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    NOVEL INDOCYANINE COMPOUND, SYNTHESIS METHOD THEREOF, PURIFICATION METHOD THEREOF, DIAGNOSTIC COMPOSITION USING INDOCYANINE COMPOUND, AND DEVICE FOR MEASURING IN VIVO KINETICS AND DEVICE FOR VISUALIZING CIRCULATION USING DIAGNOSTIC COMPOSITION
    172.
    发明公开
    NOVEL INDOCYANINE COMPOUND, SYNTHESIS METHOD THEREOF, PURIFICATION METHOD THEREOF, DIAGNOSTIC COMPOSITION USING INDOCYANINE COMPOUND, AND DEVICE FOR MEASURING IN VIVO KINETICS AND DEVICE FOR VISUALIZING CIRCULATION USING DIAGNOSTIC COMPOSITION 审中-公开
    新型INDOCYANINVERBINDUNG，合成过程可确保清洁方法THEREFOR，诊断组合物BY INDOCYANINVERBINDUNG，用于测量体内运动与设备进行可视化循环使用诊断成分

    公开(公告)号：EP2530093A4

    公开(公告)日：2016-07-06

    申请号：EP11736813

    申请日：2011-01-28

    Applicant: NAT UNIV CORP MIE UNIV ,  UNIV NAGOYA NAT UNIV CORP

    Inventor： TERANISHI KATSUNORI ,  HIRATA HITOSHI ,  ARAI TETSUYA

    IPC: A61K49/00

    CPC classification number: A61K49/0032 ,  A61B5/0071 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/0275 ,  A61B5/201 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7275 ,  A61B5/7425 ,  A61B2576/00 ,  A61K49/001 ,  A61K49/0034 ,  A61K49/0054 ,  A61K49/0093 ,  A61M5/007 ,  C08B37/0012 ,  C08B37/0015 ,  C09B23/0066 ,  C09B23/086 ,  C09B68/41 ,  C09B68/485

    Abstract: The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.

    Abstract translation: 本发明的目的在于提供一种新的化合物的吲哚菁解决常规使用的吲哚花青绿，颜色的问题：如在水中的溶解度或生理盐水，合成方法和其纯化方法，以及诊断组合物包括新颖的吲哚菁化合物。 此外，提供了用于评估新型吲哚菁化合物和用于测量生物动力学的装置，和一种方法和用于可视化流体循环的装置的生物动力学的方法：诸如血液在生物体内，其利用所述诊断组合物。 所以发现在其中在近红外荧光的吲哚菁分子的疏水性部分被包括在环状糖链环糊精的空腔的新型吲哚化合物，以覆盖与葡萄糖的吲哚菁分子中的疏水性部分，以及合成方法和 它们的纯化方法。 进一步，发现是用于荧光的成像比通过静脉内施用肝脏以外的脏器，为了评价新的吲哚菁化合物，用于测量生物动力学的装置，和一种方法和用于可视化流体循环的装置的生物动力学的方法的方法：诸如血液 在活体中，利用所述诊断组合物包含新的吲哚菁化合物。

    VERFAHREN UND NACHWEISVORRICHTUNG ZUR BESTIMMUNG DES HARNSÄURE- UND KREATININ-GEHALTS
    176.
    发明公开
    VERFAHREN UND NACHWEISVORRICHTUNG ZUR BESTIMMUNG DES HARNSÄURE- UND KREATININ-GEHALTS 审中-公开
    VERFAHREN UND NACHWEISVORRICHTUNG ZUR BESTIMMUNG DESHARNSÄURE-UND KREATININ-GEHALTS

    公开(公告)号：EP2707697A1

    公开(公告)日：2014-03-19

    申请号：EP12714642.1

    申请日：2012-04-04

    Applicant: Ldiamon AS

    Inventor： TALISAINEN, Aleksei ,  NEIVELT, Indrek ,  KONOPLEV, Georgy ,  FRORIP, Alexander ,  NACKE, Christoph ,  VASILEVSKY, Alexander

    IPC: G01N21/33 ,  G01N21/85

    CPC classification number: A61M1/16 ,  A61B5/201 ,  A61M1/1601 ,  A61M1/1609 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3313 ,  A61M2205/52 ,  G01N21/33 ,  G01N2021/3181 ,  G01N2201/0627

    Abstract: The invention relates to a method for photometrically determining the uric acid and creatinine content of a liquid, particularly of a dialysate as a control variable in a haemodialysis treatment. The liquid is irradiated with UV radiation at three wavelengths in the range between 235 nm and 300 nm, and the radiation absorption in said liquid is measured at these predetermined wavelengths, a first of which lies in a sub-range between 235 nm and 250 nm, a second lying in a second sub-range between 255 nm and 270 nm, and a third lying in a third sub-range between 280 nm and 300 nm. The uric acid and creatinine contents, and optionally the content of a third component, are calculated from the results of this measurement.

    Abstract translation: 本发明涉及一种用于光学测定血液透析治疗中作为对照变量的液体，特别是透析液的尿酸和肌酸酐含量的方法。 在235nm和300nm之间的范围内的三个波长的紫外线照射液体，并且在这些预定波长处测量所述液体中的辐射吸收，其中第一个位于235nm和250nm之间的子范围内 ，位于255nm和270nm之间的第二子范围中的第二个，以及位于280nm和300nm之间的第三子范围的第三子范围。 根据该测量的结果计算尿酸和肌酐含量，以及任选地第三组分的含量。

    IMPROVED METHODS FOR DIAGNOSTIC IMAGING INVOLVING THE USE OF A CONTRAST AGENT AND A CORONARY VASODILATOR
    180.
    发明授权
    IMPROVED METHODS FOR DIAGNOSTIC IMAGING INVOLVING THE USE OF A CONTRAST AGENT AND A CORONARY VASODILATOR 失效
    用于诊断成像方法的改进使用造影剂和冠状动脉扩张剂

    公开(公告)号：EP1017425B2

    公开(公告)日：2010-12-15

    申请号：EP97938609.1

    申请日：1997-08-26

    Applicant: Lantheus Medical Imaging, Inc.

    Inventor： UNGER, Evan, C.

    IPC: A61K49/22

    CPC classification number: A61B5/411 ,  A61B5/201 ,  A61K49/223 ,  A61K49/227

    Abstract: Improved method for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combinationwith a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.

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