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公开(公告)号：US20170052117A1
公开(公告)日：2017-02-23
申请号：US14829355
申请日：2015-08-18
Applicant: LumaSense Technologies Holdings, Inc.
Inventor： Terry M. Stapleton , Gregor Hsiao , John Paul Jeffrey
IPC: G01N21/64
CPC classification number: G01N21/643 , G01N21/274 , G01N21/645 , G01N2021/6432 , G01N2021/6434 , G01N2021/773 , G01N2021/7786 , G01N2201/061 , G01N2201/121
Abstract: A system for obtaining a measurement of a species of interest. The system includes one or more reference regions, a sensor region, an exciter unit, a detector unit and a processing unit. The exciter unit exposes first and second chemical transducers in the reference and sensor regions, respectively, to an excitation light while they are exposed to reference environments and an analyte, respectively. The detector unit measures responses of the first and the second chemical transducers to the excitation light. The processing unit determines a compensation for aging of the first chemical transducer from a discrepancy between the measurements of the responses of the first chemical transducer and reference responses. The processing unit applies the compensation for aging to the measurement of the response of the second chemical transducer to obtain the measurement of the species of interest in the analyte.
Abstract translation: 用于获得感兴趣物种的测量的系统。 该系统包括一个或多个参考区域，传感器区域，激励器单元，检测器单元和处理单元。 激励器单元将参考和传感器区域中的第一和第二化学传感器分别暴露于激发光，同时它们分别暴露于参考环境和分析物。 检测器单元测量第一和第二化学传感器对激发光的响应。 处理单元根据第一化学传感器和参考响应的响应的测量之间的差异来确定第一化学传感器的老化的补偿。 处理单元将老化补偿应用于测量第二化学传感器的响应，以获得分析物中感兴趣物种的测量。
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公开(公告)号：US09513223B2
公开(公告)日：2016-12-06
申请号：US14829983
申请日：2015-08-19
Applicant: OLYMPUS CORPORATION
Inventor： Hiroya Fukuyama
CPC classification number: G01N21/6456 , G01N2201/10 , G01N2201/121 , G02B21/06 , G02B21/365
Abstract: A high-resolution fluorescence image in which an afterimage is suppressed is obtained, even when a fluorescence detection interval is shortened. Provided is a scanning observation apparatus including a scanning unit that spatially scans pulsed excitation light emitted from a light source at prescribed time intervals on a specimen; a fluorescence detecting unit that detects fluorescence generated by exciting a fluorescent substance inside the specimen with the excitation light scanned by the scanning unit, in synchronization with the emission of the excitation light; and a fluorescence correcting unit that subtracts, from a fluorescence intensity detected by the fluorescence detecting unit, an afterimage fluorescence component calculated on the basis of time-sequential fluorescence detected by the fluorescence detecting unit prior thereto, at each scanning position, to correct the fluorescence intensity at the scanning position.
Abstract translation: 即使在荧光检测间隔缩短的情况下也能够得到抑制残像的高分辨率的荧光图像。 本发明提供一种扫描观察装置，其具备：扫描单元，其以规定的时间间隔在样本上空间扫描从光源发出的脉冲激发光; 荧光检测单元，其与通过所述激发光的发射同步地检测利用所述扫描单元扫描的激发光来激发所述样本内的荧光物质而产生的荧光; 以及荧光校正单元，从荧光检测单元检测出的荧光强度，在每个扫描位置根据荧光检测单元检测到的时间序列荧光计算的余像荧光成分，从而校正荧光 在扫描位置的强度。
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163.发明申请METHOD FOR CORRECTING A SIGNAL BACKSCATTERED BY A SAMPLE AND ASSOCIATED DEVICE 有权用于校正由样品和相关器件分离的信号的方法公开(公告)号：US20160231249A1
公开(公告)日：2016-08-11
申请号：US15015325
申请日：2016-02-04
Inventor： Blandine ROIG , Anne KOENIG , Jean-Marc DINTEN , Francois PERRAUT
CPC classification number: G01N21/65 , G01J3/0229 , G01J3/027 , G01J3/44 , G01N21/274 , G01N21/49 , G01N21/6458 , G01N21/6486 , G01N2201/06113 , G01N2201/0833 , G01N2201/121 , G02B21/0076
Abstract: The invention relates to a method for correcting an optical signal produced by a sample comprising the following steps: illuminating a surface of the sample by a first light beam, produced by a first light source, the said first light source being coupled to a first optical system, focusing the said first light beam in an object focal plane of the first optical system, the said object focal plane being situated, in the sample, at a measuring depth z from the surface of the sample; measuring, with a first photodetector, of a first optical signal backscattered by the sample in response to the first light beam, the first photodetector producing a first measured signal representative of the said first optical signal, a spatial filter being interposed between the first optical system and the first photodetector, the spatial filter comprising a window which transmits the said first optical signal towards the said first photodetector, the window being disposed in a conjugate focal plane of the object focal plane of the first optical system; wherein the method also comprises the following steps: determining an optical scattering property of the sample; applying a correction function to the first measured signal so as to generate a first corrected signal, the said correction function taking into account the said optical scattering property.
Abstract translation: 本发明涉及一种用于校正由样品产生的光学信号的方法，包括以下步骤：通过由第一光源产生的第一光束照射样品的表面，所述第一光源耦合到第一光学 系统，将所述第一光束聚焦在第一光学系统的物体焦平面中，所述物体焦平面位于样品中，距离样品表面的测量深度z; 利用第一光电检测器响应于第一光束由样品反向散射的第一光信号，第一光电检测器产生表示所述第一光信号的第一测量信号，空间滤光器插入在第一光学系统 并且所述第一光电检测器包括将所述第一光信号朝向所述第一光电检测器传输的窗口，所述窗口设置在所述第一光学系统的物体焦平面的共轭焦平面中; 其中所述方法还包括以下步骤：确定所述样品的光学散射性质; 对第一测量信号应用校正函数，以产生第一校正信号，所述校正函数考虑所述光散射特性。
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公开(公告)号：US20150369750A1
公开(公告)日：2015-12-24
申请号：US14691966
申请日：2015-04-21
Applicant: KLA-Tencor Corporation
Inventor： Mark S. Wang , Chris Kirk , Andrey Kharisov
CPC classification number: G01N21/8851 , G01N21/9501 , G01N2201/068 , G01N2201/10 , G01N2201/121 , G02B21/0028 , G02B21/0032 , G02B21/0072 , G02B21/365 , H01L22/12
Abstract: A line scan wafer inspection system includes a confocal slit aperture filter to remove sidelobes and enhance resolution in the scanning direction. A position detector associated with the slit aperture filter monitors and corrects illumination line image positions relative to the slit aperture to keep image position variations within tolerable limits. Each detector measures a line position and then uses the line position signal to adjust optical, mechanical, and electronic components in the collection path in a feedback loop. The feedback loop may be employed in a runtime calibration process or during inspection to enhance stability.
Abstract translation: 线扫描晶片检查系统包括共焦狭缝孔径滤光器以去除旁瓣并增强扫描方向上的分辨率。 与狭缝孔径滤波器相关联的位置检测器监测和校正相对于狭缝孔径的照明线图像位置，以将图像位置变化保持在可容许的极限内。 每个检测器测量线路位置，然后使用线路位置信号在反馈回路中调整收集路径中的光学，机械和电子部件。 反馈回路可用于运行时校准过程或检查期间以增强稳定性。
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165.发明申请公开(公告)号：US20150300951A1
公开(公告)日：2015-10-22
申请号：US14648874
申请日：2013-12-04
Applicant: SP3H
Inventor： Sylvain OBERTI , Johan FOURNEL
IPC: G01N21/3577 , G01N21/27
CPC classification number: G01N21/3577 , G01N21/274 , G01N21/3504 , G01N2021/3181 , G01N2201/062 , G01N2201/0624 , G01N2201/121 , G01N2201/1211 , G01N2201/124 , G01N2201/1242 , G01N2201/1247 , G01N2201/127 , G01N2201/12723
Abstract: The present invention relates to a method for controlling a spectrometer for analyzing a product, the spectrometer including a light source including several light-emitting diodes having respective emission spectra covering in combination an analysis wavelength band, the method including steps of: supplying at least one of the light-emitting diodes with a supply current to switch it on, measuring a light intensity emitted by the light source by measuring a current at a terminal of at least another of the light-emitting diodes maintained off, determining, according to each light intensity measurement, a setpoint value of the supply current of each diode that is on, and regulating the supply current of each diode that is on so that it corresponds to the setpoint value.
Abstract translation: 本发明涉及一种用于分析产品的光谱仪的控制方法，该光谱仪包括具有多个发光二极管的光源，该发光二极管具有组合分析波长带的各发射光谱，该方法包括以下步骤：将至少一个 的发光二极管与供电电流接通，通过测量至少另一个发光二极管的端子上的电流来测量由光源发射的光强度，根据每个光 强度测量，导通的每个二极管的电源电流的设定值，以及调节导通的每个二极管的电源电流，使其对应于设定值。
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Patent Agency Ranking
公开(公告)号：US20150177148A1
公开(公告)日：2015-06-25
申请号：US14573950
申请日：2014-12-17
Applicant: Luminex Corporation
Inventor： Arnold Estrada
IPC: G01N21/64
CPC classification number: G01N21/6428 , G01N21/274 , G01N21/6408 , G01N21/6452 , G01N21/6486 , G01N2021/6441 , G01N2201/121
Abstract: Techniques are disclosed relating to analysis and reduction of crosstalk between signals. These techniques may be applicable in many fields, such as single-tube PCR or DNA melt analysis, PCR or melt data from neighboring wells of a multi-well plate, capillary electrophoresis data (e.g., DNA sequencing), gas chromatography, multispectral imaging, dual-color fluorescence correlation spectrometry, electrical crosstalk, etc. According to one embodiment, crosstalk between fluorescence signals from different species may be determined based on a correlation between the time derivatives of the fluorescence signals from the fluorescent species.
Abstract translation: 公开了关于分析和减少信号之间的串扰的技术。 这些技术可以应用于许多领域，例如单管PCR或DNA熔解分析，PCR或来自多孔板的相邻孔的熔融数据，毛细管电泳数据（例如DNA测序），气相色谱，多光谱成像， 双色荧光相关光谱，电串扰等。根据一个实施例，可以基于来自荧光物种的荧光信号的时间导数之间的相关性来确定来自不同物种的荧光信号之间的串扰。
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167.发明申请公开(公告)号：US20150177141A1
公开(公告)日：2015-06-25
申请号：US14513386
申请日：2014-10-14
Applicant: SAMSUNG ELECTRONICS CO., LTD.
Inventor： Yeong-bae YEO , Hyun-soo JANG
CPC classification number: G01N21/59 , G01N21/75 , G01N2201/0612 , G01N2201/0621 , G01N2201/0696 , G01N2201/105 , G01N2201/121 , G01N2201/127
Abstract: An optical detection apparatus for measuring detection chambers of a specimen cartridge includes: a light source unit including light sources which are arranged along a scan line on which the detection chambers are aligned to be scanned, and configured to emit light rays to the detection chambers; and an optical detector configured to detect the light rays having passed through corresponding detection chambers disposed on the scan line. The light sources include main wavelength light sources which are used for measuring samples disposed in the detection chambers, and a sub-wavelength light source which is used for correcting a measuring error.
Abstract translation: 一种用于测量样本盒的检测室的光学检测装置，包括：光源单元，包括沿扫描线布置的光源，检测室对准扫描线，并且被配置为向检测室发射光线; 以及光检测器，被配置为检测通过设置在扫描线上的相应检测室的光线。 光源包括用于测量设置在检测室中的样品的主波长光源和用于校正测量误差的亚波长光源。
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公开(公告)号：US09046485B2
公开(公告)日：2015-06-02
申请号：US13694899
申请日：2013-01-16
Applicant: Mark Salerno , I-Tsung Shih , Craig Harrison
Inventor： Mark Salerno , I-Tsung Shih , Craig Harrison
CPC classification number: G01N21/31 , G01N21/00 , G01N21/0303 , G01N21/05 , G01N21/255 , G01N21/59 , G01N2021/0346 , G01N2201/0612 , G01N2201/0853 , G01N2201/121
Abstract: This disclosure relates generally to a sampling device, and more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software controlled algorithms and methods for such a device.
Abstract translation: 本公开一般涉及采样装置，更具体地，涉及用于可变路径长度的光谱测量和用于这种装置的必要的软件控制的算法和方法的采样装置。
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169.发明申请公开(公告)号：US20150090869A1
公开(公告)日：2015-04-02
申请号：US14388358
申请日：2013-04-04
Inventor： Takeaki Shimokawa , Takashi Kosaka , Okito Yamashita , Masaaki Sato
IPC: G01N21/47
CPC classification number: G01N21/4785 , A61B5/0042 , A61B5/0073 , A61B5/0091 , A61B10/0041 , G01N2201/121 , G01N2201/12753
Abstract: In order to solve a problem that a local optical characteristic-changed region inside an object cannot be accurately estimated, an object observing apparatus includes: a light intensity information acquiring unit that acquires light intensity information received by each light-receiving probe; a light intensity change information acquiring unit that acquires, for each probe set, light intensity change information, from reference light intensity information and light intensity information; an estimating unit that acquires three-dimensional optical characteristic-changed region information, using the light intensity change information; and an output unit that outputs the optical characteristic-changed region information; wherein the estimating unit includes: a correcting part that performs correction according to sensitivity attenuation in accordance with a depth; and a sparseness applying part that introduces sparseness for improving a space resolution, thereby acquiring the optical characteristic-changed region information. Accordingly, it is possible to accurately estimate a local optical characteristic-changed region inside an object.
Abstract translation: 为了解决不能准确地估计对象内的局部光学特性变化区域的问题，物体观测装置包括：光强度信息获取单元，其获取由各受光探针接收的光强度信息; 光强度变化信息获取单元，对于每个探针组，从参考光强度信息和光强度信息获取光强度变化信息; 估计单元，使用光强度变化信息获取三维光学特性变化区域信息; 以及输出单元，其输出所述光学特性变化区域信息; 其中所述估计单元包括：校正部，其根据深度根据灵敏度衰减进行校正; 以及引入稀疏性以提高空间分辨率的稀疏性施加部，从而获取光学特性变化区域信息。 因此，可以精确地估计物体内部的局部光学特性变化区域。
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公开(公告)号：US20150080270A1
公开(公告)日：2015-03-19
申请号：US14466742
申请日：2014-08-22
Applicant: APPLIED BIOSYSTEMS, LLC
Inventor： Austin B. TOMANEY , Mark OLDHAM
CPC classification number: G01N21/6486 , G01N21/6428 , G01N2201/06113 , G01N2201/062 , G01N2201/08 , G01N2201/121 , H04N5/225 , H04N5/357 , H04N5/361 , H04N5/367
Abstract: A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the methods of the present teachings and used for signal correction by systems of the present teachings.
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