

公开(公告)日：2015-10-21

申请号：EP13717751.5

申请日：2013-04-11

Applicant: Haldor Topsøe A/S

Inventor： SCHJØDT, Niels Christian ,  BØGILD HANSEN, John ,  FRIIS PEDERSEN, Claus

IPC: C01B31/18 ,  C07C68/00 ,  C07C201/02 ,  C07D301/04 ,  C07D305/12 ,  C25B1/02 ,  C25B1/04 ,  C07C67/035 ,  C07C67/38 ,  C07C67/04 ,  C07C51/14 ,  C25B15/08 ,  C25B1/00 ,  C07C68/04

CPC classification number: C07D305/12 ,  C07C51/14 ,  C07C67/035 ,  C07C67/38 ,  C07C68/005 ,  C07C68/04 ,  C07C201/02 ,  C07D301/04 ,  C25B1/00 ,  C25B1/02 ,  C25B15/08 ,  Y02E60/366 ,  Y02P20/133 ,  Y02P20/134 ,  Y02P20/582 ,  C07C203/04 ,  C07C69/96 ,  C07C53/124 ,  C07C69/24

Abstract: Process for the production of a chemical compound from a carbon dioxide starting material, comprising the steps of a) providing a feed stream consisting mainly of carbon dioxide; b) electrolyzing in an electrolysis stage the carbon dioxide in the feed stream to a first gas stream containing carbon monoxide and a second gas stream containing oxygen, wherein the molar ratio between carbon monoxide and oxygen is about 1:0.5 in an electrolysis stage; c) adjusting the composition of the first gas stream or the second gas stream or both gas streams to include carbon dioxide, either by operating at less than full conversion of CO2 or by sweeping one or both gas streams with a gas containing CO2 or by at some stage between the electrolysis cell and the oxidative carbonylation reactor diluting one or both gas streams with a gas containing CO2; all while maintaining an overall molar ratio of carbon monoxide to oxygen of about 1:0.5; and d) introducing the first and second process stream into a reaction stage and reacting the first and second process stream combined or in succession with a substrate to the chemical compound by means of an oxidative carbonylation reaction with the carbon monoxide and oxygen contained in the process feed stream.

公开(公告)号：EP1792891B1

公开(公告)日：2010-06-16

申请号：EP06023304.6

申请日：2006-11-09

Applicant: Josef Meissner GmbH & Co. KG

Inventor： Pöhlmann, Jürgen, Dr. ,  Pottharst, Frank ,  Hermann, Heinrich, Dr. ,  Konieczny, Peter, Dr. ,  Händel, Mirko, Dr. ,  Gebauer, Jürgen

IPC: C07C201/02 ,  C07C203/04

CPC classification number: C07C201/02 ,  C07C203/04

公开(公告)号：EP1384707B1

公开(公告)日：2005-06-08

申请号：EP03102132.2

申请日：2000-07-27

Applicant: Nicox S.A.

Inventor： Benedini, Francesca ,  Oldani, Erminio ,  Castaldi, Graziano ,  Tarquini, Antonio

IPC: C07C203/04

CPC classification number: C07C201/02 ,  C07C203/04

公开(公告)号：EP1451140A1

公开(公告)日：2004-09-01

申请号：EP02791150.2

申请日：2002-11-26

Applicant: AstraZeneca AB

Inventor： BELLI, Aldo ,  CANNATA, Vincenzo ,  FONDUCA, Telly ,  HEDBERG, Martin ,  WESTERMARK, Andreas ,  VILLA, Marco

IPC: C07C203/04 ,  C07C317/04 ,  A61K31/21 ,  A61P29/00

CPC classification number: C07C309/73 ,  A61K31/21 ,  C07C67/08 ,  C07C67/58 ,  C07C201/02 ,  C07C303/28 ,  C07C309/66 ,  C07C309/67 ,  C07C69/734 ,  C07C203/04

Abstract: The present invention relates to a new process for the preparation of the (S)-naproxen 4-nitrooxybutyl ester and to new intermediates obtained and used therein. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active compounds such as (S)-naproxen 4-nitrooxybutyl ester.The invention also relates to the use of (S)-naproxen 4-nitrooxybutyl ester prepared according to the process of the present invention for the manufacturing of a medicament for the treatment of pain.