公开(公告)号：WO2013078414A1

公开(公告)日：2013-05-30

申请号：PCT/US2012/066395

申请日：2012-11-21

Applicant: STC.UNM ,  LUHRS, Claudia, Catalina ,  BROSHA, Eric ,  PHILLIPS, Jonathan

Inventor： LUHRS, Claudia, Catalina ,  BROSHA, Eric ,  PHILLIPS, Jonathan

IPC: B01J37/08 ,  B01J23/44 ,  B01J23/40 ,  B01J6/00

CPC classification number: B01J23/42 ,  B01J21/04 ,  B01J21/063 ,  B01J21/18 ,  B01J23/44 ,  B01J23/745 ,  B01J23/755 ,  B01J35/002 ,  B01J35/006 ,  B01J35/0093 ,  B01J35/1014 ,  B01J35/1028 ,  B01J37/0036 ,  B01J37/04 ,  B01J37/16 ,  H01M4/88 ,  H01M4/8842 ,  H01M4/9041 ,  H01M4/925 ,  H01M4/926

Abstract: Provided is a method for making a supported metal catalyst. The method includes forming a mixture comprising a high surface area support, a reducing agent precursor that decomposes to produce reducing gases below about 1200 °C, and a metal catalyst precursor. The mixture is heated to a temperature sufficient to decompose the reducing agent precursor to produce a reducing agent, and then cooled to form the supported metal catalyst.

Abstract translation: 提供一种制备负载型金属催化剂的方法。 该方法包括形成包含高表面积载体，分解产生低于约1200℃的还原气体的还原剂前体和金属催化剂前体的混合物。 将混合物加热到足以分解还原剂前体以产生还原剂的温度，然后冷却以形成负载的金属催化剂。

公开(公告)号：WO2012174344A2

公开(公告)日：2012-12-20

申请号：PCT/US2012/042609

申请日：2012-06-15

Applicant: STC.UNM ,  SEROV, Alexey ,  HALEVI, Barr ,  ARTYUSHKOVA, Kateryna ,  ATANASSOV, Plamen, B.

Inventor： SEROV, Alexey ,  HALEVI, Barr ,  ARTYUSHKOVA, Kateryna ,  ATANASSOV, Plamen, B.

IPC: B01J31/12 ,  B01J38/02 ,  H01M4/90

CPC classification number: H01M4/8652 ,  B01J23/70 ,  B01J23/8892 ,  B01J35/0033 ,  B01J37/084 ,  H01M4/8621 ,  H01M4/8885 ,  H01M4/9041 ,  H01M4/9083 ,  H01M4/9091 ,  H01M2004/8689

Abstract: A method of preparing M-N-C catalysts utilizing a sacrificial support approach and inexpensive and readily available polymer precursors as the source of nitrogen and carbon is disclosed. Exemplary polymer precursors include non-porphyrin precursors with no initial catalytic activity. Examples of suitable non-catalytic non-porphyrin precursors include, but are not necessarily limited to low molecular weight precursors that form complexes with iron such as 4-aminoantipirine, phenylenediamine, hydroxysuccinimide, ethanolamine, and the like.

Abstract translation: 公开了一种使用牺牲支撑方法制备M-N-C催化剂的方法，并且公开了廉价且容易获得的聚合物前体作为氮和碳的来源。 示例性聚合物前体包括没有初始催化活性的非卟啉前体。 合适的非催化非卟啉前体的实例包括但不一定限于与铁形成络合物的低分子量前体，例如4-氨基安替比林，苯二胺，羟基琥珀酰亚胺，乙醇胺等。

公开(公告)号：WO2012154944A2

公开(公告)日：2012-11-15

申请号：PCT/US2012/037300

申请日：2012-05-10

Applicant: STC.UNM ,  DERETIC, Vojo ,  CASTILLO, Eliseo ,  BRADFUTE, Steven

Inventor： DERETIC, Vojo ,  CASTILLO, Eliseo ,  BRADFUTE, Steven

IPC: A61K39/395 ,  A61P29/00

CPC classification number: A61K31/436 ,  A61K31/12 ,  A61K31/136 ,  A61K31/4184 ,  A61K31/4365 ,  A61K31/4535 ,  A61K31/472 ,  A61K31/473 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/54 ,  A61K31/546 ,  A61K31/5685 ,  A61K31/585 ,  A61K31/65 ,  C07K16/18 ,  G01N33/56972 ,  G01N33/6893 ,  G01N2333/9015

Abstract: The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.

Abstract translation: 本发明提供了治疗自噬介导的疾病和病症以及相关药物组合物，诊断，筛选技术和试剂盒的方法。 在一个实施方案中，本发明提供了一种通过评估LC3水平来确定受试者是否患有或有发展风险和自噬介导的疾病状态和/或状况的方法。

公开(公告)号：WO2012088503A2

公开(公告)日：2012-06-28

申请号：PCT/US2011/067152

申请日：2011-12-23

Applicant: STC.UNM ,  SIBBETT, Scott ,  LAU, Carolin ,  CINICIATO, Gustavo, Pio Marchesi Krall ,  ATANASSOV, Plamen

Inventor： SIBBETT, Scott ,  LAU, Carolin ,  CINICIATO, Gustavo, Pio Marchesi Krall ,  ATANASSOV, Plamen

IPC: H01M8/16 ,  H01M8/02

CPC classification number: H01M8/04216 ,  H01M8/004 ,  H01M8/023 ,  H01M8/0247 ,  H01M8/0252 ,  H01M8/08 ,  H01M8/1009 ,  H01M8/16 ,  H01M8/2455 ,  Y02E60/527

Abstract: The present disclosure provides biological fuel cells comprising a paper-based fuel delivery layer which delivery fuel to the biological anode and cathode via capillary action and/or evaporation. In some embodiments the paper-based fuel delivery layer incorporates an outwardly extending fan-shaped region which enables a constant volumetric flow rate through the cell.

Abstract translation: 本公开提供了生物燃料电池，其包括纸基燃料输送层，其通过毛细管作用和/或蒸发将生物燃料输送到生物阳极和阴极。 在一些实施例中，纸基燃料输送层结合了向外延伸的扇形区域，其使得能够通过细胞的恒定体积流速。

公开(公告)号：WO2012037078A2

公开(公告)日：2012-03-22

申请号：PCT/US2011/051330

申请日：2011-09-13

Applicant: STC.UNM ,  CHACKERIAN, Bryce, C. ,  PEABODY, David, S.

Inventor： CHACKERIAN, Bryce, C. ,  PEABODY, David, S.

IPC: A61K38/16 ,  A61K39/12 ,  A61K47/48 ,  A61K47/42 ,  A61K48/00 ,  A61P11/00 ,  A61P31/12

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K39/295 ,  A61K47/69 ,  A61K47/6901 ,  A61K47/6929 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55566 ,  A61K2039/6075 ,  C07K14/005 ,  C07K2319/40 ,  C12N7/00 ,  C12N2760/18523 ,  C12N2760/18534 ,  C12N2795/00023

Abstract: The invention provides immunotherapeutic and prophylactic bacteriophage viral-like particle (VLPs) which are useful in the treatment and prevention of Respiratory Syncytial Virus (RSV) infections and related disorders, including bronchiolitis and viral pneumonia. Related compositions (e.g, vaccines), nucleic acid constructs, and therapeutic methods are also provided. VLPs and related compositions of the invention induce high titer antibody responses against RSV. VLPs, VLP-containing compositions, and therapeutic methods of the invention induce an immunogenic response against RSV infection, confer immunity against RSV infection, protect against RSV infection, and reduce the likelihood of infection by RSV infection.

Abstract translation: 本发明提供用于治疗和预防呼吸道合胞病毒（RSV）感染和相关病症（包括毛细支气管炎和病毒性肺炎）的免疫治疗和预防性噬菌体病毒样颗粒（VLPs）。 还提供了相关的组合物（例如疫苗），核酸构建体和治疗方法。 本发明的VLP和相关组合物诱导针对RSV的高效价抗体应答。 包含VLP，VLP的组合物和本发明的治疗方法诱导针对RSV感染的免疫原性应答，赋予针对RSV感染的免疫力，防止RSV感染并降低RSV感染感染的可能性。

公开(公告)号：WO2011060334A2

公开(公告)日：2011-05-19

申请号：PCT/US2010/056628

申请日：2010-11-12

Applicant: STC.UNM ,  SMYTH, Hugh, D.C. ,  SELVAM, Parthiban ,  TRUMAN, Charles, Randall

Inventor： SMYTH, Hugh, D.C. ,  SELVAM, Parthiban ,  TRUMAN, Charles, Randall

CPC classification number: A61M15/0028 ,  A61M11/003 ,  A61M15/0031 ,  A61M15/0038 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2206/16

Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.

Abstract translation: 一种干粉吸入器，包括限定用于接收一剂粉末状药剂的腔室的壳体，与腔室流体连通的吸入端口，至少一个气流入口，所述至少一个气流入口提供腔室与外部之间的流体连通 壳体中的颤动元件以及腔室中的颤动元件并且与一定剂量的粉状药剂相关联。 颤动元件具有靠近至少一个气流入口的张紧远端和与远端相对且在入口下游的自由近端。 颤振元件构造成响应于通过腔室的气流而振动并且雾化剂量的粉状药物。

公开(公告)号：WO2009128961A2

公开(公告)日：2009-10-22

申请号：PCT/US2009/031110

申请日：2009-01-15

Applicant: STC.UNM ,  EPSTEIN, Richard, I. ,  MALLOY, Kevin, J. ,  SHEIK-BAHAE, Mansoor

Inventor： EPSTEIN, Richard, I. ,  MALLOY, Kevin, J. ,  SHEIK-BAHAE, Mansoor

IPC: G05D23/00 ,  H01H37/00 ,  H01L39/00

CPC classification number: F28F13/16 ,  F28F2013/008

Abstract: In accordance with the invention, there are thermal switches, method of operating thermal switches and methods of forming thermal switches. A thermal switch can include a thin layer of liquid crystal disposed between a first surface of a first insulating substrate and a second surface of a second insulating substrate, wherein the liquid crystals are aligned at one or more of the first surface and the second surface due to surface preparation.

Abstract translation: 根据本发明，存在热开关，操作热开关的方法以及形成热开关的方法。 热开关可以包括设置在第一绝缘基板的第一表面和第二绝缘基板的第二表面之间的薄液晶层，其中液晶在第一表面和第二表面中的一个或多个处对准 到表面准备。

公开(公告)号：WO2009102363A2

公开(公告)日：2009-08-20

申请号：PCT/US2008/083688

申请日：2008-11-14

Applicant: STC.UNM ,  JIANG, Ying-bing ,  CECCHI, Joseph, L. ,  BRINKER, Charles, Jeffery

Inventor： JIANG, Ying-bing ,  CECCHI, Joseph, L. ,  BRINKER, Charles, Jeffery

IPC: B01D69/10 ,  B01D71/00

CPC classification number: B01D69/122 ,  B01D67/0002 ,  B01D67/0079 ,  B01D67/0083 ,  B01D67/009 ,  B01D69/148 ,  C23C16/401 ,  C23C16/45536 ,  C23C16/45555 ,  Y10T428/24521 ,  Y10T428/24545 ,  Y10T428/249953

Abstract: Ultra-thin hybrid and/or microporous materials and methods for their fabrication are provided. In one embodiment, the exemplary hybrid membranes can be formed including successive surface activation and reaction steps on a porous support that is patterned or non-patterned. The surface activation can be performed using remote plasma exposure to locally activate the exterior surfaces of porous support. Organic/inorganic hybrid precursors such as organometallic silane precursors can be condensed on the locally activated exterior surfaces, whereby ALD reactions can then take place between the condensed hybrid precursors and a reactant. Various embodiments can also include an intermittent replacement of ALD precursors during the membrane formation so as to enhance the hybrid molecular network of the membranes.

Abstract translation: 提供了超薄混合和/或微孔材料及其制造方法。 在一个实施方案中，可以形成示例性混合膜，包括在图案化或非图案化的多孔载体上的连续表面活化和反应步骤。 表面活化可以使用远程等离子体暴露来局部激活多孔载体的外表面。 有机/无机混合前体例如有机金属硅烷前体可以在局部活化的外表面上缩合，由此ALD反应可以在冷凝的杂化前体和反应物之间进行。 各种实施方案还可以包括在膜形成期间ALD前体的间歇替代，以增强膜的杂合分子网络。

公开(公告)号：WO2009097174A3

公开(公告)日：2009-08-06

申请号：PCT/US2009/030304

申请日：2009-01-07

Applicant: STC.UNM ,  SITDIKOV, Ravil ,  IVNITSKIV, Dmitri ,  LOPEZ, Gabriel ,  RAMIREZ, Brianna ,  ATANASSOV, Plamen

Inventor： SITDIKOV, Ravil ,  IVNITSKIV, Dmitri ,  LOPEZ, Gabriel ,  RAMIREZ, Brianna ,  ATANASSOV, Plamen

IPC: G01N27/327 ,  G01N33/48 ,  G01N27/28 ,  G01N33/487 ,  G01N27/416

Abstract: A simple, fast, selective and highly sensitive electrochemical method assay and disposable device for detection of viruses, bacteria, proteins, DNA, and/or organic/inorganic compounds. The sensor has a multi-layered construction, with each successive layer performing a different function. The design further allows for the packing of numerous microscopic electrode transducers onto the small footprint of a biochip device, allowing for a high-density array of sensors.

公开(公告)号：WO2009070282A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/013112

申请日：2008-11-25

Applicant: STC.UNM ,  SMYTH, Hugh, D. ,  OSINSKI, Marek ,  MCGILL, Shayna, L.

Inventor： SMYTH, Hugh, D. ,  OSINSKI, Marek ,  MCGILL, Shayna, L.

IPC: A61K9/14

CPC classification number: A61K9/0009 ,  A61K9/5094 ,  A61K9/5115 ,  A61K9/7023 ,  A61K41/0052 ,  A61K47/6921 ,  A61K47/6923

Abstract: Active multifunctional nanoparticles provide significant enhancement of the efficacy of model therapeutic and gene agents due to increased diffusion and penetration through mucus and biologial barriers under the influence of a magnetic field.

Abstract translation: 活性多功能纳米颗粒由于在磁场的影响下通过粘液和生物学屏障增加扩散和渗透，从而显着提高模型治疗和基因药物的功效。