公开(公告)号：WO1993019668A1

公开(公告)日：1993-10-14

申请号：PCT/US1993002848

申请日：1993-04-02

Applicant: IMMUNOMEDICS, INC.

Inventor： IMMUNOMEDICS, INC. ,  GOLDENBERG, Milton, David

IPC: A61B05/05

CPC classification number: G01R33/5601 ,  A61K49/16 ,  A61K51/10 ,  A61K51/1018 ,  A61K51/1036 ,  A61K51/1039 ,  A61K51/1045 ,  A61K51/1057 ,  A61K51/1072 ,  A61K2123/00 ,  B82Y5/00 ,  Y10S424/81 ,  Y10S530/868

Abstract: Provided are methods and compositions for detecting and treating normal, hypoplastic, ectopic or remnant tissue, organ or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus and by a route providing access to said tissue or organ, with a composition comprising antibody/fragment which specifically binds to targeted organ, tissue or cell. The antibody/fragment may be administered alone, or labeled or conjugated with an imaging, therapeutic, cytoprotective or activating agent.

Abstract translation: 提供了用于检测和治疗哺乳动物中正常，发育不全，异位或残余组织，器官或细胞的方法和组合物。 该方法包括在一个位点和通过提供进入所述组织或器官的途径的哺乳动物受试者肠胃外注射包含特异性结合靶向器官，组织或细胞的抗体/片段的组合物。 抗体/片段可以单独施用，或者与成像，治疗，细胞保护或活化剂标记或缀合。

公开(公告)号：WO1993002617A1

公开(公告)日：1993-02-18

申请号：PCT/GB1992001371

申请日：1992-07-24

Applicant: BRITISH TECHNOLOGY GROUP LTD. ,  ZADEHKOOCHAK, Mohsen ,  BLOTT, Barry, Hugh ,  DANIELL, Geoffrey, John

Inventor： BRITISH TECHNOLOGY GROUP LTD.

IPC: A61B05/05

CPC classification number: A61B5/0536

Abstract: The invention provides a method, and apparatus for practicing the method, of producing an electrical impedance tomographic image of an object, comprising the steps of: positioning a plurality of electrodes peripherally of the object in electrical contact therewith, repeatedly applying an electrical signal between at least two selected ones of the electrodes and measuring the resulting electrical potentials at others of the electrodes, the selection of electrodes to which the electrical signal is applied being different for different applications of the signal, registering the measured electrical potentials as measured data obtained during a plurality of different applications of the applied electrical signal, and processing the measured data to provide data defining the electrical impedance tomographic image of the object, characterised in that the processing of the measured data is effected by the use of spectral expansion of a matrix representation of the sensitivity of the measurement process to an a priori assumed approximation of the object to provide data defining a series of mutually orthogonal component or basis images and by deriving from the measured data relative weightings in accordance with which some or all of the basis images are to be combined to provide a reconstructed image constituting the said electrical impedance tomographic image of the object.

Abstract translation: 本发明提供了一种用于实施该方法的方法和装置，用于制造物体的电阻抗断层图像，包括以下步骤：将物体周围的多个电极定位成与其接触，在其之间重复施加电信号 电极中的至少两个选择的电极并且测量在其他电极处的所得电位，施加电信号的电极的选择对于信号的不同应用是不同的，将测量的电位作为在 多个应用的​​电信号的不同应用，并且处理测量数据以提供定义对象的电阻抗层析图像的数据，其特征在于，通过使用矩阵表示的频谱扩展来实现测量数据的处理 测量的灵敏度 nt处理到对象的先验假设近似，以提供定义一系列相互正交的分量或基础图像的数据，并且通过根据哪个基本图像的哪些或全部组合来提供来自测量数据的相对权重，以提供 构成物体的所述电阻断层图像的重构图像。

公开(公告)号：WO1992006634A1

公开(公告)日：1992-04-30

申请号：PCT/SE1991000703

申请日：1991-10-18

Applicant: CENTRUM FÖR DENTALTEKNIK OCH BIOMATERIAL ,  OLLMAR, Stig

Inventor： CENTRUM FÖR DENTALTEKNIK OCH BIOMATERIAL

IPC: A61B05/05

CPC classification number: A61B5/0531

Abstract: A device for depth-selective, non-invasive, local measurement of electrical impedance of organic and biological materials such as tissues from vegetable or animal origin comprising a probe (Fig. 1-3, 9a, 9b) with a number of electrodes (A, B, C) driven from an electronic control unit (F), in such a way that the electric current path defining the actual tissue under test is dependent upon a control signal. The probe is pressed toward the surface of the body part under test and by varying the control signal, it is possible to select the region under test within limits determined by the shapes, sizes and distances of the electrodes and the properties of the tissue under test. By means of combining results obtained with different control signals, it is possible to compute local impedance profiles.

Abstract translation: 一种用于深度选择性，非侵入性的局部测量有机和生物材料（例如植物或动物来源的组织）的电阻抗的装置，包括具有多个电极的探针（图1-3,9a，9b）（A ，B，C），以使得限定被测实际组织的电流路径取决于控制信号的方式从电子控制单元（F）驱动。 探头被压向被测体内部分的表面，通过改变控制信号，可以根据电极的形状，尺寸和距离以及待测组织的性质确定的限度内选择被测区域 。 通过组合使用不同控制信号获得的结果，可以计算局部阻抗曲线。

公开(公告)号：WO1991014397A1

公开(公告)日：1991-10-03

申请号：PCT/US1991002102

申请日：1991-03-27

Applicant: HARDY, Tyrone, L.

IPC: A61B05/05

CPC classification number: A61N5/1031 ,  A61B90/10 ,  G06T17/00

Abstract: The disclosure is directed to the combination of actual imaging data with simulated graphics to provide a two-dimensional composite display, such as on a computer screen display, of a three-dimensional relationship between actual images and simulated images. The apparatus and method of the invention are useful for medical applications, particularly stereotactic procedures.

Abstract translation: 本公开涉及实际成像数据与模拟图形的组合，以提供例如在计算机屏幕显示器上的实际图像和模拟图像之间的三维关系的二维复合显示。 本发明的装置和方法可用于医疗应用，特别是立体定向程序。

公开(公告)号：WO1991009566A1

公开(公告)日：1991-07-11

申请号：PCT/GB1990001991

申请日：1990-12-20

Applicant: HOWELL, Martin, John ,  PAYNE, Geoffrey, John

IPC: A61B05/05

CPC classification number: A61B5/0531

Abstract: A sensory delineator comprises a common probe (5) applicable to a healthy area of the patient's skin, a test probe (6) applicable to an area of skin suspected to be subject to nerve damage, a reference probe (7) applicable to an area of similar skin suspected to be healthy, a resistance comparison circuit (20) for comparing the resistance present between the common probe (5) and the reference probe (7) (the reference resistance) with the resistance present between the common probe (5) and the test probe (6) (the test resistance), and output means (10, 11, 12) for indicating whether the test resistance (5, 6) exceeds the reference resistance (5, 7).

Abstract translation: 感官描绘器包括适用于患者皮肤健康区域的普通探针（5），适用于怀疑受到神经损伤的皮肤区域的测试探针（6），适用于区域的参考探针（7） 类似皮肤怀疑是健康的电阻比较电路（20），用于将公共探针（5）和参考探针（7）之间存在的电阻（参考电阻）与公共探针（5）之间存在的电阻进行比较， 和测试探针（6）（测试电阻）以及用于指示测试电阻（5,6）是否超过参考电阻（5,7）的输出装置（10,11,12）。

公开(公告)号：WO1990009759A1

公开(公告)日：1990-09-07

申请号：PCT/SU1989000052

申请日：1989-02-24

Applicant: INFORMATSIONNO-VYCHISLITELNY TSENTR OTDELA ... ,  SOLOMONOV, Valery Timofeevich ,  SHABANOV, Gennady Anatolievich ,  RYBCHENKO, Alexandr Alexeevich ,  PONOMAREV, Jury Vasilievich

Inventor： INFORMATSIONNO-VYCHISLITELNY TSENTR OTDELA ...

IPC: A61B05/05

CPC classification number: A61B5/0531

Abstract: The invention relates to medical means for determining the health condition in man. The method provides for selecting a symmetrical skin zone; determining on it topographic boundaries of skin sectors to be analyzed inside which the skin zone boundaries analogous to metamere tones of the human organism are determined; measuring the skin's electrical resistance in one of two neighbouring skin areas within the limits of the skin region and taking said resistance as a basis for determination of an anomaly of the pair of skin zones to be tested. The device comprises a common electrode (1), a measuring electrode (3), an electronic computing unit (8), an electric current source (4), a unit (11) for inserting the measuring electrode (3) into the skin zone to be tested, a drive for contacting the measuring electrode (3) with the skin zone to be tested and a unit (10) for processing the signal proportional to the skin's electrical resistance.

Abstract translation: 本发明涉及用于确定人体健康状况的医疗手段。 该方法提供选择对称的皮肤区域; 确定要分析的皮肤部位的地形边界，其中确定皮肤区域类似于人类生物体的metamere色调的边界; 测量在皮肤区域范围内的两个相邻皮肤区域之一中的皮肤的电阻，并将所述阻力作为确定所述一对皮肤区域的异常的基础。 该装置包括公共电极（1），测量电极（3），电子计算单元（8），电流源（4），用于将测量电极（3）插入皮肤区 待测试的驱动器，用于使测量电极（3）与待测试的皮肤区域接触的驱动器和用于处理与皮肤电阻成比例的信号的单元（10）。

公开(公告)号：WO1990007300A1

公开(公告)日：1990-07-12

申请号：PCT/CH1990000001

申请日：1990-01-04

Applicant: MEIER, Urs, A.

IPC: A61B05/05

CPC classification number: A61B5/0538 ,  A61B5/05 ,  A61B5/4255

Abstract: To detect, for example, the arrival of stools in the intestine, the electrical conditions (9) in the intestine are monitored by applying a voltage by means of a capacitative coupling (15) and electrodes (3e and 5e) to the electrolytic section (9) formed by the intestine, and the resultant current (I) is measured.

Abstract translation: 例如，为了检测粪便到达肠道，通过电容耦合（15）和电极（3e和5e）向电解部分施加电压来监测肠道中的电气条件（9） 9），测定合成电流（I）。

公开(公告)号：WO1990002513A1

公开(公告)日：1990-03-22

申请号：PCT/US1989004004

申请日：1989-09-18

Applicant: NOISE CANCELLATION TECHNOLOGIES, INC. ,  FRIEDLANDER, Paul

Inventor： NOISE CANCELLATION TECHNOLOGIES, INC.

IPC: A61B05/05

CPC classification number: G01R33/3854 ,  G10K11/178 ,  G10K2210/1081 ,  G10K2210/1161

Abstract: An active noise attenuation system (10) for patients undergoing diagnosis in equipment (1) which inherently produces undesirable sounds senses the noise experienced by the patient (P) and supplies a cancelling sound wave pattern to attenuate the noise experienced by the patient (P).

Abstract translation: 用于在设备（1）中进行诊断的患者的主动噪声衰减系统（10），其固有地产生不期望的声音感测患者（P）所经历的噪声并且提供消除声波模式以衰减患者（P）经历的噪声， 。

公开(公告)号：WO1989011822A1

公开(公告)日：1989-12-14

申请号：PCT/JP1989000542

申请日：1989-05-31

Applicant: YOKOGAWA MEDICAL SYSTEMS, LTD. ,  INOUE, Yuji

Inventor： YOKOGAWA MEDICAL SYSTEMS, LTD.

IPC: A61B05/05

CPC classification number: G01R33/4828 ,  G01R33/485

Abstract: A separative imaging is provided to obtain separate images of water and fat using quantitative MRI while eliminating separation error caused by non-uniform magnetic field. When a spin echo signal is received, there are carried out the S0 scanning in which the phases of magnetization vectors of water and fat are in agreement with each other, the S1 scanning in which the phases of magnetization vectors are different by 180° and the S2 scanning in which the phases of magnetization vectors are different by 90°. A quantitative difference between water and fat is calculated from the image data of the S1 and S2 scannings, and a separation image of water and fat is obtained from the absolute value images of the S0 and S1 scannings. According to the invention which uses absolute value images of the S0 and S1 scannings, there does not develop any separation error caused by deviation in the phase that stems from non-uniform magnetic field. Further, the phase term due to non-uniform static magnetic field is removed and a quantitative difference between water and fat is calculated based on the image data of the S1 and S2 scannings. Water and fat component are identified for the separation images found from the absolute value data.

公开(公告)号：WO1989007415A1

公开(公告)日：1989-08-24

申请号：PCT/GB1989000192

申请日：1989-02-17

Applicant: ANTEC SYSTEMS LIMITED ,  EVANS, John, Martin

Inventor： ANTEC SYSTEMS LIMITED

IPC: A61B05/05

CPC classification number: A61B5/053 ,  A61B5/0538 ,  A61M16/04 ,  A61M16/0411

Abstract: A probe for locating an endo-tracheal or endo-oesophageal tube in the trachea or oesophagus, comprises an elongate body (1) having a distal end (2) for insertion into the trachea or oesophagus of a patient, and a proximal end (10) adapted to remain external to the patient in use. A pair of electrodes (3, 4) is circumferentially spaced about the probe body, at or near the said distal end (2), and electrical conductors (5) lead between the electrodes (3, 4) and proximal end of the probe. The arrangement of the electrodes (3, 4) is such that the impedance measured between the conductors at the proximal end of the probe varies in dependance upon whether the prove is located in the oesophagus or the trachea of a patient. The probe may be a guide probe for the endo-tracheal or endo-oesophageal tube, or may itself be an endo-oesophageal tube which it is desired to insert.

Abstract translation: 用于在气管或食道中定位气管内或食道内管的探针包括细长体（1），其具有用于插入患者的气管或食道的远端（2）和近端（10 ）适于在使用中保持在患者外部。 在所述远端（2）处或附近，一对电极（3,4）围绕探针主体周向间隔开，并且电导体（5）在电极（3,4）和探针近端之间引导。 电极（3,4）的布置使得在探针近端处的导体之间测量的阻抗取决于证据是位于患者的食管还是气管中。 探针可以是用于气管内或食管内导管的引导探针，或者本身可以是期望插入的食管内管。