公开(公告)号：US20120250027A1

公开(公告)日：2012-10-04

申请号：US13344550

申请日：2012-01-05

Applicant: Guoan Zheng ,  Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer

Inventor： Guoan Zheng ,  Xiquan Cui ,  Xin Heng ,  Changhuei Yang ,  Axel Scherer

IPC: G01B9/02 ,  G02B5/18 ,  G01J3/46

CPC classification number: G02B6/1226 ,  B82Y20/00 ,  G01N21/554 ,  G02B5/008 ,  G02B21/0032 ,  G02B21/004 ,  G02B21/0056 ,  G02B21/0068 ,  G02B21/14 ,  G02B27/52

Abstract: A surface wave assisted system having an aperture layer with a surface and an aperture, and a plurality of grooves around the aperture. The plurality of grooves is configured to generate an optical transfer function at the aperture by inducing a surface wave for interfering with transmission of light of a range of spatial frequency.

Abstract translation: 表面波辅助系统，具有具有表面和孔径的孔层，以及围绕孔的多个凹槽。 多个槽被配置为通过诱导表面波来干扰空间频率范围的光的透射来在孔处产生光学传递函数。

公开(公告)号：US08273574B2

公开(公告)日：2012-09-25

申请号：US13026587

申请日：2011-02-14

Applicant: Stephen R. Quake ,  Mark A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer

Inventor： Stephen R. Quake ,  Mark A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC classification number: G01N33/00 ,  B01D57/02 ,  B01D61/18 ,  B01D61/28 ,  B01D63/081 ,  B01D63/088 ,  B01D2313/08 ,  B01D2313/90 ,  B01F5/0646 ,  B01F5/0647 ,  B01F7/00 ,  B01F11/0071 ,  B01F13/0059 ,  B01F13/1013 ,  B01F13/1022 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0415 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0633 ,  B01L2400/0655 ,  B01L2400/082 ,  C12M23/16 ,  C12M41/46 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0009 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N15/06 ,  G01N27/44743 ,  G01N27/44791 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/56966 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel.

Abstract translation: 本发明提供微流体装置及其使用方法。 特别地，本发明的微流体装置可用于进行各种测定和高通量筛选。 本发明的微流体装置包括弹性体部件并且包括主流动通道; 多个分支流动通道; 多个控制信道; 和多个阀。 优选地，每个阀包括控制通道中的一个和可响应于施加到控制通道的致动力而从阀或液流通道偏转进入或从其中缩回的弹性体段。

公开(公告)号：US20120141337A1

公开(公告)日：2012-06-07

申请号：US13348495

申请日：2012-01-11

Applicant: George Maltezos ,  John Kim Lee ,  Axel Scherer ,  Emil Kartalov

Inventor： George Maltezos ,  John Kim Lee ,  Axel Scherer ,  Emil Kartalov

IPC: B01L3/00

CPC classification number: G01N21/6456 ,  G01N21/6452 ,  Y10T137/2224

Abstract: A microfluidic filter is disclosed. The filter can be used with onchip fluid filtration such as whole blood filtration for microfluidic blood analysis. The filter is able to filter the necessary volume of fluid and in particular blood in an acceptable time frame.

Abstract translation: 公开了一种微流体过滤器。 过滤器可用于片上流体过滤，如全血过滤用于微流体血液分析。 过滤器能够在可接受的时间范围内过滤所需体积的流体，特别是血液。

公开(公告)号：US08170316B2

公开(公告)日：2012-05-01

申请号：US12243830

申请日：2008-10-01

Applicant: Mladen Barbic ,  Axel Scherer

Inventor： Mladen Barbic ,  Axel Scherer

IPC: G06K9/00

CPC classification number: A61B6/504 ,  G01R33/3415 ,  G01R33/345 ,  G01R33/4824

Abstract: Tomographic imaging using an imaging sensor that has a stripe-like shape is disclosed where a stripe sensor is mechanically scanned over a sample at different angles. For a single stripe detector imaging, linear motion and angular rotation are required. Single stripe sensor imaging may be performed using an elongated inductive coil detector. By utilizing an array of parallel stripe sensors that can be individually addressed, two-dimensional imaging can be performed with rotation only, eliminating the requirement for linear motion, e.g. with parallel coils array. Imaging with a stripe-type sensor of particular width and thickness (where width is much larger than thickness) is resolution limited only by the thickness (smaller parameter) of the sensor. Multiple sensor families can be produced where this imaging technique may be beneficial such as magneto-resistive, inductive, SQUID, and Hall effect sensors, and particularly in the field of magnetic resonance imaging (MRI).

Abstract translation: 公开了使用具有条状形状的成像传感器的层析成像，其中条纹传感器以不同的角度机械扫描样品。 对于单个条纹检测器成像，需要线性运动和角旋转。 可以使用细长的感应线圈检测器来执行单条纹传感器成像。 通过利用可以单独寻址的平行条纹传感器阵列，可以仅旋转执行二维成像，消除对线性运动的需求，例如， 具有并联线圈阵列。 具有特定宽度和厚度（宽度远大于厚度）的条纹型传感器的成像是仅由传感器的厚度（较小参数）限制的分辨率。 可以制造多个传感器系列，其中该成像技术可能是有益的，例如磁阻，感应，SQUID和霍尔效应传感器，特别是在磁共振成像（MRI）领域。

公开(公告)号：US20120085648A1

公开(公告)日：2012-04-12

申请号：US13206362

申请日：2011-08-09

Applicant: Emil P. KARTALOV ,  Axel Scherer ,  Koichi SAYANO

Inventor： Emil P. KARTALOV ,  Axel Scherer ,  Koichi SAYANO

IPC: B01D43/00 ,  B01D37/00 ,  B01D29/00

CPC classification number: B01L3/502753 ,  A61M1/3472 ,  A61M1/3496 ,  A61M1/3633 ,  A61M2205/0244 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0424 ,  Y10T436/25125 ,  Y10T436/25375

Abstract: A microfluidic fluid separator for separating target components of a fluid by filtration is described. Methods for separating target components of a fluid by filtration and methods for processing blood on a large scale with the microfluidic fluid separator are provided.

Abstract translation: 描述了用于通过过滤分离流体的目标成分的微流体流体分离器。 提供了通过过滤分离流体的目标组分的方法和用微流体分离器大规模处理血液的方法。

公开(公告)号：US20120080361A1

公开(公告)日：2012-04-05

申请号：US13250575

申请日：2011-09-30

Applicant: Sameer Walavalkar ,  Aditya Rajagopal ,  Axel Scherer ,  Thomas A. Tombrello

Inventor： Sameer Walavalkar ,  Aditya Rajagopal ,  Axel Scherer ,  Thomas A. Tombrello

IPC: B07B1/00 ,  B31D3/00 ,  B01D61/00 ,  B01D71/02 ,  B82Y40/00

CPC classification number: B01D67/0062 ,  B01D61/027 ,  B01D61/145 ,  B01D69/06 ,  B01D71/027 ,  B07B1/00 ,  B07B1/4618 ,  B81C1/00031 ,  B81C1/00111 ,  B81C1/00119 ,  B81C1/00158 ,  B81C1/00531 ,  B81C1/00539 ,  B82Y40/00 ,  G01N33/48721 ,  H01L21/0331

Abstract: Methods and devices for isolating and sorting nanoparticles are disclosed herein. Nanopores of a desired size can be formed in silicon dioxide membranes and used as filters to separate nanoparticles. Devices are also provided herein for sorting nanoparticles with multiple filters having various sized nanopores.

Abstract translation: 本文公开了用于分离和分选纳米颗粒的方法和装置。 所需尺寸的纳米孔可以在二氧化硅膜中形成并用作分离纳米颗粒的过滤器。 本文还提供了用于对具有各种尺寸的纳米孔的多个过滤器分选纳米颗粒的装置。

公开(公告)号：US20110140085A1

公开(公告)日：2011-06-16

申请号：US12949758

申请日：2010-11-18

Applicant: Andrew P. Homyk ,  Michael D. Henry ,  Axel Scherer ,  Sameer Walavalkar

Inventor： Andrew P. Homyk ,  Michael D. Henry ,  Axel Scherer ,  Sameer Walavalkar

IPC: H01L29/08 ,  H01L21/441 ,  H01L21/336 ,  B82Y99/00

CPC classification number: H01L31/035227 ,  B82Y10/00 ,  B82Y40/00 ,  H01L21/02381 ,  H01L21/0243 ,  H01L21/02521 ,  H01L21/0259 ,  H01L21/02639 ,  H01L29/0665 ,  H01L29/0676 ,  H01L29/127 ,  H01L29/267 ,  H01L29/413 ,  H01L29/66439 ,  H01L29/775 ,  H01L33/06 ,  Y10S977/762

Abstract: Methods for fabricating self-aligned heterostructures and semiconductor arrangements using silicon nanowires are described.

Abstract translation: 描述了使用硅纳米线制造自对准异质结构和半导体布置的方法。

公开(公告)号：US20110044694A1

公开(公告)日：2011-02-24

申请号：US12860723

申请日：2010-08-20

Applicant: Axel Scherer ,  Aditya Rajagopal ,  Seheon Kim ,  Andrew P. Homyk

Inventor： Axel Scherer ,  Aditya Rajagopal ,  Seheon Kim ,  Andrew P. Homyk

IPC: H04B10/00 ,  H03F3/08 ,  H01L31/09 ,  H01L31/04 ,  G01J3/44 ,  G01J3/28 ,  H01L31/18

CPC classification number: H02J50/30 ,  A61B5/0017 ,  A61B5/6867 ,  A61B2560/0219 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0283 ,  G01N21/25 ,  H01L31/03529 ,  H01L31/0475 ,  H01L31/054 ,  H02J7/025 ,  H02J17/00 ,  H02J50/80 ,  H02S40/38 ,  H03F3/082 ,  H03F3/45183 ,  H03F2203/45702 ,  H04B10/807 ,  Y02E10/52

Abstract: The present disclosure describes an optically powered transducer with a photovoltaic collector. An optical fiber power delivery method and system and a free space power delivery method are also provided. A fabrication process for making an optically powered transducer is further described, together with an implantable transducer system based on optical power delivery.

Abstract translation: 本公开描述了具有光伏收集器的光学功率传感器。 还提供了光纤功率传递方法和系统以及自由空间功率传递方法。 进一步描述用于制造光学功率传感器的制造工艺，以及基于光功率传递的可植入传感器系统。

公开(公告)号：US07894696B2

公开(公告)日：2011-02-22

申请号：US12167063

申请日：2008-07-02

Applicant: Tom Baehr-Jones ,  Michael J. Hochberg ,  Axel Scherer

Inventor： Tom Baehr-Jones ,  Michael J. Hochberg ,  Axel Scherer

IPC: G02B6/00

CPC classification number: G02B6/1223 ,  B82Y20/00 ,  G02B6/12007 ,  G02F1/065 ,  G02F1/365 ,  G02F2202/105 ,  G02F2203/15

Abstract: Systems and methods for manipulating light with high index contrast waveguides clad with crystalline substances having that exhibit large nonlinear electro-optic constants χ2 and χ3. Waveguides fabricated on SOI wafers and clad with crystalline materials such as barium titanate are described. Embodiments of waveguides having slots, electrical contacts, and input waveguide couplers are discussed. Waveguides having closed loop structures (such as rings and ovals) as well as linear or serpentine waveguides, are described. Optical signal processing methods, such as optical rectification and optical modulation, are disclosed.

Abstract translation: 用具有高非线性电光常数χ2和χ3的结晶物质包覆的高折射率对比波导管来操纵光的系统和方法。 描述了在SOI晶片上制造并用结晶材料如钛酸钡包覆的波导。 讨论了具有槽，电触点和输入波导耦合器的波导的实施例。 描述了具有闭环结构（例如环和椭圆形）以及线性或蛇形波导的波导。 公开了诸如光学校正和光学调制之类的光信号处理方法。

公开(公告)号：US20110031470A1

公开(公告)日：2011-02-10

申请号：US12822109

申请日：2010-06-23

Applicant: Axel Scherer ,  Sameer Walavalkar ,  Michael D. Henry ,  Andrew P. Homyk

Inventor： Axel Scherer ,  Sameer Walavalkar ,  Michael D. Henry ,  Andrew P. Homyk

IPC: H01L29/66 ,  H01L33/00 ,  H01L21/28 ,  H01L29/772 ,  H01L29/775 ,  B82Y40/00

CPC classification number: H01L29/0665 ,  B82Y10/00 ,  B82Y40/00 ,  H01L29/0676 ,  H01L29/413 ,  H01L29/66439 ,  H01L29/66666 ,  H01L29/775 ,  H01L29/7827 ,  H01L33/18 ,  Y10S977/762

Abstract: Methods for fabricating passivated silicon nanowires and an electronic arrangement thus obtained are described. Such arrangements may comprise a metal-oxide-semiconductor (MOS) structure such that the arrangements may be utilized for MOS field-effect transistors (MOSFETs) or opto-electronic switches.

Abstract translation: 描述了制造钝化硅纳米线的方法和由此获得的电子布置。 这种布置可以包括金属氧化物半导体（MOS）结构，使得这些布置可以用于MOS场效应晶体管（MOSFET）或光电开关。