公开(公告)号：US20120234393A1

公开(公告)日：2012-09-20

申请号：US13457199

申请日：2012-04-26

Applicant: George Maltezos ,  Jeremy Witzens ,  Axel Scherer

Inventor： George Maltezos ,  Jeremy Witzens ,  Axel Scherer

IPC: F03B11/00

CPC classification number: G01N21/6428 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/14 ,  B01L2400/0478 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638 ,  B01L2400/0655 ,  B01L2400/0683 ,  B81C1/00119 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/6456 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/0364 ,  G01N2201/024 ,  Y10T137/0318 ,  Y10T137/0396 ,  Y10T137/1714 ,  Y10T137/2202 ,  Y10T137/8811

Abstract: An apparatus for analysis of a sample and in particular of a biological sample. The apparatus contains a microfluidic chip with dies, adapted to be selectively activated or deactivated by presence of target molecules in the biological sample. The apparatus further contains a light source to emit light for illumination of the microfluidic chip and an optical filter to allow passage of the light from the dies once activated or deactivated by the presence of the target molecules. A method for pressurizing a microfluidic chip is also disclosed, where a chamber is provided, the chamber is connected with the microfluidic chip and pressure is applied to the chamber.

Abstract translation: 用于分析样品，特别是生物样品的装置。 该装置包含具有管芯的微流体芯片，适于通过生物样品中目标分子的存在而被选择性地活化或失活。 该装置还包含用于发射微流芯片照明的光源和滤光器，以允许通过靶分子的存在激活或去激活来自模具的光的通过。 还公开了一种用于对微流体芯片加压的方法，其中设置有腔室，腔室与微流体芯片连接，并且将压力施加到腔室。

公开(公告)号：US20120077282A1

公开(公告)日：2012-03-29

申请号：US13311164

申请日：2011-12-05

Applicant: Michael Katzlinger ,  Josef J. Atzler ,  Daniel M. Stock

Inventor： Michael Katzlinger ,  Josef J. Atzler ,  Daniel M. Stock

IPC: G01N21/75

CPC classification number: G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/645 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample are provided. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with a cartridge support of the apparatus in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed. The cartridge support includes a plurality of cartridge positions that receive cartridges concurrently. One of the cartridges may be a luminescence cartridge that includes an integrated detector that is movable toward and away from a sample carrier of the apparatus, and thus toward and away from a sample located at the sample carrier.

Abstract translation: 提供了用于分析样品的装置中的盒和盒系统。 该系统具有用于多模仪器的不同应用的多个盒。 墨盒以“插入”格式与装置的墨盒支架可拆卸地接合，使得一个墨盒可以从设备中取出，另一墨盒可以容易地安装。 盒支架包括同时接收盒的多个盒位置。 其中一个盒可以是发光盒，其包括集成检测器，该检测器可朝向和远离装置的样品载体移动，并且因此朝向和离开位于样品载体处的样品。

公开(公告)号：US20110304844A1

公开(公告)日：2011-12-15

申请号：US12861942

申请日：2010-08-24

Applicant: Bert WILLING ,  Markus Kohli ,  Andreas Seifert

Inventor： Bert WILLING ,  Markus Kohli ,  Andreas Seifert

IPC: G01N21/61 ,  G01J3/00

CPC classification number: G01N21/39 ,  G01N21/0332 ,  G01N33/004 ,  G01N33/006 ,  G01N2021/158 ,  G01N2021/3129 ,  G01N2021/3144 ,  G01N2021/354 ,  G01N2021/399 ,  G01N2201/024 ,  Y02A50/244

Abstract: An TDLS gas sensor with a measuring pick-up to be arranged outside of the interior chamber of an incubator or a climate chamber of similar design, and with an absorption pick-up to be arranged inside the interior chamber, and also with a window separating the measuring area and absorption area for the atmospheric separation of the laser diode from the interior chamber of the incubator, with the window being arranged at an angle to the axis of the laser beam emitted by a laser diode, and with the optronic components being arranged in a block of material in the measuring pick-up, said block being made of thermally well-conducting material and serving as heat sink, and with a heating system for the window in the measuring pick-up. The TDLS gas sensor is easy to install and remove and permits the measurement of moisture and of the carbon dioxide concentration in one measuring cycle. However, it does not need to be removed for the sterilization. By installing an additional laser diode for measuring oxygen, the TDLS gas sensor can be used to perform a wide bandwidth of measurements. In addition, the invention concerns a process for measuring the moisture and the carbon dioxide concentration.

Abstract translation: 具有测量拾取器的TDLS气体传感器将布置在孵化器或类似设计的气候室的内部室外，并且吸收拾取器布置在内部室内，并且还具有分隔开的窗口 所述测量区域和所述激光二极管与所述培养箱的内部室大气分离的吸收区域，其中所述窗口以与激光二极管发射的激光束的轴线成一定角度布置，并且所述光电子部件被布置 在测量拾取器中的一块材料中，所述块由导热材料制成并用作散热器，并且具有用于测量拾取器中的窗口的加热系统。 TDLS气体传感器易于安装和拆卸，允许在一个测量周期内测量水分和二氧化碳浓度。 但是，不需要去除灭菌。 通过安装用于测量氧气的附加激光二极管，TDLS气体传感器可用于执行宽带宽的测量。 此外，本发明涉及一种测量水分和二氧化碳浓度的方法。

公开(公告)号：US20110299289A1

公开(公告)日：2011-12-08

申请号：US12795501

申请日：2010-06-07

Applicant: William H. Wynn

Inventor： William H. Wynn

IPC: F21V19/00

CPC classification number: G01N21/01 ,  G01N21/31 ,  G01N2201/024

Abstract: Self-aligning light source and detector assembly having a sensor support mounted in a predetermined, fixed position, a light source holder mounted in a predetermined, fixed position relative to the sensor support, a sensor mounted in a fixed position on the sensor support, and a lamp assembly removably mounted to the light source holder in a predetermined position defined by mating surfaces which engage each other and seat the lamp assembly in the predetermined position whenever the lamp assembly is installed in the holder.

Abstract translation: 自对准光源和检测器组件，其具有安装在预定的固定位置的传感器支撑件，相对于传感器支撑件安装在预定的固定位置的光源保持器，安装在传感器支架上的固定位置的传感器，以及 灯组件，其可拆卸地安装到光源保持器上，该预定位置由彼此接合的配合表面限定，并且每当灯组件安装在保持器中时将灯组件安置在预定位置。

公开(公告)号：US20110133101A1

公开(公告)日：2011-06-09

申请号：US12987736

申请日：2011-01-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G01J1/58 ,  G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00117 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0646 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086 ,  G02B6/29362 ,  G02B21/16

Abstract: An imaging device including an illumination module including at least one emitter for emitting at least one excitation beam, a scanning and injection module including an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers, and a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide, and a detection module including at least one detector for detecting at least one luminous flux collected at the distal end of the image guide. At least one of the illumination module and the detection module is optically conjugated with the scanning and injection module by a conjugating optical fiber.

Abstract translation: 一种成像装置，包括包括至少一个用于发射至少一个激发光束的发射器的照明模块，包括图像引导件的扫描和注射模块，其近端和远端由多根光纤连接， 扫描和注射光学系统，被配置为将至少一个激发光束从图像引导件的近端交替地注入到图像引导件的光纤中，以及检测模块，包括至少一个检测器，用于检测在 图像引导件的远端。 照明模块和检测模块中的至少一个通过共轭光纤与扫描和注入模块光学共轭。

公开(公告)号：US07835601B2

公开(公告)日：2010-11-16

申请号：US11871389

申请日：2007-10-12

Applicant: Volker Seyfried ,  Rafael Storz

Inventor： Volker Seyfried ,  Rafael Storz

IPC: G02B6/28 ,  G02B6/36 ,  H01S3/30 ,  H01S3/10

CPC classification number: H01S3/02 ,  G01N21/6458 ,  G01N2201/024 ,  G02B21/0032 ,  H01S3/2383

Abstract: A device for generating a laser light beam includes a module. The module includes at least one laser light source, and a mechanical, an electrical and/or an optical interface defined towards an outside of the module.

Abstract translation: 用于产生激光束的装置包括模块。 该模块包括至少一个激光光源，以及朝向模块的外部限定的机械，电和/或光学接口。

公开(公告)号：US20090097806A1

公开(公告)日：2009-04-16

申请号：US12249665

申请日：2008-10-10

Applicant: Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

Inventor： Bertrand Viellerobe ,  Francois Lacombe ,  Nicolas Boularot ,  Francois Doussoux ,  Nicolas Lavillonniere

IPC: G02B6/06

CPC classification number: G01N21/6458 ,  A61B1/00165 ,  A61B1/00186 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/07 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0084 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024 ,  G01N2201/0846 ,  G01N2201/086

Abstract: An imaging device includes an illumination module comprising at least one emitter for emitting at least one excitation beam; a scanning and injection module comprising an image guide, a proximal end and a distal end of which are linked by a plurality of optical fibers; a scanning and injection optical system configured to alternately inject the at least one excitation beam into an optical fiber of the image guide from the proximal end of the image guide; a detection module comprising a detector for detecting a luminous flux collected at the distal end of the image guide, wherein at least one of the illumination module and the detection module is optically conjugated with the scanning and injection module using a conjugating optical fiber.

Abstract translation: 一种成像装置包括：照明模块，包括至少一个用于发射至少一个激发光束的发射器; 扫描和注射模块，包括图像引导件，其近端和远端由多根光纤连接; 扫描和注射光学系统，被配置为从所述图像引导件的近端交替地将所述至少一个激发光束注入到所述图像引导件的光纤中; 检测模块，包括用于检测在图像引导件的远端处收集的光通量的检测器，其中照明模块和检测模块中的至少一个使用共轭光纤与扫描和注射模块光学共轭。

公开(公告)号：US20080003142A1

公开(公告)日：2008-01-03

申请号：US11803104

申请日：2007-05-11

Applicant: Darren Link ,  Michael Weiner ,  David Marran ,  Jonathan Rothberg

Inventor： Darren Link ,  Michael Weiner ,  David Marran ,  Jonathan Rothberg

IPC: G01N21/64 ,  B01L3/00 ,  B29C33/38

CPC classification number: B01F3/0807 ,  B01F13/0062 ,  B01J19/0093 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502784 ,  B01L3/565 ,  B01L7/525 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/165 ,  B01L2400/0415 ,  B01L2400/0424 ,  B01L2400/0487 ,  B01L2400/086 ,  B03C5/005 ,  B03C5/026 ,  C12N15/1068 ,  C12N15/1086 ,  C12Q1/00 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q1/6855 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q2565/628 ,  C12Q2565/629 ,  G01N15/147 ,  G01N21/05 ,  G01N21/64 ,  G01N27/3275 ,  G01N35/08 ,  G01N2021/0346 ,  G01N2035/00237 ,  G01N2035/00326 ,  G01N2201/024 ,  Y10T137/87571 ,  Y10T137/87619 ,  Y10T137/87652 ,  C12Q2525/191 ,  C12Q2563/159 ,  C12Q2535/101 ,  C12Q2563/149 ,  C12Q2531/113

Abstract: The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.

Abstract translation: 本发明提供了可用于进行生物学，化学和诊断测定的新型微流体底物和方法。 基板可以包括多个可电寻址的通道支承流体模块，其一体地布置成使得提供用于不混溶流体流动的连续通道。

公开(公告)号：US20070183931A1

公开(公告)日：2007-08-09

申请号：US11351181

申请日：2006-02-08

Applicant: Daniel Stock ,  Josef Atzler

Inventor： Daniel Stock ,  Josef Atzler

IPC: G01N21/00

CPC classification number: G01N21/645 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0232 ,  G01J3/0235 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/427 ,  G01J3/4406 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/763 ,  G01N2021/1738 ,  G01N2021/6415 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/024 ,  G01N2201/0618 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0692 ,  G01N2201/0696

Abstract: A cartridge and cartridge system for use in an apparatus for analyzing a sample is provided. The cartridge has one or more light sources and/or optical systems and other components that are specific for a certain type of application such as fluorescence, absorbance, or luminescence. The light source, optical systems, and other components for a specific application are housed in a single cartridge. The system has a plurality of cartridges for different applications for a multimode instrument. The cartridges are removably engaged with the apparatus in a “plug-in” format such that one cartridge may be removed from the apparatus and another cartridge may be easily installed.

Abstract translation: 提供了一种用于分析样品的装置中的盒和盒系统。 盒具有一个或多个光源和/或光学系统以及其它特定于某种类型的应用，如荧光，吸光度或发光的组件。 用于特定应用的光源，光学系统和其他部件容纳在单个盒中。 该系统具有用于多模仪器的不同应用的多个盒。 盒可以以“插入”格式可移除地与设备接合，使得一个盒可以从设备移除，并且另一个盒可以容易地安装。

公开(公告)号：US07230697B2

公开(公告)日：2007-06-12

申请号：US11040709

申请日：2005-01-20

Applicant: Mark F. Hopkins ,  Yashvinder Sabharwal ,  Cynthia Vernold

Inventor： Mark F. Hopkins ,  Yashvinder Sabharwal ,  Cynthia Vernold

IPC: G01J3/28

CPC classification number: G01N21/6458 ,  G01J3/0202 ,  G01J3/0229 ,  G01J3/0235 ,  G01J3/0237 ,  G01J3/024 ,  G01J3/0291 ,  G01J3/04 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/2889 ,  G01J3/36 ,  G01N2021/6423 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/024 ,  G01N2201/10 ,  G01N2201/103 ,  G02B21/26

Abstract: A method and apparatus is disclosed for multi-mode spectral imaging. In one embodiment, the present invention comprises the steps of illuminating an object with a modified illumination profile, producing a reflected, transmitted or fluorescence image of the illuminated object, scanning the object, and re-imaging the reflected, transmitted or fluorescence light after modifying the light's optical state. The present invention preferably works in conjunction with other imaging systems to provide both high-spectral resolution images with lower temporal resolution and multiple image acquisition with high temporal resolution.

Abstract translation: 公开了用于多模式光谱成像的方法和装置。 在一个实施例中，本发明包括以下步骤：用修改的照明轮廓照亮物体，产生被照射物体的反射，透射或荧光图像，扫描物体，以及在修改之后对反射的，透射的或荧光进行重新成像 光的光学状态。 本发明优选与其他成像系统结合使用，以提供具有较低时间分辨率的高光谱分辨率图像和具有高时间分辨率的多个图像采集。