公开(公告)号：WO2014138896A1

公开(公告)日：2014-09-18

申请号：PCT/CA2014/000224

申请日：2014-03-13

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： GOKARAJU, Ramakrishma ,  RAI, Dipendra

IPC: H02J13/00 ,  G05B13/04

CPC classification number: H02J3/00 ,  G05B13/048 ,  H02J2003/007 ,  Y02E60/76 ,  Y04S40/22

Abstract: Various embodiments are described herein for a device and method for an adaptive controller for a power system. The adaptive controller has a parameter identification module and an adaptive control module. The parameter identification module determines values for parameters of a power system model based on a constrained parameter identification technique, errors between actual and estimated power system outputs and a control signal. The adaptive control module applies an adaptive pole-shift technique to generate a control signal to shift poles of the power system model. The control signal is sent to a power flow control device to alter power flow in the power system during a disturbance.

Abstract translation: 这里描述了用于电力系统的自适应控制器的装置和方法的各种实施例。 自适应控制器具有参数识别模块和自适应控制模块。 参数识别模块基于受限参数识别技术确定电力系统模型的参数值，实际和估计的电力系统输出之间的误差以及控制信号。 自适应控制模块应用自适应极点移位技术来产生控制信号以移动电力系统模型的极点。 控制信号被发送到功率流控制装置，以在干扰期间改变电力系统中的功率流。

公开(公告)号：WO2011032284A1

公开(公告)日：2011-03-24

申请号：PCT/CA2010/001460

申请日：2010-09-16

Applicant: UNIVERSITY OF SASKATCHEWAN ,  ZHANG, Xiaowei ,  HECKER, Markus ,  GIESY, John, P.

Inventor： ZHANG, Xiaowei ,  HECKER, Markus ,  GIESY, John, P.

IPC: C12N5/10 ,  C12N15/00 ,  C12N15/52 ,  C12N15/85 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/68 ,  G01N33/74 ,  G01N33/92

CPC classification number: G01N33/5008 ,  G01N33/743

Abstract: An isolated steroidogenesis modified cell comprising one or more steroid biosynthesis knock down nucleic acid operatively linked to a promoter, wherein the steroid biosynthesis knock down nucleic acid reduces the expression of a gene selected from the group CYP21A2, CYP11A1, CYP17A1, CYP19A1, 3-βHSD1, 3-βHSD2, 17-βHSD1, StAR, HMGR, CYP11 B2, CYP11 B1, 5α-Reductase 2, SULT1 E1, CYP3A4 and UTG1A1, wherein the cell comprises reduced expression of one or more of said genes. The cells are useful for identifying endocrine disruptors. Accordingly, the disclosure includes in a further aspect a screening assay for identifying an endocrine disruptor comprising: a) contacting a cell described herein with a test substance; b) determining a level of at least one steroid or steroidogenic gene mRNA or enzyme activity;wherein a modulation in the level of the at least one steroid or steroidogenic gene mRNA or enzyme activity compared to a control is indicative that the test substance is an endocrine disruptor.

Abstract translation: 包含一种或多种类固醇生物合成的分离的类固醇生成修饰细胞敲除与启动子有效连接的核酸，其中类固醇生物合成敲低核酸降低了选自CYP21A2，CYP11A1，CYP17A1，CYP19A1,3-βHSD1的基因的表达 ，3-βHSD2,17-βHSD1，StAR，HMGR，CYP11B2，CYP11B1,5α-还原酶2，SULT1E1，CYP3A4和UTG1A1，其中所述细胞包含一种或多种所述基因的表达降低。 细胞可用于鉴定内分泌干扰物。 因此，本公开在另一方面包括用于鉴定内分泌干扰物的筛选测定法，其包括：a）使本文所述的细胞与测试物质接触; b）确定至少一种类固醇或类固醇基因mRNA或酶活性的水平;其中与对照相比，所述至少一种类固醇或类固醇基因mRNA或酶活性水平的调节指示所述测试物质是内分泌 破坏者。

公开(公告)号：WO2011032281A1

公开(公告)日：2011-03-24

申请号：PCT/CA2010/001454

申请日：2010-09-16

Applicant: UNIVERSITY OF SASKATCHEWAN ,  UNIVERSITY OF WASHINGTON ,  KAMINSKYJ, Susan Gail Willets ,  BASINGER, James Frederick ,  BAO, Xiaohui ,  RODRIGUEZ, Russell John ,  REDMAN, Regina Soon

Inventor： KAMINSKYJ, Susan Gail Willets ,  BASINGER, James Frederick ,  BAO, Xiaohui ,  RODRIGUEZ, Russell John ,  REDMAN, Regina Soon

IPC: C12N1/14 ,  B09C1/10 ,  C05F11/08 ,  A01N63/04 ,  A01H17/00

CPC classification number: C12R1/885 ,  A01N63/04 ,  C05F11/08

Abstract: A novel strain of Trichoderma harzianum called TSTh20-1 is described. TSTh20-1 is useful in promoting plant growth, increasing water use efficiency of plants and in remediation of soil or water.

Abstract translation: 描述了一种叫做TSTh20-1的新型哈茨木霉菌株。 TSTh20-1有助于促进植物生长，提高植物的水分利用效率和修复土壤或水分。

公开(公告)号：WO2010115278A8

公开(公告)日：2010-10-14

申请号：PCT/CA2010/000516

申请日：2010-04-06

Applicant: UNIVERSITY OF SASKATCHEWAN ,  Bioniche Life Sciences Inc. a Body corporate pursuant to the Laws of Canada ,  POTTER, Andrew, A. ,  ASPER, David ,  ROGAN, Dragan

Inventor： POTTER, Andrew, A. ,  ASPER, David ,  ROGAN, Dragan

IPC: C07K19/00 ,  A61K39/108 ,  A61K39/385 ,  A61P31/04 ,  A61P37/04 ,  C07K14/245

Abstract: Compositions and methods for stimulating an immune response against Shiga toxin-producing Escherichia coli (STEC) antigens are disclosed. The compositions include a multiple epitope fusion protein comprising more than one epitope of an immunogenic STEC protein from more than one STEC serotype. Additional compositions include at least two purified STEC proteins, wherein the STEC proteins are selected from a full-length STEC protein, an immunogenic fragment or variant thereof, wherein at least one of the STEC proteins generates antibodies that react with STEC 0157 and at least one other STEC serotype.

公开(公告)号：WO2010111789A1

公开(公告)日：2010-10-07

申请号：PCT/CA2010/000509

申请日：2010-04-01

Applicant: UNIVERSITY OF SASKATCHEWAN ,  WU, Lingyun ,  CHANG, Tuanjie ,  WANG, Rui

Inventor： WU, Lingyun ,  CHANG, Tuanjie ,  WANG, Rui

IPC: C07K7/06 ,  A23L3/3463 ,  A61K38/06 ,  A61K38/08 ,  C07K5/083

CPC classification number: C07K5/081 ,  A61K38/00

Abstract: The present invention provides compositions and methods that inhibit non-enzymatic protein glycation and/or inhibit the formation of advanced glycation endproducts (AGEs). The compositions comprise peptides derived from the Aktl protein, said peptides comprise an ammo acid sequence selected from CLQ or CLQWTTVER. Furthermore, the compositions are useful for treating advanced glycation endproduct (AGE)-related diseases.

Abstract translation: 本发明提供抑制非酶促蛋白糖基化和/或抑制晚期糖基化终产物（AGEs）形成的组合物和方法。 所述组合物包含衍生自Akt1蛋白的肽，所述肽包含选自CLQ或CLQWTTVER的氨基酸序列。 此外，该组合物可用于治疗晚期糖基化终末产物（AGE）相关疾病。

公开(公告)号：WO2009146526A1

公开(公告)日：2009-12-10

申请号：PCT/CA2009/000719

申请日：2009-06-02

Applicant: UNIVERSITY OF SASKATCHEWAN ,  REANEY, Martin, J. ,  JIA, Yunhua ,  SHEN, Jianheng ,  RATANAPARLYANUCH, Komsulee

Inventor： REANEY, Martin, J. ,  JIA, Yunhua ,  SHEN, Jianheng ,  RATANAPARLYANUCH, Komsulee

IPC: C12F3/00 ,  B01D11/04 ,  C02F1/00 ,  C02F1/58

CPC classification number: C12F3/10 ,  A23K10/38 ,  Y02P60/873

Abstract: Methods for recovery of recyclable water and/or fermentation co-products from thin stillage process streams. Microbial metabolites and/or plant derivatives and/or plant extractives are removed from thin stillage after which, recyclable water is recovered from the processed thin stillage. Thin stillage is commingled with one or more polar organic solvents to react microbial metabolites and/or plant derivatives and/or plant extractives with the organic solvents. The reacted organic solvents are then separated from the processed thin stillage. Thin stillage may be commingled with an oil to react with certain organic compounds, after which, the reacted oil is separated from the processed thin stillage is further extracted with one or more polar organic solvents. Alternatively, thin stillage may be first processed with one or more polar organic solvents, and then processed with an oil. Useful organic compounds may recovered from the reacted oil and from the reacted organic solvents.

Abstract translation: 从稀酒糟过程流中回收可再循环水和/或发酵副产物的方法。 从稀浆中除去微生物代谢物和/或植物衍生物和/或植物提取物，之后从经处理的薄釜中回收可再循环水。 与一种或多种极性有机溶剂混合使稀薄的釜渣与有机溶剂反应微生物代谢物和/或植物衍生物和/或植物提取物。 然后将反应的有机溶剂从处理的薄釜中分离。 稀醇可以与油混合以与某些有机化合物反应，然后将反应后的油与加工的薄釜分离，进一步用一种或多种极性有机溶剂萃取。 或者，可以用一种或多种极性有机溶剂首先处理薄的釜渣，然后用油处理。 有用的有机化合物可以从反应的油和反应的有机溶剂中回收。

公开(公告)号：WO2009015479A1

公开(公告)日：2009-02-05

申请号：PCT/CA2008/001406

申请日：2008-07-31

Applicant: UNIVERSITY OF SASKATCHEWAN ,  SCHMUTZ, Sheila, M. ,  HELGESON, Sarah, C.

Inventor： SCHMUTZ, Sheila, M. ,  HELGESON, Sarah, C.

IPC: C12Q1/68 ,  A01K67/00 ,  A01K67/02 ,  C07H21/00 ,  C07K14/575 ,  C12N15/16 ,  C12P19/34

CPC classification number: C12Q1/6888 ,  C07K14/575 ,  C12Q1/6881 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: An A-to-T single nucleotide polymorphism (SNP) identified at position -134 relative to the ATG start codon, in the Pro-Melanin-Concentrating Hormone (PMCH) gene of Bos taurus and Bos indicus animals of both British and Continental type, is associated with changes in the average fat and grade fat. The A allele occurred in 67 % of cattle examined and was associated with higher average fat and grade fat levels. The cattle industry may make use of these findings to genetically select for, and/or sort, cattle using this SNP.

Abstract translation: 在英国和欧洲大陆类型的Bos金牛座和Bos indicus动物的Pro-Melanin浓缩激素（PMCH）基因中，相对于ATG起始密码子在位置-134鉴定的A至T单核苷酸多态性（SNP）是 与平均脂肪和分级脂肪的变化相关。 A等位基因发生在检查的牛中的67％，并且与较高的平均脂肪和分级脂肪水平相关。 牛业可以利用这些发现来使用该SNP对牛进行遗传选择和/或排序。

公开(公告)号：WO2008083493A8

公开(公告)日：2008-07-17

申请号：PCT/CA2008/000048

申请日：2008-01-10

Applicant: UNIVERSITY OF SASKATCHEWAN ,  GEYER, Ronald, C.

Inventor： GEYER, Ronald, C.

IPC: C12N15/62 ,  C07K16/00 ,  C07K16/46 ,  C07K19/00 ,  C07K7/64 ,  C12N15/11 ,  C12N15/13 ,  C12N15/52 ,  C12N9/00 ,  C12P21/00 ,  C12P21/04 ,  C12Q1/00 ,  G01N33/53 ,  G01N33/68

Abstract: In various aspects, the invention provides methods for cyclizing proteins, including methods for enhancing the stability of cyclized proteins under cytosolic conditions. The invention also provides various methods for using the cyclized proteins. For example, cyclized proteins of the invention may be used in screening assays analogous to the yeast two hybrid assay. Selected embodiments of the invention provide cyclized single chain variable fragment (ScFv) molecules, including molecules in the form of an immunoglobulin fold.

公开(公告)号：WO2007147256A1

公开(公告)日：2007-12-27

申请号：PCT/CA2007/001116

申请日：2007-06-22

Applicant: BIORIGINAL FOOD & SCIENCE CORP. ,  UNIVERSITY OF SASKATCHEWAN ,  MEESAPYODSUK, Dauenpen ,  QIU, Xiao

Inventor： MEESAPYODSUK, Dauenpen ,  QIU, Xiao

IPC: C12N15/53 ,  A01H5/00 ,  C07C59/42 ,  C11B1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N15/63 ,  C12N15/82 ,  C12N5/10 ,  C12N9/02 ,  C12P21/02 ,  C12P7/64

CPC classification number: C12P7/6409 ,  C07C51/42 ,  C07C51/47 ,  C07C51/48 ,  C11B1/025 ,  C12N9/0071 ,  C12N15/8247 ,  C12P7/6463

Abstract: The invention provides isolated nucleic acid molecules which encode novel fatty acid hydroxylases. The invention also provides recombinant expression vectors including hydroxylase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for the production of hydroxyl fatty acids such as 12-hydroxyoctadec-9-enoic acid (ricinoleic acid).

Abstract translation: 本发明提供编码新型脂肪酸羟化酶的分离的核酸分子。 本发明还提供了重组表达载体，包括羟化酶核酸分子，已经引入表达载体的宿主细胞，以及生产羟基脂肪酸如12-羟基十八碳-9-烯酸（蓖麻醇酸）的方法。

公开(公告)号：WO2007071046A1

公开(公告)日：2007-06-28

申请号：PCT/CA2006/002090

申请日：2006-12-21

Applicant: UNIVERSITY OF SASKATCHEWAN ,  REANEY, Martin, J., T. ,  JAYASINGHE, Dushmanthi, de A.

Inventor： REANEY, Martin, J., T. ,  JAYASINGHE, Dushmanthi, de A.

IPC: C10G3/00 ,  C10L1/02 ,  C11C1/02 ,  C11C3/04

CPC classification number: C11C3/003 ,  C10G2300/1011 ,  C10L1/026 ,  C11C1/025 ,  C11C1/08 ,  Y02E50/13 ,  Y02P30/20

Abstract: The present invention relates to a process of preparing fatty alkyl esters (biodiesel), glycerin and lithium soap comprising: a) transesterifying an oil, fat or grease with a solution of lithium base in a monohydric aliphatic alcohol to produce fatty alkyl esters and a lithium alkaline glycerin; b) separating the fatty alkyl esters and the lithium alkaline glycerin and utilizing the lithium alkaline glycerin to saponify fatty alkyl compounds to produce glycerin and lithium soap; and c) optionally, separating the glycerin and lithium soaps.

Abstract translation: 本发明涉及一种制备脂肪烷基酯（生物柴油），甘油和锂皂的方法，其包括：a）将油，脂肪或油脂与锂碱在一元脂肪醇中的溶液酯交换以产生脂肪烷基酯和锂 碱性甘油; b）分离脂肪烷基酯和锂碱性甘油，并利用锂碱性甘油皂化脂肪烷基化合物以制备甘油和锂皂; 和c）任选地，分离甘油和锂皂。