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    EP0504313A4 -
    152.
    发明公开
    EP0504313A4 - 失效
    EP0504313A4 - Google专利

    公开(公告)号：EP0504313A4

    公开(公告)日：1995-04-05

    申请号：EP91902465

    申请日：1990-11-30

    Applicant: AKZO NV

    Inventor： HULETTE WILLIAM CHESTER JR ,  KARP JOSEPH GEORGE ,  CALLAHAN JANET BLACK ,  BRAUN PAUL JOSEPH ,  RICHARDSON STEPHEN

    IPC: G01N21/01 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N21/11 ,  G01N33/50 ,  G01N35/06

    CPC classification number: G01N35/00732 ,  G01N35/026 ,  G01N35/1004 ,  G01N35/1072 ,  G01N35/1079 ,  G01N2035/00376 ,  G01N2035/00435 ,  G01N2035/00752 ,  G01N2035/0403 ,  G01N2035/0487 ,  G01N2035/1025 ,  G01N2035/1076 ,  G01N2201/0407

    Abstract: A sample handling system for an optical evaluation instrument. A cuvette storage mechanism (10) is provided for storing a plurality of cuvettes (50), each of which has a plurality of reaction wells. A temperature controlled housing (26) is provided for storing a plurality of reagent containers each containing a respective reagent, and a plurality of sample collection tubes, containing a fluid sample and each presenting an optically scannable code identifying the sample and a test to be performed on the sample. A programming station (30) is provided for optically reading the code (32) presented by the respective sample collection tubes for programming the instrument with a test to be performed. A sample insertion station (14) includes a mechanism (36) for aspirating a portion of the sample from a sample collection tube and for dispensing the aspirated sample portion into a reaction well of a cuvette. A first transporter (28) transports the sample collection tubes first to the programming station (30) and then to the sample insertion station (14). A second transporter (12) transports the cuvettes through the sample insertion station (14) and the reagent station (16, 18 and 20) and onto the monitoring means (22).

    Abstract translation: 光学评估仪器的样品处理系统。 提供比色管储存机构（10）用于储存多个比色杯（50），每个比色杯具有多个反应孔。 提供温度控制的外壳（26）用于存储多个试剂容器，每个试剂容器包含相应的试剂以及多个样品收集管，所述样品收集管包含流体样品并且每个呈现可识别样品的光学可扫描代码和待执行的测试 在样品上。 提供编程站（30）用于以光学方式读取由相应的样本收集管呈现的代码（32），以用要执行的测试对仪器进行编程。 样本插入站（14）包括用于从样本收集管吸取部分样本并将吸出的样本部分分配到反应杯的反应孔中的机构（36）。 第一运送器（28）首先将样本采集管运送到编程站（30），然后运送到样本插入站（14）。 第二运送器（12）将试管运送通过样本插入站（14）和试剂站（16,18和20）并且运送到监测装置（22）上。

    Methods and apparatus for detecting bacterial growth by spectrophotometric sampling of a fibre-optic array
    153.
    发明公开
    Methods and apparatus for detecting bacterial growth by spectrophotometric sampling of a fibre-optic array 失效
    用于通过光纤排列的分光光度法扫描的装置检测细菌的生长的方法和装置。

    公开(公告)号：EP0583066A1

    公开(公告)日：1994-02-16

    申请号：EP93305369.6

    申请日：1993-07-08

    Applicant: Becton Dickinson and Company

    Inventor： Blumenfeld, Walter ,  Berndt, Klaus W.

    IPC: G01N21/25 ,  C12M1/34

    CPC classification number: G01N21/253 ,  C12M41/36 ,  C12M41/46 ,  G01N2021/174 ,  G01N2201/0407 ,  G01N2201/08 ,  Y10S435/808 ,  Y10T436/113332

    Abstract: The detection of bacterial growth or the performance of other interrogative processes in multiple sample vials is accomplished using a moving rack that selectively couples optical locations to an optical excitation/detection system. The apparatus includes a drive mechanism combining agitation of the culture vials with a sequential scanning of an array of optical fibers, preferably by a spectrophotometric excitation/detector system. Selection of each culture vial provides, for example, optical detection of bacterial growth by fluorescence or other spectrophotometric measurements. A rack for holding vials is preferably the only moving assembly, and requires no mechanical or electrical interconnection with the excitation/detection system for its operation. In general, the present invention relates to the optically indexed presentation of the optical guides, e.g., the emission and excitation fibers, to many remote sample sites in the form of a geometric array at the interface between the moving culture vial rack assembly and the spectrophotometric excitation/detection system fixed to the body of the instrument. Methods of transmitting and receiving electromagnetic radiation to and from sample vials held in a movable rack include the steps of coupling the sample vials to an optical fiber and terminating the optical fiber at an optical coupling location. The rack is then moved to align at least one of the coupling locations with an excitation/detection system.

    Abstract translation: 细菌生长或在多个样品小瓶其他疑问进程的性能的检测来完成使用移动齿条那样有选择地在光激发/检测系统耦合光的位置，该装置包括一驱动机构相结合的培养瓶的搅动与顺序 每个培养物小瓶提供，例如，通过荧光或其它分光光度测定细菌生长的光学检测的选择的光纤阵列的扫描，优选通过分光光度的激发/检测器系统。 一种用于保持小瓶架优选是唯一的移动组件，并需要具有用于其操作的激发/检测系统没有机械或电气互连。 一般地，本发明涉及的导光体，例如，发射和激发纤维，以在几何阵列的形式许多远程样本点的光学索引呈现在移动培养瓶架组件和所述分光光度之间的界面 激发/检测系统固定到所述器械的主体。 发射的方法和接收电磁辐射和从在可动体架子中保持样品瓶包括样品瓶耦合到光纤和光纤在光耦合位置的终止的步骤。 则机架被移动到对准在激发/检测系统的联接位置中的至少一个。

    Instrument for independently and kinetically measuring light transmission through a plurality of samples
    156.
    发明公开
    Instrument for independently and kinetically measuring light transmission through a plurality of samples 失效
    通过大量样品进行独立和动态测量光传输的仪器

    公开(公告)号：EP0303524A3

    公开(公告)日：1990-05-02

    申请号：EP88400116.5

    申请日：1988-01-20

    Applicant: ASSOCIATES OF CAPE COD, INC.

    Inventor： Hoyt, Joshua K.

    IPC: G01N21/25 ,  G01N35/02

    CPC classification number: G01N21/253 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/0476

    Abstract: An analytic instrument of kinetically measuring light absorp­tion characteristics of a plurality of independent samples contained in disposable test tubes arranged in a circular pattern about a sin­gle light source. The instrument is designed to be used with a host personal computer and is not specific to any particular type of assay. The instrument obtains and temporarily stores raw data in the form of digitized output signals from the plurality of photodetectors and periodically passes them to the host computer. An incubator has test tube wells arranged in a circular array equidistant from a single incandescent light source. The circular symmetry controls the termal gradients in the incubator such that all of the samples are disposed on the same isotherm and all of the photodetectors are disposed on the same isotherm. The instrument is designed for use with disposable test tubes, and sources of error arising from optical variation in such test tubes are minimized by providing a separate detector for each tube and by holding the tube fixed with respect to the detector. The lignt output from the single light source is continuously moni­tored and is kept constant.

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