公开(公告)号：US20170074801A1

公开(公告)日：2017-03-16

申请号：US15269912

申请日：2016-09-19

Applicant: FLIR Detection, Inc.

Inventor： Brian Dwayne O'Dell ,  Marcus LaGrone ,  Martin Leuschen

IPC: G01N21/78 ,  G01N33/00

CPC classification number: G01N21/783 ,  G01N21/77 ,  G01N33/0057 ,  G01N2021/7763 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2201/024

Abstract: The invention provides for a multiple analyte detector that is capable of detecting and identifying explosive, chemical or biological substances having multiple analytes with a single system having multiple reporters. The reporters include fluorescent polymers, conducting polymers, metal oxide elements; electrochemical cells, etc. The reporters may be combinations of other reporters that are optimized for broadband detection.

Abstract translation: 本发明提供了一种多分析物检测器，其能够利用具有多个记录器的单个系统来检测和识别具有多个分析物的爆炸性，化学或生物物质。 记者包括荧光聚合物，导电聚合物，金属氧化物元素; 电化学电池等。记者可以是针对宽带检测而优化的其他记者的组合。

公开(公告)号：US20170030874A1

公开(公告)日：2017-02-02

申请号：US15294877

申请日：2016-10-17

Applicant: VUV Analytics, Inc.

Inventor： Dale A. Harrison ,  Anthony T. Hayes ,  Phillip Walsh

IPC: G01N30/78 ,  G01N21/33

CPC classification number: G01N30/78 ,  G01J3/02 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/15 ,  G01N21/33 ,  G01N30/02 ,  G01N30/74 ,  G01N33/0004 ,  G01N33/0027 ,  G01N2021/0325 ,  G01N2021/151 ,  G01N2021/158 ,  G01N2021/335 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2201/024 ,  G01N2201/0633 ,  G01N2201/12 ,  G01N30/7266

Abstract: An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples. Vacuum ultra-violet wavelengths may be utilized. Some of the disclosed techniques can be used for detecting the presence of trace concentrations of gaseous species. A preferable gas flow cell is disclosed. Some of the disclosed techniques may be used with a gas chromatography system so as to detect and identify species eluted from the column. Some of the disclosed techniques may be used in conjunction with an electrospray interface and a liquid chromatography system so as to detect and identify gas phase ions of macromolecules produced from solution. Some of the disclosed techniques may be used to characterize chemical reactions. Some of the disclosed techniques may be used in conjunction with an ultra short-path length sample cell to measure liquids.

公开(公告)号：US09500584B2

公开(公告)日：2016-11-22

申请号：US14125093

申请日：2012-06-25

Applicant: Jacobus Hermanus Maria Neijzen ,  Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko

Inventor： Jacobus Hermanus Maria Neijzen ,  Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko

IPC: G01N21/00 ,  G01N21/59 ,  G01N21/03 ,  G01N21/31 ,  G01N21/552 ,  G01N33/543 ,  G01N21/17

CPC classification number: G01N21/59 ,  G01N21/0303 ,  G01N21/31 ,  G01N21/3151 ,  G01N21/552 ,  G01N33/54326 ,  G01N2021/0325 ,  G01N2021/1738 ,  G01N2021/1742 ,  G01N2201/024 ,  G01N2201/066

Abstract: An apparatus for examination of a sample includes at least one sample chamber in which the sample can be provided, where the sample chamber has a detection surface; at least one light source for emitting a first input light beam which is totally internally reflected at the detection surface of the sample chamber into a first output light beam, and for emitting a second input light beam which is at least partially transmitted through the sample chamber into a second output light beam. The apparatus further includes at least one light detector for detecting the first and the second output light beams. The sample chamber is elongated and traversed in longitudinal direction by light of the second input light beam.

Abstract translation: 用于检查样品的装置包括至少一个样品室，其中可以提供样品，其中样品室具有检测表面; 至少一个光源，用于发射在样品室的检测表面处完全内部反射到第一输出光束中的第一输入光束，并且用于发射至少部分透射通过样品室的第二输入光束 进入第二输出光束。 该装置还包括至少一个用于检测第一和第二输出光束的光检测器。 样品室通过第二输入光束的光线在纵向方向上被细长并横越。

公开(公告)号：US09464329B2

公开(公告)日：2016-10-11

申请号：US13637303

申请日：2011-03-17

Applicant: Edward J. Cargill ,  Kevin L. Deppermann ,  Brad D. White ,  William A. Grote ,  Elias J. Yannakakis ,  Andrew M. Singleton ,  G. David Grothaus ,  Tiffany L. Stephans ,  Allen T. Christian ,  Donald W. Mittanck ,  Yelena A. Dudin

Inventor： Edward J. Cargill ,  Kevin L. Deppermann ,  Brad D. White ,  William A. Grote ,  Elias J. Yannakakis ,  Andrew M. Singleton ,  G. David Grothaus ,  Tiffany L. Stephans ,  Allen T. Christian ,  Donald W. Mittanck ,  Yelena A. Dudin ,  Ramesh Govinthasamy

IPC: C12Q1/68 ,  G01N21/64

CPC classification number: C12Q1/6895 ,  C12Q1/6844 ,  C12Q2600/13 ,  G01N21/643 ,  G01N21/645 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6441 ,  G01N2201/0221 ,  G01N2201/024 ,  G01N2201/062 ,  G01N2201/0627

Abstract: Portable systems and methods for amplifying nucleotides and for detecting nucleotide sequences in a sample are provided. The portable instruments and methods use RPA techniques for DNA amplification and detect sample fluorescence in response to amplification and/or to the presence of specific DNA sequences.

Abstract translation: 提供了用于扩增核苷酸和检测样品中核苷酸序列的便携式系统和方法。 便携式仪器和方法使用RPA技术进行DNA扩增，并响应于扩增和/或特定DNA序列的存在而检测样品荧光。

公开(公告)号：US20160003823A1

公开(公告)日：2016-01-07

申请号：US14829572

申请日：2015-08-18

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes

IPC: G01N33/569

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20150368717A1

公开(公告)日：2015-12-24

申请号：US14789930

申请日：2015-07-01

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Sunny Balwani ,  Michael Chen ,  John K. Frankovich ,  Gary Frenzel ,  Surekha Gangakhedkar ,  Samartha Anekal ,  Adrit Lath ,  Alexander Loo ,  Chinmay Pangarkar ,  Paul Patel ,  Joy Roy ,  Timothy Smith ,  Daniel Young ,  Ian Gibbons

IPC: C12Q1/68 ,  B01L7/00 ,  C12Q1/70

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

公开(公告)号：US20150362431A1

公开(公告)日：2015-12-17

申请号：US14761048

申请日：2014-01-16

Applicant: MAST GROUP LIMITED

Inventor： Ken JIN WONG ,  David Hugh WILLIAMS ,  Iain MCELARNEY ,  Elizabeth GILLIES

IPC: G01N21/64 ,  G01N35/04 ,  G01N33/487 ,  G01N35/00

CPC classification number: G01N21/6428 ,  B01L3/5027 ,  B01L3/545 ,  B01L2300/021 ,  B01L2300/0803 ,  G01J3/46 ,  G01J5/605 ,  G01J2003/466 ,  G01N33/487 ,  G01N35/00 ,  G01N35/00871 ,  G01N35/04 ,  G01N2021/6439 ,  G01N2035/00158 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00752 ,  G01N2035/00851 ,  G01N2035/0441 ,  G01N2201/024 ,  G01N2201/0256 ,  G01N2201/0407

Abstract: A system for conducting an assay comprises a power source (16), a controller (13) for controlling the assay and a plurality of assay units (14) operatively connected to one another such that the controller can communicate with the assay units and the system is capable of conducting the assay. An assay device comprises a substantially circular body (24) having a plurality of chambers in fluid connection such that fluid can pass between said chambers and a central hub (200) having a sample inlet (202) disposed therein for receiving a sample.

Abstract translation: 用于进行测定的系统包括电源（16），用于控制测定的控制器（13）和可操作地彼此连接的多个测定单元（14），使得控制器可以与测定单元和系统 能够进行测定。 测定装置包括具有流体连接的多个腔室的基本上圆形的本体（24），使得流体可以在所述室之间通过，并且具有设置在其中的用于接收样品的样品入口（202）的中心毂（200）。

公开(公告)号：US20150338428A1

公开(公告)日：2015-11-26

申请号：US14789920

申请日：2015-07-01

Applicant: Theranos, Inc.

Inventor： Elizabeth A. Holmes ,  Sunny Balwani ,  Michael Chen ,  John K. Frankovich ,  Gary Frenzel ,  Surekha Gangakhedkar ,  Samartha Anekal ,  Adrit Lath ,  Alexander Loo ,  Chinmay Pangarkar ,  Paul Patel ,  Joy Roy ,  Timothy Smith ,  Daniel Young ,  Ian Gibbons

IPC: G01N35/02 ,  G01N35/10

CPC classification number: G01N35/0092 ,  B01L3/021 ,  B01L3/5082 ,  B01L3/50855 ,  B01L7/52 ,  B01L9/06 ,  B01L9/52 ,  B01L9/543 ,  B01L2300/1827 ,  B01L2300/1855 ,  C12Q1/42 ,  C12Q1/52 ,  C12Q1/6883 ,  C12Q1/70 ,  G01N15/1475 ,  G01N21/25 ,  G01N21/27 ,  G01N33/5005 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/56983 ,  G01N33/62 ,  G01N33/6827 ,  G01N33/80 ,  G01N33/92 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/00069 ,  G01N35/00623 ,  G01N35/00871 ,  G01N35/026 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1009 ,  G01N35/1011 ,  G01N35/1065 ,  G01N35/1072 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2035/00138 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00306 ,  G01N2035/00326 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00425 ,  G01N2035/00435 ,  G01N2035/00495 ,  G01N2035/00633 ,  G01N2035/0449 ,  G01N2035/0474 ,  G01N2035/0486 ,  G01N2035/0491 ,  G01N2035/0493 ,  G01N2035/0494 ,  G01N2201/024 ,  G01N2201/04 ,  G01N2201/12 ,  Y10T436/111666 ,  Y10T436/113332

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

Abstract translation: 提供系统和方法用于样品处理。 可以提供能够接收样品并执行样品制备，样品测定和检测步骤中的一种或多种的装置。 该装置可能能够进行多个测定。 该装置可以包括一个或多个可以执行样品制备，样品测定和检测步骤中的一个或多个的模块。 该装置可以能够使用小体积的样品来执行步骤。

公开(公告)号：US08881580B2

公开(公告)日：2014-11-11

申请号：US13392098

申请日：2010-07-28

Applicant: Ulrich Lundgreen ,  Aria Farjam

Inventor： Ulrich Lundgreen ,  Aria Farjam

IPC: G01N33/00 ,  G01N21/11 ,  F04B43/12 ,  B01L3/00 ,  G01N35/10 ,  G01N21/85 ,  F04B43/08 ,  G01N21/84 ,  G01N21/03 ,  G01N33/18 ,  G01N21/78 ,  G01N21/05 ,  G01N1/40

CPC classification number: G01N21/8507 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2400/0481 ,  F04B43/082 ,  F04B43/12 ,  G01N21/05 ,  G01N21/11 ,  G01N21/78 ,  G01N33/18 ,  G01N35/1095 ,  G01N2001/4016 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/054 ,  G01N2021/8411 ,  G01N2201/0218 ,  G01N2201/024

Abstract: A process analysis unit includes a base module and an exchangeable cartridge module. The base module comprises at least one independent pump drive, and an analyte sensor without a fluidic measuring section. The cartridge module comprises a liquid reservoir tank, a sample taking device, at least one drive-less pump mechanism configured as a peristaltic membrane pump, a fluidic measuring section for the analyte sensor, and a plastic material plate with groove-like microfluidic channels configured to connect the liquid reservoir tank, the at least one drive-less pump mechanism, and a measuring section. The drive-less pump mechanism is driven pneumatically and pumps a liquid from the liquid reservoir tank. When the cartridge module is connected to the base module, the at least one drive-less pump mechanism is connected to and is driven by the at least one independent pump drive, and the fluidic measuring section is connected to the analyte sensor.

Abstract translation: 过程分析单元包括基本模块和可更换盒式模块。 基本模块包括至少一个独立的泵驱动器和不具有流体测量部分的分析物传感器。 盒式模块包括液体储存罐，取样装置，配置为蠕动膜泵的至少一个无驱动泵机构，用于分析物传感器的流体测量部分，以及配置有凹槽状微流体通道的塑料材料板 连接储液箱，至少一个无驱动泵机构和测量部。 无驱动泵机构被气动地驱动，并从液体储存罐泵送液体。 当墨盒模块连接到基座模块时，至少一个无驱动泵机构连接到并由至少一个独立泵驱动器驱动，并且流体测量部分连接到分析物传感器。

公开(公告)号：US20140118745A1

公开(公告)日：2014-05-01

申请号：US14125093

申请日：2012-06-25

Applicant: Jacobus Hermanus Maria Neijzen ,  Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko

Inventor： Jacobus Hermanus Maria Neijzen ,  Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko

IPC: G01N21/59

CPC classification number: G01N21/59 ,  G01N21/0303 ,  G01N21/31 ,  G01N21/3151 ,  G01N21/552 ,  G01N33/54326 ,  G01N2021/0325 ,  G01N2021/1738 ,  G01N2021/1742 ,  G01N2201/024 ,  G01N2201/066

Abstract: The invention relates to means for the examination of a sample, wherein a first input light beam (L1) is totally internally reflected at a detection surface of a sample chamber (111), while a second input light beam (L1′) is transmitted through the sample chamber (111). The resulting first and second output light beams (L2, L2′) are detected and can be evaluated with respect to frustrated total internal reflection and optical absorbance, respectively. Preferably, both output light beams (L2, L2′) are detected by a single image sensor (155).

Abstract translation: 本发明涉及一种用于检查样品的装置，其中第一输入光束（L1）在样品室（111）的检测表面处被全内反射，而第二输入光束（L1'）被透射 样品室（111）。 检测所得到的第一和第二输出光束（L2，L2'），并且可以分别对沮丧的全内反射和光吸收率进行评估。 优选地，两个输出光束（L2，L2'）由单个图像传感器（155）检测。