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    METHOD OF PREPARING ORGANIC POROUS SOLIDS AND SOLIDS OBTAINABLE BY THIS METHOD
    162.
    发明申请
    METHOD OF PREPARING ORGANIC POROUS SOLIDS AND SOLIDS OBTAINABLE BY THIS METHOD 审中-公开
    制备有机多孔固体的方法和通过该方法获得的固体

    公开(公告)号：US20100280216A1

    公开(公告)日：2010-11-04

    申请号：US12664755

    申请日：2008-06-16

    Applicant: Markus Antonietti ,  Arne Thomas ,  Pierre Kuhn

    Inventor： Markus Antonietti ,  Arne Thomas ,  Pierre Kuhn

    IPC: C08G73/06

    CPC classification number: C08J9/26 ,  C08J2201/0444 ,  C08J2379/04

    Abstract: The present invention relates to a method of preparing porous solids, which method comprises polymerizing, in a salt melt or a eutectic mixture of salt melt containing at least one Lewis acidic salt, cyano monomers having at least one or at least two cyano groups in their molecule, wherein the at least one or at least two cyano groups are bonded to a rigid linking group in the cyano monomer, as well as to the porous solids obtainable by that method. Owing to their porosity and the associated extremely high specific surface area, the porous solids are useful as sorbents, filtering and insulating materials, as well as catalyst carriers.

    Abstract translation: 本发明涉及一种制备多孔固体的方法，该方法包括在含有至少一种路易斯酸盐的盐熔体或共晶混合物中聚合氰化单体，其中至少一个或至少两个氰基的氰基单体 分子，其中所述至少一个或至少两个氰基键合到所述氰基单体中的刚性连接基团以及通过该方法获得的多孔固体。 由于其孔隙率和相关的极高比表面积，多孔固体可用作吸附剂，过滤和绝缘材料以及催化剂载体。

    Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
    163.
    发明授权
    Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making 失效
    由天然聚合物和合成聚合物制成的多孔聚合物基质和任选的至少一种阳离子和制备方法

    公开(公告)号：US07446131B1

    公开(公告)日：2008-11-04

    申请号：US11058034

    申请日：2005-02-15

    Applicant: LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

    Inventor： LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

    IPC: C08B37/00

    CPC classification number: C08B37/0045 ,  A61L27/26 ,  A61L27/56 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0444 ,  C08J2201/05 ,  C08J2367/04 ,  C08J2405/00 ,  C08L5/06 ,  C08L67/04 ,  C08L5/04 ,  C08L2666/18 ,  C08L2666/26

    Abstract: A porous polymeric matrix containing at least one natural polymer and at least one synthetic polymer and optionally at least one cation. Furthermore, a method of making a porous polymeric matrix involving mixing at least one natural polymer and inorganic salts with a solution comprising at least one solvent and at least one synthetic polymer to form a slurry, casting the slurry in a mold and removing the solvent to form solid matrices, immersing the solid matrices in deionized water to allow natural polymer cross-linking and pore creation to occur simultaneously, and drying the matrices to create a porous polymeric matrix; wherein the matrix contains a cation. Also, a method of making a porous polymeric matrix, involving mixing at least one natural polymer in an aqueous solvent and mixing at least one synthetic polymer in an organic solvent, combining the mixtures and casting in a mold, and separately removing said aqueous solvent and said organic solvent to form a porous polymeric matrix; wherein the porous polymeric matrix does not contain a cation.

    Abstract translation: 含有至少一种天然聚合物和至少一种合成聚合物和任选的至少一种阳离子的多孔聚合物基质。 此外，制备多孔聚合物基质的方法包括将至少一种天然聚合物和无机盐与包含至少一种溶剂和至少一种合成聚合物的溶液混合以形成浆料，将浆料浇铸到模具中并除去溶剂 形成固体基质，将固体基质浸入去离子水中以允许天然聚合物交联和孔产生同时发生，并干燥基质以产生多孔聚合物基质; 其中所述基质含有阳离子。 而且，制备多孔聚合物基质的方法，包括在水性溶剂中混合至少一种天然聚合物并在有机溶剂中混合至少一种合成聚合物，将该混合物和铸件混合在模具中，并分别除去所述水性溶剂和 所述有机溶剂形成多孔聚合物基质; 其中所述多孔聚合物基质不含阳离子。

    Polyhydroxyalkanoate compositions having controlled degradation rates
    166.
    发明授权
    Polyhydroxyalkanoate compositions having controlled degradation rates 有权
    具有受控降解速率的聚羟基链烷酸酯组合物

    公开(公告)号：US06878758B2

    公开(公告)日：2005-04-12

    申请号：US10403942

    申请日：2003-03-28

    Applicant: David P. Martin ,  Frank Skraly ,  Simon F. Williams

    Inventor： David P. Martin ,  Frank Skraly ,  Simon F. Williams

    IPC: A61K9/16 ,  A61K47/48 ,  A61L15/26 ,  A61L17/10 ,  A61L17/12 ,  A61L24/00 ,  A61L26/00 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/06 ,  A61L31/14 ,  C08G63/06 ,  C08G63/64 ,  C08G63/685 ,  C08G63/688 ,  C08G63/91 ,  C08K5/00 ,  C12N5/00 ,  C12P7/62 ,  C08L67/04

    CPC classification number: C08G63/912 ,  A61K9/1647 ,  A61K47/593 ,  A61K47/6957 ,  A61L15/26 ,  A61L17/10 ,  A61L17/12 ,  A61L24/0042 ,  A61L26/0019 ,  A61L26/009 ,  A61L27/18 ,  A61L27/34 ,  A61L27/58 ,  A61L29/06 ,  A61L31/06 ,  A61L31/148 ,  C08G63/06 ,  C08G63/64 ,  C08G63/6852 ,  C08G63/6882 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C12N5/0068 ,  C12N2533/30 ,  C12P7/625 ,  C08L67/04

    Abstract: Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physioogical conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.

    Abstract translation: 已经开发了具有受控降解速率的生物相容性聚羟基链烷酸酯组合物。 在一个实施方案中，聚羟基链烷酸酯含有改变降解速率的添加剂。 在另一个实施方案中，聚羟基链烷酸酯由单体的混合物形成或包括侧链基团或其主链中的修饰以改变其降解速率。 在另一个实施方案中，聚羟基链烷酸酯被化学改性。 用于制造增加孔隙率或暴露表面积的装置的方法可用于改变降解性。 例如，如通过实施例所证明的，多孔聚羟基链烷酸酯可以使用产生孔，空隙或间隙的方法，例如乳液或喷雾干燥技术，或者在聚合物内含有可浸出或可冷冻干燥的颗粒。 实例描述了包括泡沫，涂层，网格和微粒的聚（4HB）组合物。 如实施例所示，这些聚羟基链烷酸酯组合物具有非常有利的机械性能，并且在生理条件下在期望的时间范围内是生物相容的和降解的。 这些聚羟基链烷酸酯材料提供比目前可获得的更广泛的聚羟基链烷酸酯降解速率。 还描述了用于处理这些材料的方法，特别是用于治疗，预防或诊断应用，或可植入或注射的装置。

    Method of producing a processing substrate
    169.
    发明申请
    Method of producing a processing substrate 审中-公开
    制造处理基板的方法

    公开(公告)号：US20040154729A1

    公开(公告)日：2004-08-12

    申请号：US10364628

    申请日：2003-02-11

    Inventor： William E. LeBoeuf ,  William D. Price ,  Bryan L. Ackerman

    IPC: B32B031/12 ,  B32B005/18

    CPC classification number: C08J9/26 ,  A47J47/005 ,  B29C67/202 ,  C08J2201/0422 ,  C08J2201/0444 ,  C08J2207/12 ,  C08J2323/02

    Abstract: A method of creating a layer of a single use processing substrate includes the steps of extruding a polymeric sheet with a particulate substance dispersed therein, cooling the polymeric sheet with the particulate substance therein, removing the particulate substance from the polymeric sheet to form holes in the polymeric sheet, and attaching the polymeric sheet to an absorbent sheet.

    Abstract translation: 一种创建单一使用处理基材层的方法包括以下步骤：将分散有颗粒物质的聚合物片材挤出，用其中的颗粒物质冷却聚合物片材，从聚合物片材中除去颗粒物质以在聚合物片材中形成孔 聚合物片材，并将聚合物片材粘合到吸收片材上。

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