公开(公告)号：WO2007126411A2

公开(公告)日：2007-11-08

申请号：PCT/US2006029754

申请日：2006-07-28

Applicant: UNIV CARNEGIE MELLON ,  CAMPBELL PHIL ,  WEISS LEE E ,  SMITH JASON ,  SIPE DAVID M ,  KUMTA PRASHANT ,  FISHER GREGORY W

Inventor： CAMPBELL PHIL ,  WEISS LEE E ,  SMITH JASON ,  SIPE DAVID M ,  KUMTA PRASHANT ,  FISHER GREGORY W

CPC classification number: C09D11/30 ,  A61L27/225 ,  A61L27/50 ,  C08J3/24 ,  C08J5/18 ,  C08J9/0066 ,  C08J9/26 ,  C08J2201/024 ,  C08J2201/0446 ,  C08J2201/046 ,  C08J2207/10 ,  C08J2300/16 ,  C08J2389/00 ,  C08L5/00 ,  C08L89/00 ,  C09D7/65 ,  C09D11/08

Abstract: Compositions and methods for manufacturing polymers are disclosed. Compositions include novel plastics, including films and shaped forms comprising polymer matrices that are biologically compatible and biodegradable. Such plastics may comprise polymers derived from natural sources. Further, such plastics are useful in biological systems for wound repair, implants, stents, drug encapsulation and delivery, and other applications. The disclosed methods comprise mild manufacturing processes such that various additives, such as biologically active proteins, sugars, lipids, and the like may be incorporated into the polymer matrix without subsequent loss of bioactivity during processing. Additionally, methods of manufacture for controlling mechanical properties, such as elasticity, pliancy, and the porosity of such plastics are disclosed.

Abstract translation: 公开了制备聚合物的组合物和方法。 组合物包括新型塑料，包括膜和成形形式，其包含生物相容性和可生物降解的聚合物基质。 这种塑料可以包含衍生自天然来源的聚合物。 此外，这种塑料可用于伤口修复，植入物，支架，药物包封和递送以及其它应用的生物系统中。 所公开的方法包括温和的制备方法，使得可以将各种添加剂，例如生物活性蛋白质，糖，脂质等掺入聚合物基质中，而不会在加工过程中随后丧失生物活性。 此外，公开了用于控制这种塑料的机械性能如弹性，柔软度和孔隙率的制造方法。

公开(公告)号：WO2007060462A1

公开(公告)日：2007-05-31

申请号：PCT/GB2006/004421

申请日：2006-11-28

Applicant: THE UNIVERSITY OF SHEFFIELD ,  RYAN, Anthony, J. ,  ARMES, Steven, P. ,  FUJII, Syuji ,  IDDON, Peter

Inventor： RYAN, Anthony, J. ,  ARMES, Steven, P. ,  FUJII, Syuji ,  IDDON, Peter

IPC: C08J9/30 ,  C08J9/28 ,  G02B1/00

CPC classification number: C08J9/24 ,  C08J2201/0444 ,  C08J2201/0446 ,  C08J2319/00

Abstract: The invention relates to a particle-stabilised foam wherein the particles are derived from a polymer latex dispersion and the foam substantially retains its structure on drying.

Abstract translation: 本发明涉及一种颗粒稳定的泡沫，其中颗粒来自聚合物胶乳分散体，并且该泡沫基本上保持其结构干燥。

公开(公告)号：WO2006113984A1

公开(公告)日：2006-11-02

申请号：PCT/CA2006/000533

申请日：2006-04-07

Applicant: RIMON THERAPEUTICS LTD. ,  BUTLER, Mark, J. ,  SEFTON, Michael, Vivian ,  SKARJA, Gary, Alan

Inventor： BUTLER, Mark, J. ,  SEFTON, Michael, Vivian ,  SKARJA, Gary, Alan

IPC: A61L27/56 ,  A61L27/14 ,  A61K35/12 ,  A61L27/58 ,  A61L27/60 ,  C08J5/00

CPC classification number: A61L27/16 ,  A61L27/56 ,  A61L27/58 ,  A61L27/60 ,  C08J9/26 ,  C08J2201/0446 ,  C08J2300/10 ,  C08J2333/02 ,  C08L33/08

Abstract: A pro-angiogenic porous polymer scaffold is disclosed. The polymer has at least 20 mol-% monomeric subunits containing acidic functional groups, and has a porosity of at least 40%. The pores in the scaffold are interconnected. A method of making such a scaffold using a novel adaptation to the traditional solvent casting/particulate leaching technique technique is also disclosed. The scaffold may be used for tissue regeneration.

Abstract translation: 公开了一种促血管生成多孔聚合物支架。 聚合物具有至少20mol％的含有酸性官能团的单体亚单位，并具有至少40％的孔隙率。 支架中的孔相互连接。 还公开了使用新型适应于传统溶剂浇铸/颗粒浸出技术技术的这种支架的方法。 支架可用于组织再生。

公开(公告)号：WO98044027A1

公开(公告)日：1998-10-08

申请号：PCT/US1998/006188

申请日：1998-03-31

IPC: A61K9/20 ,  B29C44/34 ,  B29C67/20 ,  C08J9/12 ,  C08J9/18 ,  C08J9/26 ,  C08F36/00 ,  C08J9/28

CPC classification number: C08J9/26 ,  A61K9/204 ,  B29C44/3446 ,  B29C67/202 ,  C08J9/122 ,  C08J9/18 ,  C08J2201/032 ,  C08J2201/0446 ,  C08J2203/06 ,  C08J2205/05 ,  C08J2367/02 ,  C08J2367/04

Abstract: The invention is directed to a process for preparing porous polymer materials by a combination of gas foaming and particulate leaching steps. The invention is also directed to porous polymer material prepared by the process, particularly having a characteristic interconnected pore structure, and to methods for using such porous polymer material, particularly for tissue engineering.

Abstract translation: 本发明涉及通过气体发泡和微粒浸出步骤的组合制备多孔聚合物材料的方法。 本发明还涉及通过该方法制备的多孔聚合物材料，特别是具有特征互连孔结构，以及使用这种多孔聚合物材料，特别是用于组织工程的方法。

公开(公告)号：WO1991018590A1

公开(公告)日：1991-12-12

申请号：PCT/SE1991000396

申请日：1991-06-05

Applicant: KABI PHARMACIA AB ,  EK, Bo, Ragnar ,  ERIKSSON, Kjell, Gunnar ,  NYQVIST, Per, Gustaf, Håkan ,  RAGNARSSON, Gert, Anders

Inventor： KABI PHARMACIA AB

IPC: A61K09/52

CPC classification number: C08J9/26 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2081 ,  C08B15/02 ,  C08J2201/0446 ,  C08J2301/02 ,  C08L1/02

Abstract: The invention discloses a process for the manufacture of porous cellulose particles, which have regular shape, and a capacity of sorbing 1.5-9 times of their own weight of water, a tap bulk density of less than 0.85 g/ml. The process for the manufacture of these porous cellulose matrices is performed by mechanically treatment of hydrolyzed cellulose in a wet stage. The cellulose matrices have preferable a size of at least 0.1 mm and a tap bulk density of 0.1-0.7 g/ml. A bioactive substance or bioactive substances could be sorbed, precipitated or sublimized into the porous structure of the matrices. The matrices can be admixed with drugs or drug containing granules in order to improve the tabletting and tablet properties and thereafter compressed. Drug loaded matrices can be used for direct compression of tablets.

Abstract translation: 本发明公开了一种制造多孔纤维素颗粒的方法，其具有规则的形状，并且吸收其自身重量的水的1.5-9倍，堆积密度小于0.85g / ml的能力。 制造这些多孔纤维素基质的方法是通过在湿阶段中水解纤维素的机械处理来进行的。 纤维素基质的尺寸优选为至少0.1mm，堆积密度为0.1-0.7g / ml。 可以将生物活性物质或生物活性物质吸附，沉淀或升华成基质的多孔结构。 这些基质可以与药物或含药物的颗粒混合，以改善压片和片剂性质，然后压缩。 药物负载基质可用于直接压片。