公开(公告)号：WO2012039614A1

公开(公告)日：2012-03-29

申请号：PCT/NL2011/050639

申请日：2011-09-21

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  JOOSTEN, Leonardus, Antonius, Bernardus ,  NETEA, Mihai, Gheorghe ,  VAN DER MEER, Johannes, Willem, Maarten ,  KULLBERG, Bart, Julian

Inventor： JOOSTEN, Leonardus, Antonius, Bernardus ,  NETEA, Mihai, Gheorghe ,  VAN DER MEER, Johannes, Willem, Maarten ,  KULLBERG, Bart, Julian

IPC: G01N33/569 ,  G01N33/68

CPC classification number: G01N33/6866 ,  G01N33/56911 ,  G01N33/6869 ,  G01N2333/20 ,  Y02A50/57

Abstract: The present invention relates to a method for diagnosing Lyme disease in a subject, the method comprising the steps of: (a) obtaining a sample from said subject, (b) contacting said sample with a source of Borrelia antigens and (c) determining the expression level of a pro-inflammatory cytokine in said sample at the end of step (b).

Abstract translation: 本发明涉及一种用于诊断受试者中的莱姆病的方法，所述方法包括以下步骤：（a）从所述受试者获得样品，（b）使所述样品与Borrelia抗原源接触，（c）确定 在步骤（b）结束时所述样品中促炎细胞因子的表达水平。

公开(公告)号：WO2011049431A1

公开(公告)日：2011-04-28

申请号：PCT/NL2009/050629

申请日：2009-10-19

Applicant: Stichting Katholieke Universiteit, Radboud Universiteit Nijmegen ,  LOOF, Arnoud Harmen ,  VAN HEERDE, Waander Laurens

Inventor： LOOF, Arnoud Harmen ,  VAN HEERDE, Waander Laurens

IPC: G01N33/86

CPC classification number: G01N33/86 ,  G01N33/6848

Abstract: The present invention is concerned with a method for measuring blood coagulation status in a saliva sample from a subject by measuring the concentration of various proteins which have been demonstrated to correlate with the international normalized ratio in said saliva. The invention further relates to a non-invasive device for performing said method, as well as a kit suitable for performing said method.

Abstract translation: 本发明涉及通过测量已证实与所述唾液中的国际标准化比率相关的各种蛋白质的浓度来测量来自受试者的唾液样品中的凝血状态的方法。 本发明进一步涉及用于执行所述方法的非侵入式装置，以及适于执行所述方法的套件。

公开(公告)号：WO2010117264A1

公开(公告)日：2010-10-14

申请号：PCT/NL2010/050171

申请日：2010-04-02

Applicant: Stichting Katholieke Universiteit, Radboud Universiteit Nijmegen ,  DESAIN, Petrus Wilhelmus Maria ,  MCQUEEN, James Maurice

Inventor： DESAIN, Petrus Wilhelmus Maria ,  MCQUEEN, James Maurice

IPC: A61B5/00 ,  A61B5/0484 ,  A61B5/16

CPC classification number: A61B5/04845 ,  A61B5/16 ,  A61B5/486

Abstract: Method for training of a perceptual skill, e.g. using a brain computer interface, which method comprises measuring electrophysiological activity in reaction to a sequence of perceptual stimuli. Furthermore, matching the measured electrophysiological activity signal with a predefined electrophysiological signature signal is performed, in which the predefined electrophysiological signature signal corresponds to an early electrophysiological component. Feedback is provided when a match is detected.

Abstract translation: 用于训练感知技能的方法，例如 使用脑计算机界面，该方法包括测量对感知刺激序列的反应的电生理活性。 此外，执行将测量的电生理活动信号与预定的电生理学签名信号进行匹配，其中预定的电生理特征信号对应于早期的电生理学成分。 检测到匹配时提供反馈。

公开(公告)号：WO2010041938A2

公开(公告)日：2010-04-15

申请号：PCT/NL2009/050600

申请日：2009-10-07

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY THE RADBOUD UNIVERSITY NIJMEGEN MEDICAL CENTRE ,  HERMANS, Peter Wilhelmus Maria ,  BOOTSMA, Hester Jeanette ,  BURGHOUT, Pieter Jan ,  ØSTERGAARD, Christian ,  KUIPERS, Oscar Paul ,  BIJLSMA, Johanna Jacoba Elisabeth ,  KLOOSTERMAN, Tomas Gerrit

Inventor： HERMANS, Peter Wilhelmus Maria ,  BOOTSMA, Hester Jeanette ,  BURGHOUT, Pieter Jan ,  ØSTERGAARD, Christian ,  KUIPERS, Oscar Paul ,  BIJLSMA, Johanna Jacoba Elisabeth ,  KLOOSTERMAN, Tomas Gerrit

IPC: A61K39/09 ,  A61P31/04 ,  C07K16/12

CPC classification number: A61K39/092 ,  A61K39/00 ,  C07K14/3156

Abstract: The present invention provides proteins/genes, which are essential for survival, and consequently, for virulence of Streptococcus pneumoniae in vivo, and thus are ideal vaccine candidates for a vaccine preparation against pneumococcal infection. Further, also antibodies against said protein(s) are included in the invention.

Abstract translation: 本发明提供了生存所必需的蛋白质/基因，并且因此提供了体内肺炎链球菌毒力的蛋白质/基因，因此它们是疫苗制备物的理想疫苗候选物 针对肺炎球菌感染。 此外，针对所述蛋白质的抗体也包括在本发明中。

公开(公告)号：WO2010008276A1

公开(公告)日：2010-01-21

申请号：PCT/NL2009/050421

申请日：2009-07-10

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT, RADBOUD UNIVERSITEIT NIJMEGEN ,  DESAIN, Petrus Wilhelmus Maria ,  FURQUHAR, Jason

Inventor： DESAIN, Petrus Wilhelmus Maria ,  FURQUHAR, Jason

IPC: A61B5/0484 ,  G06F17/00

CPC classification number: A61B5/04845 ,  G06F3/015 ,  G06K9/00496

Abstract: Method and brain computer interface for processing a brain wave signal (14) obtained from a person using a brain wave detector (5). One or more stimuli are applied to the person which each comprise a pseudo random noise component (11a, 11b). A brain wave signal (14) is detected and mental processing of the one or more stimuli (11a, 11b) is tracked by correlating the pseudo random noise component and the brain wave signal.

Abstract translation: 用于处理从使用脑波检测器的人获得的脑波信号（14）的方法和脑计算机接口（5）。 一个或多个刺激被应用于每个包括伪随机噪声分量（11a，11b）的人。 检测脑波信号（14），并通过将伪随机噪声分量与脑波信号相关联来跟踪一个或多个刺激（11a，11b）的心理处理。

公开(公告)号：WO2007073151A1

公开(公告)日：2007-06-28

申请号：PCT/NL2005/050090

申请日：2005-12-21

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  SCHALKWIJK, Josephus ,  LAMME, Evert, Nicolaas ,  BERGERS, Anna, Maria, Gertruda ,  ZEEUWEN, Patrick, Laurentius, Johannes, Maria ,  DE JONGH, Gerardus, Johannes ,  TJABRINGA, Geuranne, Sandra

Inventor： SCHALKWIJK, Josephus ,  LAMME, Evert, Nicolaas ,  BERGERS, Anna, Maria, Gertruda ,  ZEEUWEN, Patrick, Laurentius, Johannes, Maria ,  DE JONGH, Gerardus, Johannes ,  TJABRINGA, Geuranne, Sandra

IPC: C12N5/06

CPC classification number: G01N33/5082 ,  C12N5/0629 ,  C12N2501/11 ,  C12N2501/117 ,  C12N2501/23 ,  C12N2501/25 ,  C12N2503/06 ,  C12N2533/90

Abstract: The present invention relates to the field of psoriasis. Psoriatic skin equivalents are provided in vitro, as well as methods for making and using these.

Abstract translation: 本发明涉及银屑病领域。 在体外提供银屑病皮肤等同物，以及制备和使用它们的方法。

公开(公告)号：WO2007071454A3

公开(公告)日：2007-06-28

申请号：PCT/EP2006/012536

申请日：2006-12-27

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  ADEMA, Gosse, Jan ,  TRIANTIS, Vassilis ,  FIGDOR, Carl, Gustav ,  ANSEMS, Marleen

Inventor： ADEMA, Gosse, Jan ,  TRIANTIS, Vassilis ,  FIGDOR, Carl, Gustav ,  ANSEMS, Marleen

IPC: C07K14/47

Abstract: The present invention relates to isolated nucleic acid molecule encoding the transcription regulator DC- SCRIPT or a derivative thereof. The invention further relates to its use in therapy and to compound for interfering with the biological function of the transcription factor DC-SCRIPT. Such compounds can be compounds interfering with expression of DC-SCRIPT; or compounds interfering with binding of DC- SCRIPT to DNA.

公开(公告)号：WO2007009816A3

公开(公告)日：2007-01-25

申请号：PCT/EP2006/007241

申请日：2006-07-20

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  LEENDERS, Wilhelmus, Petrus, Johannes ,  ROODINK, Ilse ,  RAATS, Jozef, Maria, Hendrik

Inventor： LEENDERS, Wilhelmus, Petrus, Johannes ,  ROODINK, Ilse ,  RAATS, Jozef, Maria, Hendrik

IPC: C07K14/705 ,  C07K16/28 ,  C12Q1/68 ,  G01N33/53 ,  A61K39/00

Abstract: The present invention relates to plexin Dl for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin Dl. Diagnosis is suitably effected by detecting the presence of plexin Dl in the body or a bodily tissue or fluid, whereas treatment is effected by targeting plexin Dl for delivery of therapeutics to the site where treatment is needed. The invention further relates to the use of molecules that bind plexin Dl, a nucleic acid encoding plexine Dl or a ligand of plexin Dl for the preparation of a therapeutical composition for the treatment or diagnosis of disorders that involve expression of plexin Dl. The disorders comprise disorders in which plexin Dl is expressed on tumor cells, tumor blood vessels or activated macrophages.

公开(公告)号：WO2005094806A1

公开(公告)日：2005-10-13

申请号：PCT/EP2004/003629

申请日：2004-03-31

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  UNIVERSITY COURT OF UNIVERSITY OF EDINBURGH ,  DEEN, Peter, Meinardus, Theodorus ,  DETMERS, Frank, Johan, Marinus ,  HOHMANN, Stefan ,  NIELSEN, Søren ,  FRØKIAER, Jørgen ,  ENGEL, Andreas ,  GRUBMÜLLER, Karl, Helmut ,  DE GROOT, Berend, Lammert ,  MÜLLER, Emil, Matthias ,  FLITSCH, Sabine, Lahja ,  BROWN, Fraser, Kendall ,  WERTEN, Paul, Johan, Louis

Inventor： DEEN, Peter, Meinardus, Theodorus ,  DETMERS, Frank, Johan, Marinus ,  HOHMANN, Stefan ,  NIELSEN, Søren ,  FRØKIAER, Jørgen ,  ENGEL, Andreas ,  GRUBMÜLLER, Karl, Helmut ,  DE GROOT, Berend, Lammert ,  MÜLLER, Emil, Matthias ,  FLITSCH, Sabine, Lahja ,  BROWN, Fraser, Kendall ,  WERTEN, Paul, Johan, Louis

IPC: A61K31/14

CPC classification number: A61K31/435 ,  A01N1/021 ,  A01N33/12 ,  A01N43/40 ,  A61K31/14

Abstract: The present invention relates to the use of quaternary ammonium compounds for the preparation of a composition for specifically blocking transport through a particular type of aquaporin. The invention further relates to compositions comprising such quaternary ammonium compounds for use in various applications.

Abstract translation: 本发明涉及季铵化合物用于制备用于特异性阻断通过特定类型水通道蛋白的转运的组合物的用途。 本发明还涉及包含用于各种应用的这种季铵化合物的组合物。

公开(公告)号：WO2004026326A2

公开(公告)日：2004-04-01

申请号：PCT/IB2003/004661

申请日：2003-09-19

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT ,  FIGDOR, Carl, Gustav ,  TORENSMA, Ruurd

Inventor： FIGDOR, Carl, Gustav ,  TORENSMA, Ruurd

IPC: A61K38/00

CPC classification number: A61K38/08 ,  A61K31/702 ,  A61K38/1774 ,  A61K2039/505 ,  C07K16/2851 ,  C07K2317/34 ,  C07K2317/76

Abstract: Dendritic cells (DC) that express the type II C-type lectin DC-SIGN (CD209) are located in the submucosa of tissues, where they mediate HIV-1 entry. Interestingly, the pathogen Candida albicans , the major cause of hospital-acquired fungal infections, is found at similar sites. Here it is demonstrated that DC-SIGN is able to bind Candida albicans both in DC-SIGN transfected cell lines and in human monocyte derived DC. Moreover, in immature DC, DC-SIGN is able to internalize Candida in specific DC-SIGN enriched vesicles, distinct from those containing the mannose receptor (MR; CD206), which is another Candida receptor on DC. Together, these results demonstrate that C . albicans has two major receptors on human monocyte derived DC, these receptors being DC-SIGN and MR. Targeting of DC-SIGN offers novel opportunities to combat chronic forms of candidiasis.

Abstract translation: 表达II型C型凝集素DC-SIGN（CD209）的树突细胞（DC）位于介导HIV-1进入的组织的粘膜下层中。 有趣的是，病原体假丝酵母白色念珠菌是医院获得性真菌感染的主要原因，发现于类似的部位。 在此证明DC-SIGN能够在DC-SIGN转染的细胞系和人单核细胞衍生的DC中均结合白色念珠菌。 此外，在未成熟的DC中，DC-SIGN能够在富含特异性DC-SIGN的囊泡中内化Candida，与含有甘露糖受体（MR; CD206）的那些不同，后者是另一种假丝酵母 / DC受体。 这些结果一起证明了C 。 白色念珠菌在人单核细胞衍生的DC上具有两种主要受体，这些受体是DC-SIGN和MR。 靶向DC-SIGN为慢性念珠菌病的治疗提供了新的机会。