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公开(公告)号：KR1020140069899A
公开(公告)日：2014-06-10
申请号：KR1020120137748
申请日：2012-11-30
Applicant: (주)아모레퍼시픽
Abstract: The present invention relates to a composition containing deep ocean water for skin moisturizing and, more specifically, to a composition containing deep ocean water for skin moisturizing which comprises manganese, calcium, and potassium in a content ratio (w/v) of 2-4: 0.5-1.5: 0.5-1.5.
Abstract translation: 本发明涉及含有用于皮肤保湿的深海水的组合物，更具体地说，涉及包含含有比例（w / v）为2-4的锰，钙和钾的皮肤保湿深层海水的组合物 ：0.5-1.5：0.5-1.5。
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公开(公告)号：KR1020140057054A
公开(公告)日：2014-05-12
申请号：KR1020120123693
申请日：2012-11-02
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61K48/00 , A61K31/7105 , G01N33/15
Abstract: Disclosed are isolated miRNA nucleic acid molecules comprising SEQ ID No. 1 or SEQ ID No. 2; a fragment or an analog thereof having hybridization ability of the miRNA to regulate expression of one or more of keratin 1 and keratin 10; or a skin external application composition comprising the same. In one aspect of the present invention, disclosed is a method of screening a keratogenesis regulatory substance using the miRNA nucleic acid molecules, or the fragment or the analog thereof.
Abstract translation: 公开了包含SEQ ID No.1或SEQ ID No.2的分离的miRNA核酸分子; 其具有miRNA调节角蛋白1和角蛋白10中的一种或多种的表达的杂交能力的片段或类似物; 或包含其的皮肤外用施用组合物。 在本发明的一个方面，公开了使用miRNA核酸分子或其片段或类似物筛选角化生成调节物质的方法。
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公开(公告)号：KR1020140052569A
公开(公告)日：2014-05-07
申请号：KR1020120118765
申请日：2012-10-25
Applicant: (주)아모레퍼시픽
Abstract: The present invention relates to a composition comprising cellobiose as an active ingredient, and more specifically, to a skin external application composition for skin whitening which contains cellobiose as an active ingredient thereby inhibiting melanin production of skin and accordingly having a skin whitening effect.
Abstract translation: 本发明涉及包含纤维二糖作为活性成分的组合物，更具体地说，涉及含有纤维二糖作为活性成分的皮肤外用施用组合物，从而抑制皮肤的黑色素生成并因此具有皮肤美白效果。
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公开(公告)号：KR1020140017259A
公开(公告)日：2014-02-11
申请号：KR1020120083963
申请日：2012-07-31
Applicant: (주)아모레퍼시픽
IPC: A61K31/375 , A61K31/352 , A61K31/35 , A61P17/00
Abstract: The present invention relates to a whitening composition and more specifically, to a whitening composition comprising trolox. The composition of the present invention has an outstanding whitening effect by inhibiting or suppressing a generation of melanin by inhibiting activation of tyrosinase. In addition, the composition is harmless since it does not contain any cytotoxic component while having the whitening effect. The present invention has its significance in discovering a synergy effect of using vitamin C and trolox in combination.
Abstract translation: 本发明涉及一种美白组合物，更具体地说，涉及一种含有特氟洛氟的美白组合物。 通过抑制或抑制酪氨酸酶的活化来抑制或抑制黑色素的产生，本发明的组合物具有优异的美白效果。 此外，组合物是无害的，因为它不具有任何细胞毒性成分，同时具有美白效果。 本发明在发现组合使用维生素C和trolox的协同作用方面具有重要意义。
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公开(公告)号：KR1020130138677A
公开(公告)日：2013-12-19
申请号：KR1020130062652
申请日：2013-05-31
Applicant: (주)아모레퍼시픽
Abstract: The present invention relates to a cosmetic composition which contains more than one compound selected from methylinositol, betaine, vitamin C, and dipalmitoyl hydroxyproline as active ingredients for improving skin elasticity, anti-wrinkling, and moisturizing effects. [Reference numerals] (AA) Relative expression of Collagen i gene
Abstract translation: 本发明涉及含有多于一种选自甲基肌醇，甜菜碱，维生素C和二棕榈酰羟脯氨酸的化合物作为改善皮肤弹性，抗皱和保湿效果的活性成分的化妆品组合物。 （参考号）（AA）胶原蛋白i基因的相对表达
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Patent Agency Ranking
公开(公告)号：KR1020130049589A
公开(公告)日：2013-05-14
申请号：KR1020110114689
申请日：2011-11-04
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
IPC: C12N15/63 , C12N15/861 , C12Q1/68 , G01N33/53
CPC classification number: C12N15/635 , C12N15/861 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G01N33/5023 , G01N33/5302 , G01N33/6881
Abstract: PURPOSE: A method for screening a material which enhances a skin barrier function is provided to effectively screening the material, and to diagnose diseases related to the skin barrier function. CONSTITUTION: A method for screening a material which enhances a skin barrier function comprises a step of determining a material which suppresses the expression of PDZK1 genes as the material which enhances the skin barrier function by screening the material which suppresses the expression of the PDZK1 genes. The method comprises a step of treating a nucleic acid molecule of PDZK1 with a candidate material, and a step of detecting expression change. The treatment with the candidate material comprises a step of treating a skin cell which is transformed with a vector containing the nucleic acid molecule with the candidate material. The skin cell is keratinocyte. The vector is adenovirus. A composition for enhancing the skin barrier function contains the material which suppresses the expression of the PDZK1 genes as an active ingredient. [Reference numerals] (AA) Comparative example 1; (BB) Example 1
Abstract translation: 目的：提供一种筛选增强皮肤屏障功能的材料的方法，以有效筛选材料，并诊断与皮肤屏障功能相关的疾病。 构成：用于筛选增强皮肤屏障功能的材料的方法包括测定通过筛选抑制PDZK1基因表达的材料来抑制PDZK1基因表达的材料作为增强皮肤屏障功能的材料的步骤。 该方法包括用候选物质处理PDZK1的核酸分子的步骤和检测表达变化的步骤。 用候选材料的处理包括用候选材料处理用含有核酸分子的载体转化的皮肤细胞的步骤。 皮肤细胞是角质形成细胞。 载体是腺病毒。 用于增强皮肤屏障功能的组合物含有抑制作为活性成分的PDZK1基因表达的材料。 （附图标记）（AA）比较例1; （BB）实施例1
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公开(公告)号：KR1020130035935A
公开(公告)日：2013-04-09
申请号：KR1020120108461
申请日：2012-09-28
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A keratinocyte-adapted melanocyte and a method for preparing the same are provided to obtain melanocyte with excellent adhesion and high survival rate. CONSTITUTION: A method for preparing keratinocyte-adapted melanocytes comprises: a step of culturing keratinocytes in a keratinocyte medium; a step of removing keratinocytes from a culture; and a step of collecting cells adhered on the bottom of a dish and culturing the cells in a melanocyte medium.
Abstract translation: 目的：提供角质形成细胞适应的黑素细胞及其制备方法，以获得具有优异粘附性和高存活率的黑素细胞。 构成：一种制备角质形成细胞适应黑素细胞的方法，包括：在角质细胞培养基中培养角化细胞的步骤; 从培养物中去除角质形成细胞的步骤; 以及收集附着在皿底部并在黑素细胞培养基中培养细胞的细胞的步骤。
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公开(公告)号：KR1020130000039A
公开(公告)日：2013-01-02
申请号：KR1020110060484
申请日：2011-06-22
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61Q7/00 , A61Q19/00 , C12Q1/68
CPC classification number: C12N15/1136 , A61Q7/00 , A61Q19/00 , C12Q1/6813 , C12Q2600/148 , C12Q2600/158 , C12Q2600/178
Abstract: PURPOSE: A composition containing miRNA or antisense nucleic acid molecules is provided to regulate the expression of tyrosinase-related proteins, PAX3, and melan-A. CONSTITUTION: A composition for regulating the expression of a pigmentation-related gene contains miRNA of sequence number 1 as an active ingredient. The miRNA is selected from bases of sequence number 1 and is selected among oligonucleic acid molecules with 15-23 continuous base sequences. The composition is a cosmetic or pharmaceutical composition for generating black hair or preventing grey hair. The pigmentation-related gene expresses PAX3, tyrosinase-related protein 1, or melan-A. [Reference numerals] (AA) Relative mRNA expression of TYRP1/GAPDH; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) Embodiment 1
Abstract translation: 目的：提供含有miRNA或反义核酸分子的组合物，以调节酪氨酸酶相关蛋白（PAX3）和黑色素A的表达。 构成：用于调节色素沉着相关基因表达的组合物含有序列号1的miRNA作为活性成分。 miRNA选自序列号1的碱基，并且选自具有15-23个连续碱基序列的寡核酸分子。 该组合物是用于产生黑发或防止灰白头发的化妆品或药物组合物。 色素沉着相关基因表达PAX3，酪氨酸酶相关蛋白1或黑色素A。 （AA）相关mRNA表达TYRP1 / GAPDH; （BB）比较实施例1; （CC）比较实施例2; （DD）实施例1
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公开(公告)号：KR1020130000038A
公开(公告)日：2013-01-02
申请号：KR1020110060483
申请日：2011-06-22
Applicant: (주)아모레퍼시픽
IPC: C12N15/11 , A61K31/7105 , A61P17/14 , A61Q19/02
Abstract: PURPOSE: A composition containing miRNA or antisense nucleic acid molecules for preventing grey hair or improving a skin whitening effect is provided to regulate the expression of genes expressing tyrosinase, tyrosinase-related proteins, and melan-A. CONSTITUTION: A composition for regulating the expression of pigmentation-related genes contains miRNA of sequence number 1 as an active ingredient. The miRNA is selected among base sequences of sequence number 1, and contains 15-22 continuous base sequences including ugaaaug. The pigmentation-related genes express tyrosinase, tyrosinase-related protein 1, or melan-A. A method for screening a material which regulates the expression of the pigmentation-related genes among test materials comprises: a step of transfectioning the miRNA of sequence number 1 or antisense nucleic acid molecules of sequence number 2 into cells; a step of treating the test materials to the cells; and a step of identifying if the test materials promote or suppress the expression of the pigmentation-related genes. [Reference numerals] (AA) Relative mRNA expression of TYRP1/GAPDH; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) Embodiment 1
Abstract translation: 目的：提供含有用于预防灰白发或改善皮肤美白效果的miRNA或反义核酸分子的组合物，以调控表达酪氨酸酶，酪氨酸酶相关蛋白和黑色素A的基因的表达。 构成：用于调节色素沉着相关基因表达的组合物含有序列号1的miRNA作为活性成分。 miRNA选自序列号1的碱基序列，并且包含15-22个连续碱基序列，包括ugaaaug。 色素沉着相关基因表达酪氨酸酶，酪氨酸酶相关蛋白1或黑色素A。 用于筛选调节试验材料中色素沉着相关基因表达的材料的方法包括：将序列号1的miRNA或序列号2的反义核酸分子转染入细胞的步骤; 将测试材料处理到细胞的步骤; 以及鉴定测试物质是否促进或抑制色素沉着相关基因表达的步骤。 （AA）相关mRNA表达TYRP1 / GAPDH; （BB）比较实施例1; （CC）比较实施例2; （DD）实施例1
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公开(公告)号：KR1020120088895A
公开(公告)日：2012-08-09
申请号：KR1020100115853
申请日：2010-11-19
Applicant: (주)아모레퍼시픽
CPC classification number: C12Q1/6881 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , A61K8/00 , G01N33/15
Abstract: PURPOSE: A method and a kit for screening a material which promotes skin cell differentiation is provided to quickly and simply screen the material. CONSTITUTION: A method for screening a material which promotes skin cell differentiation comprises: a step of treating a test material to skin cells; a step of identifying relative expression level of DUOX1(dual oxidase 1) gene(Genebank Accession No.: NM_017434) in the skin cells; and a step of determining a material which enhances the expression level is the material which promotes skin cell differentiation. The skin cells are keratinocytes. A composition for skin moisturizing, skin barrier function strengthening, or atopic dermatitis relief contains the material as an active ingredient.
Abstract translation: 目的：提供一种用于筛选促进皮肤细胞分化的材料的方法和试剂盒，以快速简便地筛选材料。 构成：筛选促进皮肤细胞分化的材料的方法包括：将测试材料处理至皮肤细胞的步骤; 识别皮肤细胞中DUOX1（双重氧化酶1）基因（Genebank登录号：NM_017434）的相对表达水平的步骤; 并且确定增强表达水平的材料的步骤是促进皮肤细胞分化的材料。 皮肤细胞是角质形成细胞。 用于皮肤保湿，皮肤屏障功能增强或特应性皮炎缓解的组合物含有作为活性成分的材料。
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