公开(公告)号：WO1992005778A1

公开(公告)日：1992-04-16

申请号：PCT/US1991007297

申请日：1991-10-04

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  PENNSYLVANIA RESEARCH CORPORATION

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  PENNSYLVANIA RESEARCH CORPORATION ,  COHEN, Smadar ,  BANO, Carmen ,  VISSCHER, Karyn, B. ,  CHOW, Marie, B. ,  ALLCOCK, Harry, R. ,  LANGER, Robert, S.

IPC: A61K09/50

CPC classification number: A61K49/223 ,  A61K9/1271 ,  A61K9/1641 ,  A61K9/5031 ,  A61K49/225 ,  A61K49/226 ,  A61K51/1258 ,  A61K2123/00 ,  B01J13/14 ,  C08G79/025 ,  C12N11/04 ,  Y10T428/2984 ,  Y10T428/2985 ,  Y10T428/2987

Abstract: A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked with multivalent ions of the opposite charge to form a gel encapsulating biological material, that is optionally further stabilized by interactions with multivalent polyions of the same charge as those used to form the gel. In the preferred embodiment, hydrolytically stable polyphosphazenes are formed of monomers having carboxylic acid side groups that are crosslinked by divalent or trivalent cations such as Ca?2+? or Al?3+¿, then stabilized with a polycation such as poly-L-lysine. A variety of different compositions can be formed from the crosslinked polymer. In a preferred embodiment, microcapsules are made by spraying an aqueous solution of polyphosphazene and material to be encapsulated into a calcium chloride solution. A semi-permeable membrane is formed on the microspheres by complexation of the surface carboxylate groups with poly(L-lysine).

公开(公告)号：WO1992004752A1

公开(公告)日：1992-03-19

申请号：PCT/US1991006507

申请日：1991-09-06

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  WANG, Christine, A. ,  WALPOLE, James, N. ,  CHOI, Hong, K. ,  DONNELLY, Joseph, P.

IPC: H01S03/10

CPC classification number: H01L33/30 ,  B82Y20/00 ,  H01L33/0062 ,  H01S5/20 ,  H01S5/34313

Abstract: A strained quantum-well diode laser (30) with an AlInGaAs active layer (32) and AlGaAs cladding and/or confining layers (34) on a GaAs substrate (37) is provided. AlInGaAs/AlGaAs lasers can be configured in laser geometries including ridge, waveguide, buried heterostructure, oxide-defined, proton-defined, narrow-stripe, broad-stripe, coupled-stripe and linear arrays using any epitaxial growth technique. Broad-stripe devices were fabricated in graded-index separate confinement heterostructures, grown by organometallic vapor phase epitaxy on GaAs substrates, containing a single Al y In x Ga 1-x-y As quantum well with x between 0.14 and 0.12 and y between 0.05 and 0.17. With increasing Al content, emission wavelengths from 890 to 785 nm were obtained. Threshold current densities, J th's, less than 200 A cm-2 and differential quantum efficiencies in the range 71 to 88 percent were observed.

公开(公告)号：WO1992003702A1

公开(公告)日：1992-03-05

申请号：PCT/US1991006155

申请日：1991-08-28

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  ADELSON, Edward, H.

IPC: G01C03/08

CPC classification number: G01C3/08

Abstract: An optical ranging apparatus is provided which resolves the depth of objects (26) in an object field of a main lens. Light is directed by the main lens (12) to an array of lenticules (18) each of which generates an image of the lens surface. Each image is directed to a photodetector array (23) divided into macropixels each of which receives one of the lenticule images. Each macropixel is made up of a number of subpixels. A data processor receives the signals from the subpixels and assembles subimages, each of which consists of one subpixel from each macropixel. Each subimage represents a view of the entire object field through one portion of the main lens. The data processor determines depth of objects in the object field by comparing the parallex between subimages.

公开(公告)号：WO1992002215A1

公开(公告)日：1992-02-20

申请号：PCT/US1991005681

申请日：1991-08-09

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  WURTMAN, Richard, J. ,  WURTMAN, Judith, J.

IPC: A61K31/135

CPC classification number: A61K31/135

Abstract: A method of treating disturbances of appetite, disturbances of mood, or both, associated with premenstrual syndrome. The method involves administering to the afflicted woman an effective quantity of a serotoninergic drug, such as d-fenfluramine, d,l-fenfluramine, fluoxetine, fluvoxamine or sertraline.

Abstract translation: 与经前综合征相关的一种治疗食欲不振，情绪紊乱或两者兼而有之的方法。 该方法涉及向受影响的妇女施用有效量的5-羟色胺能药物，例如氟芬拉明，d，l-芬氟拉明，氟西汀，氟伏沙明或舍曲林。

公开(公告)号：WO1992001267A1

公开(公告)日：1992-01-23

申请号：PCT/US1991004790

申请日：1991-07-08

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  CHIANG, Alice, M.

IPC: G06G07/19

CPC classification number: H04N19/51

Abstract: A full search block matching algorithm includes a charge-domain serial tapped delay line as an input buffer, and an array of charge domain signal processors. The delay line shifts and holds analog sampled data which are in the form of charge packets. At each stage of delay, the signals are nondestructively sensed and coupled to a corresponding signal processor, and the sampled data are transferred and subsequently processed in parallel. The processed data from all the processors can be read out either in a parallel or serial format through a parallel-in-serial-out output buffer. In this structure, only the serial input buffer has to be clocked at the system throughout rate; the internal clock rate of each processor is reduced by the number of parallel processors. Within each processor, all of the computation functions are performed in the charge domain, and local charge domain memories are included for storing the processed signal.

公开(公告)号：WO1992000448A1

公开(公告)日：1992-01-09

申请号：PCT/US1991003604

申请日：1991-05-22

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  VAN DUYNE, Edward, A.

IPC: F02M07/00

CPC classification number: F02D35/023 ,  F02B1/04 ,  F02B3/06 ,  F02D41/1406 ,  F02D41/18

Abstract: System for controlling a spark ignition engine to maximize fuel efficiency over its entire range of operating conditions. The system includes apparatus (20) for controlling the amount of fuel delivered to the engine and apparatus (26) for measuring the internal cylinder pressure in at least one cylinder of the engine. Apparatus is provided for estimating the air mass entering the engine and computing apparatus (20) calculates the engine efficiency from the amount of fuel delivered, the internal cylinder pressure and the estimated air mass entering the engine. In one embodiment, efficiency is measured by calculation of the approximate indicated specific fuel consumption. Apparatus (20) is provided for varying the amount of fuel delivered to the engine to minimize the indicated specific fuel consumption over the entire range of operating conditions of the engine. In this embodiment, apparatus is provided which is responsive to a desired engine power output beyond wide open throttle plate and apparatus is provided for delivering a greater quantity of fuel beyond the wide open throttle plate posiiton maximum efficiency point.

公开(公告)号：WO1991018638A1

公开(公告)日：1991-12-12

申请号：PCT/US1991003669

申请日：1991-05-28

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  POON, Chi-Sang

IPC: A61M16/20

CPC classification number: A61M16/20 ,  A61M16/08 ,  A61M16/0833 ,  A61M16/0858 ,  A61M16/0866 ,  A61M16/206 ,  A61M39/228 ,  A61M2016/0024

Abstract: Mechanism for triggering the inspiratory phase of a respirator having a three-way connector with an inspiratory conduit (2) and an expiratory conduit (4), each communicating with the respiratory and with a patient communicating conduit (6). Valve mechanism (12, 14) associated with both the expiratory and inspiratory conduits are automatically operated by a patient attempting to breathe, such that he is only exposed to the air volume in the three-way connector and not to the greater air volume of the respirator and its connected tubing.

Abstract translation: 用于触发具有吸气管道和呼气管道的三通连接器的呼吸器的吸气相的机构，每个呼吸器与呼吸器和患者连通导管连通。 与吸气管道和吸气管道相关联的阀门机构由试图呼吸的患者自动操作，使得他仅暴露于三通连接器中的空气体积，而不暴露于呼吸器及其连接的管道 。

公开(公告)号：WO1991017245A1

公开(公告)日：1991-11-14

申请号：PCT/US1991003177

申请日：1991-05-08

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  VARSHAVSKY, Alexander, J. ,  TOBIAS, John, W.

IPC: C12N09/60

CPC classification number: C12N15/62 ,  C07K14/00 ,  C07K2319/00 ,  C07K2319/95 ,  C12N9/60

Abstract: A ubiquitin-specific protease which cleaves ubiquitin from any protein or peptide to which ubiquitin is joined and the gene encoding the protease are disclosed. The protease specifically cleaves the peptide bond in a fusion of ubiquitin to a protein or peptide between the carboxyl-terminal amino acid residue of a ubiquitin moiety and the alpha -amino group of any non-ubiquitin protein or peptide to which ubiquitin is joined. Recombinant expression vectors containing a DNA sequence encoding the ubiquitin-specific protease can be used to transform cells for production of the protease or to provide the cell with the ability to proteolytically deubiquitinate, in vivo, ubiquitin fusions co-produced by the cell. The protease can also be isolated and used to deubiquitinate ubiquitin fusions in vitro. For those proteins or peptides whose functional activity is inhibited or otherwise modified by th e presence of a ubiquitin moiety, this moiety can be used as a temporary inhibitor (or modifier) of the activity of a protein or peptide, whith the ubiquitin-specific protease employed to restore, by deubiquitination, the original activity of the protein or peptide.

Abstract translation: 公开了从泛蛋白连接的任何蛋白质或肽切割泛素的泛素特异性蛋白酶和编码蛋白酶的基因。 蛋白酶在泛素部分的羧基末端氨基酸残基与泛素结合的任何非泛素蛋白质或肽的α-氨基之间的泛素与蛋白质或肽的融合中特异性切割肽键。 含有编码泛素特异性蛋白酶的DNA序列的重组表达载体可用于转化细胞以产生蛋白酶，或为细胞提供在细胞内共同产生的泛素融合蛋白质内泛素化的能力。 蛋白酶也可被分离并用于体内泛素泛素融合。 对于功能活性被泛素部分的存在抑制或另外修饰的那些蛋白质或肽，该部分可以用作蛋白质或肽的活性的临时抑制剂（或修饰剂），与泛素特异性蛋白酶 通过去泛素化来恢复蛋白质或肽的原始活性。

公开(公告)号：WO1991011771A1

公开(公告)日：1991-08-08

申请号：PCT/US1991000489

申请日：1991-01-23

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  HARVEY, Robert, L.

IPC: G06F15/18

CPC classification number: G06N3/126

Abstract: A genetic algorithm search is applied to determine an optimum set of values (Fig. 16A) (e.g., interconnection weights in a neural network), each value being associated with a pair of elements (Fig. 3) drawn from a universe of N elements, N an integer greater than zero, where the utility of any possible set of said values may be measured. An initial possible set of values is assembled, the values being organized in a matrix whose rows and columns correspond to the elements. A genetic algorithm operator (Fig. 8) is applied to generate successor matrices from said matrix. Matrix computations are performed on the successor matrices to generate measures of the relative utilities of the successor matrices. A surviving matrix is selected from the successor matrices on the basis of the metrics. The steps are repeated until the metric of the surviving matrix is satisfactory.

Abstract translation: 应用遗传算法搜索来确定最佳值集合（图16A）（例如，神经网络中的互连权重），每个值与从N个元素的宇宙中绘制的一对元素（图3）相关联 ，N是大于零的整数，其中可以测量任何可能的所述值集合的效用。 组合初始可能的一组值，这些值被组织成一个矩阵，其行和列对应于元素。 应用遗传算法算子（图8）从所述矩阵生成后继矩阵。 对后继矩阵执行矩阵计算，以生成后继矩阵的相对效用度量。 基于指标从后继矩阵中选择幸存矩阵。 重复这些步骤，直到幸存矩阵的度量令人满意。

公开(公告)号：WO1991009825A1

公开(公告)日：1991-07-11

申请号：PCT/US1991000090

申请日：1991-01-04

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  SCHROCK, Richard, R. ,  TOREKI, Robert

IPC: C07C06/04

CPC classification number: C08G61/06 ,  B01J31/2226 ,  B01J31/2265 ,  B01J2231/543 ,  B01J2531/74 ,  C07C2/02 ,  C07C2/38 ,  C07C6/04 ,  C07C67/475 ,  C07C2531/12 ,  C07C2531/22 ,  C07F13/00 ,  C07C69/593

Abstract: The invention pertains to rhenium (VII) compounds which are catalysts for metathesis of ordinary olefins (hydrocarbons) and functionalized olefins in a homogeneous phase and to methods of synthesizing these compounds. The rhenium compounds comprise a rhenium (VII) atom centrally linked to an alkylidene ligand, an alkylidyne ligand, and two other ligands of which at least one ligand is sufficiently electron withdrawing to render the rhenium atom significantly active for metathesis.