公开(公告)号：WO2010091049A3

公开(公告)日：2011-04-07

申请号：PCT/US2010022994

申请日：2010-02-03

Applicant: CHILDRENS MEDICAL CENTER ,  ZON LEONARD I ,  CEOL CRAIG ,  HOUVRAS YARIV J

Inventor： ZON LEONARD I ,  CEOL CRAIG ,  HOUVRAS YARIV J

IPC: C12Q1/68 ,  C07K16/18 ,  C12N15/12 ,  G01N33/574 ,  G01N33/68

CPC classification number: G01N33/5743 ,  A61K39/39558 ,  C07K16/40 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Y201/01043 ,  G01N33/574 ,  G01N2333/91011 ,  G01N2333/91017

Abstract: Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an inhibitor of SETDB1 to a subject in need thereof.

Abstract translation: 本文提供了通过确定生物样品中SETDB1的表达水平来诊断癌症的方法。 本文还提供了通过向有需要的受试者施用SETDB1抑制剂来治疗癌症的方法。

公开(公告)号：WO2005118796A3

公开(公告)日：2006-06-01

申请号：PCT/US2005018840

申请日：2005-05-27

Applicant: UNIV NORTH CAROLINA ,  ZHANG YI ,  CAO RU

Inventor： ZHANG YI ,  CAO RU

IPC: C12N9/10 ,  C07H21/04 ,  C12N5/06 ,  C12N5/10 ,  C12N9/00 ,  C12N9/16 ,  C12P21/06 ,  C12Q1/68

CPC classification number: C12N9/1007 ,  C07K14/82 ,  C07K2319/20 ,  C12N2799/026 ,  C12Y201/01043 ,  G01N2333/91011

Abstract: The present invention provides a reconstituted complex including EED, EZH2 and SUZ12 wherein the reconstituted complex has histone methyltransferase (HMTase) activity for lysine 27 of histone H3 (H3-K27). The reconstituted complex may further include RbAp48, AEBP2 or both. Also disclosed are methods of producing the reconstituted complex, methods of identifying compounds that inhibit the HTMase activity of the reconstituted complex and methods of identifying candidate compounds for treating cancer. Reagents and kits including the reconstituted complex are further provided.

Abstract translation: 本发明提供了包含EED，EZH2和SUZ12的复原复合物，其中重构的复合物对组蛋白H3（H3-K27）的赖氨酸27具有组蛋白甲基转移酶（HMTase）活性。 重构的复合物还可以包括RbAp48，AEBP2或两者。 还公开了生产重建复合物的方法，鉴定抑制重构复合物的HTMase活性的化合物的方法和鉴定用于治疗癌症的候选化合物的方法。 还提供了试剂和试剂盒，包括重构的复合物。

公开(公告)号：WO2004076623A2

公开(公告)日：2004-09-10

申请号：PCT/JP2004/002446

申请日：2004-02-27

Applicant: ONCOTHERAPY SCIENCE, INC. ,  JAPAN AS REPRESENTED BY THE PRESIDENT OF THE UNIVERSITY OF TOKYO ,  NAKAMURA, Yusuke ,  FURUKAWA, Yoichi

Inventor： NAKAMURA, Yusuke ,  FURUKAWA, Yoichi

IPC: C12N

CPC classification number: C12N15/1135 ,  C12N2310/14 ,  C12N2310/531 ,  C12Y201/01043

Abstract: The invention features a method for inhibiting growth of a cancer cell by contacting the cell with a composition of a ZNFN3A1 siRNA. Methods of treating cancer are also within the invention. The invention also features products, including nucleic acid sequences and vectors as well as to compositions comprising them, useful in the provided methods. The invention also provides a method for inhibiting of tumer cell, for example liver or colon cancer cell, particularly HCC or colorectal adenocarcinoma.

Abstract translation: 本发明的特征在于通过使细胞与ZNFN3A1 siRNA的组合物接触来抑制癌细胞生长的方法。 治疗癌症的方法也在本发明的范围内。 本发明还包括可用于所提供的方法的产品，包括核酸序列和载体以及包含它们的组合物。 本发明还提供抑制肿瘤细胞的方法，例如肝脏或结肠癌细胞，特别是HCC或结肠直肠腺癌。