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    Luminescence test and exposure apparatus
    171.
    发明授权
    Luminescence test and exposure apparatus 失效
    发光测试和曝光设备

    公开(公告)号：US5772967A

    公开(公告)日：1998-06-30

    申请号：US237239

    申请日：1994-05-02

    Applicant: Jon C. Wannlund ,  Jerry W. Smith

    Inventor： Jon C. Wannlund ,  Jerry W. Smith

    IPC: B01L3/00 ,  C12M1/20 ,  G01N21/03 ,  G01N21/76

    CPC classification number: B01L3/5025 ,  B01L3/50255 ,  G01N21/03 ,  G01N21/76 ,  G01N2021/0325 ,  G01N2021/0328 ,  G01N2021/0357 ,  G01N2021/1768 ,  G01N2201/0446 ,  Y10T436/111666 ,  Y10T436/25375

    Abstract: Apparatus for performing and measuring chemical reactions includes a reaction test apparatus having reaction wells wherein reactants are controllably mixed, and exposure apparatus which receives and positions the reaction test apparatus adjacent a photographic film. Each of the reaction wells includes at least two reaction chambers, arranged in a side by side fashion. All but the final reaction chamber have upwardly sloping sides, so that liquid placed in one reaction chamber can flow to the next reaction chamber when the apparatus is tilted. In a preferred embodiment, the reaction wells are supported in a plate that is structurally integral with the wells but separates the wells from each other. The test plate is retained in the exposure apparatus, and liquid is controllably flowed from one reaction chamber to the next by tilting the exposure apparatus. The apparatus of the invention is particularly suited for measuring reactions that produce luminescence of short duration, as the reactants can be conveniently mixed in darkness, while the film is being exposed.

    Abstract translation: 用于进行和测量化学反应的装置包括具有可反应混合反应物的反应孔的反应试验装置，以及将反应试验装置接收并定位在照相胶片附近的曝光装置。 每个反应井包括至少两个以并排排列的反应室。 除最终反应室之外的所有反应室都具有向上倾斜的侧面，使得当设备倾斜时，放置在一个反应​​室中的液体可以流到下一个反应室。 在优选的实施方案中，将反应孔支撑在与孔结构一体的板中，但将孔彼此分离。 测试板保持在曝光装置中，并且通过倾斜曝光装置可控地从一个反应室流向液体。 本发明的装置特别适用于测量产生短持续时间的发光的反应，因为反应物可以在黑暗中方便地混合，同时曝光该膜。

    Photometer
    172.
    发明授权
    Photometer 失效
    光度计

    公开(公告)号：US5307144A

    公开(公告)日：1994-04-26

    申请号：US984535

    申请日：1992-12-01

    Applicant: Tamura Hiroshi ,  Tanaka Shigenori

    Inventor： Tamura Hiroshi ,  Tanaka Shigenori

    IPC: G01N21/01 ,  B01L3/00 ,  B01L7/02 ,  C12M1/34 ,  G01N21/03 ,  G01N21/25 ,  G01N21/59 ,  G01N21/75 ,  G01N21/27

    CPC classification number: B01L3/50851 ,  B01L3/50853 ,  B01L7/02 ,  G01N21/031 ,  G01N21/253 ,  G01N2021/0325 ,  G01N21/0332 ,  G01N2201/0446 ,  Y10S436/809

    Abstract: The present invention intends to generally maintain the microplate having added test samples in wells therein at even temperature for measuring biochemical or biological reaction accompanying changes in absorbance such as enzyme reaction. Monochromatic lights with various wave lengths from a light source 3 are transmitted through the test samples added to a plurality of wells in a microplate 1 to measure absorbance of the test sample. For this end, a metal plate 2 with good heat conductivity is substantially contacted with the bottom of each well in the microplate 1 and a perforated board 7 is disposed with an air space over the microplate 1 at the starting position thereof. Warmed air heated by a heater 17 is blown onto the microplate 1 through the perforated board 7 and is circulated along the metal plate 2 within a chamber 9.

    Abstract translation: 本发明旨在通常在均匀温度下保持在孔中加入测试样品的微板，用于随着吸光度如酶反应的变化而测量生物化学或生物反应。 来自光源3的具有各种波长的单色光通过添加到微板1中的多个孔的测试样品传输，以测量测试样品的吸光度。 为此，具有良好导热性的金属板2基本上与微板1中的每个孔的底部接触，并且多孔板7在微孔板1的起始位置处设置有空气空间。 通过加热器17加热的暖气被穿孔板7吹送到微量板1上，并在室9内沿着金属板2循环。

    Apparatus for measuring aggregation patterns on a microplate
    173.
    发明授权
    Apparatus for measuring aggregation patterns on a microplate 失效
    用于测量麦克风上的聚集图案的装置

    公开(公告)号：US5234665A

    公开(公告)日：1993-08-10

    申请号：US700567

    申请日：1991-05-15

    Applicant: Masato Ohta ,  Yasuhiko Yokomori ,  Toshiyuki Furuta ,  Hideo Suda ,  Naoki Ozawa ,  Shogo Kida

    Inventor： Masato Ohta ,  Yasuhiko Yokomori ,  Toshiyuki Furuta ,  Hideo Suda ,  Naoki Ozawa ,  Shogo Kida

    IPC: G01N21/17 ,  G01N21/25 ,  G01N21/59 ,  G01N21/82 ,  G01N33/543

    CPC classification number: G01N21/253 ,  G01N21/82 ,  G01N2021/5957 ,  G01N2201/0446

    Abstract: An aggregation pattern detecting apparatus includes a microplate having a plurality of reactive vessels in which aggregation patterns are formed, a light source arranged above the microplate, and a light sensor arrangement positioned below the microplate. The microplate is removably fastened to a main body, and a movable frame is movably supported on the main body. The light source and light sensor arrangement are carried on the movable frame for movement therewith. A driving mechanism effects movement of the movable frame and is controlled by a main control section. A reference plate is provided separately from the microplate, and has a plurality of through holes therein which correspond to the reactive vessels of the microplate. The reference plate is removably fastenable to the main body at the normal operative position of the microplate. With the reference plate in this position, the distance from a starting point of the driving mechanism to the through holes of the reference plate is measured and stored in the main control section. Based on these stored distances, the main control section determines appropriate operational positions for the light sensor.

    Abstract translation: 聚集图案检测装置包括具有形成聚集图案的多个反应性血管的微孔板，布置在微孔板上方的光源和位于微板下方的光传感器装置。 微板可拆卸地固定在主体上，可移动的框架可移动地支撑在主体上。 光源和光传感器装置承载在可移动框架上以与其一起运动。 驱动机构实现可动框架的移动，由主控制部控制。 参考板与微孔板分开设置，并且在其中具有多个对应于微孔板的反应性容器的通孔。 参考板可移除地在微板的正常操作位置处紧固到主体。 在该位置的参考板上，测量从驱动机构的起点到参考板的通孔的距离并将其存储在主控制部分中。 基于这些存储的距离，主控制部分确定光传感器的适当操作位置。

    Luminescence exposure apparatus
    174.
    发明授权
    Luminescence exposure apparatus 失效
    发光曝光装置

    公开(公告)号：US4985631A

    公开(公告)日：1991-01-15

    申请号：US308718

    申请日：1989-02-13

    Applicant: Jon C. Wannlund ,  Jerry W. Smith

    Inventor： Jon C. Wannlund ,  Jerry W. Smith

    IPC: B01L3/00 ,  C12M1/20 ,  G01N21/03 ,  G01N21/76

    CPC classification number: B01L3/5025 ,  B01L3/50255 ,  G01N21/03 ,  G01N21/76 ,  G01N2021/0325 ,  G01N2021/0328 ,  G01N2021/0357 ,  G01N2021/1768 ,  G01N2201/0446 ,  Y10T436/111666 ,  Y10T436/25375

    Abstract: Apparatus for performing and measuring chemical reactions includes a reaction test apparatus having reaction wells wherein reactants are controllably mixed, and exposure apparatus which receives and positions the reaction test apparatus adjacent a photographic film. Each of the reaction wells includes at least two reaction chambers, arranged in a side by side fashion. All but the final reaction chamber have upwardly sloping sides, so that liquid placed in one reaction chamber can flow to the next reaction chamber when the apparatus is tilted. In a preferred embodiment, the reaction wells are supported in a plate that is structurally integral with the wells but separates the wells from each other. The test plate is retained in the exposure apparatus, and liquid is controllably flowed from one reaction chamber to the next by tilting the exposure apparatus. The apparatus of the invention is particularly suited for measuring reactions that produce luminescence of short duration, as the reactants can be conveniently mixed in darkness, while the film is being exposed.

    Method and apparatus for providing quality assurance and calibration assurance in a spectrophotometer
    175.
    发明授权
    Method and apparatus for providing quality assurance and calibration assurance in a spectrophotometer 失效
    在分光光度计中提供质量保证和校准保证的方法和设备

    公开(公告)号：US4892405A

    公开(公告)日：1990-01-09

    申请号：US256568

    申请日：1988-10-12

    Applicant: Keld Sorensen ,  James N. Macri ,  Timothy J. Douros ,  Paul Sajda ,  Emiddio V. Ippolito

    Inventor： Keld Sorensen ,  James N. Macri ,  Timothy J. Douros ,  Paul Sajda ,  Emiddio V. Ippolito

    IPC: G01N21/27 ,  G01N21/29 ,  G12B13/00

    CPC classification number: G01N21/274 ,  G12B13/00 ,  G01N21/293 ,  G01N2201/0446 ,  G01N2201/126

    Abstract: An apparatus for the calibration and quality assurance of a multichannel spectrophotometer, particularly an ELISA spectrophotometer, comprises a series of filters having a known first color and linearly increasing optical density. The response of the spectrophotometer is measured against the known color and linearly increasing optical density. Additional filters of at least one additional color permit checking the color response of the spectrophotmeter. An algorithm determines whether the response conforms to predetermined conditions. An output is produced to provide a record of the calibration and quality assurance of the spectrophotometer. The invention has particular utility for conducting calibration and quality assurance of ELISA spectrophotometers used in clinical laboratory screening for infectious diseases, such as Hepatitis B and the AIDS viruses.

    Abstract translation: 用于多通道分光光度计，特别是ELISA分光光度计的校准和质量保证的装置包括具有已知的第一颜色和线性增加的光密度的一系列滤光器。 根据已知的颜色和线性增加的光密度测量分光光度计的响应。 至少一种额外的颜色的附加过滤器允许检查分光光度计的颜色响应。 算法确定响应是否符合预定条件。 产生输出以提供分光光度计的校准和质量保证的记录。 本发明具有用于进行临床实验室筛查感染性疾病如乙型肝炎和艾滋病病毒的ELISA分光光度计的校准和质量保证的特殊用途。

    Sample-scanning photometer
    177.
    发明授权
    Sample-scanning photometer 失效
    采样扫描光度计

    公开(公告)号：US4580895A

    公开(公告)日：1986-04-08

    申请号：US546451

    申请日：1983-10-28

    Applicant: Shailen S. Patel

    Inventor： Shailen S. Patel

    IPC: G01N21/25 ,  G01N33/48

    CPC classification number: G01N21/253 ,  G01N2201/0446

    Abstract: An apparatus and method for reading agglutination tests and other procedures by scanning the contents of a microtest well or other sample-holding vessel to determine a certain charactersitic of the contents, such as the size of an agglutination button or other solid mass in the well.

    Abstract translation: 通过扫描微孔或其他样品保持容器的内容物来确定内容物的某些特征，例如孔中的凝集按钮或其它固体块的尺寸，来读取凝集试验和其它程序的装置和方法。

    Method of analyzing liquid samples, microplate reader and computer program
    179.
    发明授权
    Method of analyzing liquid samples, microplate reader and computer program 有权

    公开(公告)号：US11946859B2

    公开(公告)日：2024-04-02

    申请号：US17874091

    申请日：2022-07-26

    Applicant: Life Technologies Holding PTE LTD

    Inventor： Adyary Fallarero ,  Marika J. Raitio ,  Tommi Suvanto ,  Katja Eklin

    IPC: G01N21/25

    CPC classification number: G01N21/253 ,  G01N2201/0446

    Abstract: The method of analyzing absorbance of one or more liquid samples (3) arranged in the wells (2) of a microplate (1) comprises the steps of setting a desired wavelength falling within the wavelength range of 380 nm-750 nm for absorbance measurement (101), illuminating the samples (3) using electromagnetic radiation having a bandwidth of at most 20 nm around the set wavelength (102), measuring radiant flux transmitted through each sample (3) (103), on the basis of measured radiant flux values, determining an absorbance value for each sample (3) (104), and visualizing the absorbance values on a display (12) as a matrix comprising a plurality of cells (23), each cell (23) corresponding to a well (2) of the microplate (1) (105). The set wavelength is used as an input for determining the visual properties of the cells (23).

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