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    METHOD FOR PRODUCING epsilon-CAPROLACTAM
    155.
    发明专利
    METHOD FOR PRODUCING epsilon-CAPROLACTAM 审中-公开

    公开(公告)号：JP2003128655A

    公开(公告)日：2003-05-08

    申请号：JP2001329105

    申请日：2001-10-26

    Applicant: MITSUBISHI CHEM CORP

    Inventor： LAMPERS HANS ,  SETOYAMA TORU ,  TAKEWAKI TAKAHIKO ,  FUJII KATSU

    IPC: C07D223/10 ,  B01J29/76 ,  C07B61/00 ,  C07D201/02

    Abstract: PROBLEM TO BE SOLVED: To provide a method in which ε-caprolactam is produced from cyclohexene with high conversion and high selectivity and is further produced while reducing total production cost. SOLUTION: The method is characterized by comprising a series of sequential processes of (1) an oxidation reaction process in which the cyclohexene is reacted with oxygen or a polyhydric alcohol in the presence of a catalyst to produce cyclohexanone and/or its ketal, (2) an oxidation reaction process in which the cyclohexanone obtained from the oxidation reaction process (1) is oxidized with molecular oxygen in the presence of an immobilized catalyst to obtain an oxidation reaction product containing adipaldehyde acid, (3) a hydrogenation process in which the oxidation reaction product containing the adipaldehyde acid obtained from the oxidation reaction process (2) is reacted with ammonia and hydrogen in the presence of a hydrogenation catalyst to produce 6-aminocaproic acid, and (4) a ring closure reaction process in which the 6-aminocaproic acid obtained from the hydrogenation process (3) is heated to produce the ε-caprolactam.

    PRODUCTION OF N-SUBSTITUTED LACTAM
    158.
    发明专利
    PRODUCTION OF N-SUBSTITUTED LACTAM 失效

    公开(公告)号：JPH1087610A

    公开(公告)日：1998-04-07

    申请号：JP21922397

    申请日：1997-07-30

    Applicant: POUDRES & EXPLOSIFS STE NALE

    Inventor： DENARIE MICHEL ,  LY KOK KHANN

    IPC: B01J31/02 ,  C07B61/00 ,  C07D201/02 ,  C07D207/26 ,  C07D207/27 ,  C07D223/10

    Abstract: PROBLEM TO BE SOLVED: To produce a N-substituted lactam economically and advantageously in an industrial scale by a reaction of a specified lactam with an organic halogen compound in the presence of a specific catalyst and specific base without solvents. SOLUTION: This N-substituted lactam is produced by a reaction of a lactam the N site of which is not substituted, preferably a compound of formula I (R' is an aliphatic hydrocarbon), as a starting material, with an organic halogen compound, preferably octyl chloride, dodecyl bromide, etc., in the presence of a solid-liquid interphase mobile catalyst, preferably a tertiary ammonium salt of formula II (R -R are each an alkyl, aralky or a heterocyclic group formed by a combination of two or three of R -R with N; X is an anion), specifically tetrabutylammonium bromide, and a solid inorganic base, preferably sodium hydroxide. This reaction is preferably carried out while restricting the presence of water in the reaction mixture as far as possible.

    159.
    发明专利
    失效

    公开(公告)号：JPH05271186A

    公开(公告)日：1993-10-19

    申请号：JP7377192

    申请日：1992-03-30

    IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18

    Abstract: PURPOSE:To obtain the subject compound useful as an intermediate for producing penem compounds without employing a toxic mercury compound in a short process by reacting an azetidinone derivative with a thiocarboxylic acid in the presence of a copper compound. CONSTITUTION:A 2-azetidinone derivative of formula I (OR is protected hydroxyl group; X is alkyl, (substituted)aromatic group] with a thiocarboxylic acid of formula II (Y is alkyl, alkoxy, etc.; n is 0,1; but when Y is alkoxy, n is not 0) in the presence of a copper compound (preferably cuprous oxide) in an organic solvent (preferably toluene) preferably at 10-30 deg.C to obtain the objective compound of formula III. The compound of formula I includes (3S,4 R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-phenylthio-2-azetidin one. The compound of formula II includes 2R-tetrahydrofuran-2-thiocarboxylic acid.

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